Association of Corticosteroid Inhaler Type with Saliva Microbiome in Moderate-to-Severe Pediatric Asthma by Amir Hossein Alizadeh Bahmani, Mahmoud I. Abdel-Aziz, Simone Hashimoto, Corinna Bang, Susanne Brandstetter, Paula Corcuera-Elosegui, Andre Franke, Mario Gorenjak, Susanne Harner, Parastoo Kheiroddin, Leyre López-Fernández, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Antoaneta A. Toncheva, Christine Wolff, Michael Kabesch, Aletta D. Kraneveld, Susanne J. H. Vijverberg, Anke H. Maitland-van der Zee, on behalf of the SysPharmPediA consortium

“…<b>Methods</b>: Saliva samples collected from 143 children (6–17 yrs) with moderate-to-severe asthma across four European countries (The Netherlands, Germany, Spain, and Slovenia) as part of the SysPharmPediA cohort were subjected to 16S rRNA sequencing. …”
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Exploring the Nuclear Chart via Precision Mass Spectrometry with the TITAN MR-TOF MS by Annabelle Czihaly, Soenke Beck, Julian Bergmann, Callum L. Brown, Thomas Brunner, Timo Dickel, Jens Dilling, Eleanor Dunling, Jake Flowerdew, Danny Fusco, Leigh Graham, Zach Hockenbery, Chris Izzo, Andrew Jacobs, Brian Kootte, Yang Lan, Stephan Malbrunot-Ettenauer, Fernando Maldonado Millán, Ali Mollaebrahimi, Erich Leistenschneider, Eleni Marina Lykiardopoulou, Ish Mukul, Stefan F. Paul, Wolfgang R. Plaß, Moritz Pascal Reiter, Christoph Scheidenberger, James L. Tracy, A. A. Kwiatkowski

“…Experimentally, exotic nuclides are challenging to address due to their low production cross-sections, overwhelming amounts of contamination, and lifetimes of typically less than a second. To this end, a Multiple-Reflection Time-of-Flight mass spectrometer at the TITAN-TRIUMF facility was built to determine atomic masses. …”
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Association of Sociodemographic Factors With Overtriage, Undertriage, and Value of Care After Major Surgery by Tyler J. Loftus, MD, Matthew M. Ruppert, MS, Benjamin Shickel, PhD, Tezcan Ozrazgat-Baslanti, PhD, Jeremy A. Balch, MD, Kenneth L. Abbott, MD, Die Hu, MS, Adnan Javed, MD, Firas Madbak, MD, Faheem Guirgis, MD, David Skarupa, MD, Philip A. Efron, MD, Patrick J. Tighe, MD, William R. Hogan, MD, Parisa Rashidi, PhD, Gilbert R. Upchurch, Jr, MD, Azra Bihorac, MD

“…Compared with controls, overtriaged admissions had a predominance of male patients (56.2% vs 43.1%, P < 0.001) and commercial insurance (6.4% vs 2.5%, P < 0.001); undertriaged admissions had a predominance of Black patients (28.4% vs 24.4%, P < 0.001) and greater socioeconomic deprivation. …”
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Hepatic Fat Content and Liver Enzymes Are Associated with Circulating Free and Protein-Bound Advanced Glycation End Products, Which Are Associated with Low-Grade Inflammation: The... by Mitchell Bijnen, Marleen M. J. van Greevenbroek, Carla J. H. van der Kallen, Jean L. Scheijen, Marjo P. H. van de Waarenburg, Coen D. A. Stehouwer, Kristiaan Wouters, Casper G. Schalkwijk

“…It is unknown if the AGE accumulation in fatty livers results in elevated circulating AGEs. In a cohort study, we investigated the association of liver fat and hepatocellular damage with circulating AGEs and soluble RAGE (sRAGE) and subsequently the association of circulating AGEs and sRAGE with LGI. …”
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mTOR downregulation promotes anti-inflammatory responses via the CCL3-CCR5 axis in hypoxic retinopathy by Tae Kwon Moon, Im Kyeung Kang, Kyoung Jin Lee, Ji Hyun Kim, Hee Jong Kim, A. Reum Han, Ha-Na Woo, Joo Yong Lee, Jun-Sub Choi, Keerang Park, Heuiran Lee

“…These findings thus highlight the potential of AAV2-shmTOR to exert anti-inflammatory effects by influencing the mTOR and subsequent CCL3-CCR5 pathways in hypoxic retinopathies, presenting a novel therapeutic approach for retinal diseases marked by hypoxia-driven inflammation.…”
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Cardiovascular Reactivity to Mental Stress and Adverse Cardiovascular Outcomes in Patients With Coronary Artery Disease by Kasra Moazzami, Samaah Sullivan, Maggie Wang, Alexis K. Okoh, Zakaria Almuwaqqat, Brad Pearce, Amit J. Shah, Yan V. Sun, Yi‐An Ko, Paolo Raggi, J. Douglas Bremner, Viola Vaccarino, Arshed A. Quyyumi

“…A total of 629 participants were included. After adjustment for demographic and traditional risk factors, a blunted hemodynamic response, a greater decrease in flow‐mediated vasodilation, and a greater degree of peripheral vasoconstriction to mental stress were all independently associated with a higher risk of adverse outcomes in both cohorts. …”
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Clostridium difficile Infection Worsens the Prognosis of Ulcerative Colitis by María E Negrón, Herman W Barkema, Kevin Rioux, Jeroen De Buck, Sylvia Checkley, Marie-Claude Proulx, Alexandra Frolkis, Paul L Beck, Levinus A Dieleman, Remo Panaccione, Subrata Ghosh, Gilaad G Kaplan

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Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing by Mikko Haapio, Andrew A. House, Massimo de Cal, Dinna N. Cruz, Paolo Lentini, Davide Giavarina, Antonio Fortunato, Luigi Menghetti, Matteo Salgarello, Andrea Lupi, Giuliano Soffiati, Alessandro Fontanelli, Pierluigi Zanco, Claudio Ronco

“…BNP rose with stress to a greater degree in patients with detectable NGAL (10.2 vs. 3.5 pg/mL, P=.03). …”
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Assessment of Physicochemical Properties of Rituximab Related to Its Immunomodulatory Activity by Mariana P. Miranda-Hernández, Carlos A. López-Morales, Nancy D. Ramírez-Ibáñez, Nelly Piña-Lara, Nestor O. Pérez, Aarón Molina-Pérez, Jorge Revilla-Beltri, Luis F. Flores-Ortiz, Emilio Medina-Rivero

“…Rituximab is a chimeric monoclonal antibody employed for the treatment of CD20-positive B-cell non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis and microscopic polyangiitis. …”
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Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L. by Zouhri Aziz, Bouddine Toufik, Menyiy Naoual El, El-Mernissi Yahya, Laaroussi Hassan, Chebaibi Mohamed, Amhamdi Hassan, Elharrak Abdelhay, Nafidi Hiba-Allah, Sitotaw Baye, Jardan Yousef A. Bin, Bourhia Mohammed, Hajji Lhoussain

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Serum α1-AT Levels and <i>SERPINA1</i> Molecular Analysis in Breast Cancer: An Experimental and Computational Study by Guadalupe Ávalos-Navarro, Luis A. Bautista-Herrera, Asbiel Felipe Garibaldi-Ríos, Ramiro Ramírez-Patiño, Marisol Gutiérrez-García, Perla Briseño-Álvarez, Luis Felipe Jave-Suárez, Emmanuel Reyes-Uribe, Martha Patricia Gallegos-Arreola

“…Background/Objectives: Breast cancer (BC) is a heterogeneous disease with multifactorial origins, including environmental, genetic, and immunological factors. …”
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Clinical confocal laser endomicroscopy for imaging of autofluorescence signals of human brain tumors and non-tumor brain by Marlen Reichenbach, Sven Richter, Roberta Galli, Matthias Meinhardt, Katrin Kirsche, Achim Temme, Dimitrios Emmanouilidis, Witold Polanski, Insa Prilop, Dietmar Krex, Stephan B. Sobottka, Tareq A. Juratli, Ilker Y. Eyüpoglu, Ortrud Uckermann

“…Therefore, we investigated the potential of a commercial confocal laser scanning endomicroscopy (CLE) system for clinical imaging of brain tumors. …”
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The Beveled Rim Technique for Labral Reconstruction by Ady H. Kahana-Rojkind, M.D., Jessica C. Keane, B.S., Yasemin E. Kingham, B.A., Roger Quesada-Jimenez, M.D., Tyler R. McCarroll, M.D., Benjamin G. Domb, M.D.

“…Arthroscopic trimming of the acetabular rim in labral reconstruction is used to create a suitable bony surface with adequate blood flow, thereby promoting the biological conditions necessary for the healing of the labrum. …”
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Reaching Syrian migrants through Dutch municipal registries for hepatitis B and C point-of-care testing. by Chrissy P B Moonen, Elfi E H G Brouwers, Christian J P A Hoebe, Nicole H T M Dukers-Muijrers, Jamila Bouchaara, Inge H M van Loo, Casper D J den Heijer

“…This study aimed to reach Syrian migrants for HBV and HCV testing using point-of-care tests (POCT). A multifaceted strategy was employed to reach Syrian migrants aged ≥16 years from two Dutch municipalities for free-of-charge HBsAg and anti-HCV POCT using finger prick blood at the regional Public Health Service. …”
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Impaired Resolution of Inflammation in the Endoglin Heterozygous Mouse Model of Chronic Colitis by Madonna R. Peter, Mirjana Jerkic, Valentin Sotov, David N. Douda, Daniela S. Ardelean, Niousha Ghamami, Flavia Lakschevitz, Meraj A. Khan, Susan J. Robertson, Michael Glogauer, Dana J. Philpott, Nades Palaniyar, Michelle Letarte

“…Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells. …”
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Using machine learning to predict outcomes following transcarotid artery revascularization by Ben Li, Naomi Eisenberg, Derek Beaton, Douglas S. Lee, Leen Al-Omran, Duminda N. Wijeysundera, Mohamad A. Hussain, Ori D. Rotstein, Charles de Mestral, Muhammad Mamdani, Graham Roche-Nagle, Mohammed Al-Omran

“…Abstract Transcarotid artery revascularization (TCAR) is a relatively new and technically challenging procedure that carries a non-negligible risk of complications. …”
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The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis by Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Sonia Santana Varela, Yagnesh Umrania, Michael J Deery, Wei Q Shi, Josué Diaz-Delgado, Francisco J Salguero, Rachel E Simmonds

“…Unbiased quantitative proteomics identified a profound effect on proteoglycans, driven by rapid loss of type II transmembrane proteins of the Golgi, including enzymes required for glycosaminoglycan (GAG) synthesis, combined with a reduction in the core proteins themselves. …”
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Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment by Mohamed E. Awad, Khaled A. Hussein, Inas Helwa, Mohamed F. Abdelsamid, Alexandra Aguilar-Perez, Ibrahim Mohsen, Monte Hunter, Mark W. Hamrick, Carlos M. Isales, Mohammed Elsalanty, William D. Hill, Sadanand Fulzele

“…A systematic review was conducted according to the guidelines of PRISMA protocol and the Cochrane Handbook for Systematic Reviews of Interventions. …”
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Updates on hosts and distribution of pepper yellow leaf curl Indonesia virus and squash leaf curl China virus in Central Java Province, Indonesia by Adyatma Irawan Santosa, Adenisa Hanifah Irbati, Geby Nandita Cahyaning Pratiwi, Antama Surwadinata, Putri Laeshita, Krisnanda Surya Dharma, Reko Saputra Jaya, Annisa Lisa Andriyani, Chilya Qurrota A'yun, Chusnu Naura Syifa Fatika

“…PepYLCIV OR924279 and OR924280 formed a subgroup with LC542629 from Bali in the phylogenetic tree constructed using MEGA11, and shared 95.8 – 96.7% identities at nucleotide (nt) and 98.4 – 99.5% at amino acid (aa) levels according to Sequence Demarcation Tool v1.2 software. …”
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Self-propelled ferroptosis nanoinducer for enhanced cancer therapy by Wenxin Xu, Hao Tian, Yanzhen Song, Hanfeng Qin, Junbin Gao, Yichi Chen, Weichang Huang, Lin Lin, Haixin Tan, Yicheng Ye, Xiaoting Zhang, Daniela A Wilson, Guang Yang, Fei Peng, Yingfeng Tu

“…Ferroptosis is a newly proposed type of programmed cell death, which has been associated with a variety of diseases including tumors. …”
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