Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat by Caroline E. Rasmussen, Jette Nowak, Julie M. Larsen, Emma Moore, David Bell, Kai Chiu Liu, Nanna Skall Sorensen, Wendela A. Kappers, Thomas Krogh-Meibom, Hanne Offenberg

“…Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the treatment of hemophilia A. …”
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Ultrasonographic Assessment of Fetal Viability in Pregnant Women with First-Trimester Bleeding at Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria by Chisolum O. Okafor, Odira C. Anajuba, Chinekwu S. Nwosu, Charles I. Okafor, Munachi O. Nwabunike, Ifeanyi O. Uzukwu, Ugochukwu A. Aguwamba, Kelechi U. Okoye, Adaobi C. Emegoakor

“…Background: Vaginal bleeding in the first trimester is a fairly common problem, which may be associated with lower abdominal pain. …”
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Aproximación al manejo del ureterocele y los desenlaces clínicos en la población pediátrica: una revisión sistemática by Ana Ma. Ortiz-Zableh, Diana L. Garzón-Correa, Andrés F. Quiñones-Roa, Ana I. López, Camila Pérez, Eliana Calderón, Víctor H. Figueroa-Arenas, Paul A. Camacho

“…Existe controversia y escasa literatura sobre las pautas de manejo del ureterocele y sus desenlaces, debido a que el abordaje varía desde procedimientos endoscópicos hasta reconstrucción completa. …”
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Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination by Anurag Maheshwari, Kris Janssens, Jeroen Bogie, Chris Van Den Haute, Tom Struys, Ivo Lambrichts, Veerle Baekelandt, Piet Stinissen, Jerome J. A. Hendriks, Helena Slaets, Niels Hellings

“…Interleukin-11 (IL-11), a member of the gp130 family of cytokines, is upregulated in MS lesions. …”
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Laboratory Rotational Spectroscopy Leads to the First Interstellar Detection of Singly Deuterated Methyl Mercaptan (CH2DSH) by Hayley A. Bunn, Silvia Spezzano, Laurent H. Coudert, Jean-Claude Guillemin, Yuxin Lin, Christian P. Endres, Brant Billinghurst, Olivier Pirali, Jes Jørgensen, Valerio Lattanzi, Paola Caselli

“…A spectroscopic catalog built from this analysis for a temperature of 125 K has led to the first interstellar detection of CH _2 DSH toward the solar-like protostar IRAS 16293-2422 B. …”
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Geology of the Michelangelo quadrangle (H12), Mercury by Salvatore Buoninfante, Valentina Galluzzi, Luigi Ferranti, David A. Rothery, Harald Hiesinger, Laura Guzzetta, Felix Prüße, Benjamin Man, Annie R. Lennox, Alistair Blance, Maurizio Milano, Pasquale Palumbo

“…The quadrangle covers almost 6.5% of the planet’s surface with a total area of almost 5 million km2. Geologic contacts and linear features were drawn at a mapping scale between 1:300,000 and 1:600,000, based on photointerpretation of MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) Mercury Dual Imaging System (MDIS) imagery. …”
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Prediction of Rooftop Photovoltaic Solar Potential Using Machine Learning by K. Mukilan, K. Thaiyalnayaki, Yagya Dutta Dwivedi, J. Samson Isaac, Amarjeet Poonia, Arvind Sharma, Essam A. Al-Ammar, Saikh Mohammad Wabaidur, B. B. Subramanian, Adane Kassa

“…In this paper, we develop a prediction of solar potential across large photovoltaic panels from the roof tops using a machine learning method. …”
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Unraveling the degradation mechanism of multiple pyrethroid insecticides by Pseudomonas aeruginosa and its environmental bioremediation potential by Hui Liu, Wen-Juan Chen, Zeling Xu, Shao-Fang Chen, Haoran Song, Yaohua Huang, Kalpana Bhatt, Sandhya Mishra, Mohamed A. Ghorab, Lian-Hui Zhang, Shaohua Chen

“…Herein, Pseudomonas aeruginosa PAO1 exhibited exceptional degradation capabilities towards a range of pyrethroid family insecticides including etofenprox, bifenthrin, tetramethrin, D-cypermethrin, allethrin, and permethrin, with a degradation efficiency reaching over 84 % within 36 h (50 mg·L-1). …”
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Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity by Said Mougari, Valérie Favède, Camilla Predella, Olivier Reynard, Stephanie Durand, Magalie Mazelier, Edoardo Pizzioli, Didier Decimo, Francesca T. Bovier, Lauren M. Lapsley, Candace Castagna, Nicole A. P. Lieberman, Guillaume Noel, Cyrille Mathieu, Bernard Malissen, Thomas Briese, Alexander L. Greninger, Christopher A. Alabi, N. Valerio Dorrello, Stéphane Marot, Anne-Geneviève Marcelin, Ana Zarubica, Anne Moscona, Matteo Porotto, Branka Horvat

“…The peptide-protected mice develop cross-reactive neutralizing antibodies against both SARS-CoV-2 used for the initial infection and recently circulating variants, and are completely protected from a second lethal infection, suggesting that they developed SARS-CoV-2-specific immunity. …”
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Corrigendum: The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis by Femke Van Gaever, Femke Van Gaever, Fleur Mingneau, Fleur Mingneau, Sam Vanherle, Sam Vanherle, Yasmine Driege, Yasmine Driege, Mira Haegman, Mira Haegman, Elien Van Wonterghem, Elien Van Wonterghem, Junhua Xie, Junhua Xie, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Jerome J. A. Hendriks, Rudi Beyaert, Rudi Beyaert, Jens Staal, Jens Staal, Jens Staal

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Early tolerance and late persistence as alternative drug responses in cancer by Simona Punzi, Davide Cittaro, Guido Gatti, Gemma Crupi, Oronza A. Botrugno, Antonino Alex Cartalemi, Alon Gutfreund, Caterina Oneto, Valentina Giansanti, Chiara Battistini, Giovanni Santacatterina, Lucrezia Patruno, Ilaria Villanti, Martina Palumbo, Daniel J. Laverty, Francesca Giannese, Alex Graudenzi, Giulio Caravagna, Marco Antoniotti, Zachary Nagel, Ugo Cavallaro, Luisa Lanfrancone, Timothy A. Yap, Giulio Draetta, Nathalie Balaban, Giovanni Tonon

“…The central regulator of mitophagy PINK1 drives this reduction in DNA repair via the cytoplasmic relocalization of the cell identity master HNF4A, thus hampering HNF4A transcriptional activation of DNA repair genes. …”
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Emerging Themes in the Ecology and Management of North American Forests by Terry L. Sharik, William Adair, Fred A. Baker, Michael Battaglia, Emily J. Comfort, Anthony W. D'Amato, Craig Delong, R. Justin DeRose, Mark J. Ducey, Mark Harmon, Louise Levy, Jesse A. Logan, Joseph O'Brien, Brian J. Palik, Scott D. Roberts, Paul C. Rogers, Douglas J. Shinneman, Thomas Spies, Sarah L. Taylor, Christopher Woodall, Andrew Youngblood

“…The 7th North American Forest Ecology Workshop, consisting of 149 presentations in 16 oral sessions and a poster session, reflected a broad range of topical areas currently under investigation in forest ecology and management. …”
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Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion by Risheng Xu, Max Wintermark, Gregory W Albers, Jeremy J Heit, Adam A Dmytriw, Adrien Guenego, Yasmin Aziz, Kambiz Nael, Benjamin Pulli, Victor Urrutia, Dhairya A Lakhani, Tobias D Faizy, Argye Hillis, Vivek Yedavalli, Dylan Wolman, Licia P Luna, Elisabeth B Marsh, Hamza Adel Salim, Janet Mei, Vaibhav Vagal, Aakanksha Sriwastwa, Raf Llinas, Hanzhang Lu, Mona N Bahouth

“…Background Acute ischaemic stroke (AIS) is a leading cause of mortality and disability globally, with volume contracted state (VCS), as indicated by an elevated blood urea nitrogen to creatinine (BUN/Cr) ratio, potentially influencing outcomes. …”
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Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrumResearch in context by Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sullivan, Yi Lu

“…Summary: Background: Psychotic major depressive disorder (MDD), a subtype of MDD characterised by psychotic symptoms that occur exclusively during mood episode, is clinically significant yet underexplored genetically due to its rarity. …”
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Estimation and Characterization of Dengue Serotypes in Patients Presenting with Dengue Fever at Makkah Hospitals by Sami Melebari, Abdul Hafiz, Hatim A. Natto, Mohamed Osman Elamin, Naif A. Jalal, Ashwaq Hakim, Safiah Rushan, Othman Fallatah, Kamal Alzabeedi, Feras Malibari, Hutaf Mashat, Aisha Alsaadi, Amani Alhakam, Anoud Hadidi, Ghazi Saad Alkhaldi, Ahmed Alkhyami, Ali Alqarni, Abdulaziz Alzahrani, Mohammed Alghamdi, Abdullah Siddiqi, Abdullah Alasmari, Rowaida Bakri, Saleh Alqahtani, Juman M. Al-Bajaly, Asim Khogeer

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Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease by Lindsey Van Haute, Petra Páleníková, Jia Xin Tang, Pavel A Nash, Mariella T Simon, Angela Pyle, Monika Oláhová, Christopher A Powell, Pedro Rebelo-Guiomar, Alexander Stover, Michael Champion, Charulata Deshpande, Emma L Baple, Karen L Stals, Sian Ellard, Olivia Anselem, Clémence Molac, Giulia Petrilli, Laurence Loeuillet, Sarah Grotto, Tania Attie-Bitach, Jose E Abdenur, Robert W Taylor, Michal Minczuk

“…Abstract Pathogenic variants in either the mitochondrial or nuclear genomes are associated with a diverse group of human disorders characterized by impaired mitochondrial function. …”
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The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis by Femke Van Gaever, Femke Van Gaever, Fleur Mingneau, Fleur Mingneau, Sam Vanherle, Sam Vanherle, Yasmine Driege, Yasmine Driege, Mira Haegman, Mira Haegman, Elien Van Wonterghem, Elien Van Wonterghem, Junhua Xie, Junhua Xie, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Jerome J. A. Hendriks, Rudi Beyaert, Rudi Beyaert, Jens Staal, Jens Staal, Jens Staal

“…IntroductionOver the past few decades, there has been a sudden rise in the incidence of Multiple Sclerosis (MS) in Western countries. …”
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Lung transplant outcomes for recipients with alpha-1 antitrypsin deficiency, by use of alpha-1 antitrypsin augmentation therapy by Atharv V. Oak, MEng, Jessica M. Ruck, MD, PhD, Alfred J. Casillan, MD, PhD, Armaan F. Akbar, BS, Ramon A. Riojas, MD, PhD, Pali D. Shah, MD, Jinny S. Ha, MD, MHS, Sara Strout, PharmD, Allan B. Massie, PhD, Dorry L. Segev, MD, PhD, Christian A. Merlo, MD, MPH, Errol L. Bush, MD

“…However, for those who require a lung transplant (LT), there is currently only limited information to guide the use of AAT augmentation therapy post-LT. …”
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Adaptation of the nutrition care process for metabolic diseases in the Mexican population by Magdalena Sevilla-González, Magdalena Sevilla-González, Magdalena Sevilla-González, Ailema González-Ortiz, Ailema González-Ortiz, María Victoria Landa-Anell, Marco A. Melgarejo-Hernández, Marco A. Melgarejo-Hernández, Ana Teresa Arias-Marroquín, Fabiola Mabel Del Razo-Olvera, Fabiola Mabel Del Razo-Olvera, Berenice Monserrat Román-Calleja, Ana Victoria Monreal-Lugo, Angélica J. Martin-Vences, Karime Haua-Navarro, Angeles Espinosa-Cuevas

“…BackgroundThe Nutrition Care Process (NCP) is a systematic framework designed to enhance the quality of nutrition care. …”
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Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes by Yong Li, Steven A Rosenberg, Paul F Robbins, Zhiya Yu, Maria Parkhurst, Billel Gasmi, Nikolaos Zacharakis, Todd D Prickett, Jared J Gartner, Sri Krishna, Stephanie L Goff, Satyajit Ray, Frank J Lowery, Sivasish Sindiri, Alakesh Bera, Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Lior Levy, Tiffany Benzine, Robert V Masi, Rafiqul Islam

“…Background Tumor-infiltrating lymphocytes (TILs) targeting neoantigens can effectively treat a selected set of metastatic solid cancers. However, harnessing TILs for cancer treatments remains challenging because neoantigen-reactive T cells are often rare and exhausted, and ex vivo expansion can further reduce their frequencies. …”
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