Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases by Pei Wen, Zhixin Sun, Dongming Yang, Jie Li, Zhiping Li, Mengyang Zhao, DongDong Wang, Fengting Gou, Jingjing Wang, Yuexin Dai, Deming Zhao, Lifeng Yang

“…Abstract Prion diseases are a group of fatal neurodegenerative disorders characterized by the abnormal folding of cellular prion proteins into pathogenic forms. …”
Get full text

Penerapan Hidden Markov Model (HMM) dan Mel-Frequency Cesptral Coefficients (MFCC) pada E-Learning Bahasa Madura untuk Anak Usia Dini by Ubaidi Ubaidi, Nindian Puspa Dewi

“…Abstract Bahasa Madura is a regional language used in Madura island. This language has many variations of pronunciation and dialect that makes it not easy to learn, even by the local people especially children. …”
Get full text

Combined induction by Cu(II) and veratrole enhances the degradation of high molecular weight polyaromatic hydrocarbons by Fusarium dlaminii ZH-H2 by Jiayuan Gao, Mingyue Qi, Xiaomin Wang, Xuan Feng, Jiahui Li, Guangwei Zhang, Shengdong Feng, Zhixin Yang, Guohui Ning

“…Transcriptome analysis revealed that the expression of 910 Fusarium genes had changed as a result of the combination treatment, with 510 up-regulated genes and 443 down-regulated genes. …”
Get full text

Balanced displacement methods and effect evaluation of heterogeneous combination flooding in different reservoirs by Dejun WU, Jian HOU, Lijie LIU, Kang ZHOU, Zhibin AN

“…Heterogeneous combination flooding further played a role in conformance control and oil displacement at different layers, enhancing the sweep effect and improving oil displacement efficiency, effectively extracting the remaining oil controlled by the interbeds. …”
Get full text

Testosterone exacerbates neutrophilia and cardiac injury in myocardial infarction via actions in bone marrow by Elin Svedlund Eriksson, Marta Lantero Rodriguez, Bente Halvorsen, Inger Johansson, Anna K. F. Mårtensson, Anna S. Wilhelmson, Camilla Huse, Thor Ueland, Pål Aukrust, Kaspar Broch, Lars Gullestad, Brage Høyem Amundsen, Geir Øystein Andersen, Mikael C. I. Karlsson, Malin Hagberg Thulin, Alessandro Camponeschi, Dana Trompet, Ola Hammarsten, Björn Redfors, Jan Borén, Elmir Omerovic, Malin C. Levin, Andrei S. Chagin, Tuva B. Dahl, Åsa Tivesten

“…Abstract Men develop larger infarct sizes than women after a myocardial infarction (MI), but the mechanism underlying this sex difference is unknown. …”
Get full text

Incidence and temporal trends of out-of-hospital cardiac arrest in Shenzhen, China (2011–2018) by Hong Zhu, Junpeng Liu, Tianqi Yang, Yan Zhang, Yanjun Xu, Yunfeng Xu, Hao Wu, Li Li, Yufeng Luo, Cai Wen, Tao Yu

“…Background: Out-of-hospital cardiac arrest (OHCA) is a significant global public health issue, few studies describe characteristics and trends in China. …”
Get full text

Evaluación del Sistema Acuapónico de Pequeña Escala para la Producción de Tilapia y Lechuga by Delia Jazmín Sánchez-Morales, Juan Enrique Rubiños-Panta, Guillermo Crespo-Pichardo, Cándido Mendoza-Pérez, Ma. de Lourdes Pérez-Ávila, Maruja Peralta-Inga, Cesar Enrique Rubiños-Hernández

“…Se concluye que este sistema de producción puede ser una alternativa viable y eficiente a implementar para una producción sustentable de peces y cultivos agrícolas al mismo tiempo.…”
Get full text

Perbandingan Metode Supervised Machine Learning untuk Prediksi Prevalensi Stunting di Provinsi Jawa Timur by M Syauqi Haris, Ahsanun Naseh Khudori, Wahyu Teja Kusuma

“…The support vector regression method in this study has a lower error value, namely 0.91 for MAE and 1.30 for MSE. …”
Get full text

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells by Ignacio Melero, Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel

“…Background Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is a dead cell-sensing receptor highly restricted to cDC1s. …”
Get full text

Epidemiology and impact of device-specific infections on patients receiving left ventricular assist devices by Amit Iyengar, MD MSE, Jason Feinman, MD, Joyce Jiang, BS, Cindy Song, BA, Spencer Kim, BA, Alvin Mathew, MD, Sophia Golec, MD, Aarti Rao, MD, Ankitha Radakrishnan, MD, Michaela Asher, MPhil, David Rekhtman, BS, John DePaolo, MD PhD, Noah Moss, MD, Shinobu Itagaki, MD, Anelechi Anyanwu, MD, Joyce Wald, DO, Marisa Cevasco, MD MPH, Aditya Parikh, MD

“…Background: Left ventricular assist device-specific infections (LSIs) remain a persistent problem facing patients with durable left-ventricular assist devices (LVADs). …”
Get full text

Risk factors associated with degenerative glenohumeral osteoarthritis by Ravi Prakash, Nitin B Jain, Ziyi Chen, Folefac D Atem, Michael S Khazzam, Rashmi Pathak, Daniel Tai, Ursa BezanPetric, Estefanie Garduno Rapp

“…Since the shoulder is not a weight-bearing joint, the BMI-GH OA link is likely molecular and systemic, warranting further investigation.Level of evidence Prognostic level III.…”
Get full text

Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2023 – cohort description, test volumes, predictors of viraemia and the road ahead by Tracy Glass, Frédérique Chammartin, Jochen Ehmer, Thomas Klimkait, Alain Amstutz, Josephine Muhairwe, Irene Ayakaka, Blaise Lukau, Jennifer Anne Brown, Lipontso Motaboli, Malebanye Lerotholi, Maurus Kohler, Kathrin Haenggi, Moliehi Mokete, Makobefo Gladys Chakela, Mpho Kao, Mathebe Kopo, Moleboheng Mokebe, Lorena Urda, Bienvenu Lengo Nsakala, Anna Klicpera, Nadine Tschumi, Niklaus Daniel Labhardt

“…Specifically, VICONEL allows for the monitoring of HIV treatment outcomes and health system performance, encompasses a biobank for further research with routinely collected blood plasma samples of consenting participants and provides a valuable framework for nested observational and interventional studies.Participants VICONEL captures routine viral load test results alongside associated demographic and treatment information among people in care for HIV in Lesotho, southern Africa. …”
Get full text

The endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses by Marianna Tolve, Janine Tutas, Ebru Özer-Yildiz, Ines Klein, Anne Petzold, Veronika J. Fritz, Melina Overhoff, Quinn Silverman, Ellie Koletsou, Filip Liebsch, Guenter Schwarz, Tatiana Korotkova, Silvana Valtcheva, Graziana Gatto, Natalia L. Kononenko

“…Summary: The loss of cerebellar Purkinje cells is a hallmark of neurodegenerative movement disorders, but the mechanisms remain enigmatic. …”
Get full text

Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section by Mathieu Di Miceli, Moïra Rossitto, Maud Martinat, Flore Marchaland, Sarah Kharbouche, Marion Graland, Farah Younes, Alexandra Séré, Agnès Aubert, Lydia Rabbaa Khabbaz, Charlotte Madore, Jean-Christophe Delpech, Rebeca Martín, Sophie Layé

“…In this study, we used a validated model of mice born by C-section (CSD), which mimics clinical observations of dysregulated gut microbiota. …”
Get full text

Implementasi Simple Additive Weight pada Sistem Pendukung Keputusan Penerima Bantuan Stimulan Perumahan Swadaya Berbasis Web di Dinas Perumahan dan Kawasan Pemukiman Kota Magelang by Eko Joko Pamungkas, Uky Yudatama, Emilya Ully Artha

“…Unfit for habitation, hereinafter abbreviated as RTLH, is a house that does not meet the requirements for building safety, minimum adequacy of building area, and occupant health. …”
Get full text

Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model by Rashedul Haque, Sajib Paul, Md. Tipu Sultan, Faizul Islam Chowdhury, Md. Kawser, Shariful Islam Nayan, S.M. Hafiz Hassan, Afsana Kabir Chowdhury, Raiyana Huda, Sauda Sumaya Dina, Sheikh Zahir Raihan

“…Oxidative stress induces renal injury, resulting in a range of problems including renal damage, renal dysfunction, and chronic kidney disease. …”
Get full text

The molecular receptor NKBB enhances the persistence and anti-hepatocellular carcinoma activity of GPC3 CAR-T cells by Minghao Sui, Tiantian Liu, Xuanli Song, Ji Li, Han Ding, Yuqian Liu, Xinyu Wang, Huimin Liu, Yuchan Xue, Jianni Qi, Miao Zhang, Songbo Zhao, Qiang Zhu

“…Therefore, to treat HCC more effectively, we connected the molecular receptor NKBB to a second-generation glypican-3 (GPC3) CAR to construct GC3328z-NKBB CAR-T cells, which have double specific targets of GPC3 and NKG2DLs (natural killer group 2, member D ligands), dual co-stimulation of CD28 and 41BB, and a single CD3ζ chain. …”
Get full text

Brain transcriptome analysis of snakehead (Channa argus) under starvation and satiation conditions and identification of differentially expressed gene response to feeding regulatio... by Xiao-yan Jin, Xiu-mei Chen, Gui-liang Guo, Li Sun, Xue-qin Wu, Yun-jie Lin, Xiao-tian Niu, Yi-di Kong, Min Li, Gui-qin Wang

“…The Channa argus (C. argus), a warm-water piscivorous fish, is an important economic breed with high nutritional value, but there are some problems such as difficulty in domestication and feeding. …”
Get full text

Subtyping Social Determinants of Health in the "All of Us" Program: Network Analysis and Visualization Study by Suresh K Bhavnani, Weibin Zhang, Daniel Bao, Mukaila Raji, Veronica Ajewole, Rodney Hunter, Yong-Fang Kuo, Susanne Schmidt, Monique R Pappadis, Elise Smith, Alex Bokov, Timothy Reistetter, Shyam Visweswaran, Brian Downer

“…For example, the Socioeconomic barriers subtype included 6 SDoH factors (eg, not employed and food insecurity) and had a significantly higher odds ratio (4.2, 95% CI 3.5-5.1; P<.001) for depression when compared to other subtypes. …”
Get full text

Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections by Xiaoyi Liu, Wenxiu Xu, Junkun Feng, Ying Wang, Kai Li, Yi Chen, Wenjun Wang, Weiwei Zhao, Shaohua Ge, Jianhua Li

“…Abstract Bacterial infections pose a significant threat to human health. Catalytic antibacterial nanoparticles that generate reactive oxygen species (ROS) are emerging, as a promising therapeutic approach in treating bacterial infection by boosting the innate immune defenses. …”
Get full text