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Optimized gene transduction in human lung organoids: A high-efficiency method for advanced research applications
Published 2025-02-01“…Abstract Human induced pluripotent stem cell (iPSC)-derived lung organoids, engineered to carry targeted genes, offer a robust platform for investigating mechanistic insights in lung research. …”
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69203
Changes in sexual activities and risky sexual behaviors during the COVID-19 pandemic: A systematic review
Published 2025-01-01“…Several studies reported changes in sexual activities during the COVID-19 pandemic. However, there is a lack of comprehensive systematic reviews in this field. …”
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69204
Understanding the nature of substance use in Zimbabwe: State of the art and ways forward: A scoping review protocol.
Published 2023-01-01“…Reports of substance use in Zimbabwe paint a concerning picture of escalating prevalence of use, with over half of people admitted to inpatient mental health units reportedly experiencing a substance induced disorder. …”
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69205
Bacterial Profile among Patients with Suspected Bloodstream Infections in Ethiopia: A Systematic Review and Meta-Analysis
Published 2020-01-01“…Globally, the emergency and raised resistance rate of bacterial antimicrobial resistance is becoming a prominent problem, and it is difficult to treat patients having sepsis. …”
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69206
Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A2 α for targeted cancer therapy
Published 2025-01-01“…Targeting their production by inhibiting Group IVA cytosolic phospholipase A2 (cPLA2α) offers a promising approach for cancer therapy. …”
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69207
Effect of Physically Realistic Potential Energy Form on Spatial Pattern Complexity in a Collective Motion Model
Published 2023-01-01“…To address this, in this paper, a collective motion model with a pairwise potential energy function that conserved the total energy and momentum of the particles was implemented. …”
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69208
A data-driven semi-parametric model of SARS-CoV-2 transmission in the United States.
Published 2023-11-01“…To support decision-making and policy for managing epidemics of emerging pathogens, we present a model for inference and scenario analysis of SARS-CoV-2 transmission in the USA. …”
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69209
A Real-Time Safe Navigation Proposal for Mobile Robots in Unknown Environments Using Meta-Heuristics
Published 2025-01-01“…Autonomous navigation in mobile robots represents a significant challenge in unknown and dynamic environments, where the need to avoid obstacles and find safe trajectories in real-time requires efficient solutions. …”
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69210
Factores asociados a la mortalidad de pacientes geriátricos graves ingresados en cuidados intensivos
Published 2020-10-01“…Introducción: La determinación de factores asociados a la mortalidad de los pacientes geriátricos graves, permite tomar las medidas que mejoren el pronóstico. …”
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69211
The effects of Thymus capitatus essential oil topical application on milk quality: a systems biology approach
Published 2025-02-01“…Our study is the first to demonstrate that a local application of 10% TCEO on cow’s quarters does not significantly alter milk quality or microbiota composition in milk and skin. …”
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69212
Reinforcement Learning-Based Autonomous Soccer Agents: A Study in Multi-Agent Coordination and Strategy Development
Published 2025-01-01“…We studied the learning progress and performance of agents taught using Q-learning in a series of experiments carried out in a simulated soccer setting. …”
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69213
Infinitely Many Solutions for a Superlinear Fractional p-Kirchhoff-Type Problem without the (AR) Condition
Published 2019-01-01“…In this paper, we investigate the existence of infinitely many solutions to a fractional p-Kirchhoff-type problem satisfying superlinearity with homogeneous Dirichlet boundary conditions as follows: [a+b(∫R2Nux-uypKx-ydxdy)]Lpsu-λ|u|p-2u=gx,u, in Ω, u=0, in RN∖Ω, where Lps is a nonlocal integrodifferential operator with a singular kernel K. …”
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69214
KL-optimal experimental design for discriminating between two growth models applied to a beef farm
Published 2015-09-01“…The paper is concerned with a problem of finding an optimal experimental design for discriminating between two competing mass growth models applied to a beef farm. …”
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69215
Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A
Published 2021-01-01“…PPARA activation inhibited DNMT1 activity and abolished methylation-mediated CDKN2A repression. Downregulation of cyclin-CDK complexes led to the restoration of CDKN2A, which caused cell cycle arrest in the G1 phase via regulation of the CDKN2A/RB/E2F pathway. …”
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69216
Severe palmoplantar keratoderma: a cutaneous complication from sub-optimally controlled type 2 diabetes
Published 2025-01-01“…Palmoplantar keratoderma (PPK), characterised by excessive epidermal thickening of the skin on the palms and/or plantar surfaces of the feet, can be hereditary or acquired. Here, we report a case of a 53-year-old woman with a history of sub-optimally controlled diabetes mellitus presenting with fevers and decreased Glasgow Coma Scale (GCS) to a tertiary hospital. …”
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69217
Endogenous Third-Degree Price Discrimination in a Supply Chain with One Common Manufacturer and Duopoly Retailers
Published 2020-01-01“…Consequently, the manufacturer designs a fixed fee contract to stimulate retailers to price discriminate and to achieve a win-win situation for them finally.…”
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Role of community health workers in type 2 diabetes mellitus self-management: A scoping review.
Published 2018-01-01“…<h4>Method</h4>The review was guided by a stepwise approach outlined in the framework for scoping reviews developed by Arksey and O'Malley. …”
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69220
Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron
Published 2025-01-01“…Abstract Serial macromolecular crystallography has become a powerful method to reveal room temperature structures of biological macromolecules and perform time-resolved studies. …”
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