Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics by Angelica Frusteri Chiacchiera, Michela Casanova, Massimo Bellato, Aurora Piazza, Roberta Migliavacca, Gregory Batt, Paolo Magni, Lorenzo Pasotti

“…Meropenem, colistin and cefotaxime susceptibility was successfully increased in terms of MIC (up to > 4-fold) and growth delay (up to 11 h) in a medium-dependent fashion. ARG repression also worked in a pathogenic strain grown in human urine, as a demonstration of CRISPRi-mediated re-sensitization in host-mimicking media. …”
Get full text

Vertisols infiltration rate and model performance evaluation of various land-use conditions during Southern Ethiopia's dry season by Edmealem Temesgen, Destaw Akil, Guchie Gulie

“…The experimental infiltration depth of the above soil conditions is measured using a double-ring infiltrometer. The research aims to figure out the field-measured infiltration rate, model infiltration rates, and basic infiltration rate, identify the impact of infiltration factors on infiltration rate, and find the best-fitted infiltration model. …”
Get full text

The degradation mechanism of multi-resonance thermally activated delayed fluorescence materials by Byung Hak Jhun, Yerin Park, Hwang Suk Kim, Ji Hye Baek, Joonghyuk Kim, Eunji Lee, Hyejin Moon, Changjin Oh, Yongsik Jung, Seunghee Choi, Mu-Hyun Baik, Youngmin You

“…The mechanism is further supported by enhanced stability observed in a deuterated MR-TADF emitter, attributed to a secondary kinetic isotope effect. …”
Get full text

Impact of Microwave Time on the Structure and Functional Properties of Glycosylated Soy 7S Globulins by Jixin Zhang, Tao Cui, Lan Zhang, Huiqing Xu, Jingguo Xu, Jun Wang

“…The results indicated that microwaving for 60 s significantly altered the structure of 7S, resulting in a more ordered protein configuration. The treated protein exhibited the largest particle size (152.3 nm), lowest polydispersity index (0.248), highest α-helix content (47.86%), and lowest β-sheet, β-turn, and random coil contents (12.33%, 16.07%, and 22.41%, respectively). …”
Get full text

Ecological study of the association between the English national vaccination programme and area deprivation inequalities in COVID-19 mortality by Clare Bambra, Adam Todd, Fiona Matthews, David Sinclair, Natalie Bennett

“…We use the 2019 edition of the Index of Multiple Deprivation, transformed into quintiles.Results Relative inequalities in age-standardised mortality rates 28 days after a positive COVID-19 test reduced substantially (from around 6.9 times higher in most deprived to least deprived to 1.2 times higher) in the 25 months after the national vaccination rollout began. …”
Get full text

Early Cessation of Breastfeeding and Determinants: Time to Event Analysis by Ebrahim Babaee, Babak Eshrati, Mehran Asadi-Aliabadi, Majid Purabdollah, Marzieh Nojomi

“…The onset of breastfeeding has a high success rate in most countries, but the time for termination of breastfeeding varies between countries. …”
Get full text

Deep learning-based prediction of HER2 status and trastuzumab treatment efficacy of gastric adenocarcinoma based on morphological features by Zhida Wu, Tao Wang, Junlin Lan, Jianchao Wang, Gang Chen, Tong Tong, Hejun Zhang

“…Results We developed a convolutional neural network (CNN) model using surgical specimens that achieved an area under the curve (AUC) value of 0.847 in predicting HER2 amplification, and achieved an AUC of 0.903 in predicting HER2 status specifically in patients with HER2 2 + expression. …”
Get full text

Evaluation of Corrosion Resistance of Corrosion Inhibitors for Concrete Structures by Electrochemical Testing in Saturated Ca(OH)2 Solutions with NaCl and Na2SO4 by Hwa Sung Ryu, Chang Gil Lim, Tae Won Kang, Seungmin Lim, Hong Tae Kim, Sang Heon Shin

“…In addition, the 4-aminobutyric acid corrosion inhibitors had the corrosion protection efficiency of 67.87–77.80%, which is a higher value than that of the inorganic nitrite corrosion inhibitor (lithium nitrite: 69.36–75.93%) and other amino acid corrosion inhibitors (diethanolamine: 35.69–39.91%; methyl diethanolamine: 66.07–69.09%).…”
Get full text

Research on Performance and Mechanism of the NH3-SCR Reaction over Fly Ash-derived Mn-Ce/Zeolite X by Weijia Ren, Qi Xin, Zhesheng Hua, Zhong Zheng, Lifeng Xiao, Shaojun Liu, Chenghang Zheng, Yang Yang

“…According to the FTIR results, the Eley-Rideal mechanism has a great influence on the reaction below 250°C, and the Brønsted acid sites adsorb a large amount of NH3, resulting in an excellent low-temperature activity. …”
Get full text

Genotypic difference in green stem disorder severity and vegetative storage protein accumulation affected by different degrees of sink limitation in soybeans [Glycine max (L.) merr... by Jiuning Zhang, Tatsuhiko Shiraiwa, Tomoyuki Katsube-Tanaka

“…In the depodding experiments over three years, a negative correlation tended to be found after 28 DAR3 between VSP accumulation and GSD severity in Th but not in Tc, suggesting that the mechanism underlying N metabolism and GSD occurrence was different between cultivars.…”
Get full text

Girişimci Liderlik Davranışının Çalışan Yaratıcılığına Etkisi by Kürşad Zorlu, Fatma Tetik

Get full text

Validity of Digital Imaging of Fiber-Optic Transillumination in Caries Detection on Proximal Tooth Surfaces by Marja-Liisa Laitala, Liina Piipari, Noora Sämpi, Maria Korhonen, Paula Pesonen, Tiina Joensuu, Vuokko Anttonen

“…The noninvasive DIFOTI method seems to offer a potential tool for everyday clinical practice. …”
Get full text

Self-assembly by anti-repellent structures for programming particles with momentum by Junghyun Bae, Jinsik Yoon, Sangmin Oh, Kibeom Kim, Hyeli Kim, Kahyun Hur, Hyesung Cho, Wook Park

“…For granular materials, however, a particle’s momentum in air leads to random collisions and the formation of disordered phases, eventually producing jammed configurations when densely packed. …”
Get full text

Sexual spores in edible mushroom: bioactive components, discharge mechanisms and effects on fruiting bodies quality by Yunting Li, Yao Feng, Yuling Shang, Heran Xu, Rongrong Xia, Zhenshan Hou, Song Pan, Li Li, Yuanyuan Bian, Jiayi Zhu, Zijian Wang, Guang Xin

“…Mature mushrooms can actively discharge spores in a process affected by light, relative humidity, and temperature. …”
Get full text

Challenges and future perspectives of sustainable supplements, functional foods, and nutrigenomics in athletic performance by Flores Naselli, Paola Sofia Cardinale, Sonya Vasto, Patrizia Proia, Sara Baldassano, Fabio Caradonna

“…Nutrition plays a key role in the lives of athletes, sustaining and enhancing sports performance by significantly influencing their performance and general well-being. …”
Get full text

Mahuang Fuzi Xixin Decoction Ameliorates Allergic Rhinitis in Rats by Regulating the Gut Microbiota and Th17/Treg Balance by Xiao Liang, Chang-Shun Liu, Xiao-Han Wei, Ting Xia, Fei-Long Chen, Qing-Fa Tang, Meng-Yue Ren, Xiao-Mei Tan

“…Mahuang Fuzi Xixin Decoction (MFXD), a Chinese traditional herbal formulation, has been used to treat allergic rhinitis (AR) in China for centuries. …”
Get full text

Stability Analysis of Host Claystone under T-M Coupling of HLW Disposal Repository in China: Experiments and Numerical Simulation by Haian Liang, Tan Tang, Longpeng Zhang, Xiaodong Liu, Shuai Liu, Ting Yang, Xinjun Cheng, Juan Zhang

“…The in-situ stress as well as the variational characteristics of ambient temperature caused by nuclide decay during HLW storage should be noticeable. A series of thermal property tests and thermo-mechanical coupled strength (T-M) tests of rock samples in the target formation are carried out. …”
Get full text

Adherence to iron deficiency interventions among pregnant women attending antenatal clinics in Ubungo municipality, Dar es Salaam, Tanzania by Glory Benjamin, Ezra J. Mrema, Nchang’wa Nhumba, Albert Burudi Wakoli, Hussein H. Mwanga

“…Abstract Background Iron deficiency anemia in pregnant women remains a public health concern despite iron deficiency interventions that have been implemented. …”
Get full text

Site-specific N-glycosylation characterization and allergenicity analysis of globulin-1 S allele from wheat by Linglin Fu, Rongrong Wang, Jinru Zhou, Chong Wang, Yanbo Wang

“…Triticum aestivum (bread wheat), a major food crop, is known as one of the “Big Eight” allergenic groups. …”
Get full text

Anaerobic fermentation slurry from kitchen waste as carbon source for wastewater treatment by CHE Dongni, ZHANG Liqiang, ZHANG Minghui, LIU Yongxia, LI Ning

“…These suggested that the H2O2 pretreatment achieved a significant improvement in the production efficiency of VFAs. …”
Get full text