Localized Drug Delivery in Different Gastrointestinal Cancers: Navigating Challenges and Advancing Nanotechnological Solutions by Hasan AM, Cavalu S, Kira AY, Hamad RS, Abdel-Reheim MA, Elmorsy EA, El-kott AF, Morsy K, AlSheri AS, Negm S, Saber S

“…As a result, localized delivery within gastrointestinal (GI) cancers is favorable in overcoming these limitations. …”
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Oleanolic Acid Cubic Liquid Crystal Nanoparticle-Based Thermosensitive Gel Attenuates Depression Symptoms in Chronic Unpredictable Mild Stress Rats by Shi Z, Wang Q, Li Q, Jia F, Xu W

“…In this study, building upon a previous formulation of OA cubic liquid crystal nanoparticles (OA-LCNP), we combined nanoparticles with a thermosensitive gel for nasal administration and investigated the pharmacological effects of OA-LCNP thermosensitive gel (OANG) on depression. …”
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Positively charged cytoplasmic residues in corin prevent signal peptidase cleavage and endoplasmic reticulum retention by Hui Li, Shijin Sun, Wenjun Guo, Lina Wang, Zihao Zhang, Yue Zhang, Ce Zhang, Meng Liu, Shengnan Zhang, Yayan Niu, Ningzheng Dong, Qingyu Wu

“…Herein, we studied the function of cytoplasmic residues in corin, a type II transmembrane serine protease in cardiovascular biology. …”
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Fertilization Induced Soil Microbial Shifts Show Minor Effects on <i>Sapindus mukorossi</i> Yield by Juntao Liu, Zhexiu Yu, Yingyun Gong, Jie Chen, Ling Zhou, Weihua Zhang, Liming Jia

“…Among the dominant groups of soil bacteria at the phylum level, the relative abundance of <i>Chloroflexi</i> showed an increase and then a decrease trend with the increase in N application. …”
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Government and farmer responses to the fall armyworm outbreak in mainland Southeast Asia by Eiichi Kusano, Nipon Poapongsakorn, Urairat Jantarasiri, Kamphol Pantakua, Cuong H. Tran, Khin Akari Tar, Khin Akari Tar, Thong Kong, Viengsavanh V. Phimphachanhvongsod, Youichi Kobori

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Investigating Smartphone-Based Sensing Features for Depression Severity Prediction: Observation Study by Yannik Terhorst, Eva-Maria Messner, Kennedy Opoku Asare, Christian Montag, Christopher Kannen, Harald Baumeister

“… BackgroundUnobtrusively collected objective sensor data from everyday devices like smartphones provide a novel paradigm to infer mental health symptoms. …”
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Evaluation of Juice Production Characteristics and Analysis of Characteristic Flavor Components of Phyllanthus emblica Fruit Varieties by Zifen ZHENG, Xiaowei CHEN, Bo ZOU, Yuanshan YU, Gengsheng XIAO, Lukai MA

“…The comprehensive ranking was 'Bingtian'>'Chipi'>'Boli'>'Baiyu'>'Lingshan No.4'>'Pingdan No.1'>'Shuijing'>'Zhishengmiao', which had a high positive correlation with the ranking results of sensory evaluation. …”
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Is routine preoperative head ultrasound screening before congenital cardiac surgery mandatory? by Shawana Farooq, Hanan Rashid Abu Hassan, Omai Mohammed AlSassi, Tarek Alfawzan, Abdullah Eltayeb, Seifeldin Mohamed, Suffura Rafique, Ghaida Mohammed Ali, Tarek Jamal Alanezi, Ali Hussain Alharbi, Brahim Tabarki, Abdullah Al Wadai

“…Conclusions The HUS showed a high percentage of abnormal findings in children with congenital heart disease; however, these findings were not necessarily correlated with the outcome. …”
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Application of quality control circle activity in improving team members' knowledge and skills for psychological care (提高心理护理学组成员心理护理知识与技能的品管圈实践)... by XU Qiong (徐琼), CHEN Ping (陈萍), LIU Wei (刘玮)

“…Objective To explore the application effect of quality control circle (QCC) activities in improvement of knowledge and practice skills for psychological care in members of a nursing team. Methods From June to October, 2021, a QCC group was established to carry out QCC activities for improving the psychological nursing knowledge and skills on the basis of the principle of spontaneity and voluntariness. …”
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The impact of dietary phosphorus levels on growth, slaughter, and digestive metabolism in growing sheep by Shoupei Zhao, Xiaojun Ni, Jia Zhou, Xiaoqi Zhao, Xiao Wen, Xiaolin Wang, Mingyu Cao, Yanfei Zhao, Chong Shao, Lianghao Lu, Yuanyuan Chen, Bao Zhang, Huaming Yang, Bai Xue, Guobo Quan

“…Forty-five sheep (30.33 ± 0.56 kg) were randomly assigned to five dietary P levels (0.40, 0.51, 0.68, 0.82, and 0.97%) over a 44-day trial, including a 14-day pre-feeding and 30-day formal trial period. …”
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Efficacy of sacubitril/valsartan among patients with chronic heart failure with reduced ejection fraction by Madiha Butt, Ayesha Niazi, Zahra Rafique, Nadia Shams, Lubna Meraj, Asma Rauf

“…Methods: This prospective simple experimental study was conducted over a 6-month duration from Feb. 1st, 2023 to July 30th, 2023 at Islamabad Medical Complex after ethical approval. …”
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Serum Level Alteration of IL-6, IL-1β, and IFN-γ in Groups of Healthy Adults with Oxidative DNA Damage in Najaf Governorate by Dhuha S. Saleh, Hayder S. Hussain, Hasan N. Al-Haidari, Samia K. Abbas, Ayaid K. Zgair, Seenaa M. Ali

“…The change in the proinflammatory cytokines (IL-6, IFN-γ, and IL-1β) levels indicates a persistent inflammatory response in the participants and may reflect immune system impairment as a consequence of exposure to long-term low-dose ionizing radiation.…”
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Characteristics of the Approximate-Optimal Training Indicators of Goalkeepers in Modern Football by Igor Doroshenko, Andrii Svatyev, Valerij Shamardin, Bogdan Khorkavyy, Daria Vaniuk, Eduard Doroshenko

“…Analysis of the competitive activity of qualified goalkeepers allows us to state that the average goalkeeper in modern football – a participant in the latest world and European championships, UEFA tournaments has the following anthropometric parameters: height – 195 ± 2 cm; weight – 90 ± 2 kg; weight-height index – 0.45 ± 0.01 c.u. …”
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City information models for optimal EV charging and energy-resilient renaissance by Zhaohui Dan, Aoye Song, Yuyu Zheng, Xinyue Zhang, Yuekuan Zhou

“…Broader context: Electric vehicles (EVs) are being increasingly adopted, particularly in China, Europe, and the United States, as they offer a cleaner alternative to conventional vehicles. …”
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Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence by Ji‐Hua Shi, Wen‐Zhi Guo, Yang Jin, Hua-Peng Zhang, Chun Pang, Jie Li, Pål‐Dag Line, Shui‐Jun Zhang

“…Abstract Background The ERBB2 oncogene hypothesis is challenged in hepatocellular carcinoma (HCC) with the conflicting evidences of human epidermal growth factor receptor 2 (HER2) overexpression. HER2 could be a new target as a treatment option for HCC as well as tumor recurrence after surgery. …”
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Season of conception and risk of hypertensive disorder during pregnancy by Yanxia Xie, Yi Mu, Peiran Chen, Yanping Wang, Xiaohong Li, Li Dai, Zheng Liu, Qi Li, Mingrong Li, Juan Liang, Jun Zhu

“…Maternal conception in spring was associated with a 10% increased risk of HDP (aOR, 1.10 [95% CI, 1.08–1.12]) compared with summer conceptions. …”
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Longitudinal DNA methylation profiles in saliva of offspring from mothers with gestational diabetes: associations with early childhood growth patterns by Teresa M. Linares-Pineda, Alfonso Lendínez-Jurado, Alberto Piserra-López, María Suárez-Arana, María Pozo, María Molina-Vega, María José Picón-César, Sonsoles Morcillo

“…Differential methylation positions (DMPs) were identified with the limma package, using a significance threshold of p < 0.01 and delta β ≥ 5%. …”
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Influence of Rapid Urbanization on Thyroid Autoimmune Disease in China by Yingchao Chen, Bing Han, Jie Yu, Yi Chen, Jing Cheng, Chunfang Zhu, Fangzhen Xia, Ningjian Wang, Yingli Lu

“…We intended to explore the relationship between rapid urbanization and HT. Methods. A total of 2946 subjects in Zhejiang Shangyu (SY) (n = 1546) and Jiangsu Nanjing (NJ) (n = 1400) were enrolled in this study. …”
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The Upregulation of IL-1&beta; Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

“…Both MMP9 and PI3K-AKT inhibitors abrogated IL-1β-induced changes.Conclusion: Our findings suggest that CDDP initiates a cascade of events starting with IL-1β release from endothelial cells. …”
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ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1 by Živa Frangež, Deborah Gérard, Zhaoyue He, Marios Gavriil, Yuniel Fernández-Marrero, Yuniel Fernández-Marrero, S. Morteza Seyed Jafari, Robert E. Hunger, Philippe Lucarelli, Shida Yousefi, Thomas Sauter, Lasse Sinkkonen, Hans-Uwe Simon, Hans-Uwe Simon, Hans-Uwe Simon, Hans-Uwe Simon

“…Autophagy is a highly conserved cellular process in which intracellular proteins and organelles are sequestered and degraded after the fusion of double-membrane vesicles known as autophagosomes with lysosomes. …”
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