Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations by Paula Climent-Cantó, Marc Subirana-Granés, Mireia Ramos-Rodríguez, Estela Dámaso, Fátima Marín, Covadonga Vara, Beatriz Pérez-González, Helena Raurell, Elisabet Munté, José Luis Soto, Ángel Alonso, GiWon Shin, Hanlee Ji, Megan Hitchins, Gabriel Capellá, Lorenzo Pasquali, Marta Pineda

“…Abstract Background Lynch syndrome (LS), characterised by an increased risk for cancer, is mainly caused by germline pathogenic variants affecting a mismatch repair gene (MLH1, MSH2, MSH6, PMS2). …”
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Clinical Characteristics and Optimization of Empirical Antimicrobial Therapy for Febrile Neutropenia in Patients With Hematologic Malignancies by Cui Y, Liu X, Feng S

“…The study aims to update and optimize empirical treatment strategies for hematological malignancy (HM) patients, a population particularly vulnerable to these evolving threats.Methods: A literature review was conducted on studies published between January 2010 and December 2023 regarding empirical treatment of FN in HM patients, focusing on pathogen characteristics, treatment regimens, and duration of therapy.Results: Approximately one-third of HM patients with FN experience fever of unknown origin (FUO), while 40– 50% have clinically documented infections (CDI), and 10– 30% present with microbiologically documented infections (MDI), with a predominance of Gram-negative bacteria (GNB). …”
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Five years comparation of efficacy and safety after ICL-V4c implantation for high and super high myopia correction by Qi Wan, Li Chen, Peiyuan He, Ran Wei, Ke Ma, Hongbo Yin, Jing Tang, Ying-ping Deng

“…Compared to baseline, we observed a significant increase in IOP at the 1-week follow-up, which decreased significantly at the one-month visit. …”
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Association between lifestyle factors and thyroid function in young sedentary euthyroid adults by Elisa Merchan-Ramirez, Guillermo Sanchez-Delgado, Lucas Jurado-Fasoli, Francisco M Acosta, Manuel Muñoz-Torres, Jose M. Llamas-Elvira, Jonatan R Ruiz

“…Purpose: The present work examines the associations of dietary habits, sedentarism, physical activity (PA) levels and sleep habits, with thyroid function in young euthyroid adults. Methods: A total of 105 young euthyroid adults participated in this cross-sectional study. …”
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Sustainable alternative of palm wine analogue from different tiger nut milk-sugar syrup blends for local production by Adindu O. Onyeodili, Gabriel I. Okafor, Chigozie F. Okoyeuzu, Onyekachukwu Chukwuebuka Nduka, Queency N. Okechukwu, Mouandhe Imamou Hassani, Szymon Juchniewicz, Katarzyna Leicht, Charles Odilichukwu R. Okpala, Małgorzata Korzeniowska, Raquel P.F. Guiné

“…Besides, tiger nut milk (Kunuaya) is among the non-alcoholic refreshing drinks with dairy appearance. A sustainable alternative could therefore emerge from blends of tiger nut milk and sugar syrup to serve a resembling role as palm wine. …”
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Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia by Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong

“…Abstract Background Gastric intestinal metaplasia (GIM) represents an important precancerous lesion in intestinal-type gastric cancer, triggered by persistent Helicobacter pylori (H. pylori) infection. In a previous study, we unveiled SlyD as a novel virulence factor of H. pylori, establishing its role in GIM induction through TPT1. …”
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Application of Nucleic Acid Reference Material for Rapid Detection of Cronobacter sakazakii (Cronobacter spp.) in Flammulina velutipes by Huandie Yang, Danyang Guo, Leilei Chen, Alexander Suvorov, Qingxin Zhou, Junhua Wang, Xiaofeng Gao, Jinyu Yang, Xiangyan Chen

“…This study has developed a kind of genomic nucleic acid reference material as a positive reference for the rapid detection of C. sakazakii in the edible fungus Flammulina velutipes. …”
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Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences by Pål Møller, Aysel Ahadova, Matthias Kloor, Toni T. Seppälä, John Burn, Saskia Haupt, Finlay Macrae, Mev Dominguez-Valentin, Gabriela Möslein, Annika Lindblom, Lone sunde, Ingrid Winship, Gabriel Capella, Kevin Monahan, Daniel D. Buchanan, D. Gareth Evans, Eivind Hovig, Julian R. Sampson

“…Colorectal cancer (CRC) carcinogenesis in carriers of pathogenic APC (path_APC) and pathogenic mismatch repair gene (path_MMR) variants is initiated by a second hit affecting the corresponding wild-type allele. …”
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T-bet+ILC3 in peripheral blood is increased in the ankylosing spondylitis with high disease activity by Yang Liu, Yi Shen, Hongbai Ding, Dongyi He, Peng Cheng, Xinyao Wu, Zheng Xiang, Lei Shen, Yanqin Bian, Qi Zhu

“…Objective: Ankylosing spondylitis (AS) is a chronic autoimmune disease characterized by systemic inflammation, often resulting in fusion of the spine and peripheral joints. …”
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Genome-wide association mapping and genomic prediction analyses reveal the genetic architecture of grain yield and agronomic traits under drought and optimum conditions in maize by Manigben Kulai Amadu, Yoseph Beyene, Vijay Chaikam, Pangirayi B. Tongoona, Eric Y. Danquah, Beatrice E. Ifie, Juan Burgueno, Boddupalli M. Prasanna, Manje Gowda

“…Abstract Background Drought is a major abiotic stress in sub-Saharan Africa, impacting maize growth and development leading to severe yield loss. …”
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Comparison of safety and effectiveness of medical adhesive and metal spring coil in preoperative localization of peripheral pulmonary nodules by Yifei Wang, Zhenhua Yue, Xiaoqian Shi, Guozhan Xia, Linlin Qin, Qi Sun, Yiling Huang, Rong Chen, Xuewei Zhao, Mingdong Wang

“…Preoperative patients were randomly divided into two groups, with 205 patients undergoing preoperative medical adhesive positioning (Group A) and 83 patients undergoing metal spring coil positioning (Group B). …”
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Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism by Simon Nicolas, Vincent Blasco‐Baque, Audren Fournel, Jerome Gilleron, Pascale Klopp, Aurelie Waget, Franck Ceppo, Alysson Marlin, Roshan Padmanabhan, Jason S Iacovoni, François Tercé, Patrice D Cani, Jean‐François Tanti, Remy Burcelin, Claude Knauf, Mireille Cormont, Matteo Serino

“…Abstract Gut microbiota dysbiosis has been implicated in a variety of systemic disorders, notably metabolic diseases including obesity and impaired liver function, but the underlying mechanisms are uncertain. …”
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Qualitative evaluation of the Rehabilitation Exercise and psycholoGical support After COVID-19 InfectioN (REGAIN) randomised controlled trial (RCT): ‘you are not alone’ by Gordon McGregor, Susanne Finnegan, Martin Underwood, Joyce Yeung, James Mason, Peter Heine, Nigel Edwards, Julie Bruce, Kate Seers, Harbinder Kaur Sandhu, Helen Atherton, Sharisse Alleyne, Katie Booth, Ranjit Lall, Vivien P Nichols, Stuart Ennis, Scott McGuire, Rachel Potter, Jessica Smith, Chen Ji, Shilpa Patel, Henry Nwankwo, Kate Evans, Susie Hennings, Alastair Canaway, Grace Lobley, David Mcwilliams, Christina Jones, Emma Padfield, David Montgomery, Beatriz Lara, Becky Haley, Francesca Denton, Bartholomew Sheehan, Mariam Ratna, Elaine Fairbrother, Zoe Noakes, Bogdan Zutic, Lee Austin, Tom Forsyth, Anne Bush, Alan Bush, Patrick Sawdon, Jonathon Prosser, Lee Tompkins, Jonathon Guck, Danielle Hale, Juwairia Said, Georgie Ray, Rowena Williams, Gail Evans, Thillini Hettiarachchi, Abeesh Panicker

“…Background This qualitative evaluation was embedded in the Rehabilitation Exercise and psycholoGical support After COVID-19 InfectioN (REGAIN) study, a randomised controlled trial (RCT) for those with post-COVID-19 condition (‘long COVID’) after hospital admission for COVID-19, comparing weekly home-based, live online supervised group exercise and psychological support sessions with ‘best practice usual care’ (a single session of advice).Objective To increase our understanding of how and why the REGAIN programme might have worked and what helped or hindered this intervention.Design A qualitative evaluation which utilised interviews with participants and practitioners delivering the intervention. …”
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Antimicrobial Activities of Polysaccharide-Rich Extracts from the Irish Seaweed <i>Alaria esculenta</i>, Generated Using Green and Conventional Extraction Technologies, Against Foo... by Ailbhe McGurrin, Rahel Suchintita Das, Arturo B. Soro, Julie Maguire, Noelia Flórez Fernández, Herminia Dominguez, Maria Dolores Torres, Brijesh K. Tiwari, Marco Garcia-Vaquero

“…A rise in antimicrobial resistance coupled with consumer preferences towards natural preservatives has resulted in increased research towards investigating antimicrobial compounds from natural sources such as macroalgae (seaweeds), which contain antioxidant, antimicrobial, and anticancer compounds. …”
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Biomimetic ECM nerve guidance conduit with dynamic 3D interconnected porous network and sustained IGF-1 delivery for enhanced peripheral nerve regeneration and immune modulation by Teng Wan, Qi-Cheng Li, Feng-Shi Zhang, Xiao-Meng Zhang, Na Han, Pei-Xun Zhang

“…The biomimetic ECM NGCs comprising a 3D interconnected porous network in a 10-mm sciatic nerve defect rat model sustain IGF-1 delivery, promoting early infiltration of macrophages and polarisation towards M2-type macrophages. …”
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Machine learning‐assisted performance analysis of organic photovoltaics by Sijing Zhong, Jiayi Huang, Hengyu Meng, Zhuo Feng, Qianyue Wang, Zhenyu Huang, Lijie Zhang, Shiwei Li, Weiyang Gong, Yusen Huang, Lei Ying, Ning Li

“…Abstract Although the power conversion efficiency of organic solar cells (OSCs) has been rapidly improved, there is still a lot of room for designing and developing new materials and their combinations to approach the efficiency limit. …”
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Regeneration of Tracheal Tissue in Partial Defects Using Porcine Small Intestinal Submucosa by Nelson Bergonse Neto, Lianna Ferrari Jorge, Julio C. Francisco, Bruna Olandoski Erbano, Barbara Evelin Gonçalves Barboza, Larissa Luvison Gomes da Silva, Marcia Olandoski, Katherine Athayde Teixeira de Carvalho, Luiz Felipe Pinho Moreira, Jose Rocha Faria Neto, Eltyeb Abdelwahid, Luiz Cesar Guarita-Souza

“…Surgical correction of tracheal defects is a complex procedure when the gold standard treatment with primary end-to-end anastomosis is not possible. …”
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Association of combined pulmonary fibrosis and emphysema in rheumatoid arthritis with high titer of rheumatoid factor and autoimmunity to the lung by Aiping Ma, Renliang Huang, Jiaxi Guo, Guangdong Wang, Heqing Huang, Xinze Li, Shan Zhong, Yan Huang, Shaowei Lin, Yikai Lin, Qiaomiao Zhou, Susanne Krauss-Etschmann, Frank Petersen, Zhanxiang Wang, Xinhua Yu, Xinhua Yu

“…This study aimed to characterize CPFE using a large cohort of consecutive RA patients and to elucidate potential risk factors associated with RA- CPFE development.MethodsA total of 976 RA patients were enrolled in this cross-sectional study to characterize RA-CPFE. …”
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Coordination Chemistry of Mixed-Donor Pyridine-Containing Macrocyclic Ligands: From Optical to Redox Chemosensors for Heavy Metal Ions by Alessandra Garau, Alexander J. Blake, Maria Carla Aragoni, Massimiliano Arca, Claudia Caltagirone, Francesco Demartin, Vito Lippolis, Giacomo Picci, Enrico Podda

“…2,8-Dithia-5-aza-2,6-pyridinophane (<b>L1</b>) has been used as a receptor unit in the construction of the conjugated redox chemosensor 5-ferrocenylmethyl-2,8-dithia-5-aza-2,6-pyridinophane (<b>L3</b>). …”
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Film Recommender System Menggunakan Metode Neural Collaborative Filtering by Ni’mah Khoiriyah Ayyiyah, Retno Kusumaningrum, Rismiyati Rismiyati

“…This study using a Collaborative Filtering prediction approach by implementing deep learning based on Neural Collaborative Filtering technology on the MovieLens dataset. …”
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