尼氟灭酸对糖尿病人血小板胞浆游离钙及聚集功能的影响 by 聂大年, 尹松梅, 谢双锋, 王晓刚, 李益清, 马丽萍, 王秀菊, 吴裕丹, 冯坚红

“…【结果】① 糖尿病人血小板聚集率为( 74.9±13.7) %, 高于正常人( P< 0.05) ; 糖尿病人的静息血小板[Ca2+]i 值、钙释放、钙內流分别为( 124.5±38.1) nmol/L、( 497.1±95.1) nmol/L、( 354.3±75.0) nmol/L, 均高于正常人(P 均< 0.05);② 尼氟灭酸及硝苯地平抑制血小板钙内流呈浓度依赖性, 半数抑制浓度( IC50) 的尼氟灭酸( 50 μmol/L) 对糖尿病人血小板钙内流的抑制率为 ( 54.7±14.5) %, 对血小板聚集率的抑制率为 ( 32.3±21.4) %; IC50 的硝苯地平(7.5 μmol/L)对糖尿病人血小板钙内流的抑制率为( 17.9±11.9) %, 对血小板聚集率的抑制率为 ( 32.3±20.4) %;③ 尼氟灭酸联合硝苯地平对糖尿病人血小板钙有抑制作用, 联合作用时尼氟灭酸对钙内流抑制率为 ( 51.9± 12.8) %; 硝苯地平对钙内流抑制率为( 12.4±8.5) % (P 均< 0.05), 两者间不存在交互效应。…”
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Characteristics and Surgical Results of Patients with Hypertrophic Obstructive Cardiomyopathy without Intrinsic Mitral Valve Diseases Undergoing Mitral Subvalvular Procedures durin... by Qiang Ji, YuLin Wang, Ye Yang, LiMin Xia, WenJun Ding, Kai Song, ChunSheng Wang

“…Comparatively, the combined group was younger (52.9 ± 11.2 years vs. 56.8 ± 11.8 years, p=0.045) and had a better New York Heart Association (NYHA) class (p=0.034) and less septal hypertrophy (16.4 ± 2.3 mm vs. 18.5 ± 3.2 mm, p<0.001). …”
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Retrospective Comparison of 27-Gauge and 25-Gauge Microincision Vitrectomy Surgery with Silicone Oil for the Treatment of Primary Rhegmatogenous Retinal Detachment by Jie Li, Bo Zhao, Sanmei Liu, Fang Li, Wentao Dong, Jie Zhong

“…Baseline and final visit best-corrected visual acuity (BCVA) were 1.9 ± 1.1 and 1.0 ± 0.8 in the 25G group, and 1.7 ± 1.0 and 1.1 ± 0.8 in the 27G group. …”
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Outcomes of minimal access retroperitoneal para-aortic lymphadenectomy in patients with locally advanced cervical cancer by Claire Newton, Radha Graham, Viola Liberale, Matthew Burnell, Usha Menon, Tim Mould, Adeola Olaitan, Nicola Macdonald, Martin Widschwendter, Kostas Doufekas, Mary McCormack, Anita Mitra, Rupali Arora, Ranjit Manchanda

“…The intra-operative and post-operative 30 day complication rates were 8.8% (CI: 4.3%, 15.7%) and 5.3% (CI: 1.9%, 11.2%) respectively.Para-aortic nodes were apparently positive on CT/MRI in 5/110 (5%) cases. …”
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Quantification of Volatile Acetone Oligomers Using Ion-Mobility Spectrometry by Tobias Hüppe, Dominik Lorenz, Felix Maurer, Tobias Fink, Ramona Klumpp, Sascha Kreuer

“…Exhaled acetone concentrations were only slightly greater in rats (10.3 ppbv; 95% CI 9.7–10.9) than in critically ill patients (9.5 ppbv; 95% CI 7.9–11.1; p<0.001). Vaporization yielded acetone monomers (1.3–5.3 mV) and dimers (1.4–621 mV). …”
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Development of a pediatric obstructive sleep apnea triage algorithm by D. S. Heath, H. El-Hakim, Y. Al-Rahji, E. Eksteen, T. C. Uwiera, A. Isaac, M. Castro-Codesal, C. Gerdung, J. Maclean, P. J. Mandhane

“…Using only tonsil size, the second algorithm had an OR to predict AT of 9.11 (sensitivity = 0.72, specificity = 0.78). The third algorithm, where MOS was used to stratify risk for AT among those children with 2+ tonsils, had the same OR, sensitivity, and specificity as the tonsil-only algorithm. …”
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Transforming Non-Digital, Clinical Workflows to Detect and Track Vision-Threatening Diabetic Retinopathy via a Digital Platform Integrating Artificial Intelligence: Implementation... by Peranut Chotcomwongse, Paisan Ruamviboonsuk, Chaiwat Karavapitayakul, Koblarp Thongthong, Anyarak Amornpetchsathaporn, Methaphon Chainakul, Malee Triprachanath, Eckachai Lerdpanyawattananukul, Niracha Arjkongharn, Varis Ruamviboonsuk, Nattaporn Vongsa, Pawin Pakaymaskul, Turean Waiwaree, Hathaiphan Ruampunpong, Richa Tiwari, Viroj Tangcharoensathien

“…The remaining 164 cases were appointed for later examination by a visiting general ophthalmologist; 11 of these 116 examined (9.5%) were referred for non-DR-related eye conditions with 81.8% (9/11) referral adherence. No system failure or interruption was found. …”
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Medication underuse in real-life practice: the impact of galcanezumab towards achieving very low frequency episodic migraine in a southeast Asian middle-income nation by Wanakorn Rattanawong, Prakit Anukoolwittaya, Akarin Hiransuthikul, Thanakit Pongpitakmetha, Auranee Trisataya, Sekh Thanprasertsuk, Alan Rapoport

“…Among 15 patients who achieved VLFEM at month 3, 81.8% (9/11) of those who received galcanezumab and 50.0% (2/4) of those who received OMPM were able to sustain VLFEM at month 6. …”
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A Risk Management Approach to Global Pandemics of Infectious Disease and Anti-Microbial Resistance by Annie Sparrow, Meghan Smith-Torino, Samuel M. Shamamba, Bisimwa Chirakarhula, Maranatha A. Lwaboshi, Christine Stabell Benn, Konstantin Chumakov

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3D nanocomposites of β-TCP-H3BO3-Cu with improved mechanical and biological performances for bone regeneration applications by Sarvesh Kumar Avinashi, Rajat Kumar Mishra, Shweta, Saurabh Kumar, Amreen Shamsad, Shama Parveen, Surajita Sahu, Savita Kumari, Zaireen Fatima, Sachin Kumar Yadav, Monisha Banerjee, Monalisa Mishra, Neeraj Mehta, Chandki Ram Gautam

“…Moreover, the mechanical study showed excellent compressive strength (188 MPa), a high Young’s modulus (2.84 GPa), and elevated fracture toughness (9.11 MPa.m1/2). An in vitro study by MTT assay on osteoblast (MG-63) cells demonstrated no or minimal cytotoxicity at the higher concentration, 100 µg/ml after 24 h and it was found a more pronounced result at 20 µg/ml on increasing the concentration of Cu nanoparticles after incubating 72 h. …”
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Impact of Nasal Anatomical Variation Subtype on Surgical Outcomes for Rhinogenic Contact Point Headache by Salvatore Lavalle, Annalisa Pace, Giuseppe Magliulo, Mario Lentini, Jerome Rene Lechien, Christian Calvo-Henriquez, Federica Maria Parisi, Giannicola Iannella, Antonino Maniaci, Daniela Messineo

“…<b>Results:</b> The surgery group showed significant reductions in VAS scores (6.02 to 2.51, <i>p</i> < 0.001) and headache frequency (9.11 to 3.04, <i>p</i> < 0.001). The medical group did not improve significantly. …”
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Antioxidant and α-glucosidase inhibitiory activity of Cercis chinensis flowers by Juanjuan Zhang, Li Zhou, Lili Cui, Zhenhua Liu, Jinfeng Wei, Wenyi Kang

“…Eight compounds, ethyl gallate (1), stearic acid (2), docosanoic acid (3), 5α-stigmast-9(11)-en-3β-ol (4), kaempferol-3-O-α-rhamnopyranoside (5), vanillic acid (6), fisetin (7), and β-sitosterol (8), were isolated and identified from CLEa and CLBu. …”
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Role of IPF genetic risk loci in post-COVID-19 lung abnormalities: a cohort study by James Johnston, Christopher Carlsten, Christopher J Ryerson, Alyson W Wong, Cameron J Hague, Julia Yang, Janice Leung, Daniel-Costin Marinescu, Aditi Shah, Darra Murphy

“…Mean age was 63±16 years, 62% were male, 31% were ever-smokers and median hospital length of stay was 9±11 days, with 23% requiring mechanical ventilation. …”
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Real-world effectiveness of Semaglutide treatment on weight loss maintenance after weight loss in patients with obesity or overweight and diabetes by Michela Del Prete, Lidia Gavazzi, Olga Eugenia Disoteo, Federico Vignati, Gianleone Di Sacco, Fabrizio Muratori

“…After 24 months, 92 patients in the IS group of therapy achieved a mW and mBMI reduction of − 15.9 ± 11.4 kg and − 5.8 ± 3.7 kg/m2. There was a mean percentage reduction of glycated hemoglobin (HBA1C) of − 1.9 ± 1.4%, − 1.5 ± 1.9%, and − 1.5 ± 1.7% after 6, 12 and 24 months in the IS group. …”
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Implicancias sobre la Adaptación de la Escala de Inteligencia para Niños de Wechsler IV (WISC-IV) en Argentina. Corrección de WISC-IV según diferentes baremos argentinos by Álvaro Muchiut, Paola Vaccaro, Marcos Pietto, Constanza Dri

“…Por lo tanto, se realizó una investigación cuantitativa no experimental, exploratoria- descriptiva, con el objetivo de determinar la importancia de contar con baremos adaptados de la WISC-IV para diferentes regiones de un mismo país; para ello, se analizaron comparativamente los índices obtenidos por 520 escolares de 6 a 14 años (agrupados según los rangos de edad 6-8, 9-11 y 12-14) al aplicar dos baremos argentinos (Buenos Aires y Resistencia) para su corrección mediante un análisis de ANOVA mixto. …”
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Equivalent experimental study on rock breaking of SC-CO2 and industrial emulsion explosive by Nan JIANG, Yingkang YAO, Bin ZHU, Xuedong LUO

“…The combined vibration velocity at industrial explosive blasting points is 9–11 times higher than at SC-CO2 rock breaking points. …”
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Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications by Brix ATH, Petersen TG, Nymark T, Schmal H, Lindberg-Larsen M, Rubin KH

“…For pneumonia, it was 10.5% (CI 7.1– 13.9) in women and 14.9% (11.6– 18.2) in men.Conclusion: We observed an increased mortality in the month following MLEA, which remained elevated for years compared to the matched unamputated cohort. …”
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What’s Going On With Me and How Can I Better Manage My Health? The Potential of GPT-4 to Transform Discharge Letters Into Patient-Centered Letters to Enhance Patient Safety: Prospe... by Felix Eisinger, Friederike Holderried, Moritz Mahling, Christian Stegemann–Philipps, Anne Herrmann–Werner, Eric Nazarenus, Alessandra Sonanini, Martina Guthoff, Carsten Eickhoff, Martin Holderried

“…A qualitative analysis based on Bloom’s taxonomy revealed that learning objectives in the “Understand” category (9/11) were more frequently omitted than those in the “Remember” category (2/11). …”
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General practitioner-centered rural obesity management: Design, protocol and baseline data of the German HAPpEN pragmatic trial by Marika Haderer, Reiner Hofmann, Tina Bartelmeß, Laura König, Constanze Betz, Mirna Al Masri, Alisa Bader, Natascha von Schau

“…Results: The baseline cohort (mean age: 46.9 ± 11.8 years, 74.1 % female) exhibited high obesity rates (mean BMI: 40.1 ± 6.1 kg/m2), with 48.5 % classified as grade III obese. …”
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Late Miocene Tapiridae from Vallès-Penedès Basin (NE Iberian Peninsula): taxonomic and paleoenvironmental implications by Luca Pandolfi, Sara G. Arranz, Sergio Almécija, Jordi Galindo, Àngel H. Luján, Marta Pina, Alessandro Urciuoli, Isaac Casanovas-Vilar, David M. Alba

“…Here, we describe new material from three Vallesian (Late Miocene) sites of the Vallès-Penedès Basin (NE Iberian Peninsula): Creu de Conill 20 (CCN20; earliest MN9, 11.2 Ma), Can Llobateres 1 (CLL1; earliest MN10, 9.8 Ma), and Can Gambús-Illeta 5 (CGS-I5; MN10, 9.7–9.1 Ma). …”
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