Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1,7-Heptadiamine in the Formation of Bis-Isoquinolinones by Varadhan Krishnakumar, Kesarla Mohan Kumar, Badal Kumar Mandal, Fazlur-Rahman Nawaz Khan

“…The diversified bis-isoquinolinones were obtained in two steps, utilizing homophthalic acid and various acid chlorides providing 3-substituted isocoumarins in the first step which on further condensation with 1,7-heptadiamine involving C–N bond formation from the lactone in the presence of 10 mol% zinc oxide nanoparticles (ZnO NPs) (<150 nm) afforded the desired bis-isoquinolinones in high yield and purity. …”
Get full text

The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice by Irene Santos-García, Pablo Bascuñana, Mirjam Brackhan, María Villa, Ivan Eiriz, Thomas Brüning, Jens Pahnke

Subjects: Get full text

Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist by Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

“…We hypothesized that: (1) applying melanoma-derived peptides topically, in proximity to LC, could be immunogenic and safe, with low vaccine-site toxicity and (2) topical toll-like receptor 7 (TLR7) agonist would increase immunogenicity of the peptide vaccine.Methods Twelve melanoma peptides plus a tetanus helper peptide were combined with granulocyte macrophage colony stimulating factor (GM-CSF) and were administered topically on days 1, 8, and 15, to 28 patients randomized to one of four adjuvant preparations: (1) incomplete Freund’s adjuvant (IFA); (2) IFA plus a TLR7 agonist (imiquimod) administered on days 0, 7, 14; (3) dimethyl sulfoxide (DMSO) or (4) DMSO+ imiquimod administered on day 0, 7, 14. …”
Get full text

Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide by Martin Javorský, Eva Babjaková, Lucia Klimčáková, Zbynek Schroner, Jozef Židzik, Mária Štolfová, Ján Šalagovič, Ivan Tkáč

“…Previous studies showed associations between variants in TCF7L2 gene and the therapeutic response to sulfonylureas. …”
Get full text

Comprehensive analysis of ESCRT transcriptome-associated signatures and identification of the regulatory role of LMO7-AS1 in osteosarcoma by Shibing Zhao, Dasheng Tian, Fei Huang, Lei Wang, Jinhao Cheng, Zhitao He, Qitian Shen, Shuai Liang, Deliang Gong, Jun Liu, Chengfeng Yi, Chun Zhang, Erbao Bian, Juehua Jing, Tao Wang

“…First, we built a prognostic signature using 7 ESCRT-related genes (ERGs) to predict OS patient prognosis. …”
Get full text

Structure Design and Kinematics Simulation of a Novel 7-DOF Upper Limb Rehabilitation Exoskeleton Robot by Tongtong Zhao, Yue Zhang, Gangsheng Cao, Chunming Xia

“…Aiming at the existing problems of rehabilitation robots in passive rehabilitation training for patients with severe upper limb hemiplegia， a novel 7-DOF upper limb exoskeleton robot is proposed， and a new hand fixator is designed to replace the grip of the traditional exoskeleton to better achieve the effective wrist training for patients with severe upper limb hemiplegia. …”
Get full text

ADAPTATION TO CLIMATE CHANGE IN CULTIVATION OF RESIDENTS IN DALAT CITY, LAMDONG PROVINCE: CASE STUDY IN WARD 7 by Phạm Hồng Hải

“…This paper contributes to an initial assessment of some of the manifestations of climate change in Dalat city and its impact on crop production in the area of Ward 7, as well as how households respond to climate change. …”
Get full text

Roles of Copper Transport Systems Members in Breast Cancer by Yichang Chen, Chen Li, Mengxin Li, Bing Han

Subjects: “…ATP7A and ATP7B…”
Get full text

KİLİS 7 ARALIK ÜNİVERSİTESİ ÖĞRENCİLERİNİN KİLİS EKONOMİSİNE KATKISI: 2011-2012 EĞİTİM-ÖĞRETİM YILI ÖRNEĞİ by Abdullah Soysal, Sumru Bakan, Mehmet Özçalıcı, Yunus Kaymaz, Cevat Söylemez

Subjects: Get full text

EIF4A3-induced circ_0022382 promotes breast cancer cell progression through the let-7a-5p/PI3K/AKT/mTOR signaling pathway and SLC7A11 axis by Wei Liu, Wei Liu, Jun Zhang, Jiawen Zhang, Yu Ye, Jianqin Zhu, Qiwen Yu, Tao Li, Tao Li, Xiaochun Sun, Huabiao Chen, Huabiao Chen

Subjects: Get full text

Cost-effective whole-cell biosynthesis of ursodeoxycholic acid using engineered Escherichia coli with a multienzyme cascade by Xue Zhang, Xue Zhang, Jiagang Xin, Mengyu Liu, Mengyu Liu, Yue Zhang, Yue Zhang, Haoni Luan, Haoni Luan, Wei Feng, Wei Feng, Fei Wang, Fei Wang, Wei Xu, Wei Xu, Peng Song, Peng Song

Subjects: Get full text

Dış Ticaretin Bölgesel Rekabetteki Yeri: Sivas Örneği by Nevzat Balıkçıoğlu

Subjects: “…tr 7 central anatolia region…”
Get full text

Esters of quinoxaline-7-carboxylate-1,4-di-N-oxide as Trichomonas vaginalis triosephosphate isomerase inhibitors by Palos Isidro, Moo-Puc Rosa, Vique-Sánchez José Luis, Benítez-Cardoza Claudia G., Monge Antonio, Villalobos-Rocha Juan Carlos, Paz-Gonzalez Alma D., Rivera Gildardo

“…In this work, esters of quinoxaline-7-carboxylate-1,4-di-N-oxide (EQX-NO) were evaluated in in vitro assays as novel trichomonicidal agents. …”
Get full text

Effective strategies for controlling physical fitness in 7-8 year old tennis players for optimal health and performance by Oleg Shevchenko, Marina Jagiello

“…The purpose of this article is to provide effective strategies for controlling physical fitness in 7-8 year old tennis players to promote optimal health and performance. …”
Get full text

Nanning Automatic Flow Regime Forecasting and Reporting System and Its Role in 01·7Flood on Yongjiang River by 张祖汉, 黄立爵

Get full text

Identification of lethality-related m7G methylation modification patterns and the regulatory features of immune microenvironment in sepsis by Dan Wang, Rujie Huo, Lu Ye

Subjects: Get full text

KLEBSIELLA PNEUMONIAE NECROTIZING FASCIITIS OF THE LOWER EXTREMITY IN A 7-MONTH-OLD MALE: A CASE REPORT by Marelno Zakanito, Iswinarno Doso Saputro

“…Case Illustration: A 7-month-old male presented with large areas over both left and right inferior side of the lower limbs to the emergency department of Dr. …”
Get full text

Biological characterization of novel Escherichia coli O157:H7 phages and their bacteriostatic effects in milk and pork by Qinghai Ren, Qinghai Ren, Qinghai Ren, Zhiwei Wang, Yichen Ge, Yucui Huang, Wei Zhang, Chunxue Liu, Yubao Li, Shengliang Cao

Subjects: “…Escherichia coli O157:H7…”
Get full text

小鼠肝脏特异性表达载体ALB-ATP7B的构建

“…［目的 l 构建人肝豆状核变性病ATP7B基因野生型及常见突变型的小鼠肝脏特异性表达载体 ALB-ATP7B, 为制备转基因小鼠及相关基因治疗作准备。…”
Get full text

Differential between Protein and mRNA Expression of CCR7 and SSTR5 Receptors in Crohn's Disease Patients by Nathalie Taquet, Serge Dumont, Jean-Luc Vonesch, Didier Hentsch, Jean-Marie Reimund, Christian D. Muller

“…The aim of the present study was to explore if mRNA over-expression of SSTR5 and CCR7 found in CD patients could be correlated to respective protein expression. …”
Get full text