The Patient-Reported Outcomes Thermometer–5-Item Scale (5T-PROs): Validation of a New Tool for the Quick Assessment of Overall Health Status in Painful Rheumatic Diseases by Fausto Salaffi, Marco Di Carlo, Marina Carotti, Sonia Farah

“…To investigate the construct validity, reliability (internal consistency and retest reliability), and feasibility of the patient-reported outcomes thermometer–5-item scale (5T-PROs), a new tool to measure overall health status in patients with painful chronic rheumatic diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), axial spondyloarthritis (axialSpA), and fibromyalgia (FM). …”
Get full text

EQ-5D-5L and SF-6Dv2 utility scores in people living with chronic low back pain: a survey from Quebec by Thomas G Poder, Liang Wang, Nathalie Carrier

“…Objective To describe how chronic low back pain (CLBP) impacts on utility scores and which patients’ characteristics most affect these scores in the province of Quebec.Settings Province of Quebec, Canada.Participants 569 adult patients with CLBP.Methods and outcomes An online survey on low back pain was conducted between October 2018 and January 2019. The EuroQol Five Dimensions (EQ-5D-5L) and the Short Form Six Dimensions version 2 (SF-6Dv2) are two generic preference-based measures used to evaluate health-related quality of life (HRQoL) and provide quality-adjusted life-year utility values.Results The number of subjects who agreed to participate was 610, but 41 were excluded because 8 had low back pain for less than 3 months and 33 did not start the survey. …”
Get full text

Critical Care Management for Novel 2019 SARS-CoV-2 and HCoV-NL63 Coinfection in a Young Immunocompromised Patient: A Chicago Experience by Alejandro Sanchez-Nadales, Miguel Treminio-Quezada, Hasan Abad, Jessica Navarro-Motta, Pamela Contreras-Chavez, Anil Kachru, Chae Chu

“…Background. SARS-CoV-2 is a newly emerged virus that has spread rapidly, exhibiting tremendous morbidity and mortality. …”
Get full text

In Situ Carbon Coated LiNi0.5Mn1.5O4 Cathode Material Prepared by Prepolymer of Melamine Formaldehyde Resin Assisted Method by Wei Yang, Haifeng Dang, Shengzhou Chen, Hanbo Zou, Zili Liu, Jing Lin, Weiming Lin

“…Carbon coated spinel LiNi0.5Mn1.5O4 were prepared by spray-drying using prepolymer of melamine formaldehyde resin (PMF) as carbon source of carbon coating layer. …”
Get full text

ASSIMILATION OF PRODUCTION OF THERMO-MECHANICALLY HARDENED REINFORCING BAR WITH EFFECTIVE AND ECONOMICAL CUT, EQUIVALENT DIAMETER 5,5—8,0 mm and 500 H/mm2 by V. A. Matochkin, V. V. Savinkov, A. V. Gontaij, V. I. Shcherbakov

Get full text

Operando real-space imaging of a structural phase transformation in the high-voltage electrode Li x Ni0.5Mn1.5O4 by Yifei Sun, Sunny Hy, Nelson Hua, James Wingert, Ross Harder, Ying Shirley Meng, Oleg Shpyrko, Andrej Singer

“…By leveraging operando Bragg Coherent Diffractive Imaging (BCDI), we investigate the discontinuous phase transformation in Li x Ni0.5Mn1.5O4 within an operational Li metal coin cell. …”
Get full text

Differences between Influenza H5N1, A/H1N1 2009, and SARS-CoV-2 in a pandemic risk scenario by Pablo I. Plaza, Sergio A. Lambertucci

Get full text

Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer—results from the FIRE‐4.5 study by Susanne Klein‐Scory, Alexander Baraniskin, Wolff Schmiegel, Thomas Mika, Roland Schroers, Swantje Held, Kathrin Heinrich, David Tougeron, Dominik P. Modest, Ingo Schwaner, Jan Eucker, Rudolf Pihusch, Martina Stauch, Florian Kaiser, Christoph Kahl, Meinolf Karthaus, Christian Müller, Christof Burkart, Sebastian Stintzing, Volker Heinemann

“…The randomized FIRE‐4.5 (AIO KRK0116) trial compared first‐line therapy with FOLFOXIRI (folinic acid, fluorouracil, oxaliplatin, and irinotecan) plus either cetuximab or bevacizumab in B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) V600E‐mutant metastatic colorectal cancer (mCRC) patients. …”
Get full text

Reduced Presence of SARS-CoV-2 microRNA-like Small RNA in the Serum of Patients with Post-Acute Sequelae SARS-CoV-2 Infection by Maria Alfreda Stincarelli, Isabella Abbate, Giulia Matusali, Michele Tanturli, Marta Camici, Rosaria Arvia, Elisabetta Lazzari, Eleonora Cimini, Alessandra Vergori, Fabrizio Maggi, Simone Giannecchini

Subjects: “…SARS-CoV-2…”
Get full text

Modeling the Saddle-like GeV–TeV Spectrum of HESS J1809–193: Gamma Rays Arising from Reverse-shocked Pulsar Wind Nebula? by Jiaxu Sun, Yang Chen, Yiwei Bao, Xiao Zhang, Xin Zhou

“…Thus, the combination of contributions from these two populations of electrons naturally reproduces the saddle-like SED of HESS 1809–193 and J1810.3–1925e from 5 GeV to 30 TeV, together with the spectral hardening around 100 GeV. …”
Get full text

Measurement of multidifferential cross sections for dijet production in proton–proton collisions at $$\sqrt{s} = 13\,\text {Te}\hspace{-.08em}\text {V} $$ s = 13 Te V by CMS Collaboration

“…Abstract A measurement of the dijet production cross section is reported based on proton–proton collision data collected in 2016 at $$\sqrt{s}=13\,\text {Te}\hspace{-.08em}\text {V} $$ s = 13 Te V by the CMS experiment at the CERN LHC, corresponding to an integrated luminosity of up to 36.3 $$\,\text {fb}^{-1}$$ fb - 1 . …”
Get full text

...ISBN 978-80-87341-57-5. ... by Jan Krčál

Get full text

Influence of Al addition on the thermal stability and mechanical properties of Fe76.5-xCu1Si13.5b9Alx amorphous alloys by Sun Y.Y., Song M.

“…This paper fabricated Fe76.5-xCu1Si13.5B9Alx (x=0,1,2,3,5,7 at.%) amorphous ribbons using singleroller melt-spinning method. …”
Get full text

Harald SKALA, Zapomenuté obrazy ze zámku v Lipové, Děčín, Oblastní muzeum v Děčíně 2024, 143 s. ISBN 978-80-88481-07-2. by Ivana Austová

Get full text

Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5’ untranslated region by Zhichao Tang, Shalakha Hegde, Siyuan Hao, Manikandan Selvaraju, Jianming Qiu, Jingxin Wang

“…In this report, we discovered a series of coumarin derivatives that bind to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome. To locate the binding site, we developed a sequencing-based method namely cgSHAPE-seq, in which an acylating probe was directed to crosslink with the 2’-OH group of ribose at the binding site to create read-through mutations during reverse transcription. cgSHAPE-seq unambiguously determined a bulged G in SL5 as the primary binding site, which was validated through mutagenesis and in vitro binding experiments. …”
Get full text

In silico analysis of the effect of HCV genotype-specific polymorphisms in Core, NS3, NS5A, and NS5B proteins on T-cell epitope processing and presentation by Samina Baig, Samina Baig, Assel Berikkara, Ramsha Khalid, Syed A. Subhan, Tanveer Abbas, Syed Hani Abidi

“…Therefore, this study employed several in silico methods to examine the impact of genotype/subtype-specific polymorphisms in Core, NS3, NS5A, and NS5B sequences on T cell epitope processing and HLA-epitope interactions.MethodsFor this study, 8,942, 17,700, 14,645, and 3,277 HCV Core, NS3, NS5A, and NS5B sequences, respectively, from eight genotypes and 21 subtypes were retrieved from the Los Alamos HCV Database. …”
Get full text

A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo. by Nadeene E Riddick, Emilia A Hermann, Lamorris M Loftin, Sarah T Elliott, Winston C Wey, Barbara Cervasi, Jessica Taaffe, Jessica C Engram, Bing Li, James G Else, Yingying Li, Beatrice H Hahn, Cynthia A Derdeyn, Donald L Sodora, Cristian Apetrei, Mirko Paiardini, Guido Silvestri, Ronald G Collman

“…SIVsmm primary isolates infected both homozygous mutant and wild-type PBMC in a CCR5-independent manner in vitro, and Envs from both CCR5-null and wild-type infected animals used CXCR6, GPR15 and GPR1 in addition to CCR5 in transfected cells. …”
Get full text

Crystal structure of (2-(1-hydroxyheptyl)octahydro-8aH-chromene-5,8,8a-triol), C16H30O5 by Wang Guangdi, Qian Shihao, Yan Sun, Wen Tingchi

“…C16H30O5, monoclinic, P21 (no. 4), a = 5.6814(5) Å, b = 13.0181(12) Å, c = 22.833(2) Å, β = 96.473(2)°, V = 1677.9(3) Å3, Z = 4, R gt(F) = 0.0508, wRref (F 2) = 0.1346, T = 296(2) K.…”
Get full text

Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. by Bryce M Warner, Robert Vendramelli, Amrit S Boese, Jonathan Audet, Nikesh Tailor, Courtney Meilleur, Nathan Glowach, Marnie Willman, Thang Truong, Estella Moffat, Kevin Tierney, Beata Kosak, Irfan Dhanidina, Jarret Engstrom, Bozena Korczak, Ian McGowan, Carissa Embury-Hyatt, Darwyn Kobasa

“…Here we evaluated whether OB-002, an analog of human CCL5 and a potent antagonist of CCR5, provides therapeutic benefit in SARS-CoV-2 infected Syrian hamsters. …”
Get full text

In Vivo Biodistribution and Lifetime Analysis of Cy5.5-Conjugated Rituximab in Mice Bearing Lymphoid Tumor Xenograft Using Time-Domain Near-Infrared Optical Imaging by Stefania Biffi, Chiara Garrovo, Paolo Macor, Claudio Tripodo, Sonia Zorzet, Erika Secco, Francesco Tedesco, Vito Lorusso

“…Herein we report the conjugate of rituximab with the near-infrared (NIR) fluorophore Cy5.5 (RI-Cy5.5) as a tool for in vitro, in vivo, and ex vivo NIR time-domain (TD) optical imaging. …”
Get full text