Deciphering the safeguarding role of cysteine residues in p53 against H2O2-induced oxidation using high-resolution native mass spectrometry by Manuel David Peris-Díaz, Artur Krężel, Perdita Barran

“…Our approach has found that two reactive cysteines in p53 protect against H2O2-induced oxidation by forming reversible sulfenates.…”
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Butyric acid alleviates LPS-induced intestinal mucosal barrier damage by inhibiting the RhoA/ROCK2/MLCK signaling pathway in Caco2 cells. by Luqiong Liu, Tong Chen, Zhenrong Xie, Yongjin Zhang, Chenglu He, Yongkun Huang

“…Given that the Ras homolog gene family, member A (RhoA)/Rho-associated kinase 2 (ROCK2)/Myosin light chain kinase (MLCK) signaling pathway is crucial for maintaining the permeability of the intestinal epithelium, we further investigated whether BA exerts a protective effect on epithelial barrier function by inhibiting this pathway in LPS-induced Caco2 cells. …”
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Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole by Shiv K. Gupta, P. K. Sharma, M. Bansal, B. Kumar

“…New series of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. …”
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Total Ionizing Dose Effects of Si Vertical Diffused MOSFET with SiO2 and Si3N4/SiO2 Gate Dielectrics by Jiongjiong Mo, Xuran Zhao, Min Zhou

“…The total ionizing dose irradiation effects are investigated in Si vertical diffused MOSFETs (VDMOSs) with different gate dielectrics including single SiO2 layer and double Si3N4/SiO2 layer. Radiation-induced holes trapping is greater for single SiO2 layer than for double Si3N4/SiO2 layer. …”
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A 22% Efficient Semiconductor/Liquid Junction Solar Cell—the Photoelectrochemical Behavior of n-WSe2 Electrodes in the Presence of I2/I- in Aqueous Electrolyte by G. Campet, C. Azaiez, F. Levy, H. Bourezc, J. Claverie

“…Both electrodes are immersed in a 2M KI + 0.005M I2 aqueous electrolyte. The calculations of the main physical parameters determining the high value (22%) of the visible light-to-electrical energy conversion efficiency have been carried out. …”
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Deficiency of purinergic P2Y2 receptor impairs the recovery after renal ischemia-reperfusion injury and accelerates renal fibrosis and tubular senescence in mice by Kyuho Jeong, Jihyun Je, Theodomir Dusabimana, Jacques Karekezi, Tatang Aldi Nugroho, Edvard Ntambara Ndahigwa, Hyun Joon Kim, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park

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Rh(III)-Catalyzed Double Annulation of 3-Phenyl-1,2,4-oxadiazoles with 2-Diazo-1,3-diketones: Access to Pyran-Fused Isoquinolines by Enshen Zhang, Mei Sun, Lvlv Gao

“…Efficient access to pyranoisoquinoline derivatives via rhodium-catalyzed double C-H functionalization of phenyl oxadiazoles and diazo compounds has been developed. Two C-C bonds and one C-O and C-N bond formation was realized by this tandem reaction, along with the formation of two heterocycles, affording diversified pyran-fused isoquinolines in moderate to good yields with broad functional group tolerance under mild reaction conditions.…”
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Application of Gel Method Ba2TiSi2O8 Ferroelectric Thin Film in Contemporary Handicraft Three-Dimensional Fiber Art Works by Zhe Li

“…This article aims to explore the application analysis of the gel method Ba2TiSi2O8 ferroelectric thin film in contemporary handicraft three-dimensional fiber art works. …”
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Solid state interactions in the systems CaO(CaCO3)-Fe2O3 and CuFe2O4-CaO by Boyanov B.S.

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Navigating Industrial Action: The Guidance for Medical Students During Resident Doctor Strikes in England [version 2; peer review: 2 approved, 1 approved with reservations] by Hannah Okechukwu, Shonnelly Novintan

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Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…Microglial purine sensing and motility capacities, regulated by P2RY12/P2RY13, displayed age-related alterations. …”
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Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke by Xi-chen Yang, Ya-ju Jin, Rong Ning, Qiu-yue Mao, Peng-yue Zhang, Li Zhou, Cheng-cai Zhang, Yi-chen Peng, Na Chen

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Enhanced Hydrogen Production over C-Doped CdO Photocatalyst in Na2S/Na2SO3 Solution under Visible Light Irradiation by Quan Gu, Huaqiang Zhuang, Jinlin Long, Xiaohan An, Huan Lin, Huaxiang Lin, Xuxu Wang

“…The results indicated that the H2 production was due to the existence of CdS and the enhancement of visible light photocatalytic activity of H2 production was originated from the doping of carbon into the CdO lattice. …”
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Synthesis of Mannich N-bases based on benzimidazole derivatives using SiO2OAlCl2 catalyst and their potential as antioxidant, antibacterial, and anticancer agents by Antonius Herry Cahyana, Ikrimah Desta, Laely Amaliyah, Aida Nadia, Hilna Diana Sahaya, Dicky Annas, Bayu Ardiansah, Mohammad Jihad Madiabu, Inda Mapiliandari, Kang Hyun Park

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Research note: The critical role of the interaction between Eimeria tenella invasion protein RON2 and host receptor annexin A2 in mediating parasite invasion by Junli Ni, Xiangjie Chen, Yunyun Sun, Yibin Zhu, Haiming Cai, Yongle Song, Minna Lv, Juan Li, Shenquan Liao, Nanshan Qi, Mingfei Sun, Jianfei Zhang, Youfang Gu, Xinchao Liu, Xuhui Lin

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Enhanced antitumor efficacy of STING agonist MSA-2 by lipid nanoparticles delivering circular IL-23 mRNA and platinum-modified MSA-2 combination by Tian He, Yating Li, Weiqi Li, Muqing Zhang, Guishuan Wang, Peng Zhou, Guoqi Song, Wenqing Li

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P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion by Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Vanessa Figliuolo, Claudia Lucia Martins Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva

“…Damage-associated molecular patterns (DAMPs) such as UTP and ATP are released from infected cells and, once in the extracellular medium, activate P2 purinergic receptors. P2Y2 and P2X7 receptors cooperate to control Leishmania amazonensis infection. …”
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Impact of type 2 diabetes variants identified through genome-wide association studies in early-onset type 2 diabetes from South Indian population by Samuel Liju, Manickam Chidambaram, Viswanathan Mohan, Venkatesan Radha

Subjects: “…early-onset type 2 diabetes…”
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TECHNIQUE AND TECHNOLOGY OF PRODUCTION OF TWO-LAYER ROLLED WIRE SPIRAL CONSTRUCTIONS 2+7 AND 3+9 WITH DIFFERENT STEPS OF DISCHARGING BY LAYS IN ONE TECHNOLOGICAL OPERATION by Ju. L. Hudolej

“…The way of the production of steel wire cord of the two-layer spiral constructions with the different lay paces in one technological operation, developed at RUP ''BMZ”, is presented. …”
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In silico molecular docking and molecular dynamic simulation of agarwood compounds with molecular targets of Alzheimer’s disease  [version 2; peer review: 2 approved, 1 not approved] by Tewin Tencomnao, Krishna Swamy V. K. D, Prem Kumar Borugadda, Vishwambar Vishnu Bhandare, Vishal S. Patil, Phaniendra Alugoju

“…Additionally, ADMET (absorption, digestion, metabolism, excretion, and toxicity) properties were predicted using ADMETlab 2.0. Computational methods such as AutoDock Vina and molecular dynamic (MD) simulations were employed for the docking of 41 selected agarwood compounds with AD-related molecular targets. …”
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