Altered Viral Replication and Cell Responses by Inserting MicroRNA Recognition Element into PB1 in Pandemic Influenza A Virus (H1N1) 2009 by Xiaoyue Shen, Wenkui Sun, Yi Shi, Zheng Xing, Xin Su

“…Engineering mutant viruses by inserting cell-specific miRNA recognition element (MRE) into viral genome may alter viral infectivity and host responses in vital tissues and organs infected with pandemic influenza A virus (H1N1) 2009 (H1N1pdm). Methods. In this study, we employed reverse genetics approach to generate a recombinant H1N1pdm with a cell-specific miRNA target sequence inserted into its PB1 genomic segment to investigate whether miRNAs are able to suppress H1N1pdm replication. …”
Get full text

Allelic diversity of the <i>FaOMT</i> gene (mesifurane biosynthesis) in promising strawberry cultivars and selected forms developed at the I.V.... by A. S. Lyzhin, I. V. Luk’yanchuk

“…The research materials were strawberry cultivars and promising selected forms developed at the I.V. Michurin FSC using the methods of introgressive and intervarietal hybridization. …”
Get full text

ENO1 promotes PDAC progression by inhibiting CD8+ T cell infiltration through upregulating PD-L1 expression via HIF-1α signaling by Aziguli Tulamaiti, Shu-Yu Xiao, Yan Yang, Musitaba Mutailifu, Xia-Qing Li, Shi-Qi Yin, Hong-Tai Ma, Hong-Fei Yao, Lin-Li Yao, Li-Peng Hu, Jun Li, Shu-Heng Jiang, Zhi-Gang Zhang, Yan-Miao Huo, Dong-Xue Li, Xue-Li Zhang

Subjects: “…α-Enolase (ENO1)…”
Get full text

The crystal structure of 1,2-bis(4-pyridyl)ethane - 4,4-dihydroxydiphenylmethane (1/1), C25H21N2O2 by Cheng Jie, Chen Jue

“…C25H21N2O2, monoclinic, C2/c (no. 15), a = 11.041(2) Å, b = 7.859(2) Å, c = 24.131(5) Å, β = 95.26(3)°, V = 2085.1(7) Å3, Z = 4, R gt(F) = 0.0486, wR ref(F 2) = 0.1402, T = 295 K.…”
Get full text

XV. ASIR ŞÂİRİ UŞŞÂKÎ’YE ÂİT YENBÛ-I HİKMET ADLI MESNEVİNİN NECMEDDÎN-İ DÂYE’NİN MİRSÂDU’L-İBÂD’I İLE MÜNÂSEBETİ by Kübra Yılmaz

“…Bu çalışma, XV. asrın en hacimli manzumeserlerinden kabul edilebilecek olan Yenbû-ı Hikmet ve Yenbû-ıHikmet’in temel kaynaklarından biri olan Mirsâdu’l-İbâd’ınkarşılaştırması üzerinedir. …”
Get full text

Depth-dependent PD-L1 sampling of head and neck squamous cell carcinoma (HNSCC) – implications for PD-1/PD-L1 checkpoint inhibitor immunotherapy by Madhusudan Roy, Jing-Tang Lin, Sohidul Mondal, Mei-Chun Lin, Chih-Yu Leu, Yen-Lin Huang, Chen-Yuan Dong, Pei-Jen Lou

Subjects: Get full text

Fruit and seed plumpness, germination and viability of rare plants in Yakutia by D. N. Androsova, N. S. Danilova, K. G. Tkachenko, N. E. Staroverov, A. Yu. Gryaznov

Subjects: Get full text

The Interspecific Competition Between Larvae of <i>Aedes aegypti</i> and Major African Malaria Vectors in a Semi-Field System in Tanzania by Sperancia Coelestine Lushasi, Yohana A. Mwalugelo, Johnson K. Swai, Arnold S. Mmbando, Letus L. Muyaga, Nhandi K. Nyolobi, Anitha Mutashobya, Augustino T. Mmbaga, Hamisi J. Kunambi, Simoni Twaha, Mwema Felix Mwema, Dickson W. Lwetoijera

Subjects: Get full text

Effects of Climatic, Chemical, and Cultural Control Strategies on Community Composition of Auchenorrhyncha and Population Dynamics of Two Major Green Leafhopper Pests in Peach Orch... by Patrícia Monteiro Nascimento, Ana Carina Neto, Vera Guerreiro, Anabela Barateiro, Hugo Anjos, José Pereira Coutinho, Marília Antunes, Maria Teresa Rebelo

Subjects: Get full text

Screening Wild Birds for Tick-Borne Zoonotic Pathogens in Portugal by Filipa Loureiro, João R. Mesquita, Luís Cardoso, Sérgio Santos-Silva, Guilherme Moreira, Jaqueline T. Bento, Vanessa Soeiro, Andreia Gonçalves, Filipe Silva, Patrícia F. Barradas, Ana C. Matos, Manuela Matos, Ana Cláudia Coelho

Subjects: “…<i>Babesia</i>…”
Get full text

The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-<span style="font-variant: small-caps">d</span>-Xylulose 5-Phosphate Reductoisomerase from <i>Plasmodium falciparum</i> Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying <i>N</i>-Substituents by Sana Takada, Mona A. Abdullaziz, Stefan Höfmann, Talea Knak, Shin-ichiro Ozawa, Yasumitsu Sakamoto, Thomas Kurz, Nobutada Tanaka

“…It is established that reverse hydroxamate analogs of fosmidomycin inhibit the growth of <i>Plasmodium falciparum</i> by inhibiting 1-deoxy-<span style="font-variant: small-caps;">d</span>-xylulose 5-phosphate reductoisomerase (DXR), the second enzyme of the non-mevalonate pathway, which is absent in humans. …”
Get full text

A modular approach to catalytic stereoselective synthesis of chiral 1,2-diols and 1,3-diols by Sheng Xu, Yuanyuan Ping, Yinyan Su, Haoyun Guo, Aowei Luo, Wangqing Kong

“…Abstract Optically pure 1,2-diols and 1,3-diols are the most privileged structural motifs, widely present in natural products, pharmaceuticals and chiral auxiliaries or ligands. …”
Get full text

Molecular and Biochemical Mechanisms of Scutellum Color Variation in <i>Bactrocera dorsalis</i> Adults (Diptera: Tephritidae) by Guangli Wang, Weijun Li, Jiazhan Wu, Ye Xu, Zhaohuan Xu, Qingxiu Xie, Yugui Ge, Haiyan Yang, Xiaozhen Li

Subjects: “…<i>Bactrocera dorsalis</i>…”
Get full text

<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells by V. G. Subrakova, S. V. Kulemzin, T. N. Belovezhets, A. N. Chikaev, N. A. Chikaev, O. A. Koval, A. A. Gorchakov, A. V. Taranin

“…We hypothesized that stronger cytotoxicity of NK cells could be achieved via gene editing aimed at enhancing the activating signaling cascades and/or weakening the inhibitory ones, thereby shifting the balance of signals towards NK cell activation and target cell lysis. …”
Get full text

Regulation of the G1/S Transition in Hepatocytes: Involvement of the Cyclin-Dependent Kinase Cdk1 in the DNA Replication by Anne Corlu, Pascal Loyer

“…We identified the mitogen dependent restriction point located at the two-thirds of the G1 phase and the concomitant expression and activation of both Cdk1 and Cdk2 at the G1/S transition. …”
Get full text

Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for <i>Trypanosoma cruzi</i> Infection by Citlali Vázquez, Rusely Encalada, Isabel Jiménez-Galicia, Rogelio Gómez-Escobedo, Gildardo Rivera, Benjamín Nogueda-Torres, Emma Saavedra

“…Infection with the protozoan parasite <i>Trypanosoma cruzi</i> causes human Chagas disease. …”
Get full text

Histone Deacetylation Regulated by KDM1A to Suppress DACT1 in Proliferation and Migration of Cervical Cancer by Lingjuan Zeng, Chunyan Chen, Chanjiao Yao

“…Increased expression of KDM1A and decreased expression of DACT1 in cervical cancer cells were noticed in a previous study. …”
Get full text

Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors by Mohammed S. I. Makki, Reda M. Abdel-Rahman, Khalid A. Khan

“…Fluorine substituted 1,2,4-triazinones have been synthesized via alkylation, amination, and/or oxidation of 6-(2-amino-5-fluorophenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one 1 and 4-fluoro-N-(4-fluoro-2-(5-oxo-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)phenyl)benzamide 5 as possible anti-HIV-1 and CDK2 inhibitors. …”
Get full text

Cadmium Tolerance and Detoxification Mechanisms of <i>Lentinula edodes</i>: Physiology, Subcellular Distribution, and Chemical Forms by Gaigai Chen, Bowen Han, Wene Nan, Xiaobo Dong

Subjects: Get full text