Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial by Guoshuang Shen, Zhilin Liu, Miaozhou Wang, Yi Zhao, Xinlan Liu, Yujin Hou, Wenbiao Ma, Jingqi Han, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Zitao Li, Shifen Huang, Yongzhi Chen, Yingjian He, Yan Liu, Zijun Zhu, Yongxin Li, Jinming Li, Mengting Da, Hongnan Mo, Feng Du, Liang Cui, Jing Bai, Zhen Liu, Fei Ma, Jiuda Zhao

“…Our study suggests that apatinib, sintilimab combined with carboplatin and nab-paclitaxel chemotherapy showed a promising clinical activity and manageable safety profile in early TNBC and merits further study. ClinicalTrials.gov registration: NCT04722718.…”
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Adherence to a digital therapeutic mediates the relationship between momentary self-regulation and health risk behaviors by Enzo G. Plaitano, Enzo G. Plaitano, Daniel McNeish, Sophia M. Bartels, Sophia M. Bartels, Kathleen Bell, Jesse Dallery, Michael Grabinski, Michaela Kiernan, Hannah A. Lavoie, Hannah A. Lavoie, Shea M. Lemley, Michael R. Lowe, David P. MacKinnon, Stephen A. Metcalf, Stephen A. Metcalf, Lisa Onken, Judith J. Prochaska, Cady Lauren Sand, Cady Lauren Sand, Emily A. Scherer, Luke E. Stoeckel, Haiyi Xie, Lisa A. Marsch

“…Clinical Trial RegistrationClinicalTrials.gov, identifier (NCT03774433).…”
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Panitumumab plus 5-fluorouracil and folinic acid or 5-fluorouracil and folinic acid alone as maintenance therapy in RAS wild-type metastatic colorectal cancer (PanaMa, AIO KRK 0212... by Arndt Stahler, Meinolf Karthaus, Stefan Fruehauf, Ullrich Graeven, Lothar Müller, Ludwig Fischer von Weikersthal, Karel Caca, Eray Goekkurt, Alexej Ballhausen, Greta Sommerhäuser, Annabel H.S. Alig, Swantje Held, Armin Jarosch, David Horst, Anke Reinacher-Schick, Stefan Kasper, Volker Heinemann, Sebastian Stintzing, Tanja Trarbach, Dominik P. Modest

“…The trial is registered with ClinicalTrials.gov (NCT01991873). Findings: In 248 patients of the Full Analysis Set recruited between May 2014 and February 2021, with a median observation of 64.0 (range 12.5–86.3) months and 59.7 (range 3.7–97.3) months in the treatment arms, 230 events for PFS (92.7%) and 196 events for OS (79.0%) were recorded. …”
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Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights by Juan Li, Xuan Wang, Li Zhou, Jun Guo, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xiangyong Gu, Binlei Liu, Hui Tian, Han Hu

“…A phase III clinical trial is ongoing in China (NCT05868707).Conclusions OH2 oncolytic virotherapy exhibited a favorable safety profile without dose-limiting toxicities (DLTs) and demonstrated durable antitumor efficacy in patients with melanoma, especially in those who had progressed on anti-PD-1 treatment.Trial registration number ClinicalTrials.gov identifier NCT04386967.…”
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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

“…The safety profile was consistent with previous reports.DiscussionDeep longitudinal immunophenotyping, analysis of transcriptional changes, reduction in cells expressing pro-inflammatory cytokines, along with the marker of neuroaxonal damage provide novel and innovative evidence of CladT rebalancing the immune system towards a more homeostatic and less pathogenic state.Clinical Trial Registrationhttps://clinicaltrials.gov/study/, identifier NCT03364036.…”
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Initial clinical experience with [177Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer: dosimetry, safety, and efficacy from the lead-in cohort o... by Aaron R. Hansen, Stephan Probst, Jean-Mathieu Beauregard, Benjamin L. Viglianti, Jeff M. Michalski, Scott T. Tagawa, Oliver Sartor, Ronald F. Tutrone, Orhan K. Oz, Kevin D. Courtney, Ebrahim S. Delpassand, Luke T. Nordquist, Medhat M. Osman, Kim N. Chi, Richard Sparks, Noble George, Sara M. Hawley, Wenting Wu, Jessica D. Jensen, Neil E. Fleshner

“…Median (95% CI) rPFS was 11.5 (9.2-19.1) months, a PSA decline of ≥50% occurred in 42.3% (11/26) of participants, and confirmed ORR for evaluable disease was 50% (5/10).Conclusion[177Lu]Lu-PNT2002, administered at 6.8 GBq/cycle for 4 cycles, demonstrated a favorable dosimetry and safety profile, as well as promising preliminary efficacy.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT04647526.…”
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Long-term safety of dexamethasone sodium phosphate encapsulated in autologous erythrocytes in pediatric patients with ataxia telangiectasia by Mary Kay Koenig, Vincenzo Leuzzi, Riadh Gouider, Riadh Gouider, Eppie M. Yiu, Eppie M. Yiu, Barbara Pietrucha, Asbjørg Stray-Pedersen, Susan L. Perlman, Steve Wu, Trudy Burgers, Rupam Borgohain, Rukmini Mridula Kandadai, Isabelle Meyts, Giorgia Bucciol, Anaita Udwadia-Hegde, Ravi Yadav, Donna Roberts, Aaron Dane, Maureen Roden, Dirk Thye, Biljana Horn, Howard M. Lederman, William P. Whitehouse

“…Adverse events typically observed with prolonged glucocorticoid use such as Cushingoid features, weight gain, hypertension, hirsutism, diabetes or stunted growth were rarely reported.Clinical trial registrationClinicalTrials.gov, identifiers: NCT02770807 and NCT03563053.…”
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Identification of new candidate genes for the hereditary predisposition to uveal melanoma: IGCMU trial by Mélanie Godiveau, Mélanie Godiveau, Mélanie Godiveau, Angeline Ginzac, Angeline Ginzac, Angeline Ginzac, Yannick Bidet, Yannick Bidet, Flora Ponelle-Chachuat, Flora Ponelle-Chachuat, Maud Privat, Maud Privat, Xavier Durando, Xavier Durando, Xavier Durando, Xavier Durando, Mathias Cavaillé, Mathias Cavaillé, Mathis Lepage, Mathis Lepage

“…This study could also contribute to a better understanding of the genetic landscape of UM, potentially leading to more personalized and effective options for its detection.Trial registrationClinicalTrials.gov, identifier NCT06550674, registered in August 2024. …”
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Efficacy of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke: a randomized phase 2 controlled pilot trial by Verónica V. Olavarría, Paola R. Campodónico, Valeska Vollrath, Paula von Geldern, Carolina Velásquez, Patricia Pavez, Barbara Valente, Pamela Donoso, Alexandra Ginesta, Gabriel Cavada, Enrico Mazzon, Víctor Navia, Matías Guzmán, Pablo Brinck, Andrés Gallardo, Pablo Gonzalez, Pablo M. Lavados

“…The study is registered under ADD-SPISE at www.clinicaltrials.gov . Identifier: NCT03524742.…”
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Mental health disorder symptom changes among public safety personnel after emotional resilience skills training by R.N. Carleton, S. Sauer-Zavala, T.A. Teckchandani, K.Q. Maguire, L. Jamshidi, R.E. Shields, T.O. Afifi, J. Nisbet, K.L. Andrews, S.H. Stewart, A.J. Fletcher, R. Martin, R.S. MacPhee, J.C. MacDermid, T.M. Keane, A. Brunet, M. McCarron, L.M. Lix, N.A. Jones, G.P. Krätzig, J.P. Neary, G. Anderson, R. Ricciardelli, H. Cramm, J. Sareen, G.J.G. Asmundson

“…Trial registration: ClinicalTrials.gov, NCT05530642.…”
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HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals by Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, Maria-Cruz Martin Delgado, Yaseen Arabi, Carole Boulanger, Giovanni Mistraletti, Maria Theodorakopoulou, Vernon Van Heerden, José-Artur Paiva, Oktay Demirkýran, Gabriel Heras La Calle, Abdulrahman Al Fares, Gaston Burghi, Guy Francois, Anita Barth, Jan De Waele, Samir Jaber, Michael Darmon, Maurizio Cecconi

“…Trial registration: This trial was registered on ClinicalTrials.Gov on June 18, 2024. Registration: NCT06453616.…”
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Differential Prognosis of True Bifurcation Lesions According to Left Main Versus Non–Left Main Location and Treatment Strategy by Ki Hong Choi, Chang‐Wook Nam, Francesco Bruno, Yun‐Kyeong Cho, Leonardo De Luca, Jeehoon Kang, Alessio Mattesini, Young Bin Song, Alessandra Truffa, Hyo‐Soo Kim, Wojciech Wańha, Woo Jung Chun, Sebastiano Gili, Gerard Helft, Seung Hwan Han, Bernardo Cortese, Cheol Hyun Lee, Javier Escaned, Hyuck‐Jun Yoon, Alaide Chieffo, Joo‐Yong Hahn, Guglielmo Gallone, Seung‐Hyuk Choi, Gaetano De Ferrari, Bon‐Kwon Koo, Giorgio Quadri, Seung‐Ho Hur, Fabrizio D'Ascenzo, Hyeon‐Cheol Gwon, Ovidio de Filippo

“…Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT03068494, NCT03544294, and NCT05205148.…”
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Addressing Shortcomings in Contingency Standards of Care by Alexander Quan

“…Baker-Polito Administration Provides COVID-19 Update on Mask Advisory, Hospital Support | Mass.gov. https://www.mass.gov/news/baker-polito-administration-provides-covid-19-update-on-mask-advisory-hospital-support [13] The Lancet Rheumatology. (2021). …”
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Advanced Restriction Imaging and Reconstruction Technology for Prostate Magnetic Resonance Imaging (ART-Pro): A Study Protocol for a Multicenter, Multinational Trial Evaluating Bip... by Madison T. Baxter, Christopher C. Conlin, Aditya Bagrodia, Tristan Barrett, Hauke Bartsch, Anja Brau, Matthew Cooperberg, Anders M. Dale, Arnaud Guidon, Michael E. Hahn, Mukesh G. Harisinghani, Juan F. Javier-DesLoges, Sophia C. Kamran, Christopher J. Kane, Joshua M. Kuperman, Daniel J.A. Margolis, Paul M. Murphy, Nabih Nakrour, Michael A. Ohliger, Rebecca Rakow-Penner, Ahmed Shabaik, Jeffry P. Simko, Clare M. Tempany, Natasha Wehrli, Sean A. Woolen, Jingjing Zou, Tyler M. Seibert

“…This trial is registered in the US National Library of Medicine Trial Registry (NCT number: NCT06579417) at ClinicalTrials.gov. Patient accrual at the first site (UC San Diego) began in December 2023. …”
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برآورد مقدارتبخیر-تعرق محدوده متاثر از عرصه پخش سیلاب با استفاده از الگوریتم متریک by قباد رستمی زاد, مجتبی پاک پرور, پرویز عبدی نژاد, زهرا عبداللهی, جعفر خلفی

“…تصاویر Landsat در فواصل 16 روزه با وضوح مکانی 30 متر و از سایت سازمان زمین‌‌شناسی ایالات متحده (http://glovis.usgs.gov) به‌دست آمد. پس از پردازش تصاویر، شار خالص تشعشع سطح زمین و شار حرارتی زمین با استفاده از شارهای تشعشعی ورودی-خروجی از آلبدو، گسیل‌‌مندی، دمای سطح زمین و شاخص‌های گیاه به‌دست آمد. …”
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Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM by Krzysztof Kalwak, Laura M. Moser, Ulrike Pötschger, Peter Bader, Katharina Kleinschmidt, Roland Meisel, Jean-Hugues Dalle, Akif Yesilipek, Adriana Balduzzi, Gergely Krivan, Evgenios Goussetis, Raquel Staciuk, Petr Sedlacek, Herbert Pichler, Peter Svec, Melissa Gabriel, Tayfun Güngör, Ernest Bilic, Jochen Buechner, Marleen Renard, Kim Vettenranta, Marianne Ifversen, Cristina Diaz-de-Heredia, Jerry Stein, Jacek Toporski, Marc Bierings, Christina Peters, Marc Ansari, Franco Locatelli

“…This trial was registered at www.ClinicalTrials.gov as #NCT01949129.…”
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A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings by Steven P. Treon, Camille N. Kotton, David J. Park, Giorgia Moranzoni, Camilla K. Lemvigh, Joseph C. Gathe, Tilly A. Varughese, Christopher F. Barnett, Johnny M. Belenchia, Nina M. Clark, Charles M. Farber, Muhammad Bilal Abid, Gulrayz Ahmed, Christopher J. Patterson, Maria L. Guerrera, Jacob D. Soumerai, Vipheaviny A. Chea, Isabel P. Carulli, Jackson Southard, Shuqiang Li, Catherine J. Wu, Kenneth J. Livak, Eric Holmgren, Pil Kim, Carrie Shi, Holly Lin, Vanitha Ramakrishnan, Ying Ou, Scott Olszewski, Lars Rønn Olsen, Derin B. Keskin, Derin B. Keskin, Zachary R. Hunter, Christopher Tankersley, Todd Zimmerman, Binod Dhakal

“…Investigation of zanubrutinib may be warranted in other settings where cytokine release and immune cell exhaustion are important.Clinical Trial Registrationhttps://www.clinicaltrials.gov/study/NCT04382586, identifier NCT04382586.…”
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Characteristics of adherent and non-adherent patients with hypertension in a Norwegian cross-sectional study by Eirik Olsen, Lene V. Halvorsen, Stine Rognstad, Arleen Aune, Karl Marius Brobak, Ola Undrum Bergland, Vibeke N. Kjær, Knut Liestøl, Marit D. Solbu, Rune Mo, Eva Gerdts, Morten Rostrup, Sverre E. Kjeldsen, Aud Høieggen, Mimi S. Opdal, Anne Cecilie K. Larstorp, Camilla L. Søraas

“…Adherence was significantly and negatively related to younger age, non-European ethnicity, and increasing number of prescribed antihypertensive pills, and positively to the type of prescribed medication, especially angiotensin receptor blocker (www.ClinicalTrials.gov identifier: NCT03209154).…”
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Public assistance in patients with acute heart failure: a report from the KCHF registry by Yuji Nishimoto, Takao Kato, Takeshi Morimoto, Ryoji Taniguchi, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Erika Yamamoto, Yusuke Yoshikawa, Takeshi Kitai, Moritake Iguchi, Masashi Kato, Mamoru Takahashi, Toshikazu Jinnai, Tomoyuki Ikeda, Kazuya Nagao, Takafumi Kawai, Akihiro Komasa, Ryusuke Nishikawa, Yuichi Kawase, Takashi Morinaga, Kanae Su, Mitsunori Kawato, Yuta Seko, Moriaki Inoko, Mamoru Toyofuku, Yutaka Furukawa, Yoshihisa Nakagawa, Kenji Ando, Kazushige Kadota, Satoshi Shizuta, Koh Ono, Koichiro Kuwahara, Neiko Ozasa, Yukihito Sato, Takeshi Kimura

“…Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT02334891 (NCT02334891) and https://upload.umin.ac.jp/cgi‐open‐bin/ctr_e/ctr_view.cgi?…”
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Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system by Xueqian Yang, Meiqi Wu, Menglin Liang, Haiqiong Zhang, Bo Li, Chenhui Mao, Liling Dong, Yuan Wang, Haiqun Xing, Chao Ren, Zhenghai Huang, Qingxiang Wen, Qi Ge, Zhengqing Yu, Feng Feng, Jing Gao, Li Huo

“…Registered September 2022 https://clinicaltrials.gov/search?term=NCT05023564 .…”
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