Non-Immersive Virtual Reality Exercise Can Increase Exercise in Older Adults Living in the Community and in Long-Term Care: A Randomized Controlled Trial by Sheehy L, Bharadwaj L, Nissen KA, Estey JL

“…Most were interested to continue beyond the study.Conclusion: Non-immersive virtual reality for home-based and facility-based older adults is safe, enjoyable and feasible and may increase users’ weekly levels of physical activity leading to clinical benefits for functional walking in facility-based users.Trial Registration: ClinicalTrials.gov (NCT04083885; registered 2019– 09-06).Plain language summary: Regular exercise is so important for older adults. …”
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Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trialResearch in context by Abha A. Gupta, Anna Tinker, Derek Jonker, Rahma Jamal, Hal Hirte, Eric W. Winquist, Quincy Chu, Christian Kollmannsberger, Ralph Wong, Thierry Alcindor, Torsten O. Nielsen, Ming Tsao, Tricia R. Cottrell, Diane Provencher, John Hilton, Monika K. Krzyżanowska, Christine Elser, Sebastien Hotte, Joana Sederias, Siwei Zhang, Wei Tu, Janet Dancey

“…This trial is registered with ClinicalTrials.gov, NCT02879162. Findings: From December 14th, 2016, to August 14, 2019, 140 patients enrolled into seven cohorts. …”
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Design of the Focus on Restaurant Engagement to Strengthen Health (FRESH) study: leveraging systems science to work with independently-owned restaurants to increase access to and p... by Uriyoán Colón-Ramos, Emma C. Lewis, Anna Claire Tucker, Lisa Poirier, Chathurangi H. Pathiravasan, Michelle Estradé, Takeru Igusa, Julia A. Wolfson, Yeeli Mui, Veronica Vélez-Burgess, Audrey E. Thomas, Shuxian Hua, Lawrence J. Cheskin, Lawrence J. Cheskin, Antonio J. Trujillo, Ayoyemi T. Oladimeji, Stacey Williamson, Rosalinda Romero, Patricia Sánchez Hernández, Joel Gittelsohn

“…The design of the FRESH intervention and its evaluation are described, as well as plans for the development of a system dynamics simulation model for policymakers and other stakeholders to virtually test future restaurant-based interventions.Clinical trial registrationhttps://clinicaltrials.gov, identifier, NCT05869149.…”
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Prebiotics as an adjunct therapy for posttraumatic stress disorder: a pilot randomized controlled trial by Robin M. Voigt, Robin M. Voigt, Robin M. Voigt, Phillip A. Engen, Michelle Villanueva, Simona A. Bambi, Stefan J. Green, Stefan J. Green, Ankur Naqib, Ankur Naqib, Shohreh Raeisi, Maliha Shaikh, Bruce R. Hamaker, Bruce R. Hamaker, Thaisa M. Cantu-Jungles, Thaisa M. Cantu-Jungles, Sarah A. Pridgen, Philip Held, Ali Keshavarzian, Ali Keshavarzian, Ali Keshavarzian, Ali Keshavarzian

“…., mechanism).ResultsThis study found that PTSD severity may be associated with reduced abundance of taxa capable of producing the SCFA propionate, and that a subset of individuals with PTSD may benefit from a microbiota-modifying prebiotic intervention.ConclusionThis study suggests that targeting the intestinal microbiome through prebiotic supplementation could represent a promising avenue for enhancing treatment outcomes in some individuals with PTSD.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT05424146.…”
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Individual participant data meta-analysis of trials comparing frozen versus fresh embryo transfer strategy (INFORM): a protocol by Lan N Vuong, Rui Wang, Ben W Mol, Rong Li, Karin Hammarberg, Kate Brian, Yun Sun, Pollyanna Hardy, Anja Pinborg, Siladitya Bhattacharya, Sacha Stormlund, David J McLernon, Zi-Jiang Chen, Richard S Legro, Carlos Simon, Shimona Lai, Marian G Showell, Daimin Wei, Ze Wang, Keliang Wu, Xavier Santamaría, Christophe Blockeel, Femke Mol, Anna P Ferraretti, Bruce S Shapiro, Forest C Garner, Christos A Venetis, Abha Maheshwari, Gwenda Burns

“…Therefore, we plan a systematic review and individual participant data meta-analysis of RCTs comparing a freeze-all and a fresh transfer policy.Methods and analysis We will search electronic databases (Medline, Embase, PsycINFO and CENTRAL) and trial registries (ClinicalTrials.gov and the International Clinical Trials Registry Platform) from their inception to present to identify eligible RCTs. …”
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Impact of periodontal microRNAs associated with alveolar bone remodeling during orthodontic tooth movement: a randomized clinical trial by Alessandro Polizzi, Angela Alibrandi, Antonino Lo Giudice, Alfio Distefano, Laura Orlando, Amer M. Analazi, Giuseppe Pizzo, Giovanni Li Volti, Gaetano Isola

“…Trial registration ClinicalTrials.gov NCT06023433 (retrospectively registered).…”
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Efficacy and safety of everolimus for patients with focal cortical dysplasia type 2 by Se Hee Kim, Hoon‐Chul Kang, Yun Ho Roh, Jongsung Hahn, Kyung Lok Min, Seok‐Jin Lee, Donghwa Yang, Han Som Choi, Soyoung Park, Jeong Ho Lee, Sang‐Guk Lee, Se Hoon Kim, Min Jung Chang, Heung Dong Kim

“…Methods A prospective, crossover, placebo‐controlled clinical trial (ClinicalTrials.gov: NCT03198949) enrolled patients aged 4–40 years with pathologically confirmed FCD 2 and a history of ≥3 seizures per month for two out of the 3 months prior to screening. …”
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Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study by Chenyu Mao, Anwen Xiong, Jiong Qian, Wenxiang Wang, Ying Liu, Tao Zhang, Zhihai Wu, Haiqing Ni, Jia Lu, Sixiang Long, Li Zhao, Yuling Chen, Caicun Zhou, Nong Xu

“…Trial registration ClinicalTrials.gov Identifier: NCT04085185.…”
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شناسایی و بررسی سیلیمارین قارچ اﻧﺪوﻓﻳﺖ ﺟﺪاﺳﺎزی شده از بذر گیاه خارمریم (Silybum marianum (L) Gaert.) by هدی السادات عقیلی, حسین مرادی, محمد علی تاجیک قنبری, ولی الله قاسمی

“…و چند گونه قارچ دیگر از پایگاه اطلاعاتی NCBI (http://www.ncbi.nlm.nih.gov) انجام شد.مواد و روش‌ها: بدین منظور بذرهای خارمریم از محوطه دانشگاه علوم کشاورزی و منابع طبیعی ساری جمع‎آوری و پس از ضدعفونی در محیط MS کشت شدند. …”
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Depressive symptoms in older adults are associated with changes in stress-related markers, functional connectivity and brain volume by Edelweiss Touron, Robin de Flores, Laurent Coulbault, Cassandre Palix, Anne Chocat, Elizabeth Kuhn, Brigitte Landeau, Florence Mézenge, Daniel Roquet, Léa Chauveau, Sacha Haudry, Denis Vivien, Vincent de La Sayette, Natalie L. Marchant, Gaël Chételat, Géraldine Poisnel, for the Medit-Ageing Research Group

“…Trial registration ClinicalTrials.gov Identifier: NCT02977819, Registration Date: 2016–11-25.…”
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Saturated hydraulic conductivity and steady-state infiltration rate database for Brazilian soils by Marta Vasconcelos Ottoni, Wenceslau Geraldes Teixeira, Aline Mari Huf dos Reis, Letícia Guimarães Pimentel, Luciana Rodrigues Souza, Jackson Adriano Albuquerque, Valdinar Ferreira Melo, Karina Maria Vieira Cavalieri-Polizeli, José Miguel Reichert, João Herbert Moreira Viana, Ademir Fontana, Lucas de Castro Medrado, Glenio Guimarães Santos, Luís Gustavo Henriques do Amaral, Lúcia Helena Cunha dos Anjos, José Coelho de Araújo Filho, Silvio Barge Bhering, Gabrielle Fernandes de Brito, Pedro Gomes de Campos do Valle, Pablo Nieto Campos, Adriana Monteiro da Costa, Jean Dalmo de Oliveira Marques, Alba Leonor da Silva Martins, Michele Bruna de Souza do Nascimento, Norberto Cornejo Noronha, Ricardo Duarte de Oliveira, Jeane Cruz Portela, Milson Evaldo Serafim, Marlen Barros e Silva, Sueli Rodrigues, Wilk Sampaio de Almeida, Margareth Lopes de Moraes, Nilton Curi

“…It is open access and can be accessed at https://www.sgb.gov.br/ksat-ssir-dbbase-de-dados-de-condutividade-hidraulica-saturada-e-de-taxa-de-infiltracao-basica-emsolos-brasileiros, which also includes the python script for data analysis.…”
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Effect of radiotherapy exposure on fruquintinib plus sintilimab treatment in refractory microsatellite stable metastatic colorectal cancer: a prospective observation study by Jing Wang, Tao Zhang, Lei Zhao, Min Jin, Pindong Li, Shengli Yang, Hong Ma, Zhenyu Lin, Junli Liu, Hongli Liu, Kunyu Yang, Dandan Yu, Jianli Hu, Jun Xue, Mingxia Cheng, Chuying Huang

“…Gut microbiota, metabolites, and cytokines may help predict F&S outcomes for mCRC, which may be helpful in treatment decision-making.Trial registration number ClinicalTrials.gov identifier: NCT05635149.…”
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A qualitative process evaluation of SBIRT implementation in pediatric trauma centers using the Science to Service Laboratory implementation strategy by Kelli Scott, Michael J. Mello, Geraldine Almonte, Emely Arenas Lemus, Julie R. Bromberg, Janette Baird, Anthony Spirito, Mark R. Zonfrillo, Karla Lawson, Lois K. Lee, Emily Christison-Lagay, Stephanie Ruest, Jeremy Aidlen, Andrew Kiragu, Charles Pruitt, Isam Nasr, Robert Todd Maxson, Beth Ebel, Sara J. Becker

“…Trial registration Clinicaltrials.gov NCT03297060 . Registered 29 September 2017.…”
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Effect of a prepartum and postpartum, complex interdisciplinary lifestyle and psychosocial intervention on metabolic and mental health outcomes in women with gestational diabetes m... by Umberto Simeoni, Antje Horsch, Arnaud Chiolero, Yvan Vial, Nicole Sekarski, Jardena J Puder, Pascal Bovet, Yvan Mivelaz, Adina Mihaela Epure, Bobby Stuijfzand, Leah Gilbert, Stefano Lanzi, Justine Gross, Didier Hans, Stefano Di Bernardo, Elena Gonzalez-rodriguez, Alain Lacroix, Jean-Benoît Rossel, Dan Yedu Quansah, Amar Arhab, Sandrine Estoppey Younes, Seyda Mayerat

“…However, the intervention decreased gestational weight gain and increased the proportion of women without weight retention.Trial registration Clinicaltrials.gov NCT02890693.…”
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Efficacy and safety of Jianpi Qinghua granules for non-erosive reflux disease with spleen deficiency and damp-heat syndrome: a multicenter, randomized, double-blind, placebo-contro... by Tai Zhang, Tai Zhang, Tai Zhang, Tai Zhang, Guang Bai, Wei Wang, Lin Liu, Zhenghua Zhou, Haijie Ji, Beihua Zhang, Beihua Zhang, Beihua Zhang, Xudong Tang, Xudong Tang

“…They effectively address spleen deficiency and damp-heat syndrome, improving patients' social functioning, and have a favorable safety profile.Clinical trial registrationhttps://clinicaltrials.gov/study/NCT04324138?term=NCT04324138&rank=1, identifier: NCT04324138.…”
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The MyLungHealth study protocol: a pragmatic patient-randomised controlled trial to evaluate a patient-centred, electronic health record-integrated intervention to enhance lung can... by Rachel Hess, Angela Fagerlin, Devin Mann, Tanner Caverly, Yue Zhang, Guilherme Del Fiol, Jorie Butler, Michael Flynn, Kensaku Kawamoto, Douglas Martin, Chelsey R Schlechter, Haojia Li, Polina Kukhareva, Christian Balbin, Elizabeth Stevens, Victoria Tiase, Kim Kaphingst, Chakravarthy Reddy, Phillip Warner, Joshua Choi, Claude Nanjo, Quyen Metzger

“…Results will be disseminated through peer-reviewed publications.Trial registration number Clinicaltrials.gov, NCT06338592.…”
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Multimodal machine learning enables AI chatbot to diagnose ophthalmic diseases and provide high-quality medical responses by Ruiqi Ma, Qian Cheng, Jing Yao, Zhiyu Peng, Mingxu Yan, Jie Lu, Jingjing Liao, Lejin Tian, Wenjun Shu, Yunqiu Zhang, Jinghan Wang, Pengfei Jiang, Weiyi Xia, Xiaofeng Li, Lu Gan, Yue Zhao, Jiang Zhu, Bing Qin, Qin Jiang, Xiawei Wang, Xintong Lin, Haifeng Chen, Weifang Zhu, Dehui Xiang, Baoqing Nie, Jingtao Wang, Jie Guo, Kang Xue, Hongguang Cui, Jinwei Cheng, Xiangjia Zhu, Jiaxu Hong, Fei Shi, Rui Zhang, Xinjian Chen, Chen Zhao

“…(The clinical trial was registered on June 26, 2023, on ClinicalTrials.gov under the registration number NCT05930444.).…”
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Thymosin alpha 1 in the prevention of infected pancreatic necrosis following acute necrotising pancreatitis (TRACE trial): protocol of a multicentre, randomised, double-blind, plac... by Tao Chen, Jing Zhou, Jianfeng Tu, Weiqin Li, XinTing Pan, Wenjian Mao, Lu Ke, Wenhua He, Miao Chen, Chengjian He, Weili Gu, Jingyi Wu, Jingchun Song, Haibin Ni, Junli Sun, Guoxiu Zhang, Weiwei Chen, Bing Xue, Xiangyang Zhao, Min Shao, Yuxiu Liu, Zhihui Tong

“…The results of this trial will be disseminated in peer-reviewed journals and at scientific conferences.Trial registration number ClinicalTrials.gov Registry (NCT02473406).…”
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A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive... by Zhiwei Chen, Jianhua Chen, Dingzhi Huang, Wei Zhang, Lin Wu, Tienan Yi, Qiming Wang, Liang Han, Liping Tan, Yinyin Li, Zhihong Zhang, Na Li, Jie li, Tongmei Zhang, Ying Hu, Hongmei Sun, Youhua Wu, Zhiyong He, Runxiang Yang, Peng Cheng, Xingya Li, Jianhua Shi, Guohua Yu, Daiyuan Ma, Benjamin Xiaoyi Li, Xiangrong Dai, Michael Wong, Yujie Li, Xiaohui Yu, Shun Lu, for the Socazolimab Study Group

“…Abstract This is a randomized, double-blind, placebo-controlled phase 3 clinical trial (ClinicalTrials.gov, NCT04878016) conducted in 54 hospitals in China. …”
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Women's experiences and acceptability of self-administered, home delivered, intravaginal 5-Fluorouracil cream for cervical precancer treatment in Kenya by Konyin Adewumi, Aparna Ghosh Kachoria, Everlyn Adoyo, Mercy Rop, Mercy Rop, Antony Owaya, Jennifer H. Tang, Jennifer H. Tang, Lisa Rahangdale, Lisa Rahangdale, Lisa Rahangdale, Chemtai Mungo, Chemtai Mungo, Chemtai Mungo

“…In a recent Phase I trial (ClinicalTrials.gov NCT05362955), we demonstrated safety and adherence to self-administered intravaginal 5% 5-Fluorouracil (5FU) cream as an adjuvant therapy for cervical precancer among women living with HIV (WLWH) in rural Kenya. …”
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