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  1. 2541

    Acute beneficial effects of a functional energy shot on cognitive performance and mood states during cognitively demanding task performance: a randomized, double-blind, placebo-con... by Olivia K. O’Shea, Olivia K. O’Shea, Nathan Lawley, Anna Azzopardi, Allison Gutkowski, Michelle Murphy Niedziela, Rachel Horn, David O. Kennedy, Jason Adamson

    Published 2025-01-01
    “…Working memory tasks showed faster performance post-consumption, and mood assessments revealed positive effects on vigor, fatigue and overall mood disturbance.DiscussionThese results indicate wide cognitive and mood effects of this functional energy shot, potentially attributable to synergistic combination of active ingredients.Clinical trial registrationclinicaltrials.gov, identifier NCT06384586.…”
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    MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial by Mrinal Gounder, Melissa Johnson, Rebecca S. Heist, Geoffrey I. Shapiro, Sophie Postel-Vinay, Frederick H. Wilson, Elena Garralda, Gerburg Wulf, Caroline Almon, Salah Nabhan, Elia Aguado-Fraile, Peng He, Mathilde Romagnoli, Mohammad Hossain, Rohini Narayanaswamy, Amel Sadou-Dubourgnoux, Michael Cooper, Vasileios Askoxylakis, Howard A. Burris, Josep Tabernero

    Published 2025-01-01
    “…We report results from the first-in-human, phase 1 trial of AG-270/S095033 as monotherapy in patients with advanced malignancies (ClinicalTrials.gov Identifier: NCT03435250). Eligible patients had tumors with homozygous deletion of CDKN2A/MTAP and/or loss of MTAP protein by immunohistochemistry. …”
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  10. 2550

    Timed Bromocriptine-QR Therapy Reduces Progression of Cardiovascular Disease and Dysglycemia in Subjects with Well-Controlled Type 2 Diabetes Mellitus by Bindu Chamarthi, J. Michael Gaziano, Lawrence Blonde, Aaron Vinik, Richard E. Scranton, Michael Ezrokhi, Dean Rutty, Anthony H. Cincotta

    Published 2015-01-01
    “…Methods. 1834 subjects (1219 bromocriptine-QR; 615 placebo) with baseline HbA1c ≤7.0% derived from the Cycloset Safety Trial (this trial is registered with ClinicalTrials.gov Identifier: NCT00377676), a 12-month, randomized, multicenter, placebo-controlled, double-blind study in T2DM, were evaluated. …”
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    Comparative Efficacy and Safety of Targeted Therapies for Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review and Network Meta-Analysis by Yusi Chen, Fang Li, Jun Luo, Jingyuan Chen, Peng Luo, Jiang Li

    Published 2021-01-01
    “…We searched PubMed, EMBASE, Web of Science, the Cochrane Central Register, https://clinicaltrials.gov, and who.int/trialsearch/, for relevant RCTs published up to January 2020. …”
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    Symptom-related experience and sexual health of female patients with pulmonary arterial hypertension: protocol for a systematic review and qualitative meta-synthesis by Ye He, Zhu Yang, Lixiao Yang, Fangfang Ma

    Published 2025-01-01
    “…A comprehensive search will encompass seven electronic databases and search engines (Ovid Medline, CINAHL, EMBASE, APA PsycINFO, Cochrane Database of Systematic Reviews, PubMed, Scopus) and grey literature sources (ProQuest Dissertations, ClinicalTrials.gov). Building on insights from previous reviews centred on symptom-related experience and sexual health. …”
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