The course and outcomes of COVID-19 in patients with ANCA-associated systemic vasculitis, receiving biological therapy (Rituximab, Mepolizumab): The results of the first 8 months o... by T. V. Beketova, V. V. Babak, M. D. Suprun

“…When analyzing the 5-year survival rate according to the registry of AAV patients treated with rituximab, prognosis worsening was noted; in 2020 there were 3 deaths due to COVID-19, in the previous 5 years – only 2 deaths.Discussion. …”
Get full text

Do Patient-Reported Outcomes Differ Between Open and Minimally Invasive Hallux Cheilectomy? by Nathaniel Zona BA, Samuel D. Stark, Eric Villarreal MD, Kenneth Hunt MD

“…These corresponding improvements for the open approach were 5.18±8.67, -5.99±8.33 and 17.83±30.5 while the arthroscopic approach improvements were 3.33±7.69, -5.03±7.33, and 15.66±28.34 respectively. …”
Get full text

CHANGES IN THE LEVEL OF FoxP3+ REGULATORY T LYMPHOCYTES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS DURING METHOTREXATE THERAPY by A. S. Avdeeva, Yu. P. Rubtsov, T. V. Popkova, D. T. Dyikanov, E. L. Nasonov

“…At 24 weeks after starting the therapy, median DAS28, SDAI, and CDAI were 3.1 [2.7; 3.62], 7.4 [4.2; 11.4], and 7.0 [4.0; 11.0], respectively; DAS28 and SDAI remission/low disease activity was reached by 22 (56.4%) and 25 (64.1%) patients, respectively; 4 (10.3%) patients had no MTX treatment effect according to the EULAR criteria. …”
Get full text

Comparative immunohistochemical characteristics of expression of estrogen receptors-alpha, progesterone receptors, p16, p53, Ki-67 and caspase 3 in invasive endometrial adenocarcin... by V. A. Tumanskiy, A. V. Chepets

“…In the stromal component of tumor medians of expression of p16 and caspase 3 were 3.22 and 43.87 CUOD. This was statistically significantly lower than in normal endometrial tissue (the median for p16 – 10.33 CUOD and for caspase 3 – 53.50 CUOD, respectively). …”
Get full text

The relationships between some biochemical parameters and sperm quality in rams by Nuri Başpınar, Abdullah Kaya, Vahdettin Altunok, Bülent Güven, Firuze Kurtoğlu, Mehmet Bozkurt Ataman

“…Mean sperm concentration (x10⁶/mm³) of the breeds were 3.16±0.26, 2.70±0.25, 2.93±0.30, 2.42±0.33 and 1.66±0.23 respectively. …”
Get full text

Development of a Serious Game to Simulate Neonatal Intensive Care Unit Experiences: Collaborative Quasi-Experimental Study by Yukihide Miyosawa, Koichi Hirabayashi, Kodai Yamada, Fumiya Kobayashi, Nanami Ogihara, Noa Takeda, Eri Okamura, Shogo Matsumura

“…Mean scores for length, difficulty, and gameplay were 3.05 (SD 0.62), 2.49 (SD 0.76), and 3.65 (SD 0.77), respectively, indicating a well-balanced design. …”
Get full text

Fibromyalgia Patients Have Markedly Greater Postoperative Opioid Use and Emergency Department Visits Following Bunionectomy by Andrew Sauer BA, Jung Yoo MD, Lara Atwater MD

“…Fibromyalgia patients were 3.2 times more likely to use opioids preoperatively and took 7.6 times more opioids per day. …”
Get full text

Programa de diagnóstico, manejo y prevención de enfermedades genéticas y defectos congénitos en el municipio Rafael Freyre by Ángel Ramón Maldonado Batista, Yusel Moreno Domínguez

“…In the program for the prevention of falciform red blood-cell anemia were 3 523 pregnant women, from which 91 were carriers and 4 couples at risk were identified. …”
Get full text

EC50 and EC95 of Remifentanil for Inhibiting Bronchoscopy Responses in Elderly Patients During Fiberoptic Bronchoscopy Under Ciprofol Sedation: An Up-and-Down Sequential Allocation... by Lan H, Liu S, Liao Y, Xu B, Lin Y, Wu X, Chen Q, Chen H, Guan X

“…The EC50 values (plasma concentration) of remifentanil for blunting FOB responses under ciprofol sedation were 3.25 (2.75 to 3.26) ng/mL and 2.25 (1.75 to 2.25) ng/mL in males and females, respectively (p = 0.0023). …”
Get full text

Changes of endogenous hormone concentrations and transcriptome analysis during the healing process of greenwood grafting in grape by DENG Jiayi, WEI Jiayan, CHEN Aisai, HE Fei, YU Keji, WANG Jun

“…There were 3 differentially expressed genes were involved in ethylene signal transduction, including ethylene receptor (ETR), EIN3-binding F-box protein (EBF) and ethylene-responsive transcription factor (ERF). …”
Get full text

In Vitro Evaluation of Rosemary Essential Oil: GC-MS Profiling, Antibacterial Synergy, and Biofilm Inhibition by Daniel E. K. Kabotso, David Neglo, Sarah E. Gaba, Emmanuel K. Danyo, Alberta D. Dayie, Anastasia A. Asantewaa, Fleischer C. N. Kotey, Nicholas T. K. D. Dayie

“…The MIC and MBC ranges of REO for all bacteria were 3.13–6.25 mg/mL and 3.12–12.5 mg/mL, respectively. …”
Get full text

Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mice by Vaskar Das, Isabella Milejczyk, Michael B. Basovich, Mario Moric, Jay Kaila, Craig J. Thomas, Asokumar Buvanendran, Robert J. McCarthy

“…Brain, spinal cord, and dorsal root ganglion tissues were obtained for immunohistochemistry and western blot analysis.ResultsPrior to disk puncture paw withdrawal thresholds were 3.44 ± 0.51 g before surgery and were reduced to 0.54 ± 0.38 g at day 7 without a difference by sex; however, sex-specific responses were evident in other behavioral outcomes. …”
Get full text

Synthesis and Evaluation of ⁶⁸Ga- and ¹⁷⁷Lu-Labeled [diF-Pro¹⁴]Bombesin(6−14) Analogs for Detection and Radioligand Therapy of Gastrin-Releasing Pe... by Lei Wang, Chao-Cheng Chen, Devon Chapple, Antonio A. W. L. Wong, Sara Kurkowska, Wing Sum Lau, Carlos F. Uribe, François Bénard, Kuo-Shyan Lin

“…Tumor uptake values of [⁶⁸Ga]Ga-LW02060 and [⁶⁸Ga]Ga-LW02080 at 1 h pi were 16.8 ± 2.70 and 7.36 ± 1.33 %ID/g, respectively, while their pancreas uptake values were 3.12 ± 0.89 and 0.38 ± 0.04 %ID/g, respectively. …”
Get full text

Double‐bundle versus single‐bundle medial patellofemoral ligament reconstruction for recurrent patellar dislocation: A meta‐analysis by Yiheng Wu, Junran Li, Hongbo Zhao, Hongyan Zhou, Bokai Wang, Jinlong Zhang, Shengkun Zhao

“…The level of evidence for the four randomized controlled studies was Ⅰ, and the nine cohort studies were Ⅲ. A total of 862 (891 knees) patients were included, of which 448 (465 knees) underwent double‐bundle MPFL reconstruction and 414 (426 knees) underwent single‐bundle MPFL reconstruction. …”
Get full text

Predictors of metabolic response in propensity-matched lymphoma patients on interim 18F-fluorodeoxyglucose positron-emission tomography/computed tomography using standardized imagi... by Nosheen Fatima, Maseeh Uz Zaman, Areeba Zaman, Unaiza Zaman, Rabia Tahseen, Sidra Zaman

“…%Δ changes in fasting blood sugar,18FDG dose, uptake time, and liver SUV mean were 3.96%, 2.83%, 2.49%, and 12.15%, respectively. …”
Get full text

Construction of a diagnostic model for chronic mountain sickness among young male migrants to high-altitude areas by ZHANG Quan, CHEN Jian, LIU Bao

“…Further analysis revealed that creatine kinase-MB/creatine kinase （CK-MB/CK， OR=2.17， 95%CI： 1.43~3.28）， high-altitude residence time （OR=2.44， 95%CI： 1.08~5.54）， and body mass index （BMI， OR=1.62， 95%CI： 1.05~2.50） were 3 major independent risk factors for CMS. The area under the curve （AUC） value of the CMS diagnostic model in the training set and test set was 0.821 （95%CI： 0.756~0.886） and 0.821 （95%CI： 0.700~0.944）， the specificity was 66.30% and 73.90%， the sensitivity was 89.50% and 81.20%， respectively， indicating good discrimination ability. …”
Get full text

Up-front dissection of the uterovesical space or “bladder-first approach” reduces hemorrhage and bladder injury during hysterectomy for placenta accreta spectrum: reconfirmed in 78... by Pradip Kumar Saha, MD, MAMS, Rashmi Bagga, MD, DNB, Rimpi Singla, MD, Aashima Arora, MD, Vanita Jain, MD, Vanita Suri, MD, Kajal Jain, MD, Parveen Kumar, MD, DM, Nalini Gupta, MD, Ashish Jain, MD, Tulika Singh, MD, Ravimohan S. Mavuduru, MS, MCh

“…Histology was available in 73 of 78 women (19 with placenta percreta, 23 with placenta increta, and 31 with placenta accreta). There were 3 of 78 antenatal stillbirths. Of note, 75 women had live-born neonates, including 2 pairs of twins. …”
Get full text

Measurement of calcitonin and cea in the needle washout fluid from thyroid nodule for the diagnosis of medullary thyroid carcinoma by N. V. Severskaya, I. V. Chebotareva, N. V. Zhelonkina, A. S. Belyakova, P. A. Isaev, V. V. Polkin, A. A. Ilyin, S. A. Ivanov, A. D. Kaprin

“…The false positive FNA-CT values were 3.7 % and 1.2 % at the cut-off values of 590 pg/ml and 1721 pg/ml, respectively. …”
Get full text

Remote Monitoring of Psoriasis: Comparing Care Models and Evaluating Quality of Life Outcomes: Mixed Methods Study by Jana Arsenjeva, Priit Kruus, Riina Hallik, Secil Matasova, Laura Prett, Katrin Kaarna, Liisi Raam, Oliver Taul, Liis Ilves, Kaisa Viljar, Pille Konno, Peeter Ross, Külli Kingo

“…Patients receiving specialist care were 3.91 times more likely to achieve a clinically significant improvement (MCID≤–3) compared with those in primary care (P=.04). …”
Get full text

Impact of initial screening strategies on compliance with colonoscopy for colorectal carcinoma in residents aged 50 years and above by XIANG Fang, HU Zhihao, WANG Yawei, ZHANG Yiying, HUANG Fang, PENG Qian, YU Hongjie, FU Chaowei

“…Those with one positive FOBT test result were 2.64 times more likely to undergo colonoscopy screening than those with negative FOBT results, while individuals with two positive FOBT results were 3.18 times more likely to do so. After adjusting for FOBT results, individuals with positive questionnaire survey results were 1.43 times more likely to undergo colonoscopy screening than those with negative results (95%CI: 1.34‒1.52). …”
Get full text