Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study by Li X, Liu S, Yu M, Xi W, Wu X, Liu D, Liu A, Wang H

“…Precisely quantifying their plasma levels is crucial for clinical pharmacokinetic assessments and therapeutic drug monitoring.Aim: This study aimed to establish a generic and efficient ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) assay for the determination of five PPIs (esomeprazole, rabeprazole, ilaprazole, lansoprazole, and pantoprazole) and the P-CAB (vonoprazan) in human plasma.Methods: The six analytes were extracted from human plasma via protein precipitation and a single dilution step. …”
Get full text

Reaction kinetics and molecular characterization of the compounds formed by photosensitized degradation of the plastic additive bisphenol A in the atmospheric aqueous phase by Yiting Wang, Qingxin Deng, Yiqun Wang, Pan Li, Biao Jin, Jiangping Liu, Peng Cheng, Marcello Brigante, Dario D’Antuono, Luca Carena, Hui Chen, Davide Vione, Sasho Gligorovski

“…Bromide levels as per seawater conditions have the potential to slow down BPA photodegradation, a phenomenon that could not be offset by reaction of BPA with Br2 •− (second-order reaction rate constant of (2.54 ± 0.09) × 108 M−1 s−1). Ultra-high resolution mass spectrometry revealed that the presence of inorganic salts (NaCl and NaBr) markedly increased the complexity of the observed CHO product compounds formed upon photosensitized degradation of BPA. …”
Get full text

Marginal and Internal Adaptation Evaluation of Dental Composites Using Micro-CT by Adrian Tudor Stan, Laura Cîrligeriu, Laura Idorași, Meda Lavinia Negruțiu, Cosmin Sinescu, Daniela Maria Pop, Tareq Hajaj, Şerban Talpoș, Mihai Romînu

“…A curing lamp (Kerr Demi Ultra) was used with different curing times. Micro-CT scanning was performed by using Nikon XTH 225ST to reveal any defects in adaptation or gaps at the tooth restoration interface. …”
Get full text

Hydrothermal Pre-Carbonization Triggers Structural Reforming Enabling Pore-Tunable Hierarchical Porous Carbon for High-Performance Supercapacitors by Cuihua Kang, Mingyuan Zuo, Chang Qiu, Fanda Zeng, Yuehui Wang, Zhuo Chen, Tingting Liang, Daping Qiu

“…Owing to the large ion-accessible, remarkable supermesoporous and macroporous pore volume, HJPC-4 exhibited ultra-high specific capacitance (6 M KOH: 316 F g⁻¹ at 1 A g⁻¹; EMIMBF₄: 204 F g⁻¹ at 1 A g⁻¹), excellent rate performance (6 M KOH: 231 F g⁻¹ at 100 A g⁻¹; EMIMBF₄: 154 F g⁻¹ at 30 A g⁻¹), outstanding cycling stability (6 M KOH: the retention rate is 92.11% after 60,000 cycles at 10 A g⁻¹; EMIMBF₄: the retention rate is 80% after 10,000 cycles at 5 A g⁻¹), and ultimate energy/power density up to 91.09 Wh kg⁻¹/24.25 kW kg⁻¹ in EMIMBF₄ two-electrode systems. …”
Get full text

Rapid Determination of Pemetrexed Concentration and Distribution in Human Breast Cancer Cells (McF-7) Based on UHPLC-MS/MS by Mengwei Zhang, Zhipeng Wang, Qiqiang Zhang, Qing Ye, Fengjing Xu, Lili Cui, Yanping Liu, Shouhong Gao, Wansheng Chen, Yan Liu

“…Pemetrexed is a new multitarget folate antagonist with pyrrolidine group as its core structure. An ultra high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed for rapid quantification of pemetrexed concentration in human breast cancer cells (MCF-7). …”
Get full text

Altered functional brain connectivity in Dyt1 knock-in mouse models by R. Z. Adury, B. J. Wilkes, P. Girdhar, Y. Li, D. E. Vaillancourt, D. E. Vaillancourt, D. E. Vaillancourt

“…In both models, we performed in vivo neuroimaging at ultra-high field (11.1T). We employed functional magnetic resonance imaging (fMRI) to assess resting-state and sensory-evoked brain connectivity and activation, along with diffusion MRI (dMRI) to evaluate microstructural changes. …”
Get full text

THC degradation does not impair the accuracy of THC doses aerosolized by the metered-dose SyqeAir inhaler: a 24-month stability trial by Joshua Aviram, Daniella Atzmony, Anna Frenklakh, Asaf Kroll, Ilana Zaks, Arno Hazekamp

“…Concentrations of the major phytocannabinoids therein were analyzed at different time points using ultra-high performance liquid chromatography (U-HPLC). …”
Get full text

Thin film sputter-deposition of AlN crystals in oxygenated chamber: a pilot study by Muhammad Izzuddin Abd Samad, Syazwani Izrah Badrudin, Marwan Mansor, Nafarizal Nayan, Ahmad Shuhaimi Abu Bakar, Mohd Zamri Yusop, Rhonira Latif

“…In many cases, the thin film deposition of high quality AlN crystals requires the application of heat and bias to the substrate, highly pure nitrogen reactant gas, argon sputtering gas and Al target, low sputtering pressure, high sputtering power, post-deposition AlN annealing, ultra-low base pressure of the sputtering chamber and a distinctive crystal orientation of the nucleation layer or substrate underneath. …”
Get full text

Adhesion-induced MoS2 layer transfer via in-situ TEM-nanoindentation: Effects of curvature and substrate mediated residual stress by Jhih H. Liang, Mehdi Rouhani, J. David Schall, Takaaki Sato, Christopher Muratore, Nicholas R. Glavin, Robert W. Carpick, Yeau-Ren Jeng

“…To address this, we conducted a comprehensive study investigating the interaction forces originating from the bonding between atoms that govern the adhesion of ultra-thin 2D MoS2. Our pioneering in situ experiments, utilizing TEM-based nanoindentation, provided precise imaging and force monitoring of MoS2's interaction with a diamond. …”
Get full text

Hypoxylon luteogranulatum (Hypoxylaceae, Xylariales), a novel species from Thailand with distinct chemical and ecological traits by Sarunyou Wongkanoun, Esteban Charria-Girón, Marjorie Cedeño-Sanchez, Boonchuai Chainuwong, Sayanh Somrithipol, Eric Kuhnert, Prasert Srikitikulchai, Natapol Pornputtapong, Frank Surup, Jennifer Luangsa-ard, Marc Stadler

“…During the course of our ongoing study of the diversity of Thai fungi and their secondary metabolites, numerous specimens within the Hypoxylaceae have been characterised by traditional morphology, chemotaxonomy using ultra-high-performance liquid chromatography coupled to diode array detection and ion mobility tandem mass spectrometry (UHPLC-DAD-IM-MS/MS), and molecular phylogenetic analyses. …”
Get full text

Protocol for a prospective quasi-experimental study on SARS-CoV-2 transmission during outdoor sports events in France: the COVID-ESO project by Frédéric Laurent, Philippe Vanhems, Christelle Elias, Pascal Roy, Sandrine Nail-Billaud, Patrick Basset, Emmanuelle Dantony, Mathieu Fauvernier

Get full text

Puerariae Radix protects against ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation by Yu Ga, Yuanyuan Wei, Qingyu Zhao, Yimeng Fan, Yannan Zhang, Zhifang Zhang, Sijia Hao, Lixia Wang, Zhifen Wang, Jinlong Han, Shuang Wu, Zhihui Hao

“…The chemical constituents of PR via ultra-performance liquid chromatography/tandem mass spectrometry and identifi ed potential PR and UC targets using a network pharmacology (NP) approach were obtained to guide mouse experiments. …”
Get full text

The Impact of Carbon on Electronic Structure of N-Doped ZnO Films: Scanning Photoelectron Microscopy Study and DFT Calculations by Elzbieta Guziewicz, Sushma Mishra, Matteo Amati, Luca Gregoratti, Oksana Volnianska

“…The samples were cleaved under ultra-high vacuum (UHV) conditions to open atomically clean cross-sectional areas for SPEM experiment. …”
Get full text

Evolution of free amino acids, biogenic amines and volatile compounds in fermented sausages inoculated with Lactiplantibacillus plantarum and Staphylococcus simulans by Xuefei Shao, Huhu Wang, Xiangyu Song, Mingyuan Huang, Jian Sun, Xinglian Xu

“…In this study, the effects of inoculation with different starter cultures (Lactiplantibacillus plantarum HN108 and Staphylococcus simulans NJ209) on the free amino acids (FAAs), biogenic amines (BAs) and volatile compounds of fermented sausages were investigated using an amino acid analyzer, ultra performance liquid chromatography and gas chromatography-ion mobility spectrometry, respectively. …”
Get full text

A predictive risk‐scoring model for survival prognosis of multiple myeloma based on gain/amplification of 1q21: Experience in a tertiary hospital in South‐Western China by Yanqiu Xiong, Shanshan Liang, Wenjiao Tang, Li Zhang, Yuhuan Zheng, Ling Pan, Ting Niu

“…This model, termed the ultra‐high‐risk (UHR) model, demonstrated superior performance in predicting shorter PFS compared to the R‐ISS stage 3 and R2‐ISS stage 4. …”
Get full text

A New Four‐Component L*‐Dependent Model for Radial Diffusion Based on Solar Wind and Magnetospheric Drivers of ULF Waves by Kyle R. Murphy, Jasmine Sandhu, I. Jonathan Rae, Thomas Daggitt, Sarah Glauert, Richard B. Horne, Clare E. J. Watt, Sarah Bentley, Adam Kellerman, Louis Ozeke, Alexa J. Halford, Sheng Tian, Aaron Breneman, Leonid Olifer, Ian R. Mann, Vassilis Angelopoulos, John Wygant

“…Abstract Waves which couple to energetic electrons are particularly important in space weather, as they drive rapid changes in the topology and intensity of Earth's outer radiation belt during geomagnetic storms. This includes Ultra Low Frequency (ULF) waves that interact with electrons via radial diffusion which can lead to electron dropouts via outward transport and rapid electron acceleration via inward transport. …”
Get full text

Yunvjian decoction attenuates lipopolysaccharide-induced acute lung injury by inhibiting NF-κB/NLRP3 pathway and pyroptosis by Fanxuan Zhang, Fang Wang, Lisha Zhao, Leqian Wang, Wenjing Li, Feihua Huang, Feihua Huang, Nani Wang, Nani Wang

“…The mechanism of action of YNJ on these model systems was studied using RNA sequencing, immunohistochemical analysis, immunoblotting, immunofluorescence, ELISA, and polymerase chain reaction assays. Ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied to identify the absorbed components of YNJ.ResultsYNJ attenuated pulmonary damage in LPS-treated mice, as evidenced by reduced protein content in bronchoalveolar lavage fluid, decreased lung wet/dry weight ratio, and improved respiratory function. …”
Get full text

Identification of Adulterated Deer Blood Crystals in Traditional Chinese Medicine Based on MALDI-TOF MS Peptide Fingerprints Technique by Shen-xing WANG, Ling CAO, Qing HUANG, Cong-yu MA, Jian-bin PAN, Hao-dong ZHAO, Hai-wei SHI, Bin DI, Hong-yuan CHEN

“…Firstly, Skyline software was used to predict candidate peptides by identifying the theoretical characteristic peptides for each species, and the mass spectrometry data of the tryptic digests were collected using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometer (UPLC-Q-TOF MS). …”
Get full text

Three-year course of clinical high-risk symptoms for psychosis in the community: a latent class analysis by C. Michel, N. Osman, G. Rinaldi, B. G. Schimmelmann, J. Kindler, F. Schultze-Lutter

“…., mild delusions or hallucinations) indicative of an ultra-high risk for psychosis. Class 3, the largest group (comprising over 90% of participants), exhibited the lowest probability of experiencing any psychosis-related symptoms (CHR-P symptoms). …”
Get full text

A Run-Time Reconfigurable Ge Field-Effect Transistor With Symmetric On-States by Andreas Fuchsberger, Lukas Wind, Daniele Nazzari, Larissa Kuhberger, Daniel Popp, Johannes Aberl, Enrique Prado Navarrete, Moritz Brehm, Lilian Vogl, Peter Schweizer, Sebastian Lellig, Xavier Maeder, Masiar Sistani, Walter M. Weber

“…Thereto, we have monolithically integrated an ultra-thin epitaxial and defect-free Ge layer on a Si on insulator platform. …”
Get full text