Comprehensive geological analysis and evaluation of the feasibility of renovating the Wanshunchang gas reservoir into a gas storage facility by Zebin Tong, Zhonggui Hu, Longwei Qiu, Na Zhang, Huayin Zhu, Daoyong Zhou, Gang Zhou, Xiao Chen, Yanlin Shao, Jiuzhen Hu

“…The reservoir’s caprock comprises a superimposed composite system, including the direct caprock of the Liangshan Formation and an overlying ultra-thick dense rock layer, which is extensive and exhibits high breakthrough pressure. …”
Get full text

Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases by Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García

“…Nevertheless, modifications in the expression due to mutations or their dysregulation can lead to diseases, including autoimmune disorders, cardiovascular problems, diabetes, neurological diseases, and cancers. Cyclic ultra-short peptides are amazing structures with unique properties. …”
Get full text

UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research by Zhan R, Liu Y, Wu J, Shen Y, Xu X, Lin G, Chen X

“…Ruanjuan Zhan,1,* Yanan Liu,1,2,* Jun Wu,1,2 Yuxin Shen,1,2 Xinhao Xu,1,2 Guanyang Lin,1,2 Xiaocheng Chen1 1The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China; 2School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanyang Lin; Xiaocheng Chen, Email 13867702133@163.com; cxcwzcn@139.comBackground: Givinostat, a potent histone deacetylase (HDAC) inhibitor, is promising for the treatment of relapsed leukemia and myeloma.Purpose: This study aimed to develop and verify a quick assay for the measurement of givinostat concentration using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) with eliglustat as the internal standard (IS), establishing a basic pharmacokinetic profile for its pre-clinical application and metabolic stability in vitro.Methods: Sample preparation was performed via protein precipitation using acetonitrile. …”
Get full text

Formation Pathways and Emission Characteristics of PCDD/Fs during Co-combustion Tests of Sewage Sludge in Coal-fired Power Plants by Xiangbo Zou, Ji Ye, Chuangting Chen, Hui Huang, Wenxin Yu, Yuxuan Ying, Tieying Mao, Yunfeng Ma, Bingjian Zhu, Xiaoqing Lin

“…The introduction of SS enhanced the formation of major air pollutants such as NOx, SO2, and dust, but their emission concentrations still met the ultra-low emission requirements. By adding 3% and 6% SS, the formation concentrations of PCDD/Fs in flue gas at the economizer increased from 0.1317 to 0.2651 and 0.6023 ng m−3, respectively, and the corresponding I-TEQ concentrations increased from 0.0104 to 0.023 and 0.058 ng I-TEQ m−3, respectively. …”
Get full text

Multifunctional 2D FETs exploiting incipient ferroelectricity in freestanding SrTiO3 nanomembranes at sub-ambient temperatures by Dipanjan Sen, Harikrishnan Ravichandran, Mayukh Das, Pranavram Venkatram, Sooho Choo, Shivasheesh Varshney, Zhiyu Zhang, Yongwen Sun, Jay Shah, Shiva Subbulakshmi Radhakrishnan, Akash Saha, Sankalpa Hazra, Chen Chen, Joan M. Redwing, K. Andre Mkhoyan, Venkatraman Gopalan, Yang Yang, Bharat Jalan, Saptarshi Das

“…Our observation includes ultra-fast polarization switching (~10 ns), low switching voltage (<6 V), over 10 years of nonvolatile retention, 100,000 endurance cycles, and 32 conductance states (5-bit memory) in SrTiO3-gated MoS2 transistors at 15 K and up to 100 K. …”
Get full text

Taming of trinitromethyl-oxadiazole to access high density and high oxygen balance via a dual modulation strategy by Jinya Zhang, Teng Fei, Jingwei Meng, Jinxiong Cai, Lei Zhang, Siping Pang, Chunlin He

“…Encouragingly, while maintaining ultra-high oxygen balance (21.73%), 3 achieves impressive densities (1.97–1.98 g/cm3). …”
Get full text

Fabrication and high temperature electrical conductivity of polymer-derived SiHfBCN ceramic coating by Xichao Dong, Qinghua Zhao, Yao Li, Shaomin Gu, Xinming Xu, Dianwei He, Fang Ye, Laifei Cheng, Xingang Luan, Zhaoju Yu

“…However, the thin-film electrode as the SAW sensor core unit with excellent high-temperature conductivity, stability, and oxidation resistance is still a challenge, especially in harsh ultra-high-temperature environments. In this study, we employed a polymer-derived ceramic approach to fabricate smooth and dense SiHfBCN ceramic coatings on YCa4O(BO3)3/BN substrate. …”
Get full text

TOPS-speed complex-valued convolutional accelerator for feature extraction and inference by Yunping Bai, Yifu Xu, Shifan Chen, Xiaotian Zhu, Shuai Wang, Sirui Huang, Yuhang Song, Yixuan Zheng, Zhihui Liu, Sim Tan, Roberto Morandotti, Sai T. Chu, Brent E. Little, David J. Moss, Xingyuan Xu, Kun Xu

“…In parallel with the successes and extensive efforts made in electronics, optical neuromorphic hardware is promising to achieve ultra-high computing performances due to its inherent analog architecture and wide bandwidth. …”
Get full text

Direct seawater splitting for hydrogen production: Recent advances in materials synthesis and technological innovation by Yilin Zhao, Zhipeng Yu, Aimin Ge, Lujia Liu, Joaquim Luis Faria, Guiyin Xu, Meifang Zhu

“…However, efficient seawater splitting is hindered by slow kinetics caused by the ultra- low conductivity and the presence of bacteria, microorganisms, and stray ions in seawater. …”
Get full text

Assessing type-2 diabetes risk based on the Indian diabetes risk score among adults aged 45 and above in India by Karthika Maniyara, Prakash Babu Kodali

“…Educational programs on diet and physical activity, creation of public spaces conducive to physical activity, promotion of fruit and vegetable intake, and discouragement of processed and ultra-processed diets can directly address inadequate physical activity and obesity, the two primary modifiable risk factors for type-2 diabetes. …”
Get full text

Femtomolar hydrogen sulfide detection via hybrid small-molecule nano-arrays by Xing Xing, Luyan Wu, Yuchen Zhang, Jiahao Pan, Yusuke Ishigaki, Huaqing Xie, Takanori Suzuki, Deju Ye, Jianhua Zhang, Weihua Zhang, Zhenda Lu

“…On-chip immunoassays, particularly nanoarray-based interfacial detection, offer promising avenues for ultra-sensitive analysis due to their confined reaction volumes and precise signal localization. …”
Get full text

Relationship Between the Salivary Microbiome and Oral Malodor Metabolites in Older Thai Individuals with Periodontitis and the Cytotoxic Effects of Malodor Compounds on Human Oral... by Witsanu Srila, Kritsana Sripilai, Thunwa Binlateh, Peungchaleoy Thammanichanon, Watcharaphol Tiskratok, Parinya Noisa, Paiboon Jitprasertwong

“…<b>Methods</b>: Saliva samples were collected and analyzed using Ultra-High Performance Liquid Chromatography–Mass Spectrometry (UHPLC-MS) to identify metabolites. …”
Get full text

Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…Haiou Wang,1 Wenkang Huang,1 Xiaoya Pan,1 Meizi Tian,1 Jiahui Chen,1 Xiaotong Liu,1 Qin Li,1 Jianhua Qi,2 Yiping Ye,1 Lijuan Gao1 1School of Pharmacy, Hangzhou Medical College, Hangzhou, 310013, People’s Republic of China; 2College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence: Lijuan Gao; Yiping Ye, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou, Zhejiang, 310013, People’s Republic of China, Email gaolijuan04141002@126.com; yeyiping2005@163.comPurpose: To explore the protective effect and underlying mechanism of Quzhou Aurantii Fructus flavonoids (QAFF) on Ulcerative colitis (UC).Methods: The constituents of QAFF were accurately determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). …”
Get full text

Untargeted Metabolomics Reveals Key Differences Between Yak, Buffalo, and Cow Colostrum Based on UHPLC-ESI-MS/MS by Yuzhuo Wang, Changhui Li, Jiaxiang Huang, Qingkun Zeng, Ling Li, Pan Yang, Pengjie Wang, Min Chu, Jie Luo, Fazheng Ren, Hao Zhang

“…Methods: This study employed ultra-high performance liquid chromatography-electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) for untargeted metabolomics analysis of YC, BC, and CC. …”
Get full text

A New Device Improves Signs and Symptoms of TMD by Ruggero Cattaneo, Davide Pietropaoli, Barry C. Cooper, Dino Capparè, Eleonora Ortu, Annalisa Monaco

“…The study group received the ELIBA device (lingual elevator by Balercia) constructed under ULF-TENS (ultra-low-frequency transcoutaneous electrical nervous stimulation). …”
Get full text

Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway by Su Qing, Xu Baolin, Tian Zhoubin, Gong Ziling

“…The compounds were synthesized and evaluated for their PI3K and mTOR inhibitory activity using luminescent kinase assay, and Lance ultra assay, resp. The entire set of compounds showed significant to moderate inhibition of both kinases in the nanomolar range. …”
Get full text

Analysis of the mechanism of Zangjiangzhi capsule in the treatment of hyperlipidemia based on its ingredients identified by UHPLC-Q-Exactive-Orbitrap-MS by Changting He, Yuling Zhao, Yongchun Huang, Yudong Su, Shoude Zhang

“…Methods: The components of ZJZC were analyzed and identified using ultra-high performance liquid chromatography with Q-Exactive Orbitrap tandem mass spectrometry (UHPLC-Q-Exactive-Orbitrap-MS/MS). …”
Get full text

Chemical Profile and Antibacterial Activity of <i>Vitis vinifera</i> L. cv Graciano Pomace Extracts Obtained by Green Supercritical CO₂ Extraction Method Against Multidr... by Rocío Fernández-Pérez, Silvia Ayuso, Cristina Moreta, María-José Saiz-Abajo, Miguel Gastón-Lorente, Fernanda Ruiz-Larrea, Carmen Tenorio

“…The SE and SFE methods were optimised, and ultra-performance liquid chromatography/mass spectrometry (UPLC/QqQ-MS/MS) analysis revealed 38 phenolic compounds in the SE sample, with anthocyanins being the predominant polyphenols, and 21 phenolic compounds in the SFE samples, among which hydroxybenzoic acids and flavonols were the predominant compounds. …”
Get full text

Differences in Metabolites of Different Varieties from Xinjiang Large-fruit Sea Buckthorn as Analyzed by Non-targeted Metabolomics by Rong HAN, Yan MA, Shengjie LI, Xintao MENG, Mingqiang XU, Ting ZHANG, Yan PAN

“…This experiment aimed to investigate the differences in metabolites of different varieties from Xinjiang large-fruit sea buckthorn, ultra high performance liquid chromatography-mass spectrometry (UPLC-QTOF-MS) coupled with multivariate statistical analysis and pathway enrichment analysis were used to characterize the metabolites of six Xinjiang large-fruit sea buckthorn species ('Mixed Fruit', 'Giant', 'Shenqunhon', 'Wucifeng', 'Xiangyang' and 'Zhuangyuan Yellow') were subjected to non-targeted metabolomics study. …”
Get full text

Novel adaptive immune systems in pristine Antarctic soils by Marc W. Van Goethem, Oliver K. I. Bezuidt, Rian Pierneef, Surendra Vikram, David W. Hopkins, Thomas Aspray, Grant Hall, Stephan Woodborne, Ian D. Hogg, Trent R. Northen, Weidong Kong, Daniele Daffonchio, Don A. Cowan, Yves Van de Peer, Manuel Delgado-Baquerizo, Thulani P. Makhalanyane

“…Although several studies have investigated the phylogenetic repertoire of bacteria and viruses in these poly-extreme environments with freezing temperatures, high ultra violet irradiation levels, low moisture availability and hyper-oligotrophy, the evolutionary mechanisms governing microbial immunity remain poorly understood. …”
Get full text