Patient-derived induced pluripotent stem cell organoids for amyotrophic lateral sclerosis drug discovery by Wenyan Li, Jingqi Liu, Wenting Li, Lina Sun, Hao Zhang, Lei Gao, Chong Gao

“…Given these challenges, reliable disease models that accurately replicate ALS phenotypes with relevant biological underpinnings are essential for advancing precision medicine in ALS. …”
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Correlation of Circulating Acid-Labile Subunit Levels with Insulin Sensitivity and Serum LDL Cholesterol in Patients with Type 2 Diabetes: Findings from a Prospective Study with Ro... by Ying-Chuen Lai, Hung-Yuan Li, Ta-Jen Wu, Chi-Yuan Jeng, Lee-Ming Chuang

“…Silencing of acid-labile subunit (ALS) improved glucose metabolism in animal models. …”
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Assessment of upper GI motor activity and GI symptoms in patients with amyotrophic lateral sclerosis: an observational study by Emanuela Ribichini, Nadia Pallotta, Danilo Badiali, Maria Carlucci, Marco Ceccanti, Chiara Cambieri, Laura Libonati, Enrico Stefano Corazziari, Giovanni Ruoppolo, Maurizio Inghilleri, Maurizio Inghilleri

“…Background/aimsOro-pharyngeal dysfunction has been reported in Amyotrophic Lateral Sclerosis (ALS). We aimed to assess ALS patients upper gastrointestinal (GI) motor activity and GI symptoms according to bulbar and spinal onset and severity of ALS.MethodsALS bulbar (B) and spinal (S) patients with ALS Functional Rating Scale (ALSFRS-r) ≥35, bulbar sub-score ≥10, and Forced Vital Capacity (FVC) >50%, underwent to: Fiberoptic Endoscopic Evaluation of Swallowing (FEES); esophageal manometry; gastric emptying; Rome symptom questionnaire. …”
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Associations of Abnormal Sleep Duration and Chronotype with Higher Risk of Incident Amyotrophic Lateral Sclerosis: A UK Biobank Prospective Cohort Study by Gan Zhang, Wen Cao, Zhuoya Wang, Kailin Xia, Binbin Deng, Dongsheng Fan

“…<b>Background:</b> The occurrence of sleep disturbances in amyotrophic lateral sclerosis (ALS) patients is widely reported. However, there is still a lack of reliable evidence of a relationship between sleep disturbances and the risk of developing ALS. …”
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肌萎缩侧索硬化症疾病进展与线粒体功能紊乱 by 郑志隆, 郭兴

“…肌萎缩侧索硬化症（ALS）是一种典型的神经退行性疾病，其特征是大脑和脊髓中的运动神经元进行性病变。虽然DNA测序技术筛查出众多的ALS致病基因，拓宽了人们对ALS疾病发生的认识，但是这些功能各异的基因导致ALS疾病进程的分子机制仍是有待阐明的。…”
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Progress in Therapy Development for Amyotrophic Lateral Sclerosis by Kalina Venkova-Hristova, Alexandar Christov, Zarine Kamaluddin, Peter Kobalka, Kenneth Hensley

“…Through decades of studying sporadic and familial ALS (SALS and FALS), researchers are coming to understand ALS as a complex syndrome with diverse genetic and environmental etiologies. …”
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Staging model for amyotrophic lateral sclerosis in Singapore by Yuan Teck Tay, Josiah YH Chai, Kamilah Bte Shekh Jabin, Kexin Ang

“…Introduction: A clinical-based staging model would guide physicians in the prompt management of the evolving symptoms and functional needs of patients with amyotrophic lateral sclerosis (ALS). Methods: We aimed to delineate the clinical trajectory of ALS in Singapore and test the degree of congruity of King’s College staging for ALS (King’s staging) among Singapore patients. …”
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Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis by Jing Yang, Jing Yang, Jing Yang, Wenyi Li, Wenyi Li, Wenyi Li, Mei Tian, Mei Tian, Mei Tian, Lei Zhang, Fengping Du, Fengping Du, Fengping Du, Xin Li, Xin Li, Xin Li, Qi Liu, Qi Liu, Qi Liu, Rui Li, Rui Li, Rui Li, Zhenzhong Li, Zhenzhong Li, Zhenzhong Li, Hui Dong, Hui Dong, Hui Dong, Yaling Liu, Yaling Liu, Yaling Liu

“…Inflammation plays an important role in the development of ALS, and associated with rapid disease progression. …”
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An overlap-weighted analysis on the association of constipation symptoms with disease progression and survival in amyotrophic lateral sclerosis: a nested case-control study by Tongyang Niu, Peize Wang, Xiaomeng Zhou, Tingting Liu, Qi Liu, Rui Li, Haitao Yang, Hui Dong, Yaling Liu

“…Background: Amyotrophic lateral sclerosis (ALS) is a rapidly progressing and rare neurodegenerative disease. …”
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Mechanisms of Neuroprotection by Protein Disulphide Isomerase in Amyotrophic Lateral Sclerosis by Adam K. Walker, Julie D. Atkin

“…Although protein misfolding is a key feature of ALS, the upstream triggers of disease remain elusive. …”
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An Overview of DNA Repair in Amyotrophic Lateral Sclerosis by Fabio Coppedè

“…After a brief description of the evidence of DNA damage in ALS, this paper focuses on the available data on DNA repair activity in ALS neuronal tissue and disease animal models. …”
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Investigation of ammonium–lauric salt as shale swelling inhibitor and a mechanism study by Jie Zhang, Weimin Hu, Li Zhang, Tiehu Li, Dan Cai, Gang Chen

“…In this work, a series of ammonium–lauric salts (ALS) was prepared with lauric acid and amines as small molecular shale swelling inhibitor. …”
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Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis by Cinzia Femiano, Francesca Trojsi, Giuseppina Caiazzo, Mattia Siciliano, Carla Passaniti, Antonio Russo, Alvino Bisecco, Mario Cirillo, Maria Rosaria Monsurrò, Fabrizio Esposito, Gioacchino Tedeschi, Gabriella Santangelo

“…Particularly, apathy has been reported to be associated with poor ALS prognosis. However, the brain microstructural correlates of this behavioral symptom, reported as the most common in ALS, have not been completely elucidated. …”
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Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation by Jan Kassubek, Francesco Roselli, Simon Witzel, Johannes Dorst, Albert C. Ludolph, Volker Rasche, Ina Vernikouskaya, Hans-Peter Müller

“…Within the MND spectrum, PLS is much more slowly progressive than amyotrophic laterals sclerosis (ALS). `Classical` ALS is characterized by catabolism and abnormal energy metabolism preceding onset of motor symptoms, and previous studies indicated that the disease progression of ALS involves hypothalamic atrophy. …”
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Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale as a Novel Tool to Measure Disease Progression by Can Sun, Yong Chen, Lu Xu, Wenjing Wang, Nan Zhang, Christina N. Fournier, Nan Li, Dongsheng Fan

“…<b>Background:</b> A valuable outcome measure to monitor amyotrophic lateral sclerosis (ALS) disease progression is crucial in clinical trials. …”
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Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkins... by Dang Wei, Anna Freydenzon, Octave Guinebretiere, Karim Zaidi, Fen Yang, Weimin Ye, Niklas Hammar, Karin Modig, Naomi R. Wray, Maria Feychting, Nadine Hamieh, Bruno Ventelou, Beranger Lekens, Laurene Gantzer, Stanley Durrleman, Allan McRae, Baptiste Couvy-Duchesne, Fang Fang, Thomas Nedelec, Stanley Durrleman, Bruno Ventelou, Thomas Nedelec, Octave Guinebretiere, Karim Zaidi, Fang Fang, Dang Wei, Fen Yang, Allan McRae, Naomi Wray, Baptiste Couvy-Duchesne, Anna Freydenzon, Lydie Tran, Evans Cheruiyot

“…We aimed to identify medication use, health conditions, and blood biomarkers that might be associated with the risk of AD, PD, and ALS ten years later. Methods: We conducted population-based nested case–control studies of AD, PD, and ALS using electronic medical records in Europe (France, the UK, and Sweden) and Australia. …”
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The effect of the 7DL-7Ae#1L·7Ae#1S translocation on the productivity and quality of spring bread wheat grain by S. N. Sibikeev, E. I. Gultyaeva, A. E. Druzhin, L. V. Andreeva

“…All lines increased the f lour strength and the loaves volume, but while Saratovskaya 68 ALs had an increased porosity rating, Saratovskaya 70 ALs had the same rating as the recipient.…”
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Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion by Mirjana Babić Leko, Vera Župunski, Jason Kirincich, Dinko Smilović, Tibor Hortobágyi, Patrick R. Hof, Goran Šimić

“…Two clinically distinct diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), have recently been classified as two extremes of the FTD/ALS spectrum. …”
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Decremental response in patients with amyotrophic lateral sclerosis during repetitive nerve stimulation and its relationships with impaired homeostasis by Jinghong Zhang, Yang Li, Qiang Shi

“…BackgroundPrevious studies have suggested that neuromuscular junction (NMJ) denervation plays a critical role in amyotrophic lateral sclerosis (ALS). Repetitive nerve stimulation (RNS) has been used as a technique to test neuromuscular transmission, but the sensitivity and stability of its parameters have not been investigated in patients with ALS. …”
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Th17 Cell Response in SOD1G93A Mice following Motor Nerve Injury by Allen Ni, Tao Yang, Nichole A. Mesnard-Hoaglin, Rafael Gutierrez, Evan B. Stubbs, Susan O. McGuire, Virginia M. Sanders, Kathryn J. Jones, Eileen M. Foecking, Junping Xin

“…An increased risk of ALS has been reported for veterans, varsity athletes, and professional football players. …”
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