TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion by Xuhao Zhang, Yu Gao, Huiping Liao, Wenyan Wang, Zaili Yang, Weian Cao, Ge Li, Jing Wen, Gencheng Han, Yang-Xin Fu

“…Progressive loss of IL2-secretion is an early sign of diminished effector function in TILs, which raises the possibility of IL2 loss driving exhaustion of TILs. …”
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Differential efficacy of olfactory neurospheres from deviated nasal septum and chronic rhinosinusitis patients in regenerating olfactory epithelium by Rong-San Jiang, Chiang-Wen Lee, Yu-Hsuan Lin, Jing-Jie Wang, Jia-Bin Liao, Kuo-Ti Peng, Yao-Chang chiang, Pei-Ling Chi

“…Conclusions These findings highlight the importance of selecting the appropriate ONS source for therapeutic applications, with DNS-ONS showing greater promise for olfactory epithelium repair and olfactory function restoration.…”
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Online activity time management – dilemmas and challenges by Barbara Liliana Pabian, Arnold Grzegorz Pabian

“…Material and methods The article is of a theoretical and discussion nature, therefore non-reactive methods were selected for research. It was a desk research method, consisting in the analysis of secondary sources and the analysis of the content of written and oral messages disseminated via the media. …”
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Integration of single cell and bulk transcriptomes identifies T cell stress subtypes in LUAD by Shengping Min, Linfeng Pan, Xinyu Zhang, Huili Chen, Lixuan Qiu, Xinyu Wang, Yiluo Xie, Kai Zhang, Qiang Zhang, Chaoqun Lian, Jing Zhang

“…The exploration delved into the bio-function of CREG2 in the progression of LUAD.…”
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Application of artificial intelligence in echocardiography from 2009 to 2024: a bibliometric analysis by Yangli Liu, Lei Zhao, Bin Tu, Jie Wang, Yaqun He, Rufang Jiang, Xiaofeng Wu, Wen Wen, Jian Liu

“…The objective of this study is to explore the current status and prevailing research trends in this field from 2009 to 2024 through bibliometric analysis and to forecast future developmental trajectories.MethodsWe selected the Science Citation Index Expanded (SCI-Expanded) from the Web of Science Core Collection (WOSCC) as our primary data source and conducted a comprehensive search encompassing all articles and reviews published between 2009 and 2024 and used the online analysis platform of bibliometrics, CiteSpace and VOSviewer software to analyze countries/regions, institutions, authors, keywords, and references, used Microsoft Excel 2021 to visualize the trends of the number of articles published by year.ResultsBetween 2009 and 2024, a total of 3,411 publications on AI applications in echocardiography were identified, including 3,000 articles (87.9%) and 411 reviews (12.1%), contributed by researchers from 100 countries/regions. …”
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The evolution and competitive strategies of Akkermansia muciniphila in gut by Ji-Sun Kim, Se Won Kang, Ju Huck Lee, Seung-Hwan Park, Jung-Sook Lee

“…In addition, WapA and anSME, which function in competition and post-translational modification of sulfatase, respectively, have been a particularly important selective pressure in the evolution of group A. …”
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Influence of suturing material on wound healing: Experimental study in dogs by Gazivoda Dragan, Pelemiš Dejan, Vujašković Goran, Đurđević Slaviša

“…When using resorbable materials it is of great importance to determine whether its absorbability and tensile strength help wound healing in function of time. Sutures themselves can become a source of inflammation, that may reduce or compromise the potential of reparation and regeneration. …”
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Enhancing the socio-cultural valuation of ecosystem services in Mountain animal production: a case study from piedmont’s alpine valley (North-west Italy) by Chiara Costamagna, Valentina Maria Merlino, Danielle Borra, Lorenzo Baima, Paolo Cornale, Luca Maria Battaglini

“…The new principal components were employed to cluster the sample in the function of individuals’ perceptions of ecosystem services. …”
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Efficacy of Anti-VEGF/VEGFR Agents on Animal Models of Endometriosis: A Systematic Review and Meta-Analysis. by Shuangge Liu, Xiaoyan Xin, Teng Hua, Rui Shi, Shuqi Chi, Zhishan Jin, Hongbo Wang

“…Subgroup analyses were performed to determine the source of heterogeneity in endometriosis scores and follicle numbers.…”
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A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity. by Andrew P Holmes, Ting Y Yu, Samantha Tull, Fahima Syeda, Stefan M Kuhlmann, Sian-Marie O'Brien, Pushpa Patel, Keith L Brain, Davor Pavlovic, Nigel A Brown, Larissa Fabritz, Paulus Kirchhof

“…<h4>Methods</h4>We used high-resolution optical mapping and sharp microelectrode recordings to quantify regional differences in electrical activation and repolarisation within the intact, superfused murine left atrium and quantified regional ion channel mRNA expression by Taqman Low Density Array. We also performed selected cellular electrophysiology experiments to validate regional differences in ion channel function.…”
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Energy­Saving Lighting of Agricultural Premises and its Parameters Calculation by L. Yu. Yuferev

“…It has been noted that the LED light sources’ functioning has such features that make the application of standard calculation methods impossible. …”
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Effect of the diet level of whole-plant corn silage on the colonic microflora of Hezuo pigs by Qiaoli Yang, Longlong Wang, Pengfei Wang, Zunqiang Yan, Qiong Chen, Pengxia Zhang, Jie Li, Rui Jia, Yao Li, Xitong Yin, Shuangbao Gun

“…Background Whole-plant corn silage (WPCS) is an important roughage source for livestock, and have critical influences on rumen or intestinal microbiota, thus affecting the growth performance and feed efficiency. …”
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Biomarkers associated with cell-in-cell structure in kidney renal clear cell carcinoma based on transcriptome sequencing by Zehua Wang, Zhongxiao Zhang

“…Methods Data for this study were sourced from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and Gene Expression Omnibus (GEO) databases. …”
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Identification and characterization of the powdery mildew resistance in cultivated emmer wheat accession Lxd-682 via bulked segregant RNA sequencing by Jiatong Li, Ningning Yu, Nina Sun, Lige Geng, Yanmin Qie, Dongfeng Zhai, Yuxiang Wang, Linzhi Li, Xueqing Liu, Xusheng Sun, Jiangchun Wang, Ruishan Liu, Guantong Pan, Shengmao Zou, Guohao Han, Yuli Jin, Pengtao Ma

“…Abstract Background Common wheat (Triticum aestivum L.) is a vital source of nutrition for human consumption. However, wheat production is significantly threatened by various diseases, such as powdery mildew, a widespread fungal disease caused by Blumeria graminis f. sp. tritici (Bgt). …”
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Numerical modeling of coupled electromagnetic and thermal processes in the zone induction heating system for metal billets by V. Yu. Grytsiuk, M. A. M. Yassin

“…Multiphysics couplings use electromagnetic power dissipation as a heat sources, and the billet material properties are specified by temperature functions. …”
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Preparation Process Optimization and Physicochemical Properties Characterization of Jinhua Ham Enzymolysis Peptide by Weiqiang WANG, Yu ZHENG, Weimin XU, Yanbo WANG, Jie CHEN

“…To investigate the potential of enzymatic hydrolysis for enhancing the nutritional and functional properties of Jinhua ham, a concentrated extract produced by dialysis desalination was employed as a substrate. …”
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Key technologies of efficient extraction of coalbed methane (gas) in Guizhou coal mine area by Wang YI, Longjun LIANG, Lichong YAN, Zhihua YAN, Jie CHEN, Wei GAO, Yi LOU, Fuqin YANG, Haiyang HU, Jiawei ZHU

“…It innovated and explored the following high efficiency extraction technology of “four zones” linked Wells in coal mining areas with Guizhou characteristics: ① By laying multi-functional pumping vertical Wells or small inclination oriented Wells in the goaf, it was the first time in Guizhou to realize efficient extraction and development of pressure relief gas in the overlying coal-covered strata and coal-bed methane in the sweet coal seam below the goaf; ② Taking advantage of the characteristics of spatial and temporal dislocation in the production area, the multi-mode extraction mode of “coalbed methane well + relief well + underground drilling” is adopted for the first coal seam mined in the upper protective layer, which realizes the purpose of the upper and lower vertical combined extraction of coalbed methane (gas) Wells and effectively solves the problem of multi-source gas flooding into coal mining roadway and gas accumulation in the upper corner during coal mining under the condition of coal seam group development in Guizhou; ③ In the preparation area and planning area, combined with the terrain and geological characteristics of the two areas, the horizontal well “well factory” + “two pairs of right and wrong” overlapping well layout mode is adopted to realize the efficient extraction of coal bed methane in the plane in advance and pre-pumping of the sweet coal seam and the pressure relief gas in the overlying coal-laden rock in the subsequent mining process, and at the same time to achieve the goal of “replacing the roadway with Wells”; ④ In view of the development of multi-thin coal seam groups in the study area and the development characteristics of “three zones” in the overlying strata after mining, due to the continuous change of the role of “four zones”, the surface coalbed methane Wells are initially deployed in the production area or preparation area, and the “bridge plug bottom sealing + layer selection perforation” technology is adopted to innovate the “transformation” technology of well structure to achieve the purpose of “multi-purpose in one well”; It also provides new technical ideas and accumulated valuable engineering experience for gas management in coal mine area under the condition of multi-thin coal seam group development in Guizhou.…”
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A new fluorescent probe based on BODIPY for testing NO2 released from propellants by Ying-cui Cui, De-bin Xia, Zhong-yu Cui, Yu-jing Li, Jian Zhang, Ping Wang, Ting Guo, Kai-feng Lin, Yu-lin Yang

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Vitamin D and Osteoporosis in HIV/HCV Coinfected Patients: A Literature Review by Paola Di Carlo, Lucia Siracusa, Giovanni Mazzola, Piero Colletti, Maurizio Soresi, Lydia Giannitrapani, Valentina Li Vecchi, Giuseppe Montalto

“…The final 12 articles selected are homogeneous in terms of age but heterogeneous in terms of sample size, participant recruitment, and data source. …”
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The role of oxygenation in kidney and liver machine perfusion by M. S. Novruzbekov, A. G. Balkarov, E. Yu. Anosova, I. V. Dmitriev, Yu. A. Anisimov, N. S. Zhuravel, E. V. Klychnikova, A. S. Bogdanova, B. I. Yaremin

“…All currently available methods of preservation of donor organs are aimed at maximizing the complete preservation of the functional state of the graft from the moment of its removal to implantation and reperfusion in the recipient's body.Aim. …”
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