Whole blood RNA-seq analysis reveals the immunomodulatory effects of a supplemental multi-strain direct-fed microbial in the diet of newly weaned beef steers1 by Adekunle Ajiboye, Samanthia Johnson, Modoluwamu Idowu, Yarahy Leal, Taylor Sidney, Godstime Taiwo, Ibukun M. Ogunade, Christopher Ashwell

“…In conclusion, this study revealed that beef steers fed the PRO additive exhibited differential expression of genes related to immune function and inflammatory response, suggesting an effect on immunity and stress resilience. …”
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Performance of the HAWC Observatory and TeV Gamma-Ray Measurements of the Crab Nebula with Improved Extensive Air Shower Reconstruction Algorithms by A. Albert, R. Alfaro, C. Alvarez, A. Andrés, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, F. Carreón, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño de León, E. De la Fuente, C. de León, D. Depaoli, N. Di Lalla, R. Díaz Hernández, B. L. Dingus, M. A. DuVernois, K. Engel, T. Ergin, C. Espinoza, K. L. Fan, K. Fang, N. Fraija, S. Fraija, J. A. García-González, F. Garfias, H. Goksu, M. M. González, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernández-Cadena, I. Herzog, J. Hinton, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, S. Kaufmann, A. Lara, J. Lee, H. León Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, J. Martínez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Montes, E. Moreno, M. Mostafá, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, L. Olivera-Nieto, N. Omodei, M. Osorio-Archila, Y. Pérez Araujo, E. G. Pérez-Pérez, C. D. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, G. Schwefer, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Ureña-Mena, E. Varela, X. Wang, I. J. Watson, K. Whitaker, E. Willox, H. Wu, S. Yu, S. Yun-Cárcamo, H. Zhou, HAWC Collaboration

“…Thanks to these improvements, HAWC can now detect more sources, including the Galactic center.…”
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Effects of aspirin and omega-3 fatty acids on age-related macular degeneration in ASCEND-Eye: a randomised placebo-controlled trial in a population with diabetes by Praveen Patel, Rory Collins, Richard Peto, Mark Davies, Sanjiv Banerjee, David Simpson, John Anderson, Louise Bowman, Peter Scanlon, Amanda Adler, Andrew Farmer, Helen Cook, Laura Evans, Elizabeth Williamson, Louis Bolter, Jane Armitage, Peter Sandercock, Richard Gray, Nilesh Samani, Tasso Gazis, Richard Haynes, Arun Sachdev, Eric Wu, Elizabeth Wincott, Peter Sleight, Colin Baigent, Marion Mafham, Sarah Parish, Gavin Brown, Susan Hurley, Lynne Allsop, William Stevens, Theingi Aung, Allen Young, Emily Sammons, Georgina Buck, Imen Hammami, Jill Barton, Jonathan Bodansky, Roger McPherson, Lucy Fletcher, Murphy Kevin, Ryonfa Lee, Sandra Pickworth, Monica Willett, Michael Lay, Ola Murawska, Karen Melham, Jonathan Latham-Mollart, Anna Brewer, Mike Olson, Jude Kay, Alisha Griffiths, Helen Clayton, Philip Kirby, Mike Pennington, Dominic Clarke, Jenny Anslow, Alex Hallam, Jenny Witts, Sarah Egan, Alex Wharton, Amy Derbyshire, Katherine Hepplestone, Sujit Mithra, Su Oliver, Pauline Wiatrak-Olszewska, Kelly Alvey, Nick Gregory, Priyai Parkinson, Prema Maharajan, Rachel McFee, Donna Sowter, John Featonby, Richard Furnival, Helen Lipinski, Hazel Benjamin, Tanisha McAfee, Emma Payne Payne, Liz Still

“…Reports of AMD diagnoses were sourced from 6 monthly ASCEND follow-up questionnaires and a Visual Function Questionnaire.Participants 15 480 UK adults at least 40 years of age with diabetes but no evident cardiovascular disease.Interventions 100 mg aspirin daily versus placebo and, separately, 1 g omega-3 FAs daily versus placebo.Main outcome measure The first post-randomisation reports of AMD.Results During 7.4 years of follow-up, 122 (1.6%) participants randomised to aspirin were reported as having AMD, compared with 138 (1.8%) randomised to placebo (rate ratio 0.88; 95% CI 0.69 to 1.12; p=0.31). …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…Adolescent adaptive functioning was predicted not only by early childhood autistic symptoms and IQ and ADHD symptoms. …”
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Rapid parameter estimation for merging massive black hole binaries using continuous normalizing flows by Bo Liang, Minghui Du, He Wang, Yuxiang Xu, Chang Liu, Xiaotong Wei, Peng Xu, Li-e Qiang, Ziren Luo

“…Detecting the coalescences of massive black hole binaries (MBHBs) is one of the primary targets for space-based gravitational wave observatories such as laser interferometer space antenna, Taiji, and Tianqin. …”
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The Diversity of Cold Worlds: A Blended-light Binary Straddling the T/Y Transition in Brown Dwarfs by Daniella C. Bardalez Gagliuffi, Jacqueline K. Faherty, Genaro Suárez, Sherelyn Alejandro Merchan, Brianna Lacy, Ben Burningham, Klara Matuszewska, Rocio Kiman, Johanna M. Vos, Austin Rothermich, Jonathan Gagné, Caroline Morley, Melanie J. Rowland, Dan Caselden, Aaron Meisner, Adam C. Schneider, Marc J. Kuchner, Charles A. Beichman, Peter R. Eisenhardt, Christopher R. Gelino, Ehsan Gharib-Nezhad, Eileen C. Gonzales, Federico Marocco, Niall Whiteford, J. Davy Kirkpatrick

“…Carbon disequilibrium chemistry strongly shapes the mid-infrared spectra of these sources, as a complex function of the metallicity and surface gravity. …”
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JWST/NIRCam Narrowband Survey of Paβ Emitters in the Spiderweb Protocluster at z = 2.16 by Rhythm Shimakawa, J. M. Pérez-Martínez, Helmut Dannerbauer, Yusei Koyama, Tadayuki Kodama, Pablo G. Pérez-González, Chiara D’Eugenio, Yuheng Zhang, Abdurrahman Naufal, Kazuki Daikuhara

“…We derive the Pa β luminosity function in the Spiderweb protocluster, showing a normalization density of $\mathrm{log}{\phi }^{* }=-2.53\pm 0.15$ at a characteristic Pa β luminosity of $\mathrm{log}{L}^{* }=42.33\pm 0.17$ . …”
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Pearls on a String: Dark and Bright Galaxies on a Strikingly Straight and Narrow Filament by M. Arabsalmani, S. Roychowdhury, B. Schneider, V. Springel, E. Le Floc’h, F. Bournaud, A. Burkert, J.-C. Cuillandre, P.-A. Duc, E. Emsellem, D. Galárraga-Espinosa, E. Pian, F. Renaud, M. A. Zwaan

“…We study the cold H i gas in a 1.3 Mpc section of the filament through H i 21 cm emission line observations and detect 11 H i sources, many more than expected from the H i mass function in a similar volume. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…Treatment with insulin is aimed at replicating the function of the pancreas to manage hyperglycaemia and avoid hypoglycaemia. …”
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Growth Toxic Effects of Metal Nanoparticles on Bacillus subtilis and Vibrio parahaemolyticus by Shiyu CHEN, Bin XIA, Lin ZHU, Shuang LI, Qiufen LI, Xuemei SUN, Wei DAI

“…Based on the ecological roles and functions of these two bacteria in marine microbial communities, this study used B. subtilis and V. parahaemolyticus isolated from Bohai Bay as test organisms. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…The main literature searches were then conducted using six databases: Applied Social Sciences Index and Abstracts (ProQuest), Cumulative Index to Nursing and Allied Health Literature (EBSCO), MEDLINE (Ovid), PsycInfo (Ovid), EMBASE (Ovid) and Web of Science Core Collection (Emerging Sources Citation Index). The search covered evidence from 1 January 2001 up to 21 July 2021 and yielded 16,775 hits, which were then reduced to 14,383, after using EndNote X9’s (2013) inbuilt duplication detection function and manual de-duplication. …”
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Visible Triple-Wavelength Switchable Emission Generated in Passively Q-Switched Nd:YVO₄ Self-Raman Laser by Songtao Li, Shengxi Zheng, Bowen Zheng, Yong Wei, Yongchang Zhang, Yanmin Duan, Haiyong Zhu

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Clinical and cost-effectiveness of first contact physiotherapy for musculoskeletal disorders in primary care: the FRONTIER, mixed method realist evaluation by Nicola E Walsh, Alice Berry, Serena Halls, Rachel Thomas, Hannah Stott, Cathy Liddiard, Zoe Anchors, Fiona Cramp, Margaret E Cupples, Peter Williams, Heather Gage, Dan Jackson, Paula Kersten, Dave Foster, Justin Jagosh

“…Outcome measures were recorded at baseline, 3 and 6 months (primary end point) to track changes in pain and functioning using the Short Form questionnaire-36 items physical component summary (SF-36-PCS) primary outcome measure, and were compared across the care models. …”
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Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Secondary outcomes included: unplanned 60- and 90-day hospital re-admissions; quality of transition; health-related quality of life (EuroQol-5 Dimensions, five-level version); and self-reported healthcare resource use. Data sources National Health Service Secondary Use Services data and Hospital Episodes data for work package 2 and routinely recorded National Health Service acute trust hospital data on re-admissions for work packages 5 and 6. …”
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Molecular organization of the nanoscale surface structures of the dragonfly Hemianax papuensis wing epicuticle. by Elena P Ivanova, Song Ha Nguyen, Hayden K Webb, Jafar Hasan, Vi Khanh Truong, Robert N Lamb, Xiaofei Duan, Mark J Tobin, Peter J Mahon, Russell J Crawford

“…The molecular organization of the epicuticle (the outermost layer) of insect wings is vital in the formation of the nanoscale surface patterns that are responsible for bestowing remarkable functional properties. Using a combination of spectroscopic and chromatographic techniques, including Synchrotron-sourced Fourier-transform infrared microspectroscopy (FTIR), x-ray photoelectron spectroscopy (XPS) depth profiling and gas chromatography-mass spectrometry (GCMS), we have identified the chemical components that constitute the nanoscale structures on the surface of the wings of the dragonfly, Hemianax papuensis. …”
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PREVALENCE AND STRUCTURE OF DENTO-MAXILLOFACIAL ANOMALIES IN CHILDREN by O.-Kh.A. Byala

“…Dental health is largely characterized by the correctness of the structure of the mandibular system, its proper functioning and balance, and its condition is one of the preventive and quite clearly fixed indicators of health/ ill health of the human body in general. …”
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Genetic diversity in wild species and cultivars of strawberry for the <i>FanAAMT</i> gene controlling fruit flavor volatiles by A. S. Lyzhin, I. V. Luk’yanchuk

“…‘Karmen’, ‘Ostara’, ‘Samson’, ‘Symphony’, ‘Troubadour’ and ‘Vima Tarda’, in which the functional allele of the FanAAMT gene was found. In the remaining studied strawberry genotypes the marker FanAAMT was not detected, which presumably indicates that the FanAAMT gene is absent. cells (R9.4.1).…”
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Who Leads Trends on Q&A Platforms? Identifying and Analyzing Trend Discoverers by Yongning Li, Lun Zhang, Ye Wu, Tianlan Wei

“…The insights derived from this research have crucial implications for improving the development and functionality of Q&A platforms.…”
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Evaluation of the authenticity of Citri Grandis Exocarpium based on metabolomics and transcriptomics by Haiting Huang, Yu Liu, Jianmu Su, Xiangxiu Liang, Hong Wu, Mei Bai

“…Flavonoids related to medicinal effects, such as naringin and hesperidin, were significantly more abundant in Huazhou pomelo than in Sanhong pomelo, with compounds such as 5-demethylnobiletin detected only in Huazhou pomelo. The integrative metabolomics and transcriptomics analysis identified 11 key structural genes and transcription factors potentially involved in flavonoid biosynthesis, providing candidate targets for functional validation. …”
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Bronchial asthma in children of Ukraine: medical and environmental parallels of morbidity and prevalence by O. P. Volosovets, Y. K. Bolbot, S. P. Kryvopustov, O. V. Mozyrska, M. V. Kryvopustova, M. P. Prokhorova, A. V. Kupkina

“…Over the past 25 years in Ukraine there has been 69.3% increase in prevalence and 22.9% increase in incidence of bronchial asthma among children. Predominance of detecting this pathology was in the group of children from large industrial and agro-industrial regions of the country with significant volumes of atmospheric pollutants from stationary sources of pollution.…”
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