Exosomes as Future Therapeutic Tools and Targets for Corneal Diseases by Joshua Gamez, Daxian Zha, Shaghaiegh M. Ebrahimi, Seok White, Alexander V. Ljubimov, Mehrnoosh Saghizadeh

“…Exos influence tissue responses to injury, infection, and disease by fusion with the target cells and transferring their cargo, including cytokines, growth and angiogenic factors, signaling molecules, lipids, DNA, mRNAs, and non-coding RNAs. …”
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A Minireview on BET Inhibitors: Beyond Bromodomain Targeting by Mikhail S. Iudin, Yuri M. Khodarovich, Anna M. Varizhuk, Vladimir B. Tsvetkov, Vyacheslav V. Severov

“…BET proteins can also be hijacked by some viruses and mediate latent viral infections, making BET proteins promising targets for therapeutic intervention. …”
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Integration of MicroRNAs with nanomedicine: tumor targeting and therapeutic approaches by Pelin Telkoparan-Akillilar, Silvia Chichiarelli, Paolo Tucci, Luciano Saso

“…Their unique ability to target multiple genes simultaneously makes miRNAs highly attractive as potential therapeutic agents in oncology. …”
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Mortality from chronic ischaemic heart disease in the Russian Federation: are there enough data for analysis and decision-making? by R. N. Shepel, I. V. Samorodskaya, E. P. Kakorina, O. M. Drapkina

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Exploring microRNA targeting as a promising approach for solid tumor treatment by Behrouz Shademan, Vahidreza Karamad, Alireza Nourazarian, Cigir Biray Avci

“…Dysregulation of specific miRNAs can initiate, progress, and metastasize tumors, making them appealing targets in cancer therapy. This article explores recent studies on identifying specific miRNAs associated with solid tumors and their influence on crucial signaling pathways. …”
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Between heuristic and deliberative thinking: a multi-center qualitative study of physicians’ decision-making in infection prevention practice by Miriam Schutte, Mireille Dekker, Jonne Sikkens, Rosa van Mansfeld

“…Conclusion The heterogeneity in physicians’ decision-making and autonomous risk assessment which is different from other healthcare professionals calls for tailored interventions targeting heuristic decision making, personal beliefs, social norms and the environmental context.…”
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A comprehensive review on novel opportunities for Alzheimer therapy by targeting BIN1 by Trina Saha, Dipanjan Karati

“…Such isoform imbalance can interfere with neuronal function and play a role in AD pathogenesis, making it essential to target BIN1 splicing regulation as a therapeutic modality. …”
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HIV chromatin is a preferred target for drugs that bind in the DNA minor groove. by Clayton K Collings, Donald W Little, Samuel J Schafer, John N Anderson

“…A comparison of these results to the density of A-tracts in the HIV genome indicates that a large fraction of the nucleosomes that make up HIV chromatin should be preferred in vitro targets for the MGBDs. …”
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Role of risk perceptions and vaccine hesitancy on decision-making among low-income mothers in Kenya: a qualitative study by Stephen Gichuhi Kimotho

“…Additionally, enhancing vaccine knowledge through targeted health education programmes would be crucial for empowering mothers to make informed decisions about their children’s health.…”
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Personalized Instructional Strategy Adaptation Using TOPSIS: A Multi-Criteria Decision-Making Approach for Adaptive Learning Systems by Christos Troussas, Akrivi Krouska, Phivos Mylonas, Cleo Sgouropoulou

“…The system uses multi-dimensional learner performance data, such as error rate, time-on-task, mastery level, and motivation, to dynamically analyze and recommend the best pedagogical intervention from a pool of strategies, which includes hints, code examples, reflection prompts, and targeted scaffolding. …”
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Digital key performance indicators in corporate decision making: integrating institutional performance management to fix innovation culture in commercial agriculture by Prabath Chaminda Abeysiriwardana, Udith K. Jayasinghe-Mudalige, Saluka R. Kodituwakku

“…Abstract The commercial agriculture sector (CAS) can significantly benefit from targeted research and development (R&D) efforts aimed at achieving the Sustainable Development Goal (SDG) of ‘Zero Hunger.’ …”
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Identification of miRNAs associated with Aspergillus flavus infection and their targets in groundnut (Arachis hypogaea L.) by Pushpesh Joshi, Vinay Sharma, Arun K. Pandey, Spurthi N. Nayak, Prasad Bajaj, Hari K. Sudini, Shailendra Sharma, Rajeev K. Varshney, Manish K. Pandey

“…These two miRNAs were found to target those genes with NBS-LRR function, making them potential candidates for marker development in groundnut breeding programs aimed at enhancing resistance against A. flavus infection. …”
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*Mechanisms of circular RNA in drug resistance of lung cancer: therapeutic targets, biomarkers, and future research directions by Xuanlin Tao, Xixian Ke, Gang Xu

“…Due to their closed-loop structure, circRNAs demonstrate high stability and resistance to degradation, making them promising diagnostic and therapeutic targets. …”
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A model for analytical calculations of synthetic neutron energy spectra from beam-target reactions by A. Valentini, B.C.G. Reman, M. Nocente, J. Eriksson, H. Järleblad, D. Moseev, M. Rud, B.S. Schmidt, A. Snicker, M. Salewski

“…This makes the model several orders of magnitude faster than ordinary Monte Carlo simulations and free of any related statistical noise. …”
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Factors influencing doctors’ decisions to prescribe antibiotics to inpatients in public hospitals: a qualitative study by Lai S Kong, Farida Islahudin, Kwee C Koh, Leelavathi Muthupalaniappen, Wei W Chong

“…Thematic analysis was used to analyze data by generating codes and grouping into main themes and subthemes. …”
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A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds by A. Lina Heinzke, Barbara Zdrazil, Paul D. Leeson, Robert J. Young, Axel Pahl, Herbert Waldmann, Andrew R. Leach

“…Abstract Providing a better understanding of what makes a compound a successful drug candidate is crucial for reducing the high attrition rates in drug discovery. …”
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Splice-site mutation enhances the efficiency of CRISPR-mediated gene knockout and new germplasm creation in fish by Zhen Xu, Ma Zhuo, Leihui Wang, Shuo Yan, Shiyi Zhang, Ying Chen, Guang Xu, Chenxu Wang, Wenjing Tao, Deshou Wang

“…The knockout efficiency of the CRISPR/Cas9 system largely relies on the frameshift mutation caused by random insertions or deletions at target site of coding DNA sequence (CDS). Splice site (SS) mutations result in mRNA mis-splicing, making gRNAs targeting SS more likely to produce null mutations and thereby enhancing CRISPR efficiency. …”
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High energy gain of ion-driven flux compression in cylindrical target with initial power-law radial density profile by Soheil Khoshbinfar

“…Here, we have proposed a new DT fuel initial density profile that improves final fusion yield in cylindrical targets in MTF. We have employed the Deira-4 MHD code to investigate the performance of these configurations. …”
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Topometry Optimization of Energy Absorbing Structure through Targeting Force-Displacement Method considering Tailor Rolled Blank Process by Shigen Wang, Weigang An, Tianyu Lin, Xu Han

“…Inspired by topometry optimization, this work proposed a new design approach that mixed of targeting force-displacement (TFD) method and tailor rolled blank (TRB) process for thin-walled energy absorption structures, which has vast applied prospects in the aerospace and automotive industries. …”
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Do people like financial nudges? by Merle van den Akker, Cass R. Sunstein

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