A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients by Beatriz Bernal-Bermúdez, Beatriz Bernal-Bermúdez, Beatriz Bernal-Bermúdez, Alicia Martínez-López, Alicia Martínez-López, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Teresa Martínez-Menchón, Teresa Martínez-Menchón, Teresa Martínez-Menchón, Pablo Mesa-del-Castillo, Pablo Mesa-del-Castillo, Pablo Mesa-del-Castillo, María L. Cayuela, María L. Cayuela, María L. Cayuela, Victoriano Mulero, Victoriano Mulero, Victoriano Mulero, Diana García-Moreno, Diana García-Moreno

“…Our results demonstrate the potential of this model to further understand AGS pathological mechanisms and to identify novel therapeutic drugs by HTS.…”
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Experimental analysis of micro-cavity influence on the effective solar absorptance of white sand curtain on porous obstructions of particle heating receivers by Rageh Saeed, Shaker Alaqel, Eldwin Djajadiwinata, Nader S. Saleh, Abdulelah Alswaiyd, Hany Al-Ansary, Syed Noman Danish, Abdelrahman El-Leathy, Zeyad Al-Suhaibani, Sheldon Jeter, Redhwan Almuzaiqer, Zeyad Almutairi

“…Among DPHRs, the obstructed flow particle heating receiver (OF-PHR) emerges as a novel design under development at King Saud University (KSU), enabling particles to descend freely in a curtain-like manner through straight-shaped porous obstructions. …”
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Palette-based image recoloring based on moving least squares(基于移动最小二乘的图像重着色) by 周家伟(ZHOU Jiawei), 黄子康(HUANG Zikang), 彭俊豪(PENG Junhao), 李盛善(LI Shengshan), 刘晓静(LIU Xiaojing), 杜正君(DU Zhengjun)

“…Addressing this issue, this paper introduces a novel image recoloring algorithm based on moving least squares, significantly enhancing the locality and precision of color editing. …”
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Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice by Jia-Jin Wu, Xiaoyu Zheng, Caichi Wu, Wen Ma, Yibo Wang, Jun Wang, Yulong Wei, Xiangfang Zeng, Shihai Zhang, Wutai Guan, Fang Chen

“…Conclusion: Melatonin alleviates HS-induced low fetal weight during pregnancy via the gut-placenta-fetus axis, the first time highlighting the gut microbiota as a novel intervention target to mitigate the detrimental impact of global temperature rise on vulnerable populations.…”
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

“…Moreover, the efficacy of NDCs is biased toward dependence on host expression of PD-L1.Conclusions The novel PD-L1/TLR7 dual-targeting NDC exhibited potent efficacy against heterogeneous tumors through orchestrating innate and adaptive immunity, which could act as a promising strategy to improve ICB therapy and shows prospects for clinical development.…”
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Unveiling genetic basis of seedling emergence from deep soil depth under dry direct- seeded conditions in rice (Oryza sativa L.) by Vagish Mishra, Vagish Mishra, Shilpi Dixit, Shilpi Dixit, Swati Tyagi, Swati Tyagi, Challa Venkateswarlu, Challa Venkateswarlu, Pronob J. Paul, Pronob J. Paul, Anoop Kishor Singh Gurjar, Anoop Kishor Singh Gurjar, Shalabh Dixit, Nitika Sandhu, Smita Kurup, Arvind Kumar, Arvind Kumar, Pallavi Sinha, Pallavi Sinha, Vikas Kumar Singh, Vikas Kumar Singh, Uma Maheshwar Singh, Uma Maheshwar Singh

“…This study reported 11 novel QTLs, while 7 had been previously reported. …”
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Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands by Wanderson Ferreira da Silva Júnior, Karen Marques de Oliveira Costa, Hortência Maciel Castro Oliveira, Maísa Mota Antunes, Kassiana Mafra, Brenda Naemi Nakagaki, Pedro Sérgio Corradi da Silva, Júlia Duarte Megale, Sarah Campos de Sales, Douglas Carvalho Caixeta, Mário Machado Martins, Robinson Sabino-Silva, Cristina Maria Pinto de Paula, Luiz Ricardo Goulart, Rafael Machado Rezende, Gustavo Batista Menezes

“…Here we investigated a transient surge in hepatic lipid droplets observed in newborn mice immediately after birth. We developed a novel model to quantify liver fat content without tissue processing. …”
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Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy by Timothy J Abreo, Emma C Thompson, Anuraag Madabushi, Kristen L Park, Heun Soh, Nissi Varghese, Carlos G Vanoye, Kristen Springer, Jim Johnson, Scotty Sims, Zhigang Ji, Ana G Chavez, Miranda J Jankovic, Bereket Habte, Aamir R Zuberi, Cathleen M Lutz, Zhao Wang, Vaishnav Krishnan, Lisa Dudler, Stephanie Einsele-Scholz, Jeffrey L Noebels, Alfred L George, Atul Maheshwari, Anastasios Tzingounis, Edward C Cooper

“…These studies provide evidence for an unexpected and novel role for the KCNQ2 pore turret and introduce a valid animal model of KCNQ2 encephalopathy. …”
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Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres by Ziyue Li, Yu Qiang, Dongli Chen, Dehong Hu, Duyang Gao, Xiaohua Xu, Lei Sun, Yingjia Li, Weibao Qiu, Zonghai Sheng

“…This study introduces a novel dual-modal imaging approach that employs indocyanine green-doped porous poly (lactic-co-glycolic acid) (PLGA) microspheres (ICG-pPLGA MPs) for super-resolution ultrasound and near-infrared II (NIR-II) fluorescence imaging of ischemic stroke. …”
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Biodegradable Mg alloy modified with bioactive exosomes for cardiovascular stent application by Ya-chen Hou, Jing-an Li, Chang Cao, Chang Su, Zhen Qin, Ge Zhang, Jia-cheng Guo, Jun-nan Tang, Jin-ying Zhang, Shao-kang Guan

“…The cytocompatibility data indicated the novel MgF2-PDA/exosome coating selectively reduced the tumor necrosis factor (TNF-α) expression and ROS release from macrophage, and promoted the α-SMA expression of smooth muscle cells. …”
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Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived ModelSummary by Jun Tsuchiya, Masato Miyoshi, Sei Kakinuma, Fukiko Kawai-Kitahata, Akihide Kamiya, Taro Shimizu, Ayako Sato, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Rion Kamimae, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto

“…Conclusions: Our disease model using genetically engineered iPSCs provides the first insight into both the KMT2B function in HCC development and the oncogenic processes by HBV-KMT2B integration. We clarified the novel oncogenic mechanism in HBV-related HCC due to aberrant KMT2B function.…”
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Surface prereacted glass-ionomer particles incorporated into resin composites promote biocompatibility for restoration of subgingival dental defects by Yueyi Yang, Jing Huang, Xuchen Hu, Meiling Jing, Yujie Zhang, Chenci Xu, Wenduo Tan, Xiaoyu Liu, Chenguang Niu, Zhengwei Huang

“…Surface prereacted glass ionomer (S-PRG) is a novel glass particle characterized by a three-layered structure and the release of multiple ions with bioactive potential. …”
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γδ T Cell‐mediated Tumor Immunity is Tightly Regulated by STING and TGF‐β Signaling Pathways by Jing Luo, Shengli Wang, Quanli Yang, Qianqian Fu, Chuyun Zhu, Tao Li, Shuxian Yang, Yin Zhao, Rong Guo, Xiaosong Ben, Yuzhen Zheng, Sitao Li, Guang Yang, Hongru Zhang, Hui Xiao, Zhengfan Jiang, Nan Yan, Dieter Kabelitz, Guodong Sun, Zvi Granot, Ligong Lu, Fuping You, Jianlei Hao, Zhinan Yin

“…These findings present a novel mechanism involving STING‐mediated IFN‐γ production in γδ T cells and hold significant implications for the development of potent immunotherapeutic approaches against cancer.…”
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Pyrolysis conversion of crown-ether-based covalent networks to kagome metal-organic frameworks on Au(111) and Ag(111) by Yifan Liang, Jianing Wang, Ruoting Yin, Zhengya Wang, Xiaoqing Wang, Jie Meng, Shijing Tan, Chuanxu Ma, Qunxiang Li, Bing Wang

“…Our findings provide a comprehensive insight into the chemical reactivity of crown ethers on metal substrates and demonstrate a novel pathway to designing MOFs through an on-surface pyrolysis process.…”
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ENO1 promotes PDAC progression by inhibiting CD8+ T cell infiltration through upregulating PD-L1 expression via HIF-1α signaling by Aziguli Tulamaiti, Shu-Yu Xiao, Yan Yang, Musitaba Mutailifu, Xia-Qing Li, Shi-Qi Yin, Hong-Tai Ma, Hong-Fei Yao, Lin-Li Yao, Li-Peng Hu, Jun Li, Shu-Heng Jiang, Zhi-Gang Zhang, Yan-Miao Huo, Dong-Xue Li, Xue-Li Zhang

“…Mechanistic studies revealed that ENO1 upregulated PD-L1 to prevent CD8+ T cells infiltration through the hypoxia-inducible factor (HIF)-1α signaling pathway, leading to PDAC progression.In conclusion, our findings indicate that ENO1 might serve as a potential biomarker for PDAC and a novel onco-immunotherapeutic target via its role in altering the TIME.…”
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Investigating the Nature of Orientalism from a Philosophical-Historical Point of View Based on the Relationship between Subject and Object by Ghorban Elmi, Alireza Nahri

“…The nature of Orientalism could be located in this novel relationship between the subject and the object of knowledge. …”
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The Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team‐based approach to clinically validated, research‐ready electronic health record data by Andrea L. C. Schneider, Jennifer C. Ginestra, Meeta Prasad Kerlin, Michael G. S. Shashaty, Todd A. Miano, Daniel S. Herman, Oscar J. L. Mitchell, Rachel Bennett, Alexander T. Moffett, John Chandler, Atul Kalanuria, Zahra Faraji, Nicholas S. Bishop, Benjamin Schmid, Angela T. Chen, Kathryn H. Bowles, Thomas Joseph, Rachel Kohn, Rachel R. Kelz, George L. Anesi, Monisha Kumar, Ari B. Friedman, Emily Vail, Nuala J. Meyer, Blanca E. Himes, Gary E. Weissman

“…Conclusions The CIRCE Project represents a novel cooperative research model to capture clinically validated EHR data from a large diverse academic health system in the greater Philadelphia region and is designed to facilitate collaboration and data sharing to support learning health system activities. …”
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Neurotoxicity of aluminium chloride and okadaic acid in zebrafish: Unravelling Alzheimer's disease model via learning and memory function evaluation by S.Z. Raduan, Q.U. Ahmed, M.R.A. Rusmili, A.S.M. Sabere, M.S. Haris, M.F. Shaikh, W.A.W. Sulaiman, M.H. Mahmood

“…The behavioural tasks consisted of a novel tank test lasting 6 min, followed by a T-maze tank test lasting 5 min. …”
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Similarly, little is known on the differential effects of dual, compared with single, checkpoint inhibition.Methods We here performed in-depth characterization, including multicolor flow cytometry, single cell RNA sequencing and multiplex supernatant analysis, using tumor single cell suspensions from patients with cancer treated ex vivo with novel bispecific antibodies targeting programmed cell death protein 1 (PD-1) and TIM-3 (PD1-TIM3), PD-1 and LAG-3 (PD1-LAG3), or with anti-PD-1.Results We identified patient samples which were responsive to PD1-TIM3, PD1-LAG3 or anti-PD-1 using an in vitro approach, validated by the analysis of 659 soluble proteins and enrichment for an anti-PD-1 responder signature. …”
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A Simulated Galaxy Laboratory: Exploring the Observational Effects on UV Spectral Absorption Line Measurements by R. Michael Jennings, Alaina Henry, Valentin Mauerhofer, Timothy Heckman, Claudia Scarlata, Cody Carr, Xinfeng Xu, Mason Huberty, Simon Gazagnes, Anne E. Jaskot, Jeremy Blaizot, Anne Verhamme, Sophia R. Flury, Alberto Saldana-Lopez, Matthew J. Hayes, Maxime Trebitsch

“…In this paper, we present a novel quantitative assessment of UV absorption line measurement techniques by using mock observations of a hydrodynamical simulation. …”
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