Éloge de l’inauthenticité: le dix-huitième siècle à l’écran, autour de 'Barry Lyndon' de Stanley Kubrick by Alexis Tadié

“…If Kubrick appears in Barry Lyndon to strive for perfection through immersion in the Enlightenment, he also keeps his distance from the period, especially by re-establishing the relationship between Thackeray’s original novel and his own adaptation. I emphasise that the viewer’s essential awareness of cinematic construction creates an effect of distance from, as well as immersion in, the eighteenth century. …”
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Feasibility, Usability, and Pilot Efficacy Study of a Software-Enabled, Virtual Pulmonary Rehabilitation with Remote Therapeutic Monitoring by Flynn S, Mosher CL, Cornelison S, Rao E, Metzler KA, Pu W, Davies J, Paladenech C, Doyle D, MacIntyre N, Ohar J

“…This study evaluated the feasibility and usability of a novel home-based, virtual PR (V-PR) intervention compared to center-based PR (C-PR). …”
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TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…Here, in this study, we present a novel technology for ex vivo expansion of antigen-specific T-cells; artificial antigen-presenting scaffolds (Ag-scaffolds) consisting of a dextran-polysaccharide backbone, decorated with combinations of peptide-Major Histocompatibility Complex (pMHC), cytokines and co-stimulatory molecules, enabling coordinated stimulation of antigen-specific T-cells.Methods The capacity of Ag-scaffolds to expand antigen-specific T-cells was explored in ex vivo cultures with peripheral blood mononuclear cells from healthy donors and patients with metastatic melanoma. …”
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A cross-sectional study on the correlation between internal cerebral vein asymmetry and hemorrhagic transformation following endovascular thrombectomy by Kunxin Lin, Kunxin Lin, Wenlong Zhao, Wenlong Zhao, Quanhong Wu, Quanhong Wu, Yiru Zheng, Yiru Zheng, Bo Yang, Ying Fu, Ying Fu, Ning Wang, Ning Wang, Ling Fang, Ling Fang

“…In multivariate logistic regression, ICV asymmetry (OR 3.809, 95% CI 1.582–9.171), baseline Alberta Stroke Program Early CT Score (OR 0.771, 95% CI 0.608–0.978), intravenous recombinant tissue plasminogen activator (OR 2.847, 95% CI 1.098–2.7.385), and poor collateral circulation (OR 3.998, 95% CI 1.572–10.169) were identified as independent risk factors of HT.ConclusionICV asymmetry, likely resulting from impaired autoregulation or tissue micro-perfusion hampering cerebral blood flow (CBF), is a novel radiological sign that independently predicts HT. …”
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Circular RNA WRNIP1 activates the PI3K-AKT and ERK1/2 signaling pathways by binding to miR-129-5p/IGF2 axis and facilitates ovarian follicle development in chickens by Xiyu Zhao, Yuanhang Wei, Xinyan Li, Xinghong Yu, Zhenyu Lei, Yao Zhang, Shunshun Han, Huadong Yin, Can Cui

“…In the present study, a novel circular RNA WRNIP1 (circWRNIP1) with higher abundance in healthy follicles than in atretic follicles was identified, suggesting its important regulatory role in follicle selection and maturation. …”
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The Wayqecha Amazon Cloud Curtain Ecosystem Experiment: A new experimental method to manipulate fog water inputs in terrestrial systems by Daniel B. Metcalfe, Darcy F. Galiano Cabrera, Luis Miguel Alvarez Mayorga, Roxana Sacatuma Cruz, Daniela Corrales Alvarez, Blanca Rosa Espinoza Otazu, Walter Huaraca Huasco, Jimmy R. Chambi, Maria E. Ezquerra, Beisit L. Puma Vilca, Mark Mulligan, Matthew A. Vadeboncoeur, Heidi Asbjornsen, Paulo R. L. Bittencourt, Aline B. Horwath, David C. Bartholomew

“…Here, we present the design and performance of a novel experiment to actively manipulate low lying fog abundance in an old‐growth tropical montane cloud forest (TMCF) in Peru—the Wayqecha Amazon Cloud Curtain Ecosystem Experiment (WACCEE). …”
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Pharmacological management of gambling disorder: A systematic review and network meta-analysis by Konstantinos Ioannidis, Cinzia Del Giovane, Charidimos Tzagarakis, Jeremy E. Solly, Samuel J. Westwood, Valeria Parlatini, Henrietta Bowden-Jones, Jon E. Grant, Samuele Cortese, Samuel R. Chamberlain

“…Further clinical trials of novel compounds, and analysis of individual participant data are needed, to strengthen the evidence base, and help tailor treatments at the individual patient level.…”
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Bulk and single-cell transcriptome revealed the metabolic heterogeneity in human glioma by Yong Xiao, Mengjie Zhao, Ran Wang, Liang Liu, Chong Xiang, Taiping Li, Chunfa Qian, Hong Xiao, Hongyi Liu, Yuanjie Zou, Xianglong Tang, Kun Yang

“…Single-cell transcriptional profiles offer novel insights into tumor metabolic reprogramming, which could enhance therapies tailored to cell- or patient-specific metabolic patterns.…”
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Polygonatum kingianum polysaccharide alleviated intestinal injuries by mediating antioxidant ability and microbiota by Reng Qiu, Chuangye Pan, Yuxi Qin, Qianfei Wei, Yue Yu, Ying Zhang, Xuehan Xie, Jianqin Li, Shouhai Chen, Kun Li, Dalia Fouad, Yi Wu, Qiu Zhong

“…We revealed that Polygonatum kingianum polysaccharide could alleviate intestinal injuries by promoting oxidation resistance, decreasing inflammatory responses, and accommodating the intestinal microbiota of mice.DiscussionOur results suggest the possibility of developing novel therapies for intestinal diseases.…”
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Synergistically S/N self-doped biochar as a green bifunctional cathode catalyst in electrochemical degradation of organic pollutant by Xuechun Wang, Huizhong Wu, Jiana Jing, Ge Song, Xuyang Zhang, Minghua Zhou, Raf Dewil

“…The performance of the novel cathode for tetracycline degradation remains well under a wide pH range (3–11), maintaining excellent stability in 10 cycles. …”
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“A torch, a rope, a belly laugh”: engaging with the multiple voices of support groups for people living with rare dementia by Paul M. Camic, Emma Harding, Sam Rossi-Harries, Oliver S. Hayes, Mary Pat Sullivan, Lawrence Wilson, Nikki Zimmermann, Roberta McKee-Jackson, Joshua Stott, Nick C. Fox, Catherine J. Mummery, Jonathan D. Rohrer, Jason D. Warren, Rimona S. Weil, Sebastian James Crutch

“…The results also demonstrate that solicited words from participants can be faithfully portrayed in poems co-created by an experienced poet. This novel finding expands methodological options for the use of research poetry in healthcare and also offers support group members further creative choices for engagement, connection and communication.…”
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Cholesterol Targeted Catalytic Hydrogel Fueled by Tumor Debris can Enhance Microwave Ablation Therapy and Anti‐Tumor Immune Response by Lin Shen, Zhijuan Yang, Yi Zhong, Yanran Bi, Junchao Yu, Qinwei Lu, Yanping Su, Xiaoxiao Chen, Zhongwei Zhao, Gaofeng Shu, Minjiang Chen, Liang Cheng, Liangzhu Feng, Chenying Lu, Zhuang Liu, Jiansong Ji

“…This work highlights that cholesterol‐targeting catalytic hydrogels fueled by tumor debris can significantly improve the efficacy of MWA and ICIs, offering a novel therapeutic approach for HCC.…”
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Intelligent recognition algorithm and application of coal mine overhead passenger device based on multiscale feature fusion by Beijing XIE, Heng LI, Hang DONG, Zheng LUAN, Ben ZHANG, Xiaoxu LI

“…In the feature extraction stage, the partial convolution of the backbone network C2f module is replaced by deformable convolution, and a novel C2f_DCN module is designed. This enhancement increased the dynamic adjustment capability of the target receptive field for cmopd with different passenger-carrying statuses, allowing the model to capture different scale information and better learn the coupled features of cmopd and miners. …”
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Detection Method of Apple Alternaria Leaf Spot Based on Deep-Semi-NMF by FU Zhuojun, HU Zheng, DENG Yangjun, LONG Chenfeng, ZHU Xinghui

“…There is an urgent need to develop new methods for detecting apple Alternaria leaf spot, which can assist in the precise prevention and control of apple tree diseases.[Methods]A novel detection method named Deep Semi-Non-negative Matrix Factorization-based Mahalanobis Distance Anomaly Detection (DSNMFMAD) was proposed, which combines Deep Semi-Non-negative Matrix Factorization (DSNMF) with Mahalanobis distance for robust anomaly detection in complex image backgrounds. …”
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Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics by Julia Velz, Lena K. Freudenmann, Gioele Medici, Marissa Dubbelaar, Malte Mohme, David R. Ghasemi, Jonas Scheid, Daniel J. Kowalewski, Angelica B. Patterson, Anna M. Zeitlberger, Katrin Lamszus, Manfred Westphal, Matthias Eyrich, Martina Messing-Jünger, Andreas Röhrig, Harald Reinhard, Kévin Beccaria, Rogeiro B. Craveiro, Beat M. Frey, Martin Sill, Sven Nahnsen, Marie Gauder, Konstantina Kapolou, Manuela Silginer, Tobias Weiss, Hans-Georg Wirsching, Patrick Roth, Michael Grotzer, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Hans-Georg Rammensee, Elisabeth J. Rushing, Felix Sahm, Juliane S. Walz, Michael Weller, Marian C. Neidert

“…Functional testing of top-ranking novel candidate antigens demonstrates the induction of peptide-specific T cell responses, supporting their potential for T cell immunotherapy. …”
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Unveiling the prognostic value of ARID3A in breast cancer through bioinformatic analysis by Wen-Run Cai, Xu-Gang Sun, Yue Yu, Xin Wang, Xu-Chen Cao, Xiao-Feng Liu

“…PPI network and docking studies identified TP53 as a potential binding partner, suggesting a novel interaction influencing tumor progression. …”
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A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis by Junyue Xing, Xiaohan Ma, Yanan Yu, Yangfan Xiao, Lu Chen, Weining Yuan, Yingying Wang, Keyu Liu, Zhiping Guo, Hao Tang, Kelong Fan, Wei Jiang

“…This work introduces a novel antioxidant therapeutic approach, utilizing libraries of tannic acid and N‐acetyl‐L‐cysteine‐protected bimetallic cluster nanozymes. …”
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Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (<i>Pinus densiflora</i>) in Sprague-Dawley Rats with Loperamide-Induced Constipation by Hee-Jin Song, Ayun Seol, Jumin Park, Ji-Eun Kim, Tae-Ryeol Kim, Ki-Ho Park, Eun-Seo Park, Su-Jeong Lim, Su-Ha Wang, Ji-Eun Sung, Youngwoo Choi, Heeseob Lee, Dae-Youn Hwang

“…Overall, the finding of this study offers novel scientific evidence that MPC could be considered as a significant laxative for chronic constipation based on its antioxidant activity.…”
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Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…Nonetheless, our findings offer promising insights into the development of novel therapeutic strategies for combating COVID-19 and reducing its associated morbidity and mortality.…”
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Structural basis of a microbial trimethylamine transporter by Chao Gao, Hai-Tao Ding, Kang Li, Hai-Yan Cao, Ning Wang, Zeng-Tian Gu, Qing Wang, Mei-Ling Sun, Xiu-Lan Chen, Yin Chen, Yu-Zhong Zhang, Hui-Hui Fu, Chun-Yang Li

“…Based on our results, we proposed the TMA transport mechanism by TmaT. This study provides novel insights into TMA transport across biological membranes.IMPORTANCEThe volatile trimethylamine (TMA) plays an important role in promoting cardiovascular diseases and depolarizing olfactory sensory neurons in humans and serves as a key nutrient source for a variety of ubiquitous marine microbes. …”
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