Surface functionalization of titanium implants with controlled-release glutathione conjugate for antioxidant and osteogenesis by Huichuan Xu, Kosuke Nozaki, Ziniu Yu, Nobuyuki Kawashima, Takeshi Ueno, Huaze Wu, Hao Wu, Noriyuki Wakabayashi

“…Altogether, the proposed strategy demonstrates the potential application of novel antioxidant Ti biomaterials to promote osteogenesis against oxidative stress.…”
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Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma by Angélica Luna-Nophal, Fernando Díaz-Castillo, Vanessa Izquierdo-Sánchez, Jesús B. Velázquez-Fernández, Mario Orozco-Morales, Luis Lara-Mejía, Johana Bernáldez-Sarabia, Noemí Sánchez-Campos, Oscar Arrieta, José Díaz-Chávez, Jorge-Ismael Castañeda-Sánchez, Alexei-Fedorovish Licea-Navarro, Saé Muñiz-Hernández

“…Some species of marine snails have been demonstrated to be potential sources of novel anticancer molecules. This study analyzed the anticancer effects in vitro and in vivo of two peptides found in <i>C. californicus</i>. …”
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USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer by Fang Yuan, Juan Xu, Lingmei Xuan, Chan Deng, Wei Wang, Rong Yang

“…Ubiquitin-specific peptidase 14 (USP14) is a novel deubiquitinase and can mediate cancer cells’ response to irradiation, although the underlying mechanism remains unclear, including in ESCA. …”
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Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions by Irma Saulle, Irma Saulle, Fiona Limanaqi, Micaela Garziano, Micaela Garziano, Maria Luisa Murno, Valentina Artusa, Valentina Artusa, Sergio Strizzi, Matteo Giovarelli, Carsten Schulte, Jacopo Aiello, Mario Clerici, Mario Clerici, Claudia Vanetti, Mara Biasin

“…In these cells following 3 h or 24 h rhERAP stimulation by Western Blot, RT-qPCR, Elisa, Confocal microscopy, transwell migration assay, Oxygraphy and Flow Cytometry we assessed: i) rhERAP internalization; ii) activation; iii) migration; iv) oxygen consumption rate; v) reactive oxygen species (ROS) accumulation; granule release; vi) phagocytosis; and vii) autophagy.ResultsWe observed that following stimulation rhERAPs: i) were internalized by neutrophils; ii) triggered their activation as witnessed by increased percentage of MAC-1+CD66b+ expressing neutrophils, cytokine expression/release (IL-1β, IL-8, CCL2, TNFα, IFNγ, MIP-1β) and granule enzyme secretion (myeloperoxidase, Elastase); iii) increased neutrophil migration capacity; iv) increased autophagy and phagocytosis activity; v) reduced ROS accumulation and did not influence oxygen consumption rate.ConclusionOur study provides novel insights into the biological role of ERAPs, and indicates that extracellular ERAPs, contribute to shaping neutrophil homeostasis by promoting survival and tolerance in response to stress-related inflammation. …”
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Three different methods for ZnO-RGO nanocomposite synthesis and its adsorption capacity for methylene blue dye removal in a comparative study by Safaa A. Hussein, Gharib M. Taha, F. A. Adam, Marwa A. Moghazy

“…The synthesis of reduced graphene oxide (RGO) was accomplished through the exothermic reaction of a modified Hummer's method. In a novel approach, zinc oxide nanoparticles (ZnO NPs) were synthesized using the green Leidenfrost technique. …”
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Description of global innovative methods in developing the WHO Community Engagement Package by Jackeline Alger, Don Mathanga, Semeeh Akinwale Omoleke, Noel Juban, Meredith Labarda, Obinna Ikechukwu Ekwunife, Obioma Nwaorgu, Allan Ulitin, Jana Deborah Mier-Alpaño, María Isabel Echavarría, Yolanda Vargas Bayugo, Jose Rene Bagani Cruz, Pauline Marie Padilla Tiangco, Ukam Ebe Oyene, Alberto Ong Jr, Marvinson See Fajardo, Barwani Khaura Msiska, Lorena Abella Lizcano, Natalia Gomez Quenguan, Claudia Ivette Nieto Anderson, Briana Yasmin Beltran, Elsy Denia Carcamo Rodriguez, Eduardo Salomón Núñez, Vera Nkosi-Kholimeliwa, Glory Mwafulirwa-Kabaghe

“…The package comprises four modules organised by major themes such as mobilising communities, strengthening health systems, CE in health emergencies and CE as a driver for health equity.Conclusion After pilot implementation, tools and resources were made available for training and continuous collection of novel CE lessons and experiences from diverse socio-geographical contexts.…”
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Development and characterization of orthotopic patient-derived xenograft models of peritoneal metastatic mucinous appendiceal adenocarcinoma by I. Ito, V.K. Pattalachinti, A.M.G. Yousef, S. Chowdhury, M.M. Fanaeian, E. Haque, B.B. Gunes, M. Yousef, E.R. Salle, M.A. Zeineddine, S. Ji, R. Li, W. Wang, B.A. Helmink, M.W. Taggart, M.G. White, K.F. Fournier, N.W. Fowlkes, J.P. Shen

“…Conclusions: These molecularly profiled, orthotopic PDX models of metastatic AAs represent a unique resource for future exploration to identify novel therapies for this orphan disease.…”
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Delta radiomics modeling based on CTP for predicting hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: an 8-year retrospective pilot study by Xiaxia Wu, Xiaxia Wu, Jinfang Yang, Jinfang Yang, Xianqun Ji, Yingjian Ye, Ping Song, Lina Song, Peng An, Peng An

“…Similar results were validated in the test set, and a novel nomogram was constructed to simplify the prediction process for HT-ACI.ConclusionThe combined model established based on delta radiomics from CTP may provide early insights into the hemodynamic status of acutely ischemic brain tissue, holding significant clinical importance for predicting HT-ACI. …”
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HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAFV600E-mutant microsatellite stable colorectal cancer by Xin Li, Peng Yang, Jin Gu, Nan Chen, Dengbo Ji, Jinhong Xia, Jinying Jia, Zhuang Sun, Mengyuan Shi, Hanyang Wang, Zhaoya Gao

“…This study aims to identify a novel therapeutic strategy for this challenging subgroup.Methods We first performed a large-scale drug screening using patient-derived organoid models and cell lines to pinpoint potential therapies. …”
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Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines by Alexandra Razumovskaya, Mariia Silkina, Mariia Silkina, Mariia Silkina, Andrey Poloznikov, Timur Kulagin, Maria Raigorodskaya, Nina Gorban, Anna Kudryavtseva, Maria Fedorova, Boris Alekseev, Alexander Tonevitsky, Alexander Tonevitsky, Alexander Tonevitsky, Sergey Nikulin, Sergey Nikulin, Sergey Nikulin

“…The resulting gene expression signatures successfully stratified Stage II/III and Stage IV CRC patients, with potential clinical utility for improving treatment outcomes after further validation.DiscussionThis study highlights the advantages of integrating diverse experimental models, such as organoids and cell lines, to identify novel prognostic biomarkers and enhance the understanding of chemotherapy resistance in CRC.…”
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Global outcomes and prognosis for relapsed/refractory mature T-cell and NK-cell lymphomas: results from the PETAL consortium by Jessy Xinyi Han, Min Jung Koh, Leora Boussi, Mark Sorial, Sean M. McCabe, Luke Peng, Shambhavi Singh, Ijeoma Julie Eche-Ugwu, Judith Gabler, Maria J. Fernandez Turizo, Caroline T. MacVicar, Aditya Garg, Alexander Disciullo, Kusha Chopra, Alexandra Lenart, Emmanuel Nwodo, Jeffrey Barnes, Min Ji Koh, Eliana Miranda, Carlos Chiattone, Robert Stuver, Steven M. Horwitz, Mwanasha Merrill, Eric Jacobsen, Martina Manni, Monica Civallero, Tetiana Skrypets, Athina Lymboussaki, Massimo Federico, Yuri Kim, Jin Seok Kim, Jae Yong Cho, Thomas Eipe, Tanuja Shet, Epari Sridhar, Alok Shetty, Saswata Saha, Hasmukh Jain, Manju Sengar, Carrie Van Der Weyden, Henry Miles Prince, Ramzi Hamouche, Tinatin Murdashvili, Francine Foss, Marianna Gentilini, Beatrice Casadei, Pier Luigi Zinzani, Takeshi Okatani, Noriaki Yoshida, Sang Eun Yoon, Won-Seog Kim, Girisha Panchoo, Zainab Mohamed, Estelle Verburgh, Jackielyn Cuenca Alturas, Mubarak Al-Mansour, Josie Ford, Maria Elena Cabrera, Amy Ku, Govind Bhagat, Helen Ma, Ahmed Sawas, Khyati Maulik Kariya, Makoto Iwasaki, Forum Bhanushali, Owen A. O’Connor, Enrica Marchi, Changyu Shen, Devavrat Shah, Salvia Jain

“…Patients received either a ''novel'' single agent (SA; 35%) or cytotoxic chemotherapy (CC; 60%) for their second-line treatment. …”
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Design of the Focus on Restaurant Engagement to Strengthen Health (FRESH) study: leveraging systems science to work with independently-owned restaurants to increase access to and p... by Uriyoán Colón-Ramos, Emma C. Lewis, Anna Claire Tucker, Lisa Poirier, Chathurangi H. Pathiravasan, Michelle Estradé, Takeru Igusa, Julia A. Wolfson, Yeeli Mui, Veronica Vélez-Burgess, Audrey E. Thomas, Shuxian Hua, Lawrence J. Cheskin, Lawrence J. Cheskin, Antonio J. Trujillo, Ayoyemi T. Oladimeji, Stacey Williamson, Rosalinda Romero, Patricia Sánchez Hernández, Joel Gittelsohn

“…The study is powered to detect a 5-point change in the Healthy Eating Index (HEI) score of regular customers, which would signify a meaningful shift toward healthier eating patterns.DiscussionThe FRESH study will test a novel, multilevel, multisite intervention that aims to improve access to healthier prepared food options among small, independently-owned restaurants located in under-resourced settings. …”
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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

“…We also discovered that CDK8/CDK19 affect splicing, a novel means by which Mediator kinases control gene expression. …”
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Clinical analysis of microscopic modified ostium obstruction surgery for symptomatic sacral Tarlov cysts by HUANG Qin‐guo, WU Yan‐yu, LI Hong, ZHOU Qiang, PENG Lin, LU Yun‐tao

“…Accordingly, we present a novel method of cysts separation and ostium closure that aims to block the ostium more firmly and reliably. …”
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Subgroups of cognitive impairments in schizophrenia characterized by executive function and their morphological features: a latent profile analysis study by Yuyan Huang, Weiyan Wang, Gangrui Hei, Tiannan Shao, Li Li, Ye Yang, Xiaoyi Wang, Yujun Long, Jingmei Xiao, Xingjie Peng, Chuhan Song, Jingda Cai, Xueqin Song, Xijia Xu, Shuzhan Gao, Jing Huang, Dongyu Kang, Ying Wang, Jingping Zhao, Yunzhi Pan, Renrong Wu

“…Conclusions Our study provides novel insights into the heterogeneity of cognitive impairments in schizophrenia and the morphological features from cross-sectional and longitudinal levels, which could advance our understanding of complex cognition-morphology relationships and guide personalized interventions.…”
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Biomimetic Targeted Co‐Delivery System Engineered from Genomic Insights for Precision Treatment of Osteosarcoma by Tianqi Luo, Zhijin Fan, Anyu Zeng, Anqi Wang, Yuanwei Pan, Yanyang Xu, Hongmin Chen, Weiqing Chen, Dingmeng Nie, Jiaming Lin, Anfei Huang, Ming Gong, Yufeng Huang, Yun Ding, Xiaojun Zhu, Lang Rao, Jin Wang

“…In summary, the co‐delivery system is an effective therapeutic strategy and holds promise as a novel approach for osteosarcoma treatment.…”
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An aggregation-induced emission-active lysosome hijacker: Sabotaging lysosomes to boost photodynamic therapy efficacy and conquer tumor therapeutic resistance by Hang Zou, Pingping Wang, Zhihao Bai, Liping Liu, Jingtong Wang, Yanfang Cheng, Bairong He, Zujin Zhao, Lei Zheng

“…This innovative “lysosome hijacking” strategy significantly maximizes the efficacy of photodynamic therapy, conquering therapeutic resistance and boosting the synergistic therapeutic effect when integrated with conventional radiotherapy or chemotherapy. It provides a novel approach to the design of theranostic agents for clinical cancer theranostics.…”
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Optimal timing of organs-at-risk-sparing adaptive radiation therapy for head-and-neck cancer under re-planning resource constraints by Fatemeh Nosrat, Cem Dede, Lucas B. McCullum, Raul Garcia, Abdallah S.R. Mohamed, Jacob G. Scott, James E. Bates, Brigid A. McDonald, Kareem A. Wahid, Mohamed A. Naser, Renjie He, Aysenur Karagoz, Amy C. Moreno, Lisanne V. van Dijk, Kristy K. Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J. Schaefer, Clifton D. Fuller

“…Materials and methods: A novel Markov decision process (MDP) model was developed to determine optimal timing of re-planning based on the patient’s expected toxicity, characterized by normal tissue complication probability (NTCP), for four toxicities. …”
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ZC3H15 suppression ameliorates bone cancer pain through inhibiting neuronal oxidative stress and microglial inflammation by Li-Quan Huang, Ting-Xuan Yan, Bao-Sheng Wang, Hao Li, Nai-Bao Zhou

“…Subsequently, we made a novel discovery that ZC3H15 knockdown mice with BCP displayed improved neuronal oxidative stress and reactive oxygen species (ROS) generation in spinal cord tissues, which was confirmed in H2O2-treated mouse spinal cord neurons primarily through mediating the kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor, erythroid 2-like transcription factor 2 (NRF2) pathway. …”
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GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth by Ana Alvarez de Cienfuegos, Lawrence H Cheung, Khalid A Mohamedali, Michael G Rosenblum, Brian Aguirre, Cheng-Hsiang Lu, Anubhav Chandla, Nidhi Kejriwal, Lucia Liu, Ann M Chan, SuYin Kok, Sergio Duarte, David Casero, Madhuri Wadehra

“…Epithelial membrane protein-2 (EMP2) is highly expressed in invasive breast cancer (BC), including triple-negative BC (TNBC), and represents an attractive therapeutic target.Methods We designed a novel fusion protein (GrB-Fc-KS49) composed of an active GrB fused to an anti-EMP2 single-chain antibody tethered through the immunoglobulin G heavy chain (Fc) domain. …”
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