Molecular characterization of avian pathogenic Escherichia coli strains in Jiangxi Province, China, and development of polyvalent inactivated vaccines by Jia Tan, Ying-Xin Wang, Zhao-Feng Kang, Jiang-Nan Huang, Hai-Qin Li, Cheng-Cheng Wu, Na Li, Fan-Fan Zhang, Mei-Fang Tan

“…Eight strains were selected for in vivo pathogenicity testing in ducks, four highly pathogenic strains were then identified, which were used to develop inactivated vaccines with the novel aqueous adjuvant MONTANIDE™ GEL P PR and the traditional adjuvant alumVax hydroxide. …”
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Prognostic prediction for inflammatory breast cancer patients using random survival forest modeling by Yiwei Jia, Chaofan Li, Cong Feng, Shiyu Sun, Yifan Cai, Peizhuo Yao, Xinyu Wei, Zeyao Feng, Yanbin Liu, Wei Lv, Huizi Wu, Fei Wu, Lu Zhang, Shuqun Zhang, Xingcong Ma

“…Thus, it is necessary to establish a novel predictive model of high accuracy for the prognosis of IBC patients. …”
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Arsenic inducible islet β-cell dysfunction and ferroptosis through m6A-YTHDF2-dependent CHAC1 enhancement by Tianming Qiu, Jingyuan Zhang, Jinwei Song, Chenbing Wu, Xiaofeng Yao, Ningning Wang, Guang Yang, Jie Bai, Li Lv, Xiance Sun

“…This study uncovers a novel mechanism by which arsenic modulates CHAC1 and ferroptosis through m6A in β-cell dysfunction, highlighting potential therapeutic targets for arsenic-related T2D.…”
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Effectiveness of Virtual Reality Training in Improving Outcomes for Dialysis Patients: Systematic Review and Meta-Analysis by Xin Kang, Yiping Zhang, Chaonan Sun, Jiaxin Zhang, Zhe Che, Jinhui Zang, Rongzhi Zhang

“…Given the increasing prevalence of dialysis patients and the limitations of conventional rehabilitation approaches, VR presents a novel, interactive method that has the potential to enhance patient well-being and improve quality of life. …”
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Improving wear and corrosion resistances of Mg2Si/AZ91 composites via tailoring microstructure and intrinsic properties of Mg2Si induced by Sb modification by Peng Xiao, Yimin Gao, Yupeng Sheng, Cuicui Yang, Zhiwei Liu, Yanliang Yi, Wenyu Wu, Qiqiang Zhao, Manoj Gupta

“…To achieve simultaneous improvement in wear resistance and corrosion resistance, we propose a novel strategy to successfully develop Mg matrix composites containing blocky primary Mg2Si with small size instead of undesirable dendrite shape and large size. …”
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m6A Reader PRRC2A Promotes Colorectal Cancer Progression via CK1ε‐Mediated Activation of WNT and YAP Signaling Pathways by Xi Wu, Shiyang Wang, Yuwei Pan, Mengzhen Li, Manyu Song, Hanfu Zhang, Min Deng, Xu Yang, Jiuzhi Xu, Shuo Zhang, Jinhua Zhang, Fengchao Wang, Maksim V. Plikus, Cong Lv, Lu Yu, Zhengquan Yu

“…In summary, the work reveals a novel mechanism by which m6A reader PRRC2A promotes colorectal cancer progression via CK1ε and aberrant upregulation of WNT and YAP signaling. …”
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MiR- 146b-5p inhibits Candida albicans-induced inflammatory response through targeting HMGB1 in mouse primary peritoneal macrophages by Jing Cheng, Xiaoxing Tian, Chuanxin Wu, Jiaojiao Wang, Huiling Liu, Sha Cheng, Hang Sun

“…Conclusion: mmu-miR-146b-5p may play an anti-inflammatory role in treating C. albicans infection and provide a novel target for it.…”
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Epigenetic modifications and emerging therapeutic targets in cardiovascular aging and diseases by Yurou Qiu, Qing Xu, Peichen Xie, Chenshuang He, Qiuchan Li, Xin Yao, Yang Mao, Xiaoqian Wu, Tiejun Zhang

“…Furthermore, we highlight the role of novel histone modifications and their associated enzymes, which are emerging as potential therapeutic targets in cardiovascular diseases. …”
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Intelligent task-oriented semantic communications:theory, technology and challenges by Chuanhong LIU, Caili GUO, Yang YANG, Jiujiu CHEN, Meiyi ZHU, Lu’nan SUN

“…The semantic communication method that extracts semantic information from source information and transmits them provides a novel solution for the sixth generation (6G) communication system. …”
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Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders by Tábatha de Oliveira Silva, Guilherme Lunardon, Caroline A. Lino, Amanda de Almeida Silva, Shiju Zhang, Maria Cláudia Costa Irigoyen, Yao Wei Lu, John D. Mably, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz

“…Our results suggest that targeting senescent cells may be a novel therapeutic strategy for alleviating obesity-related metabolic and cardiac disorders.…”
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Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence by Xiaoyin Wu, Xiaoyin Wu, Buyu Guo, Buyu Guo, Xingyu Chang, Xingyu Chang, Yuxuan Yang, Yuxuan Yang, Qianqian Liu, Qianqian Liu, Jiahui Liu, Jiahui Liu, Yichen Yang, Yichen Yang, Kang Zhang, Yumei Ma, Songbo Fu, Songbo Fu, Songbo Fu

“…In vitro, ELF3, LCN2 and CD163 were induced in high glucose-induced HK-2 cell lines.ConclusionAn integrative machine learning frame established a novel diagnostic signature using glycolysis-related genes. …”
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Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death: a cross-sectional studyResearch in context by Antero Ylänen, Juhani Isojärvi, Antti Virtanen, Helena Leijon, Tiina Vesterinen, Aapo L. Aro, Heini Huhtala, Eeva Kokko, Ilkka Pörsti, Marianna Viukari, Pasi I. Nevalainen, Niina Matikainen

“…Whether primary aldosteronism constitutes a novel risk factor for sudden death warrants further study. …”
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Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Victor Osoti, Kevin Wamae, Leonard Ndwiga, Paul M. Gichuki, Collins Okoyo, Stella Kepha, Kibor Keitany, Regina Kandie, Stephen Aricha, Rosebella Kiplagat, Charles Mwandawiro, Philip Bejon, Robert W. Snow, Lynette Isabella Ochola-Oyier

“…A nested polymerase chain reaction (PCR) was used to generate amplicons that were sequenced to determine the prevalence of known and novel polymorphisms. Results Pfk13 mutations associated with artemisinin resistance were present as mixed genotype infections for the C469Y mutation in 23 samples (4%), the A675V mutation in 2 samples (1.7%), and the P553L mutation in 7 samples (1.2%). …”
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Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled... by Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba

“…We aim to study whether repurposing of clonidine can represent a novel treatment option for delirium, and the possible effects of dexmedetomidine and clonidine on long-term cognitive trajectories, motor activity patterns and biomarkers of neuronal injury, and whether these effects are associated with frailty status.Methods and analysis This five-centre, double-blind randomised controlled trial will include 900 cardiac surgery patients aged 70+ years. …”
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Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung disease by Linh T. Ngo, Michaella J. Rekowski, Devin C. Koestler, Takafumi Yorozuya, Atsushi Saito, Imaan Azeem, Alexis Harrison, M. Kristen Demoruelle, Jonathan Boomer, Bryant R. England, Paul Wolters, Philip L. Molyneaux, Mario Castro, Joyce S. Lee, Joshua J. Solomon, Koji Koronuma, Michael P. Washburn, Scott M. Matson

“…Conclusions The unsupervised clustering of BALF proteomics provided a novel stratification of IIP patients, with potential implications for prognostic and therapeutic targeting. …”
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Nutritive Parameters and Antioxidant Quality of Minimally Processed "Cime di Rapa" ( Brassica rapa subsp. sylvestris ) Vary as Influenced by Genotype and Storage Time by Donato Giannino, Giulio Testone, Chiara Nicolodi, Lucia Giorgetti, Lorenza Bellani, Maria Gonnella, Marco Ciardi, Paolo Cappuccio, Stefano Moscatello, Alberto Battistelli, Vincenzo Longo

“…In order to assess the quality and performance of bagged broccoli-raab, a recently marketed product, several nutritive parameters were determined in novel hybrid and conventional cultivars at pre- and post-packaging stages in the industrial environment. …”
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Unsupervised Visual-to-Geometric Feature Reconstruction for Vision-Based Industrial Anomaly Detection by Dinh-Cuong Hoang, Phan Xuan Tan, Anh-Nhat Nguyen, Duc-Thanh Tran, Van-Hiep Duong, Anh-Truong Mai, Duc-Long Pham, Khanh-Toan Phan, Minh-Quang Do, Ta Huu Anh Duong, Tuan-Minh Huynh, Son-Anh Bui, Duc-Manh Nguyen, Viet-Anh Trinh, Khanh-Duong Tran, Thu-Uyen Nguyen

“…To overcome this, we propose a novel framework for unsupervised industrial anomaly detection that leverages both visual and geometric information. …”
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Consensus for Operating Room Multimodal Data Management: Identifying Research Priorities for Data-Driven Surgery by Alain Garcia Vazquez, MD, Juan Verde, MD, Ariosto Hernandez Lara, MD, Didier Mutter, MD, Lee Swanstrom, MD, 5G-OR Research Committee, 5G-OR Consensus Panel, Ariosto Hernandez Lara, Barbara Seeliger, Daniel Hashimoto, Deepak Alapatt, Joel Lavanchy, Juan Verde, Lise Lecointre, Pietro Mascagni, Pr.Danail Stoyanov, Didier Mutter, MD, Dirk Willhelm, MD, Pr.Gerald Fried, MD, Gretchen Jackson, MD, PhD, Jean-Paul Mazellier, PhD, Lee Swanstrom, MD, Pr.Lena Maier-Hein, Pr.Nicolas Padoy, PhD, Pr.Sascha Treskatsch, MD, Pr.Silvana Perretta, MD, PhD, Pr.Stefanie Speidel, Pr.Teodor Grantcharov, Annika Mareike Engel, BSc, MEng, Axel Boese, DrIng, Carla M. Pugh, MD, PhD, Cesare Hassan, Fabian Dietrich, PhD, Felix Nickel, MD, MME, Franziska Jurosch, MSc, Guido Beldi, MD, Henriette Hegermann, Dr, Johannes Horsch, Dipl-Ing, Julian Rosenkranz, Ing, MSc, Keno Sponheuer, DrMed, Luca Milone, MD, PhD, FACS, Nariaki Okamoto, MD, PhD, Patrick Seeling, PhD, Pedro Filipe Pereira Gouveia, MD, PhD, Roland Croner, Prof.Dr, Sandra Keller, PhD, Sharona B Ross, Taiga Wakabayashi, MD, Ph.D, Takeaki Ishizawa, MD, PhD, Takeshi Urade, MD, PhD, Thomas Schnelldorfer, MD, PhD, Thorge Lackner, MSc, and MEng

“…This work is an international expert consensus regarding the current issues and key research targets in the promising field of data-driven surgery, highlighting the research needs of many operating room stakeholders with the aim of facilitating the implementation of novel patient care strategies in minimally invasive surgery.…”
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Development and optimization of a new competitive ELISA using recombinant (rPSA D15 and rCag11) antigens for the detection of Helicobacter pylori infection. by Biniam Moges Eskeziyaw, Naomi Maina, Rebecca Waihenya, Matthew Mutinda Munyao, Tonny Teya Nyandwaro, Shingo Inoue, Samson Muuo Nzou

“…Based on the optimized conditions, novel rPSA D15-cELISA and rCag11-cELISA assays with a respective optimum cut-off value of 20.80% PI and 24.16% PI were developed. …”
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Multi-omic biomarker panel in pancreatic cyst fluid and serum predicts patients at a high risk of pancreatic cancer development by Laura E. Kane, Gregory S. Mellotte, Eimear Mylod, Paul Dowling, Simone Marcone, Caitriona Scaife, Elaine M. Kenny, Michael Henry, Paula Meleady, Paul F. Ridgway, Finbar MacCarthy, Kevin C. Conlon, Barbara M. Ryan, Stephen G. Maher

“…Abstract Integration of multi-omic data for the purposes of biomarker discovery can provide novel and robust panels across multiple biological compartments. …”
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