CitySEIRCast: an agent-based city digital twin for pandemic analysis and simulation by Shakir Bilal, Wajdi Zaatour, Yilian Alonso Otano, Arindam Saha, Ken Newcomb, Soo Kim, Jun Kim, Raveena Ginjala, Derek Groen, Edwin Michael

“…Developing such computational systems must also overcome the cold-start problem related to the inevitable scarce early data and extant knowledge regarding a novel pathogen’s transmissibility and virulence, while addressing changing population behavior and policy options as a pandemic evolves. …”
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Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus by Rui Zhao, Jun Li, Yingtian Li, Xujuan Pei, Jingyi Di, Zhoujie Xie, Hao Liu, Weixia Gao

“…The HA MW of strain SE3 can be accurately manipulated by adjusting sucrose concentration, establishing a novel strategy for customized HA fermentation. Graphical Abstract…”
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Genome-Wide and Gene-Specific Epigenomic Platforms for Hepatocellular Carcinoma Biomarker Development Trials by Christina Michailidi, Ethan Soudry, Mariana Brait, Leonel Maldonado, Andrew Jaffe, Carmen Ili-Gangas, Priscilla Brebi-Mieville, Jimena Perez, Myoung Sook Kim, Xiaoli Zhong, Quiang Yang, Blanca Valle, Stephen J. Meltzer, Michael Torbenson, Manel Esteller, David Sidransky, Rafael Guerrero-Preston

“…The majority of the epigenomic reports in hepatocellular carcinoma have focused on identifying novel differentially methylated drivers or passengers of the oncogenic process. …”
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Integrated serum pharmacochemistry, pharmacokinetics, and network analysis to explore active components of BuShao Tiaozhi Capsule on hyperlipidemia by Ruiyin Tang, Guanlin Xiao, Yanchang Liu, Dezheng Jia, Zhihao Zeng, Canchao Jia, Dongmei Li, Yangxue Li, Jieyi Jiang, Sumei Li, Xiaoli Bi

“…BuShao Tiaozhi Capsule (BSTZC), a novel drug in China, has been used to treat hyperlipidemia (HLP) in clinical practice for many years. …”
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NutriBase – management system for the integration and interoperability of food- and nutrition-related data and knowledge by Eva Valenčič, Eva Valenčič, Eva Valenčič, Eva Valenčič, Emma Beckett, Emma Beckett, Emma Beckett, Tamara Bucher, Tamara Bucher, Clare E. Collins, Clare E. Collins, Barbara Koroušić Seljak, Barbara Koroušić Seljak

“…In the food and nutrition domain, solutions for integrating such data and knowledge with respect to the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles are still lacking.MethodsTo address this issue, we have developed a data and knowledge management system called NutriBase, which supports the compilation of a food composition database and its integration with evidence-based knowledge. This research is a novel contribution because it allows for the interconnection and complementation of food composition data with knowledge and takes what has been done in the past a step further by enabling the integration of knowledge. …”
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RETRACTED ARTICLE: Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Sna... by Yaodong Zhu, Yanqing Liu, Yayun Qian, Xiaojun Dai, Ling Yang, Jue Chen, Shiyu Guo, Tadashi Hisamitsu

“…Based on these results, COE may be considered a novel anti-cancer agent for the treatment of metastasis in gastric cancer.…”
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Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation by S. Landman, V. L. de Oliveira, M. Peppelman, E. Fasse, E. van Rijssen, S. C. Bauland, P. van Erp, I. Joosten, H. J. P. M. Koenen

“…We confirmed that human Treg injection inhibits skin inflammation and the influx of effector T cells. As a novel finding, we demonstrate that human Treg injection led to a reduction of IL-17-secreting cells while promoting a relative increase in immunosuppressive FOXP3+ Treg in the human skin, indicating active immune regulation in controlling the local proinflammatory response. …”
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Adsorption of Anionic Surfactants onto Alumina: Characteristics, Mechanisms, and Application for Heavy Metal Removal by Thi Minh Thu Nguyen, Thi Phuong Thao Do, Thi Sim Hoang, Ngoc Viet Nguyen, Huy Dong Pham, Trung Dung Nguyen, Thi Ngoc Mai Pham, Thanh Son Le, Tien Duc Pham

“…We demonstrate that SMA is a novel adsorbent for removal of Cd2+ from aqueous solution.…”
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A self-assembled nanoparticle vaccine elicits effective neutralizing antibody response against EBV infection by Ping Li, Ping Li, Ziyi Jiang, Jingjing Shi, Haochuan Sha, Zihang Yu, Yan Zhao, Sanyang Han, Lan Ma, Lan Ma, Lan Ma

“…However, none of the effective prophylactic vaccines against EBV is approved at present.MethodsIn this study, we developed a novel vaccine candidate based on epitope peptides from the receptor-binding domain of EBV-encoded gp350 glycoprotein to prevent EBV infection. …”
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Vascular involvement in idiopathic pulmonary fibrosis by Michele Mondoni, Rocco Rinaldo, Christopher J. Ryerson, Cristina Albrici, Andrea Baccelli, Claudio Tirelli, Francesca Marchetti, Jacopo Cefalo, Giulia Nalesso, Giulia Ferranti, Fausta Alfano, Giovanni Sotgiu, Marco Guazzi, Stefano Centanni

“…Pulmonary vascular volume has emerged as a novel computed tomography finding and a predictor of mortality, independent of PH. …”
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Tryptophan and/or canthaxanthin in quail diets: effects on performance, carcass traits, hematology, blood chemistry and hepatic antioxidant capacity by Khaled H. El-Kholy, Mohamed E. Sokariaa, Mohammed F. El Basuini, Sara F. Fouda, Tarek A. Ebeid, Ibrahim T. El-Ratel, Mahmoud M. Azzam, Alessandro Di Cerbo, Ahmed A. Elolimy, Mahmoud Madkour, Mahmoud Alagawany

“…To enhance the health and performance of poultry, novel approaches have to be created. Using appropriate nutritional interventions to enhance body physiology and thus enhance productivity is one of these approaches. …”
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Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China by Nan Chang, Wenzhong Huang, Yanlin Niu, Zhihu Xu, Yuan Gao, Tingting Ye, Zihao Wang, Xiaohui Wei, Yuming Guo, Qiyong Liu

“…These findings provide novel scientific evidence for the formulation and implementation of region-specific HFRS prevention policies. …”
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Repeated social defeat in male mice induced unique RNA profiles in projection neurons from the amygdala to the hippocampus by Rebecca G. Biltz, Wenyuan Yin, Ethan J. Goodman, Lynde M. Wangler, Amara C. Davis, Braedan T. Oliver, Jonathan P. Godbout, John F. Sheridan

“…Here, RSD increased anxiety-like behavior in the elevated plus maze and reduced hippocampal-dependent novel object location memory in male mice. Next, pan-neuronal (Baf53 b-Cre) RiboTag mice were generated to capture ribosomal bound mRNA (i.e., active translation) activated by RSD in the hippocampus. …”
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A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer by Shuailei Dong, Chen Wei, Xueting Wang, Xinyi Yang, Wei Shen, Shuyi Li, Jiye Xu, Yijie Ma, Liangyu Bie, Wenyue Yu, Ning Li

“…Abstract Novel therapeutic agents including disitamab vedotin (RC48, an antibody-drug conjugate) and immune-checkpoint inhibitors (e.g., PD-1 inhibitors) have provided new hope as an advanced gastric-cancer (GC) treatment. …”
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Contribution of cuproptosis and immune-related genes to idiopathic pulmonary fibrosis disease by Chengji Jin, Jia Li, Qiaoyu Li, Lipeng Zhang, Shaomao Zheng, Qiong Feng, Yongjie Li, Yu Zheng, Qiuli Nie, Jin Liang, Jing Wang, Jing Wang

“…BackgroundIdiopathic pulmonary fibrosis (IPF) is a degenerative respiratory condition characterized by significant mortality rates and a scarcity of available treatment alternatives. Cuproptosis, a novel form of copper-induced cell death, has garnered attention for its potential implications. …”
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Strategies for specific multimodal imaging of cancer-associated fibroblasts and applications in theranostics of cancer by Li Wen, Chengxue He, Yanhui Guo, Nina Zhou, Xiangxi Meng, Yuwen Chen, Cheng Ma, Hua Zhu, Zhi Yang, Lei Xia

“…These results demonstrated that this novel nanoparticles-based theranostics nanoplatform can effectively enhance multimodal imaging and targeted radionuclide-photothermal synergistic therapy for solid tumors with FAP expression.…”
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Emergence and clonal dissemination of KPC-2- and NDM-1-coharboring Citrobacter freundii in China with an IncR plasmid by Juanjuan Zhou, Minghui Zhen, Kaijie Gao, Lu Xu, Dongyu Zhang, Junmei Yang

“…The blaNDM-1 was integrated within the blaNDM-1 related region, which includes ΔISAba125, blaNDM-1, ble-MBL, trpF, dsbD, and ISCR1, while the blaKPC-2 gene was located on a novel non-Tn4401 genetic element. The blaKPC-2 genetic architectures containing blaKPC-2 differed from classical structures, underscoring the ongoing evolution of these genetic elements.IMPORTANCEOur study described the largest cohort to date of eight ST523 KPC-2-NDM-1-C. freundii isolated from children with urinary tract infections. …”
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Unveiling emerging polycyclic aromatic compounds in the urban atmospheric particulate matter by Jia-Yong Lao, Tingyu Li, Le Jing, Xian Qin, Wenyuan Su, Huiju Lin, Yuefei Ruan, Ting Ruan, Eddy Y. Zeng, Kenneth M.Y. Leung, Paul K.S. Lam

“…Additionally, absorption, distribution, metabolism, excretion, and toxicity properties were evaluated to indicate PAC’s overall abilities to cause adverse outcomes and incorporated into a novel health risk assessment model to assess their inhalation risks. …”
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Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older... by Elsa Greed, Elsa Greed, Jack Pritchard, Lauren Struszczak, Esra Bozbaş, Georgia Ek, Jordan Acheson, Jordan Acheson, Ben Winney, Aaliyah Qadir, Karl Ka-Lam Wong, Joanna Bowtell, Mary O’Leary

“…Expression of proteins related to striated muscle contraction, transcription and translation were decreased by shatavari supplementation in older women.DiscussionThese novel observations support the notion that shatavari supplementation confers resistance to neuromuscular fatigue in older women. …”
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Research progress of auricular point therapy to relieve preoperative period anxiety before elective surgery in adults (耳穴压豆缓解成年人择期手术术前焦虑的研究进展)... by GAO Yuan (高原), XU Lingzhi (徐凌志), LI Suxia (李素霞)

“…In particular, the traditional Chinese medicine technique of auricular acupressure offers a novel approach to managing preoperative anxiety through its ability to promote circulation, relieve pain, calm the mind, and induce tranquility. …”
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