The Degree of Cervical Intervertebral Disc Degeneration Is Associated With Denser Bone Quality of the Cervical Sub‐endplate and Vertebral Body by Jia‐Yu Chen, Jia‐Chen Yang, Ruo‐Yao Li, Zu‐Cheng Huang, Zhi‐Ping Huang, Xiu‐Hua Wu, Qing‐An Zhu, Yin Ding

“…Additionally, bone mineral density (BMD) of the cervical vertebrae was measured in 52 patients using a novel phantom‐less quantitative computed tomography (PL‐QCT) system. …”
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Activation of uveolymphatic outflow pathway after non-penetrating glaucoma surgery without filtering bleb: case reports by V. Kumar, K.A. Abu Zaalan, M.A. Frolov, A.S. Shradqa, G.N. Dushina, A.I. Bezzabotnov, Z.Sh. Rustamova

“…The study enrolled 11 patients with POAG. A novel surgical technique included two steps. The first step was modified deep sclerectomy and cyclodyalysis with collagen implant placed into the supraciliary space. …”
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Identification of RAD51AP1 as a key gene in hepatitis B virus-associated hepatocellular carcinoma by Meiling Wan, Yonghong Wang, Xiaoling Liu, Yaling Li, Cunliang Deng, Changfeng Sun

“…These findings provide novel insights into the underlying mechanisms and may offer potential diagnostic and therapeutic targets in HBV-associated HCC.…”
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Development and Validation of the Systemic Inflammatory Response Index-Based Nomogram for Predicting Short-Term Adverse Events in Patients With Acute Uncomplicated Type B Aortic In... by Wang Y, Wu X, Wang Y, Zhang Z, Liu X, Sun D, Liu X, Zhou T, Wang X

“…Calibration curves and DCA further supported the clinical utility of the Clinical-SIRI model.Conclusion: The SIRI-based nomogram is a valuable prognostic tool for predicting short-term ARAEs in patients with acute uncomplicated Type B IMH.Plain Language Summary: This study introduces a novel nomogram that integrates the Systemic Inflammatory Response Index with clinical variables to enhance the prediction of adverse events in patients with Type B aortic intramural hematoma, a condition marked by highly variable clinical outcomes. …”
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CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation by Donghua Cai, Chuling Li, Yingyuan Zhang, Sisi He, Yihai Guo, Wangjun Liao, Yulin Liao, Jianping Bin, Xiang He

“…Targeting CircHipk3 may offer a novel therapeutic strategy to prevent pyroptosis and AAA development, positioning it as a potential treatment target.…”
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Thermodynamics guided design and processing of a WC/HEA cermet tool for high temperature friction stir welding by Supreeth Gaddam, Surekha Yadav, Amit Kishan Behera, Noriaki Arai, Zaynab Mahbooba, Shikhar Krishn Jha, Qiaofu Zhang, Rajiv S. Mishra

“…This study is the first proof-of-concept for the design, fabrication, testing, and evaluation of a novel cermet FSW tool material with low-cost and high-performance synergy for high temperature FSW application.…”
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Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors by Jennifer Blaze, Viviana Dolores Evans, Jessica Abigail Feria Pliego, Petr Unichenko, Behnam Javidfar, Soeren Heissel, Hanan Alwaseem, Zachary Pennington, Denise Cai, Henrik Molina, Christian Henneberger, Schahram Akbarian

“…Background: The presence of treatment resistance in neuropsychiatric disease suggests that novel mechanism-based discoveries and therapies could benefit the field, with a viable candidate being transfer RNA (tRNA) epitranscriptomics. …”
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Identification of standing dead trees in Robinia pseudoacacia plantations across China’s Loess Plateau using multiple deep learning models by Li Zhang, Xiaodong Gao, Shuyi Zhou, Zhibo Zhang, Tianjie Zhao, Yaohui Cai, Xining Zhao

“…These images were then integrated with a comprehensive evaluation of multiple detection algorithms, including Faster R-CNN, EfficientDet, YOLOv4, YOLOv5, YOLOv8, YOLOv9, and a novel model, YOLOv9-ECA. Particularly, the YOLOv9-ECA was developed by incorporating the ECA module into key network layers to enhance channel dependency modeling and improve feature representation for SDTs detection. …”
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Dynamics and associations of selected agrometeorological variables in Robusta growing regions of Uganda by Ronald Ssembajwe, Catherine Mulinde, Saul D. Ddumba, Godfrey H. Kagezi, Ronald Opio, Judith Kobusinge, Frank Mugagga, Yazidi Bamutaze, Anthony Gidudu, Geoffrey Arinaitwe, Mihai Voda

“…This study aimed to analyze the long-term and recent spatiotemporal trends and associations of selected agrometeorological variables in Robusta Coffee growing regions (RCGR) of Uganda for the period 1980–2021. We employed novel trend test and signal decomposition methods along with machine learning and correlation methods. …”
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Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis by Lei Zhao, Yi-Fang Wang, Andrea Adamcakova-Dodd, Peter S. Thorne, Ranakul Islam, Ke Jian Liu, Fei Chen, Jia Luo, Ling-Zhi Liu

“…In summary, our study revealed the oncogenic role of COX-2 and identified two novel regulatory mechanisms for COX-2 overexpression in Cr(VI)-induced carcinogenesis.…”
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Mechanical properties and energy absorption of CoCrNi functionally graded TPMS cellular structures by Zhaoyi Wang, Junxian Zhou, Yunzhuo Lu, Dongming Li, Deyu Yue, Xu Zhang, Bingzhi Chen

“…By integrating appropriate parameter mapping, the mechanical properties can be predicted and regulated more flexibly, thereby paving the way for novel high-performance energy-absorbing structures.…”
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Causal associations between osteoporosis and HBV infection across Asian and European populations: evidence from Mendelian randomization and colocalization analysis by Zhengnan Li, Jiarui Cao, Ke Li, Yixin Wu, Zhanpeng Luo, Rui Cao, Zhiheng Cheng, Zhendong Tian, Yiyang Han, Yuping Lai, Bangqi Wang, Shen Chen

“…These results provided strong evidence that HBV infection augmented the risk of developing osteoporosis in East Asian populations and provided novel therapeutic targets.…”
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Multimodal magnetic resonance imaging studies on non-motor symptoms of Parkinson's disease by Weimin Qi, Xiaoyan Niu, Xiuping Zhan, Yazhou Ren, Jianhang He, Jianxia Li, Xiaolin Hou, Haining Li

“…Conclusion: Occipital hypoperfusion and cortical atrophy in the left inferior temporal gyrus may serve as novel imaging biomarkers for PD and are associated with sleep disturbances and cognitive impairment in PD patients. …”
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Advanced approach to primary microsurgical debridement of extensive scleral lacerations involving simultaneous vitrectomy and chorioretinal wound closure by S.S. Shamkin, S.N. Subbotina, A.B. Stepanyants, D.V. Salov

“…A high rate of poor treatment outcomes requires novel approaches to surgical debridement of lacerations given anatomical and pathogenic specifics. …”
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Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer’s Disease by Zhou H, Peng Y, Huo X, Li B, Liu H, Wang J, Zhang G

“…Cell experiments confirmed that SLC11A1 was significantly upregulated in inflammatory microglia induced by ferroptosis.Conclusion: This study reveals the key role of SLC11A1 in AD, particularly in the context of ferroptosis and immune inflammation. It provides a novel molecular mechanistic perspective and offers potential targets for future therapeutic strategies.Keywords: Alzheimer’s disease, single-cell RNA sequencing, microglia, ferroptosis, SLC11A1…”
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Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes by Léa Campos de Oliveira, Anna Carla Goldberg, Maria Lucia Carnevale Marin, Karina Rosa Schneidwind, Amanda Farage Frade, Jorge Kalil, Irene Kasue Miura, Renata Pereira Sustovich Pugliese, Vera Lucia Baggio Danesi, Gilda Porta

“…Furthermore, individuals presenting homozygosis for the A allele at IL4RA rs1805011 and HLA-DRB103∗ and/or 13∗ allele had sixfold greater risk to develop the disease (OR = 14.00, P<0.001). The novel association suggests an additional role for IgE-linked immune response genes in the pathogenesis of AIH.…”
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Call to Action: Lead Pharmacy into the Next Decade by Kerry K Fierke, Gardner Lepp, Bridget McGugan, Marta Brooks, Gregory Zumach

“…The evolving landscape of healthcare leadership demands novel perspectives, creative applications, and open-minded evaluations. …”
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Dual-immunomodulatory effects on RAW264.7 macrophages and structural elucidation of a polysaccharide isolated from fermentation broth of Paecilomyces hepiali by Baoming Tian, Renjian Liu, Qi Li, Hanshan Xu, Ming Cai, Rongfa Guan, Peilong Sun, Kai Yang

“…This study reveals that the fermentation broth of PHP is also a valuable resource and PHP40-2 has the potential to be developed as a novel functional food.…”
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Synthesis of Fe3O4@MIL-101-OH/Chitosan for adsorption and release of doxorubicin by Iman Najafipour, Nafiseh Emami, Pegah Sadeh, Adonis Amoli, Sareh Mosleh-Shirazi, Ali Mohammad Amani, Hesam Kamyab, Shreeshivadasan Chelliapan, Seyed Reza Kasaee, Ehsan Vafa

“…This research provides a promising approach for the development of novel drug delivery systems for cancer therapy.…”
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Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease by Jinling Li, Ting Luo, Dou Wang, Yao Zhao, Yuanxiang Jin, Guiling Yang, Xin Zhang

“…In addition, the review discusses the possible applications and challenges of PDEVs, providing a theoretical basis for exploring novel and practical therapeutic strategies for IBD. …”
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