Self-induced optical non-reciprocity by Zhu-Bo Wang, Yan-Lei Zhang, Xin-Xin Hu, Guang-Jie Chen, Ming Li, Peng-Fei Yang, Xu-Bo Zou, Peng-Fei Zhang, Chun-Hua Dong, Gang Li, Tian-Cai Zhang, Guang-Can Guo, Chang-Ling Zou

“…Furthermore, the new mechanism allows novel functional optical devices, including polarization purification and non-reciprocal leverage. …”
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Bleomycin pollution and lung health: The therapeutic potential of peimine in bleomycin-induced pulmonary fibrosis by inhibiting glycolysis by Kangchen Li, Xuefang Liu, Ruilong Lu, Peng Zhao, Yange Tian, Jiansheng Li

“…Our results contribute to the development of novel strategies for the prevention and treatment of pulmonary fibrosis and call for better management practices to mitigate the environmental impact of cytostatic drugs.…”
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Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…To address these unresolved questions, we employed a novel and highly controlled approach utilizing long-term cultivated BV-2 microglia, exempted from additional external stimuli. …”
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Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes by Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen

“…Objective. Iguratimod, a novel disease-modifying anti-rheumatic drug for the treatment of rheumatoid arthritis, has been approved in China and Japan. …”
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Synergy of Remote Sensing and Geospatial Technologies to Advance Sustainable Development Goals for Future Coastal Urbanization and Environmental Challenges in a Riverine Megacity by Minza Mumtaz, Syed Humayoun Jahanzaib, Waqar Hussain, Sadia Khan, Youssef M. Youssef, Saleh Qaysi, Abdalla Abdelnabi, Nassir Alarifi, Mahmoud E. Abd-Elmaboud

“…This integrated approach provides valuable insights for urban planners, offering a novel framework for adaptive urban planning strategies and advancing sustainable practices in similar stressed megacity regions.…”
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Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue by Nozomi Nishida, Satoru Sugimoto, Satoshi Miyagaki, Chiharu Cho, Madoka Konishi, Takeshi Goda, Mihoko Yamaguchi, Yasuhiro Kawabe, Hidechika Morimoto, Joji Kusuyama, Takuro Okamura, Masahide Hamaguchi, Jun Mori, Hisakazu Nakajima, Michiaki Fukui, Tomoko Iehara

“…Thus, this study provides novel insights into the underlying mechanism of anti-obesity effects of Ang 1–7.…”
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PD-1 cis-targeted IL-2v in combination with radiotherapy inhibits lung cancer growth and remodels the immune microenvironment by Pedro J Romero, Sara Labiano, Gregory Verdeil, Christian Klein, Pablo Umana, Tania Wyss, Christine Trumpfheller, Marie-Catherine Vozenin, Céline Godfroid, Jackeline Romero, Vincent Roh, Genrich V Tolstonog, Chia-Hsien Chuang, Andrea Kelemen, Laura Codarri Deak

“…In this regard, we used a preclinical model of metastatic lung adenocarcinoma (SV2-OVA) to assess the safety and efficacy of novel radio-immunotherapy combining hypofractionated radiotherapy (HRT) with muPD1-IL2v immunocytokine and muFAP-CD40 bispecific antibody.Methods We evaluated the changes in the lung immune microenvironment at multiple timepoints following combination therapies and investigated their underlying antitumor mechanisms. …”
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Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro by Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda

“…Hybrid peptides constitute a novel, viable, and useful strategy for the design and identification of peptide drugs with anticancer activity.…”
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Anthropometric and metabolic parameters associated with visceral fat in non-obese type 2 diabetes individuals by Ming Jiao, Jiaoli Chen, Xiaoling Wang, Wenyu Tao, Yunhua Feng, Huijun Yang, Haiying Yang, Shanshan Zhao, Ying Yang, Yiping Li

“…Anthropometric and metabolic parameters were detected. Novel insulin resistance indices, such as lipid accumulation product (LAP) was calculated. …”
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Lattice-inspired NiTi-based metamaterials with widely tunable mechanical-superelastic synergy by Zhi Zhang, Jianbao Gao, Shuaishuai Wei, Bo Song, Yonggang Yao, Xu Zheng, Yuanjie Zhang, Lei Zhang, Qiaojiao Li, Jiafeng Wu, Yusheng Shi

“…This research provides novel ideas for designing NiTi components, contributing to the future developments of different applications.…”
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Edaravone dexborneol alleviates pericyte-mediated fibrosis depositing extracellular matrix through TGF-β1/IL-11 in cerebral small vessel disease by Qingrui Duan, Zhiyang Liu, Yuxuan Xing, Haifeng Huang, Lin Zhu, Jiaxuan Liu, Peikun He, Guixian Ma, Yuhu Zhang, Kun Nie, Yuyuan Gao, Lijuan Wang

“…EDB treatment, targeting pericytes fibrosis, may be a novel therapeutic strategy for CSVD.…”
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Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regenera... by Zhaoyang Gong, Zhenhao Chen, Dachuan Li, Xiao Lu, Jianwei Wu, Hanqiu Sun, Ximeng Wang, Siyang Liu, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Chi Sun, Hongli Wang, Feng Zeng, Xiaosheng Ma

“…This study aims to develop a novel composite material combining enzymatic nanoparticles and nerve growth factor (NGF) to modulate the immune microenvironment and enhance SCI repair. …”
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Schwann Cell‐Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice by Lisa Gambarotto, Loris Russo, Silvia Bresolin, Luca Persano, Rachele D'Amore, Giulia Ronchi, Federica Zen, Luisa Muratori, Alice Cani, Samuele Negro, Aram Megighian, Sonia Calabrò, Paola Braghetta, Dario Bizzotto, Matilde Cescon

“…By knocking out Beclin 1 in SCs here a novel mouse model (Becn1 cKO) is generated, developing a severe and progressive neuropathy, accompanied by involuntary tremors, body weight loss, and premature death. …”
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The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development by Jana Vcelakova, Radek Blatny, Zbynek Halbhuber, Michal Kolar, Ales Neuwirth, Lenka Petruzelkova, Tereza Ulmannova, Stanislava Kolouskova, Zdenek Sumnik, Pavlina Pithova, Maria Krivjanska, Dominik Filipp, Katerina Stechova

“…Genes involved in Th17 and TGF-beta cascades may represent novel, promising (pre)diabetes biomarkers.…”
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Establishing an Electrophysiological Recording Platform for Epidural Spinal Cord Stimulation in Neuropathic Pain Rats by Yang CT, Shyu BC, Lin WT, Lu KH, Lin CR, Wen YR, Chen CC

“…To elucidate the mechanism of action among conventional and current novel types of SCSs, a stable and reliable electrophysiology model in the consensus animals to mimic human SCS treatment is essential. …”
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Significance of KLK7 expression, polymorphisms, and function in sheep horn growth by Mingzhu Shan, Hao Li, Xinyue Li, Guoqing Zhang, Jianxin Shi, Pingjie Feng, Lisheng Zhou, Zhangyuan Pan, Mingxing Chu

“…Our findings suggest a strong association between KLK7 and sheep horn length, indicating the potential role of KLK7 in inhibiting horn growth and providing novel insights into the functionality of KLK7.…”
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Generation and characterization of two induced pluripotent stem cell lines (ICGi052-A and ICGi052-B) from a patient with frontotemporal dementia with parkinsonism-17 associated wit... by E. V. Grigor’eva, A. A. Malakhova, E. S. Yarkova, J. M. Minina, Y. V. Vyatkin, J. A. Nadtochy, E. A. Khabarova, J. A. Rzaev, S. P. Medvedev, S. M. Zakian

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Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates by Yangyang Gao, Yuwei Xia, Yixin Chen, Shiqi Zhou, Yingying Fang, Jieru Yu, Leyin Zhang, Leyin Zhang, Leitao Sun, Leitao Sun, Leitao Sun

“…Through the selection of target antigen, the optimization of the linker, the optimization of novel small molecule toxins as payload, the optimization of ADC, overcoming the multi-drug resistance of ADC, improving the ADC tumor penetration of ADC, surface modification of ADC and surface bystander effect of ADC provide a more comprehensive and accurate framework for designing new ADCs.ResultsWe’ve expounded comprehensively on applying pharmacokinetics or pharmacodynamics while designing ADC to obtain higher efficacy and fewer side effects. …”
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Effectiveness of an online food shopping intervention to reduce salt purchases among individuals with hypertension – findings of the SaltSwitch Online Grocery Shopping (OGS) random... by Jason HY Wu, Damian Maganja, Liping Huang, Kathy Trieu, Fraser Taylor, Eden M. Barrett, Clare Arnott, Xiaoqi Feng, Aletta E. Schutte, Gian Luca Di Tanna, Cliona Ni Mhurchu, Adrian J. Cameron, Mark D. Huffman, Bruce Neal

“…Conclusions Online shopping platforms provide a novel opportunity to support purchases of lower sodium foods. …”
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Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents by Chongshan Dai, Erjie Tian, Hui Li, Subhajit Das Gupta, Zhihui Hao, Zhanhui Wang, Tony Velkov, Jianzhong Shen

“…In this original review we summarize the mechanisms of aflatoxin-induced neurotoxicity and the clinical potential of novel neuroprotective agents. Aflatoxin B1 (AFB1) is the most toxic congener among the 21 identified AFTs. …”
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