Individualized gray matter morphological abnormalities unveil two neuroanatomical obsessive-compulsive disorder subtypes by Baohong Wen, Keke Fang, Qiuying Tao, Ya Tian, Lianjie Niu, Wenqing Shi, Zijun Liu, Jin Sun, Liang Liu, Xiaopan Zhang, Ruiping Zheng, Hui-Rong Guo, Yarui Wei, Yong Zhang, Jingliang Cheng, Shaoqiang Han

“…The identified subtypes offer novel insights into nosology and the heterogeneous nature of OCD.…”
Get full text

Yunvjian decoction attenuates lipopolysaccharide-induced acute lung injury by inhibiting NF-κB/NLRP3 pathway and pyroptosis by Fanxuan Zhang, Fang Wang, Lisha Zhao, Leqian Wang, Wenjing Li, Feihua Huang, Feihua Huang, Nani Wang, Nani Wang

“…Among those, network analysis and in vitro experiments indicated that diosgenin, timosaponin BII, and mangiferin are anti-inflammatory active substances.ConclusionYNJ attenuates LPS-induced ALI in mice by inhibiting pyroptosis of lung epithelial cells and macrophages via suppression of the NF-κB/NLRP3 pathway. Our findings provide novel insights into the therapeutic effects of YNJ on ALI.…”
Get full text

Zero-BertXGB: An Empirical Technique for Abstract Classification in Systematic Reviews by Mohammad Shariful Islam, Mohammad Abu Tareq Rony, Md Rasel Hossain, Samah Alshathri, Walid El-Shafai

“…Addressing this gap, this study employs GloVe for word embedding via matrix factorization, FastText for character n-gram representation, and Doc2Vec for capturing paragraph-level semantics. A novel Zero-BertXGB technique is introduced, integrating a transformer-based language model, zero-shot learning, and an ML classifier to enhance abstract screening and classification into “Include” or “Exclude” categories. …”
Get full text

Vali@mPEG‐TK‐COS: A Dual‐Function Nano‐Pesticide for Fungicidal Action and Plant Immune Modulation by Ruixin Li, Xiaochen Jia, Hongguo Xie, Xueran Wang, Jinxuan Wen, Guanglu Yu, Chunlai Zhang, Yeqing Sun, Heng Yin

“…In this study, we developed a novel intelligent response‐controlled release nano‐pesticide, Vali@mPEG‐TK‐COS, by coupling chitosan oligosaccharide (COS), a plant immunity regulator, and methoxy polyethylene glycols (mPEG) at either end of thioketal (TK), a material responsive to reactive oxygen species (ROS), and incorporating validamycin (Vali) for controlled release. …”
Get full text

Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) by Gerald McGwin, Linda M Zangwill, Nicholas Evans, Shannon McWeeney, Cecilia S Lee, Bhavesh Patel, Jeffrey C Edberg, Cynthia Owsley, Aaron Lee, Cecilia Lee, Sally L Baxter, Michael Snyder, Samantha Hurst, Nicole Ehrhardt, Christopher Chute, Dawn S Matthies, Julia P Owen, Amir Bahmani, Sally Baxter, Edward Boyko, Aaron Cohen, Jorge Contreras, Garrison Cottrell, Virginia de Sa, Jeffrey Edberg, Irl Hirsch, Michelle Hribar, T.Y. Alvin Liu, Bonnie Maldenado, Sara Singer, Bradley Voytek, Joseph Yracheta, Linda Zangwill

“…AI-READI opens the door for novel insights in understanding T2DM salutogenesis. …”
Get full text

Uptake of HIV pre-exposure prophylaxis and contraception in South African hair salons: a study protocol for a pilot cluster randomised controlled trial by Christina Psaros, Ingrid Bassett, Sabina Medal Govere, Jana Jarolimova, Joyce Yan, Sthabile Shezi, Lungile M Ngcobo, Shruti Sagar, Dani Zionts, Nduduzo Dube, RA Parker

“…We are evaluating the feasibility, acceptability and preliminary effectiveness of a novel intervention offering PrEP, contraception and STI screening in hair salons.Methods and analysis We will conduct a pilot cluster randomised controlled trial in hair salons in urban KwaZulu-Natal, South Africa. …”
Get full text

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects by Rodrigo Moraga-Amaro, Oscar Moreno, Jordi Llop, Marion Bankstahl, Marion Bankstahl, Jens P. Bankstahl

“…New approaches to early diagnose this disease are crucial to facilitate the translation of novel treatment strategies to the clinic. Several studies have found suitable candidate biomarkers, but the results are not straightforward. …”
Get full text

Designing a Policy Making Model in Iran' Sport with the Approach of Sport for All Development by Behdad Sadeghi, Rahmatollah Gholipour, Mojtaba Amiri, Marjan Saffari

“…Furthermore, this research is exploratory in nature, as it aims to design a model on a novel and innovative topic. Methods A mixed qualitative-quantitative method was employed in this study. …”
Get full text

A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes) by Tamás Visnovitz, Dorina Lenzinger, Anna Koncz, Péter M Vizi, Tünde Bárkai, Krisztina V Vukman, Alicia Galinsoga, Krisztina Németh, Kelsey Fletcher, Zsolt I Komlósi, Csaba Cserép, Ádám Dénes, Péter Lőrincz, Gábor Valcz, Edit I Buzas

“…According to our model, upon fusion of multivesicular bodies with autophagosomes, fragments of the autophagosomal inner membrane curl up to form LC3B positive ILVs of amphisomes, while CD63 positive small EVs are of multivesicular body origin. Our data suggest a novel common release mechanism for small EVs, distinct from the exocytosis of multivesicular bodies or amphisomes, as well as the small ectosome release pathway.…”
Get full text

Relationship between CTF1 gene expression and prognosis and tumor immune microenvironment in glioma by Hongqing Cai, Shen Tian, Angsi Liu, Guanchao Xie, Hongsheng Zhang, Xiaogang Wu, Jinghai Wan, Sai Li

“…Consequently, CTF1 is a potentially promising novel therapeutic target for glioma treatment.…”
Get full text

Unity in diversity: navigating global connections through cultural exchange by Dwi Mariyono, Annis Nur Alifatul Kamila, Akmal Nur Alif Hidayatullah

“…Originality/value – This study’s originality lies in its methodological triangulation, using HTCA as a novel approach to unify content and thematic insights. …”
Get full text

Exploring the expression of DLL3 in gastroenteropancreatic neuroendocrine neoplasms and its potential diagnostic value by L. Yin, R. Wang, X. Ma, K. Jiang, Y. Hu, X. Zhao, L. Zhang, Z. Wang, T. Long, M. Lu, J. Li, Y. Sun

“…Abstract Delta-like protein (DLL3) is a novel therapeutic target. DLL3 expression in gastroenteropancreatic neuroendocrine tumors (GEP-NECs) is poorly understood, complicating the distinction between well-differentiated neuroendocrine tumors G3 (NET G3) and poorly differentiated NEC. …”
Get full text

Dynamic selectout and voting-based federated learning for enhanced medical image analysis by Saeed Iqbal, Adnan N Qureshi, Musaed Alhussein, Khursheed Aurangzeb, Atif Mahmood, Saaidal Razalli Bin Azzuhri

“…When these agents work together in the system, it is imperative to tackle the complexities of distributed deep learning. We suggest a novel approach that uses a voting mechanism and dynamic SelectOut inside the FL framework to address these problems. …”
Get full text

Medical therapy to treat obesity and optimize fertility in women of reproductive age: a narrative review by Janelle Duah, David B. Seifer

“…However, with the advent of novel pharmacologic agents, significant weight loss can be achieved, improving the chances of healthy pregnancies, and their use should be considered during periconceptual counseling. …”
Get full text

Visual and High-Efficiency Secretion of SARS-CoV-2 Nanobodies with <i>Escherichia coli</i> by Shuai Zhao, Wanting Zeng, Fang Yu, Pingping Xu, Chin-Yu Chen, Wanping Chen, Yanming Dong, Fei Wang, Lixin Ma

“…Notably, Fu2-sfGFP-ANTE can be normally secreted into the culture medium and outer membrane. The novel nanobody production system enhances the efficiency of nanobody expression and streamlines the downstream purification process, enabling large-scale, cost-effective nanobody production. …”
Get full text

Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis by Xinghong Liu, Yi Peng, Ling Guo, Weilan Xiong, Weijiang Liao, Jiangang Fan

“…The ceRNA network comprised nine nodes and eleven edges, with only FGFBP1 exhibiting a complete lncRNA-miRNA-mRNA interaction.DiscussionThis study identifies several novel biomarkers and their associated drugs for CRSwNP therapy, as well as potential therapeutic targets, such as spiperone and arnenous acid, identified through molecular docking. …”
Get full text

CD28 Genetic Variants Increase Susceptibility to Diabetic Kidney Disease in Chinese Patients with Type 2 Diabetes: A Cross-Sectional Case Control Study by Yangyang Li, Li Jin, Jing Yan, Hong Zhang, Rong Zhang, Cheng Hu

“…In conclusion, we identified that two novel SNPs, CD28-rs3116494 and CD80-rs3850890, were associated with DKD susceptibility. …”
Get full text

A satellite-based analysis of semi-direct effects of biomass burning aerosols on fog and low-cloud dissipation in the Namib Desert by A. Mass, A. Mass, H. Andersen, H. Andersen, J. Cermak, J. Cermak, P. Formenti, E. Pauli, E. Pauli, J. Quinting

“…In some synoptic settings, this layer of BBAs reaches Namibia and its desert, where it interacts with coastal fog and low clouds (FLCs). In this study, a novel 15-year data set of geostationary satellite observations of FLC dissipation time in the Namib Desert is used, along with reanalysis data, to better understand the potential semi-direct effects of BBAs on FLC dissipation in the Namib Desert, i.e., through adjustments of atmospheric stability and thermodynamics via the interaction of aerosols with radiation. …”
Get full text

Putative effects of moringa oil or its nano-emulsion on the growth, physiological responses, blood health, semen quality, and the sperm antioxidant-related genes in ram by Rehab F. S. A. Ismail, Wael A. Khalil, Sara I. Grawish, Karima Gh. M. Mahmoud, Sameh A. Abdelnour, Alaa M. A. Gad

“…This study suggests that MO may serve as a novel therapeutic agent for improving the reproductive health in Rahmani rams.…”
Get full text

Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calcu... by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

“…Conclusions: Our findings provide valuable insights into the molecular mechanisms driving the efficacy of TCM drugs against EBOV and suggest novel approaches for the development of anti-EBOV therapies.…”
Get full text