scPharm: Identifying Pharmacological Subpopulations of Single Cells for Precision Medicine in Cancers by Peng Tian, Jie Zheng, Keying Qiao, Yuxiao Fan, Yue Xu, Tao Wu, Shuting Chen, Yinuo Zhang, Bingyue Zhang, Chiara Ambrogio, Haiyun Wang

“…Overall, scPharm provides a novel approach for precision medicine in cancers by revealing therapeutic heterogeneity at single‐cell resolution.…”
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A telehealth-delivered intervention to extend the veteran HIV treatment cascade for cardiovascular disease prevention: V-EXTRA-CVD study protocol for a randomized controlled trial by Lewis Musoke, Hayden B. Bosworth, Christina Dickson, Pamela Gentry, Elizabeth Strawbridge, Soumya Subramaniam, Jennifer Gierisch, Valerie Smith, Sandra Woolson, John Pura, Willington Amutuhaire, Susanna Naggie, Julie Schexnayder, Karen Hall, Chris T. Longenecker, Nadine M. Harris, Chantrice Rogers, Puja Van Epps, for V-EXTRA-CVD Group

“…Conclusion: The proposed multicomponent intervention has the potential to improve cardiovascular outcomes in PWH using novel virtual care methods in a patient centered care approach.…”
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Kidney Function and Extreme Endurance Races: Risks, Mechanisms, and Preventing Strategies by Julia Kulbacka, Karol Dziedzic, Filip Arczewski, Michalina Wójcikiewicz, Marta Chuncia-Ileczko, Julia Kacperczyk, Witold Czyż, Damian Zys, Piotr Pasek, Julia Ryniecka

“…There is a need for improved diagnostic criteria to detect acute renal injury in this population, with novel biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and cystatin C showing promise. …”
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Survival analysis of patients with hepatocellular carcinoma based on the ratio of platelet count to spleen diameter by Huiwen Yan, Dongdong Zhou, Dongdong Zhou, Xiaoli Liu, Peng Wang, Tingting Jiang, Zhiyun Yang

“…In addition, we found that the decision curve analysis of nomogram1 and nomogram2 was also meaningful.ConclusionNovel nomogram containing PSL, based on LASSO Cox regression, had higher predictive efficacy for 3-year overall survival in patients with HCC.…”
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Screening of West Siberian patients with primary congenital glaucoma for CYP1B1 gene mutations by D. E. Ivanoshchuk, S. V. Mikhailova, O. G. Fenkova, E. V. Shakhtshneider, A. Z. Fursova, I. V. Bychkov, M. I. Voevoda

“…As a result, in the sample of the white population we examined, pathogenic variants previously described in other ethnic groups were revealed: E387K (rs55989760), R444* (rs377049098), R444Q (rs72549376), and P437L (rs56175199), as well as novel single-nucleotide deletion p.F114Lfs*38 in the CYP1B1 gene. …”
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PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer by Jiacheng Li, Jia Liu, Shifeng Yang, Yu Xia, Qingzhe Meng, Biying Sun, Yansong Liu, Bin Zhao, Jiaqi Jin, Hui Xu, Lihong Wang, Pengxia Zhang, Zhuoxin Cheng

“…Results We found that PD-L1 positive platelets are correlated with a poor prognosis, CD8 + T cell exhaustion and serve as a novel noninvasive biomarker for predicting immunotherapy efficacy in patients with CRC. …”
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Identification of the primary pollution sources and dominant influencing factors of soil heavy metals using a random forest model optimized by genetic algorithm coupled with geodet... by Tong Liu, Mingshi Wang, Mingya Wang, Qinqing Xiong, Luhao Jia, Wanqi Ma, Shaobo Sui, Wei Wu, Xiaoming Guo

“…This approach provides a novel perspective for HM source apportionment under complex environmental conditions.…”
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Exploring the Potential of SGLT-2 Inhibitors in Cancer Treatment: Mechanisms, Preclinical Findings, and Clinical Implications by Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła, Michał Mazur, Dorota Waz, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak

“…Conclusions SGLT-2 inhibitors represent a novel therapeutic strategy in oncology, with potential to improve outcomes in combination with traditional therapies. …”
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Structure–Activity Relationship Studies of Tetracyclic Pyrrolocarbazoles Inhibiting Heterotetrameric Protein Kinase CK2 by Lukas Kröger, Sebastian Borgert, Miriam Lauwers, Michaela Steinkrüger, Joachim Jose, Markus Pietsch, Bernhard Wünsch

“…Thus, <b>20a</b> represents a novel lead compound inhibiting CK2 via the inhibition of the association of the CK2α and Ck2β subunits.…”
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Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in Andrographis paniculata by Shao-Fen Jian, Shao-Fen Jian, Shao-Fen Jian, Yan-Fen Huang, Yan-Fen Huang, Yan-Fen Huang, Dong-Liang Chen, Chu Zhong, Chu Zhong, Chu Zhong

“…Dihydroporphyrin iron (DH-Fe) is a novel plant growth regulator that plays significant roles in plant stress resistance. …”
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Enhancing mechanical and thermal properties of PVA-abaca fiber biocomposites via ultrasonic vibration bath treatment by Mochamad Asrofi, Nur Achmad Asyari, Revvan Rifada Pradiza, Muhammad Abduh, Muhammad Yusuf, Melbi Mahardika, R.A. Ilyas, M.R.M. Asyraf, S.M. Sapuan, Victor Feizal Knight, Mohd Nor Faiz Norrrahim

“…The biocomposites was produced by solution casting method. The novel strategies in this study were ultrasonic vibration bath (UVB) treatment. …”
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Trends in survival of patients with stage I/II Burkitt lymphoma in the United States: A SEER database analysis by Ze‐Long Liu, Pan‐Pan Liu, Xi‐Wen Bi, De‐Xin Lei, Yu Wang, Zhi‐Ming Li, Wen‐Qi Jiang, Yi Xia

“…In conclusion, the prognosis of patients with limited‐stage BL has improved in the 2002‐2014 era, but the outcome was still much poorer in elderly patients, which needs to be improved by identifying newly molecular‐targeted drugs and developing novel personalized therapeutic approaches.…”
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Image-based anomaly detection in low-light industrial environments with feature enhancement by Dinh-Cuong Hoang, Phan Xuan Tan, Anh-Nhat Nguyen, Son-Anh Bui, Ta Huu Anh Duong, Tuan-Minh Huynh, Duc-Manh Nguyen, Viet-Anh Trinh, Quang-Huy Ha, Nguyen Dinh Bao Long, Duc-Thanh Tran, Xuan-Tung Dinh, Van-Hiep Duong, Tran Thi Thuy Trang

“…In this paper, we present DarkAD, a novel end-to-end approach specifically designed to address the difficulties of anomaly detection under low-light conditions. …”
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p54-Fc-Labeled Gold Nanoparticle-Based Lateral Flow Strip-Assisted Portable Devices for Rapid and Quantitative Point-of-Care Detection of ASFV Antibodies by Yang Yang, Yuhao Li, Ziyang Wang, Minglong Tong, Pengcheng Zhu, Juanxian Deng, Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Zhongren Zhou, Yafeng Qiu, Zhiyong Ma, Jianchao Wei

“…In this study, a novel rapid immunochromatographic (IC) test for African swine fever virus (ASFV) antibodies is presented. …”
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Growth of the prefrontal cortical glioblastoma altered cognitive and emotional behaviors via mediating miRNAs and GABA-A receptor signaling pathways in rats by Sepide Nateghi, Ameneh Rezayof, Fatemeh Kouhkan, Ladan Delphi, Yavar Bagheri Davisaraei, Fatemeh Rostami, Fatemeh Tirgar, Houri Sepehri

“…Behavioral alterations induced by GBM, including anxiety-like responses, exploratory behaviors, locomotor activity, and memory formation, were assessed using anxiety-like behavior task, the hole-board test, and the novel object recognition test. Muscimol treatment dose-dependently affected these behaviors in the animals with the mPFC-GBM, bringing their performance with that of the sham group at the dose of 1 µg/rat/2.5 μl. …”
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Lucidin from <i>Rubia cordifolia</i> Outperforms FDA-Approved Lapatinib as a Potential Multitargeted Candidate for Breast Cancer Signalling Proteins by Akram Ahmed Aloqbi, Hadil Alahdal, Amany I. Alqosaibi, Mashael M. Alnamshan, Ibtesam S. Al-Dhuayan, Ahood A. Al-Eidan, Hind A. S. Alzahrani, Nouf K. ALaqeel, Fatmah Hazza Alsharif, Abeer Al Tuwaijri

“…<b>Conclusions:</b> Lucidin shows promise as a novel, multitargeted anti-breast cancer agent with improved efficacy over Lapatinib. …”
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Comparative study of torque expression and its biomechanical effects: spherical self-ligating bracket with lock-hook system versus passive self-ligating bracket and conventional br... by Yudong Liu, Longmei Guo, Yanqing Feng, Jiahao Hua, Qingyuan Dai, Ziyang Chen, Wenlu Song, Bing Guo, Taicong Chen, Li Ji

“…This study aimed to employ finite element analysis to compare the torque capabilities of a novel spherical self-ligating bracket with a lock-hook system against those of commonly used passive self-ligating and conventional bracket systems, as well as to reveal the biomechanical changes in the periodontal ligament (PDL) during torque expression. …”
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Micro-/nanobubble oxygenation irrigation enhances soil phosphorus availability and yield by altering soil bacterial community abundance and core microbial populations by Qingyong Bian, Qingyong Bian, Zhiduo Dong, Yupeng Zhao, Yaozu Feng, Yaozu Feng, Yaozu Feng, Yanbo Fu, Yanbo Fu, Zhiguo Wang, Jingquan Zhu, Liang Ma

“…Micro-/nanobubble oxygenation irrigation, as a novel irrigation technique, has been widely utilized to enhance soil phosphorus availability and maize yield. …”
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A multi-modal multi-branch framework for retinal vessel segmentation using ultra-widefield fundus photographs by Qihang Xie, Qihang Xie, Xuefei Li, Yuanyuan Li, Yuanyuan Li, Jiayi Lu, Jiayi Lu, Shaodong Ma, Yitian Zhao, Yitian Zhao, Jiong Zhang, Jiong Zhang

“…However, the high resolution and low contrast inherent to UWF fundus images present significant challenges for accurate segmentation using deep learning methods, thereby complicating disease analysis in this context.MethodsTo address these issues, this study introduces M3B-Net, a novel multi-modal, multi-branch framework that leverages fundus fluorescence angiography (FFA) images to improve retinal vessel segmentation in UWF fundus images. …”
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Potential clinical application of the cancer antigen CA‑62 for differential diagnosis of prostate cancer and benign prostatic hyperplasia at the elevated prostate‑specific antigen... by Zh. R. Cherkasova, S. A. Tsurkan, A. I. Prostyakova, A. M. Boroda, A. A. Rozhkov, Yu. N. Pirogova, N. M. Nikitina, M. I. Sekacheva

“…It has been demonstrated that using the novel cancer marker CA‑62 makes it possible to detect up to 90 % of the early‑stage prostate cancer with 97.2 % specificity (AUC = 0.969).Conclusion. …”
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