Thyroid Hormone Activation Regulates the Crosstalk between Breast Cancer and Mesenchymal Stem Cells by Annarita Nappi, Vittoria D’Esposito, Caterina Miro, Alessia Parascandolo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Sepehr Torabinejad, Federica Restolfer, Maddalena Raia, Melania Murolo, Emery Di Cicco, Pietro Formisano, Monica Dentice

“…Results: In this study, we uncovered a novel role of THs in regulating the tumor-stroma crosstalk. …”
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Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from No... by Xinlong Zhou, Kailash Wagh, Guizhen Lv, Devender Sharma, Wei Lei

“…For neonatal care, these resistance challenges increase the risk of treatment failures and mortality, underscoring the importance of enhanced infection prevention and novel therapeutic strategies.…”
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DeepCERES: A deep learning method for cerebellar lobule segmentation using ultra-high resolution multimodal MRI by Sergio Morell-Ortega, Marina Ruiz-Perez, Marien Gadea, Roberto Vivo-Hernando, Gregorio Rubio, Fernando Aparici, Maria de la Iglesia-Vaya, Gwenaelle Catheline, Boris Mansencal, Pierrick Coupé, José V. Manjón

“…This paper introduces a novel multimodal and high-resolution human brain cerebellum lobule segmentation method. …”
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Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…These findings may provide the first line of evidence showing that Ori alleviates fibrosis in DN by inhibiting the Wnt/β-catenin signaling pathway and thereby reveal a novel therapeutic avenue for treating tubulointerstitial fibrosis.…”
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Establishment of a New Hyperglycemic Obesity Cardiac Dysfunction Mouse Model with Triacsin C by ZHAO Xiaona, WANG Peng, YE Maoqing, QU Xinkai

“…Objective This study aims to establish a novel hyperglycemic obesity mouse model by utilizing Triacsin C, an inhibitor of acyl-CoA synthetase long-chain family member 1 (ACSL1), combined with a high-fat diet, to simulate the changes in adipose tissue and cardiac function observed in patients with obesity-related type 2 diabetes.MethodsTwenty adult SPF-grade male C57BL/6J mice were randomly divided into two groups: the Control group (injected intraperitoneally with citric acid-sodium citrate buffer, Con group) and the TC group (injected intraperitoneally with Triacsin C, TC group). …”
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Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice by Elena Niccolai, Leandro Di Gloria, Maria Chiara Trolese, Paola Fabbrizio, Simone Baldi, Giulia Nannini, Cassandra Margotta, Claudia Nastasi, Matteo Ramazzotti, Gianluca Bartolucci, Caterina Bendotti, Giovanni Nardo, Amedeo Amedei

“…Further elucidating the mechanisms underlying these interactions could offer novel insights into ALS pathogenesis and potential therapeutic targets.…”
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Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes by Fresia Pareja, Rohit Bhargava, Virginia F. Borges, Edi Brogi, Rita Canas Marques, Fatima Cardoso, Christine Desmedt, Malini Harigopal, Sunil R. Lakhani, Adrian Lee, Jose Pablo Leone, Hannah Linden, Christopher J. Lord, Caterina Marchio, Sofia D. Merajver, Emad Rakha, Jorge S. Reis-Filho, Andrea Richardson, Elinor Sawyer, Pepper Schedin, Christopher J. Schwartz, Andrew Tutt, Naoto T. Ueno, Anne Vincent-Salomon, Britta Weigelt, Y. Hannah Wen, Stuart J. Schnitt, Steffi Oesterreich

“…Abstract Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. …”
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Establishment and application of a rapid new detection method for antimicrobial susceptibility testing of Klebsiella pneumoniae based on MALDI-TOF MS by Yapei Zhang, Fanghua Fan, Xuan Wang, Jie Zhu, Shilei Dong

“…Current rapid AST techniques are hampered by factors such as high costs, technological complexities, and limited detection capabilities. We present a novel rapid method and applied to the determination of the susceptibility of K. pneumoniae to imipenem. …”
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Non-lytic spread of poliovirus requires the nonstructural protein 3CD by David Aponte-Diaz, Jayden M. Harris, Tongjia Ella Kang, Victoria Korboukh, Mohamad S. Sotoudegan, Jennifer L. Gray, Neela H. Yennawar, Ibrahim M. Moustafa, Andrew Macadam, Craig E. Cameron

“…This discovery should facilitate the identification of the specific steps of the cellular secretory autophagy pathway and corresponding factors commandeered by the virus and may uncover novel targets for antiviral therapy.…”
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Dentin-Derived Inorganic Minerals Promote the Osteogenesis of Bone Marrow-Derived Mesenchymal Stem Cells: Potential Applications for Bone Regeneration by Gang Lei, Yanqiu Wang, Yan Yu, Zehan Li, Jiamin Lu, Xingyun Ge, Na Li, Ana Gloria Cuba Manduca, Jinhua Yu

“…DIM could promote BMMSC osteogenic differentiation via triggering the ERK and p38 MAPK signaling pathways and might be a novel predictable material for facilitating bone formation.…”
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Recent development of micro-nano carriers for oral antineoplastic drug delivery by Hongzheng Li, Xiang Chen, Shangrui Rao, Minyu Zhou, Jianhua Lu, Danna Liang, Bingzi Zhu, Letian Meng, Ji Lin, Xiaoya Ding, Qingfei Zhang, Danhong Hu

“…The primary objective of this review is to introduce various oral delivery methods and serve as a point of reference for the advancement of novel oral delivery carriers, with the ultimate goal of informing the development of future clinical applications.…”
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Longitudinal performance trajectories for youth female and male soccer players: 10m-sprint percentile curves adapted to biological age by Julia Hernandez, Chantal Widmer, Stephen Cobley, Dennis-Peter Born, Wolfgang Taube, Michael Romann

“…In addition to percentile curves based on chronological age, a novel approach incorporating biological age, which accounts for maturation variability during puberty, is introduced. …”
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Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse by Sara Carmela Credendino, Nicole Lewin, Miriane de Oliveira, Swaraj Basu, Barbara D’Andrea, Elena Amendola, Luigi Di Guida, Antonio Nardone, Remo Sanges, Mario De Felice, Gabriella De Vita

“…The extreme heterogeneity in the mechanisms of action of these molecules, however, makes them very difficult to study, especially regarding their molecular function. A novel lncRNA has been recently identified as the most enriched transcript in mouse developing thyroid. …”
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Sepsis in Internal Medicine: blood culture-based subtypes, hospital outcomes, and predictive biomarkers by Gaetano Zizzo, Gabriele Guazzardi, Daniela Bompane, Francesco Di Terlizzi, Giorgio Rotola, Ilario Stefani, Michela Medugno, Mario Bucalo, Antonino Mazzone

“…From 2016 to 2023, MDR+ sepsis frequency declined, due to decreased resistance to several antibiotic classes, such as cephalosporins, fluoroquinolones, and aminoglycosides; however, carbapenemase- and extended-spectrum beta-lactamase-producing Gram-negative bacteria, as well as vancomycin-resistant enterococci, increased, as did the frequency of polymicrobial sepsis following the COVID-19 outbreak.ConclusionThis work provides novel insights into sepsis management in internal medicine units, highlighting the need for validated biomarkers and implemented therapies in this scenario.…”
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3D‐Printed Talus‐Calcaneus Prosthesis in Treating Ewing's Sarcoma: A Case Report by Weiyi Wang, Jingjing An, Minxun Lu, Xuanhong He, Zhuangzhuang Li, Yitian Wang, Taojun Gong, Yong Zhou, Li Min, Yi Luo, Chongqi Tu

“…Nevertheless, a larger cohort study and with longer follow‐up is needed to evaluate the effectiveness and potential complications of this novel prosthesis.…”
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New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A by Marina Vladimirovna Silkina, Alena Sergeevna Kartseva, Alena Konstantinovna Riabko, Mariia Aleksandrovna Makarova, Metkhun Madibronovich Rogozin, Yana Olegovna Romanenko, Igor Georgievich Shemyakin, Ivan Alekseevich Dyatlov, Victoria Valerievna Firstova

“…In an effort to develop novel BoNT type A (BoNT/A) immunotherapeutics, sorted by flow cytometry plasmablasts and activated memory B cells from a donor repeatedly injected with BoNT/A for aesthetic botulinum therapy could be used due to obtain hybridomas producing native antibodies. …”
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Comprehensive evaluation of the properties of camel bone gelatin: impact of the duration of pre-treatment and extraction by Meriem Imelhayene, Abdelkader Adamou, Samira Becila, Ayad Redjeb, Dahia Saidj, Abdelhakim Senoussi, Dimitris Sarris, Eleni Naziri

“…Aim: This study investigates the extraction of gelatin from camel bones, discusses its potential as a novel protein source and assesses how its properties are affected by the duration of the pre-treatment and extraction processes. …”
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OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines by Nicola Cotugno, Alessandra Ruggiero, Veronica Santilli, Emma Concetta Manno, Salvatore Rocca, Sonia Zicari, Donato Amodio, Manuela Colucci, Paolo Rossi, Ofer Levy, Federico Martinon-Torres, Andrew J. Pollard, Paolo Palma

“…We will provide examples that show how such information can be useful to identify novel biomarkers of safety and immunogenicity for future vaccine trials. …”
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Effect of Staggered vs. Simultaneous Co-Administration of Bempedoic Acid on Pharmacokinetics of Pravastatin: Randomized, Cross-Over Clinical Trial in Healthy Volunteers by Felicitas Stoll, Salvatore Amato, Max Sauter, Jürgen Burhenne, Johanna Weiss, Walter E. Haefeli, Antje Blank

“…<b>Background/Objectives</b>: Bempedoic acid (BA) is a novel cholesterol-lowering agent with proven positive effects on cardiovascular endpoints. …”
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Screening for schistosomiasis in a non-endemic setting: Accuracy of a rapid antibody test using finger prick blood by Margherita Ortalli, Bianca Granozzi, Michele Bacchiega, Concettina Di Lillo, Greta Roncarati, Silvia Stefania Longoni, Cristina Mazzi, Elisa Vanino, Zeno Bisoffi, Stefania Varani

“…Good agreement was found with the other antibody tests, with the highest sensitivity being observed for serum-ICT (91.0 %, 84.7–96.4) and the highest specificity for ELISA (92.6 %, 87.5–96.7).The novel POC test for schistosomiasis showed satisfactory results and could improve the detection of this parasitic infection in non-endemic settings, as the lab-free approach could greatly expand the target group.…”
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