Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats by Qiujiang Li, Bowen Hu, Linan Wang, Lei Wang, Cong Feng, Zhuang Zhang, Zhipeng Deng, Yang Xiao, Bo Yuan, Xiangdong Zhu, Xiangfeng Li, Xi Yang, Yueming Song, Xingdong Zhang

“…Polyetheretherketone (PEEK) has become a commonly used alternative material for fusion cages owing to its excellent mechanical properties and biocompatibility, but its biological inertness limits bone regeneration and may lead to poor fusion. In this study, a novel strategy for preparing bioactive biomineralized PEEK cages was developed using a unique combination of osteoinductive CaP bioceramic fillings in the cage window, acid sulfonation and simulated body fluid incubation. …”
Get full text

Infectious bursal disease virus affecting interferon regulatory factor 7 signaling through VP3 protein to facilitate viral replication by Zhiyuan Wang, Yang Chen, Yanyan Chen, Rui Chen, Weiwei Wang, Shichen Hu, Yihai Li, Hongjun Chen, Ping Wei, Xiumiao He

“…These findings revealed a novel mechanism that IBDV uses to evade host antiviral defense.…”
Get full text

Mitophagy mediated by HIF-1α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury by Wenjun Zhang, Chao Guo, Yi Li, Hao Wang, Huabing Wang, Yingying Wang, Tingting Wu, Huinan Wang, Gang Cheng, Jiangwei Man, Siyu Chen, Shengjun Fu, Li Yang

“…Pretreatment of the rat RIRI model with roxadustat, a novel oral HIF-1α inhibitor, led to decreased renal injury and apoptosis in vivo. …”
Get full text

Genome-wide association study analysis of single nucleotide variants in L. infantum associated with IL-6 inflammatory response in visceral leishmaniasis by Amanda Miranda da Silva, Kátia Silene Sousa Carvalho, Caio Andrey Bezerra Januário, Raquel Gomes de Sena Carneiro Caldas, Bianka Lopes da Silva Paulino, Débora Cavalcante Braz, Dorcas Lamounier Costa, Gabriel da Luz Wallau, Wilson Jose da Silva Junior, Carlos Henrique Nery Costa

“…These findings demonstrate that IL-6 levels tended to be associated with the fatal outcome of VL and highlight 35 novel genetic variants that could serve as potential biomarkers for prognosis. …”
Get full text

Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry by Aline Menezes, Yara Martins, Fábio Nogueira, Denise De Abreu Pereira, Katia Carneiro

“…The main challenge in GBM research has been to identify novel molecular therapeutic targets and accurate diagnostic/prognostic biomarkers. …”
Get full text

Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency by Xiaofei Zhang, Linzi Ma, Xiaotong Liu, Xingyu Zhou, Ao Wang, Yunhui Lai, Jun Zhang, Ying Li, Shiling Chen

“…These findings provide a novel and promising treatment strategy for POI patients.…”
Get full text

Physical activity and content in a variety of physically active learning: an observational case study of real-world practices by Jan-Michael Johansen, Mathias Brekke Mandelid, Mathias Brekke Mandelid, Michael Reinboth, Geir Kåre Resaland, Solfrid Bratland-Sanda

“…The primary movement in PAL was mainly running and/or walking (78.3%), while the PAL activity was mainly organized as group work (83.7%) in non-competitive tasks (97.3%).ConclusionsThis study provides novel insights by being the first to investigate the organization and content of PAL enacted by experienced teachers in their teaching and the corresponding PA levels in their real-world practices. …”
Get full text

Analysis of GAA Junction Less NS FET Towards Analog and RF Applications at 30 nm Regime by Asisa Kumar Panigrahy, Sudheer Hanumanthakari, Shridhar B. Devamane, Shruti Bhargava Choubey, M. Prasad, D. Somasundaram, N. Kumareshan, N. Arun Vignesh, Gnanasaravanan Subramaniam, Durga Prakash M, Raghunandan Swain

“…This research focuses on a quantum model created using an entirely novel nanosheet FET. The standard model describes the performance of a Gate-all-around (GAA) Junction-less (JL) nanosheet device with a gate dielectric of SiO₂ and HfO₂, each having a thickness of 1 nm. …”
Get full text

A High-Salt Diet Disturbs the Development and Function of Natural Killer Cells in Mice by Xiaokang Zeng, Yan Li, Weibiao Lv, Xinhuai Dong, Chong Zeng, Liming Zeng, Zibo Wei, Xu Lin, Yanning Ma, Qiang Xiao

“…The present research discovered a novel mechanism by which HSD inhibits the function of NK cells, providing an alternative avenue for the treatment of immune diseases caused by HSD.…”
Get full text

Association between chronic kidney disease and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018 by Cong Liu, Jiju Yang, Hongdian Li, Yuanyuan Deng, Pengfei He, Jiao Zhang, Mianzhi Zhang, Mianzhi Zhang, Mianzhi Zhang

“…This study aims to explore the relationship between OBS and the risk of chronic kidney disease (CKD).MethodsThis cross-sectional study included nationally representative National Health and Nutrition Examination Survey (NHANES) participants aged 18 and above from 2005 to 2018. The OBS, a novel concept derived from multiple dietary (pro-oxidant and antioxidant nutrients) and lifestyle exposures (including smoking, alcohol consumption, obesity, and physical activity), serves as a useful tool for assessing an individual's oxidative stress status. …”
Get full text

Bottleneck Problems and Countermeasures in Operation and Maintenance of Non-Point Source Pollution Ecological Treatment Projects in China by Yungeng Jiang, Jing Zhang, Xiaoxin Liu, Han Liu, Yurui Ma, Wanhui Wang, Shaoyong Lu

“…Following this, promising countermeasures to solve these problems are proposed, including establishing an ecological treatment technology system, improving the technology selection assessment system, improving the assessment method in project operation, and establishing a systematic operation and maintenance process. Finally, a novel theory of Monitoring-Assessment-Repair (MAR) for ETP is proposed to solve the systematic bottlenecks in engineering operation and maintenance. …”
Get full text

Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice by Bing Li, Yu Cheng, Songyan Yu, Li Zang, Yaqi Yin, Jiejie Liu, Lin Zhang, Yiming Mu

“…Thus, UC-MSCs may serve as a novel therapeutic agent for T2DM patients with NAFLD.…”
Get full text

Whole-genome sequencing surveillance of Siberian tick-borne encephalitis virus (TBEV) identifies an additional lineage in Kyrgyzstan by Jake D'Addiego, Mollie Curran-French, Jack Smith, Asankadyr T Junushov, Irena Breininger, Barry Atkinson, John Hay, Roger Hewson

“…Since high viral loads are rare in TBEV clinical samples, the developed protocol adds value to TBEV-Sib endemic regions by offering a novel set of primers to further amplify the viral genome prior to sequencing.…”
Get full text

Effects of intranasal oxytocin on neural reward processing in children and adolescents with reactive attachment disorder: A randomized controlled trial by Shinichiro Takiguchi, Shinichiro Takiguchi, Kai Makita, Takashi X. Fujisawa, Takashi X. Fujisawa, Shota Nishitani, Shota Nishitani, Akemi Tomoda, Akemi Tomoda, Akemi Tomoda

“…Further investigation is needed to fully understand the neural mechanisms of intranasal OT and identify novel targets for pediatric cases with RAD.Clinical trial registration: UMIN-CTR; UMIN000013215. …”
Get full text

A fast monocular 6D pose estimation method for textureless objects based on perceptual hashing and template matching by Jose Moises Araya-Martinez, Jose Moises Araya-Martinez, Vinicius Soares Matthiesen, Vinicius Soares Matthiesen, Simon Bøgh, Jens Lambrecht, Rui Pimentel de Figueiredo

“…In this study, we propose a template-based matching algorithm that utilizes a novel perceptual hashing method for binary images, enabling fast and robust pose estimation. …”
Get full text

Diagnostic Value of Glycosylated Extracellular Vesicle microRNAs in Gastric Cancer by Wang S, Ma C, Ren Z, Zhang Y, Hao K, Liu C, Xu L, He S, Zhang J

“…This study aimed to develop a novel diagnostic model based on miRNAs from glycosylated extracellular vesicles and evaluate its effectiveness in diagnosing gastric cancer.Methods: GlyExo-capture technology was used to isolate glycosylated extracellular vesicles from serum samples. …”
Get full text

A comprehensive analysis of the epidemiological and genomic characteristics of global Serratia Marcescens by Wenqin Chen, Zheqian Li, Jie Zheng, Danwei Wang, Shuo Gao, Wanqing Zhou, Han Shen, Yan Zhang, Xiaoli Cao

“…Carbapenemase genes included blaSME, blaKPC, and blaNDM-1, though co-occurrence in individual strains was absent. Novel ARGs, including armA, rmtC, and fosA7.2, were reported. …”
Get full text

Gut Microbiome and Metabolite Characteristics Associated With Different Clinical Stages in Non-Small Cell Lung Cancer Patients by Liu F, Lu X, Tang M, Chen Y, Zheng X

“…Our findings may offer novel perspectives on the pathogenesis of NSCLC at various TNM stages. …”
Get full text

Introducing a Coopetition Model for Domestic Airlines in Iran by Saedeh Ghayourisales, Mohsen Nazari, Mohammadali Shahhoseini

“…As a result of shifts in both internal and external landscapes, along with the swift advancements in technology encapsulated by the term VUCA (signifying volatility, uncertainty, complexity, and ambiguity), the conventional dichotomy of pure competition or complete cooperation has diminished in its efficacy. In its place, a novel mode of collaboration has emerged, characterized by a blend of cooperation to generate value and competition in the pursuit of value, termed "co-competitiveness." …”
Get full text

Effectiveness of a comic book intervention on mental health literacy among adolescents and youth in Burkina Faso: a randomized controlled trial protocol by Irene Brandt, Sylvain Some, Ourohiré Millogo, Oumar Sourabié, Jacob Burns, Sachin Shinde, Matthias Haucke, Nathan Sivewright, Christine Neumann, Shraddha Bajaria, Katian Napon, Clarisse Dah, Marina Taonda, Jason T. Siegel, Mary Mwanyika Sando, Till Bärnighausen, Ali Sié, Shuyan Liu

“…Our study will provide evidence on novel interventions designed to enhance mental health literacy among adolescents and young adults in low-resource settings. …”
Get full text