Predicting the reduction in heatstroke and heart disease-related mortality under urban modification scenarios using machine learning by Yukitaka Ohashi, Ko Nakajima, Yuya Takane, Yukihiro Kikegawa, Tomohiko Ihara, Kazutaka Oka

“…This study proposes a novel approach combining machine learning (ML) techniques with meteorological model simulations to evaluate the heat-related mortality reduction potential of a climate change adaptation measure, namely, the installation of energy-saving or temperature-decreasing modifications in an urban area (e.g. greening, high-albedo paints, and photovoltaics). …”
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Hypoxia Induced Lnc191 Upregulation Dictates the Progression of Esophageal Squamous Cell Carcinoma by Activating GRP78/ERK Pathway by Sisi Wei, Xinyi Fan, Xiaoya Li, Wei Zhou, Zhihua Zhang, Suli Dai, Huilai Lv, Yueping Liu, Baoen Shan, Lianmei Zhao, Qimin Zhan, Yongmei Song

“…In the present study, a novel hypoxia‐induced long noncoding RNA (lncRNA) is identified first, lnc191, which is highly expressed in clinical ESCC tissues and is positively correlated with poor prognosis of ESCC patients. …”
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Time-resolved Hubble Space Telescope UV Observations of an X-Ray Quasiperiodic Eruption Source by T. Wevers, M. Guolo, S. Lockwood, A. Mummery, D. R. Pasham, R. Arcodia

“…X-ray quasiperiodic eruptions (QPEs) are a novel mode of variability in nearby galactic nuclei whose origin remains unknown. …”
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CCL4 Affects Eosinophil Survival via the Shedding of the MUC1 N-Terminal Domain in Airway Inflammation by Yoshiki Kobayashi, Chu Hong Hanh, Naoto Yagi, Nhi Kieu Thi Le, Yasutaka Yun, Akihiro Shimamura, Kenta Fukui, Akitoshi Mitani, Kensuke Suzuki, Akira Kanda, Hiroshi Iwai

“…Increased CCL4 induces the contact between eosinophils and airway epithelial cells by shedding the MUC1 N-terminal domain and enhances eosinophil survival in eosinophilic airway inflammation. This novel mechanism may be a therapeutic target for difficult-to-treat eosinophilic airway inflammation.…”
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Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications by Guillermo P. Lopez, Guillermo P. Lopez, Leyanet Barberia Roque, Katerine Igal, Katerine Igal, Erasmo Gámez Espinosa, Erasmo Gámez Espinosa, Natalia Bellotti, Natalia Bellotti

“…This study highlights a novel approach to developing antimicrobial materials by functionalizing Dt with QAS and citronellol. …”
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Children’s emerging concepts of resilience: insights from using body mapping in an East London cohort sample of 7-10-year-old children by Aisling Murray, Dominie Mahala Smith Scott, Milena Nikolajeva, Daniele Porricelli, Francois van Loggerenberg, Dennis Ougrin, Jennifer Y. F. Lau

“…This study aimed to use body mapping, an arts-based method, as a novel approach to understand 7-10-year-old children’s concepts of resilience (including definitions and factors that contribute to resilience) in East London. …”
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Emerging nanomedicine strategies for hepatocellular carcinoma therapy by Chen Guo, Jiayu Zhang, Xiaomeng Cai, Rui Dou, Jiaruo Tang, Zhengyuan Huang, Xueting Wang, Yan Guo, Hanqing Chen, Jun Chen

“…Consequently, there exists an urgent necessity for novel treatment strategies. Nanomedicine possesses superior attributes, such as targeted administration and responsive drug release within the tumor microenvironment. …”
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Exploring the Potential of Oxalyldihydrazide-Derived Schiff Bases as Versatile Ligands: Synthesis, Structural Characterization, and Magnetic Properties by Ernesto Costa-Villén, Marina Ortiz, Pedro Sitjar, Cristina Puigjaner, Mohamed Salah El Fallah

“…To further enrich this family and assess the potential impact of oxalyldihydrazide-derived Schiff bases in the realms of coordination chemistry and molecular magnetism, three novel ligands have been synthesized and investigated. i.e., N′1,N′2-bis((<i>E</i>)-pyridin-2-ylmethylene)oxalohydrazide (<b>H₂L1</b>), N′1-((<i>E</i>)-(3-methylpyridin-2-yl)methylene)-N′2-((<i>E</i>)-(6-methylpyridin-2-yl)methylene)oxalohydrazide (<b>H₂L2</b>) and N′1,N′2-bis((E)-phenyl(pyridin-2-yl)methylene)oxalohydrazide (<b>H₂L3</b>) were synthesized and then combined with various 3<i>d</i> metals, resulting in the formation of five new complexes with formula [Cu₅(L1)₂(H₂O)₈(MeOH)₂(NO₃)₂](NO₃)₄ (<b>1</b>), [Mn₂(HL2)₂(BzO)₂(MeOH)₂]·2MeOH (<b>2</b>), [Ni(HL2)₂]·2MeOH (<b>3</b>), [Ni₄(L2)₄]·4MeOH (<b>4</b>), [Ni₈(L3)₄(AcO)₄(H₂O)₁₂](OAc)₄ (<b>5</b>). …”
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CDC20‐Mediated Selective Autophagy Degradation of PBRM1 Affects Immunotherapy for Renal Cell Carcinoma by Yizeng Fan, Weichao Dan, Taotao Que, Yi Wei, Bo Liu, Zixi Wang, Yulin Zhang, Yuzhao Wang, Tianjie Liu, Yanxin Zhuang, Mengxing Li, Chendong Guo, Jin Zeng, Bohan Ma, Lei Li

“…Overall, this finding suggest the clinical application of PB1‐p62 and provide a novel approach for enhancing the effectiveness of immunotherapy in RCC patients with wild‐type PBRM1.…”
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Exogenous dihomo-γ-linolenic acid triggers ferroptosis via ACSL4-mediated lipid metabolic reprogramming in acute myeloid leukemia cells by Xiandong Jiang, Yingying Huang, Xiaoying Hong, Wei Wu, Yanfeng Lin, Liping Lin, Yan Xue, Donghong Lin

“…Ferroptosis is a novel type of programmed cell death caused by excessive iron-dependent lipid peroxidation. …”
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Cuproptosis-Related Signature Predicts the Prognosis, Tumor Microenvironment, and Drug Sensitivity of Hepatocellular Carcinoma by Xiangjun Qi, Jiayun Guo, Guoming Chen, Caishan Fang, Leihao Hu, Jing Li, Chi Zhang

“…Copper (Cu) metabolism is strongly associated with liver disease. Cuproptosis is a novel format of cell death, and cuproptosis-related genes (CRGs) were identified. …”
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Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era by Alberto Barchi, Giuseppe Dell’Anna, Giuseppe Dell’Anna, Luca Massimino, Luca Massimino, Francesco Vito Mandarino, Edoardo Vespa, Edi Viale, Sandro Passaretti, Vito Annese, Vito Annese, Alberto Malesci, Alberto Malesci, Silvio Danese, Silvio Danese, Federica Ungaro

“…Epigenetic alterations (such as hyper or hypo-methylation) play a meaningful role in esophageal carcinogenesis as well as the study of the tumor micro-environment, which has led to the development of novel immunological therapeutic options. Finally, the esophageal microbiome could be the protagonist to be investigated, deepening our understanding of the subtle association between the host microbiota and tumor development.…”
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Pharmacotherapy for AMD: state-of-the-art by I.A. Koroleva, A.A. Gvetadze, T.B. Romanova

“…Data on earlier and recent treatment for “wet” AMD as well as promising trends in the development of novel medications are addressed.&nbsp;</i> </p> <p> <i>It was established that AMD is one of the most common causes of low vision in people over 50 years in developed countries. …”
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Antifungal Activity of Genistein Against Phytopathogenic Fungi <i>Valsa mali</i> Through ROS-Mediated Lipid Peroxidation by Fangjie Li, Chen Yang, Maoye Li, Su Liu, Kuo Xu, Xianjun Fu

“…This finding has the potential to contribute to the development of novel biological control agents for industrial crops.…”
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Metagenomic next-generation sequencing for the clinical identification of spinal infection-associated pathogens by Tengfei Shi, Yuhan Lin, Xuexin Zheng, Hongliang Ruan, Rui Zhang, Yinhuan Liu, Shaohan Xu, Shaohan Xu, Huafeng Wang

“…Although the sensitivities of erythrocyte sedimentation rate-based assay (91.36%), magnetic resonance imaging (88.27%), and C-reactive protein-based assay (87.65%) were better than those of mNGS, their specificities were generally low (20%-40%).ConclusionThe pathogens responsible for SI are complex and diverse. As a novel diagnostic method, mNGS exhibits a high sensitivity and extensive pathogen coverage for SI diagnosis. …”
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Sustainable foam glass property prediction using machine learning: A comprehensive comparison of predictive methods and techniques by Mohamed Abdellatief, Leong Sing Wong, Norashidah Md Din, Ali Najah Ahmed, Abba Musa Hassan, Zainah Ibrahim, G. Murali, Kim Hung Mo, Ahmed El-Shafie

“…In this context, the current study proposes a novel approach by developing a thoughtful system for assessing performance and intelligent design utilizing ML models such as Gradient Boosting (GB), Random Forest (RF), Gaussian Process Regression (GPR), and Linear Regression (LR) to predict porosity and compressive strength (CS) of FG. …”
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Major facility superfamily sugar transporter protein SsMFSST1 regulates Sporisorium scitamineum mating, pathogenicity, and sugar transport/absorption by Yi Zhang, Yongding He, Meixin Yan, Shilong Zhang, Sisi Zhou, Wankuan Shen

“…In summary, this study identified a novel pathogenic gene in the S. scitamineum—the MFS sugar transporter gene, providing a molecular basis for understanding the pathogenic mechanism of the S. scitamineum. …”
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Genomic 8-oxoguanine modulates gene transcription independent of its repair by DNA glycosylases OGG1 and MUTYH by Tobias Obermann, Teri Sakshaug, Vishnu Vignesh Kanagaraj, Andreas Abentung, Mirta Mittelstedt Leal de Sousa, Lars Hagen, Antonio Sarno, Magnar Bjørås, Katja Scheffler

“…Regardless of DNA glycosylase activity, OG in promoter regions correlated with expression of genes related to metabolic processes and damage response pathways indicating that OG functions as a cellular stress sensor to regulate transcription. Our work provides novel insights into the mechanism underlying transcriptional regulation by OG and DNA glycosylases OGG1 and MUTYH and suggests that oxidative DNA damage accumulation and its repair utilize different pathways.…”
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Flavonoids and anthocyanins in seagrasses: implications for climate change adaptation and resilience by Jana Botes, Jana Botes, Xiao Ma, Xiao Ma, Jiyang Chang, Jiyang Chang, Yves Van de Peer, Yves Van de Peer, Yves Van de Peer, Yves Van de Peer, Dave Kenneth Berger, Dave Kenneth Berger

“…Certain features, such as catalytic promiscuity and metabolon interactions, allow flavonoid metabolism to expand to produce novel compounds and respond to a variety of stimuli. …”
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A noninvasive method for the detection of foetal DNA in early pregnancy based on differential methylation pattern of Ras association domain family member 1A by Yulin Sha, Wei Liu, Jiongzhi Hong, Yan Yang, Jian Yu, Xiaodong Fu

“…This study introduces a novel approach using the Ras association domain family 1 A (RASSF1A), which exhibits hypermethylation in foetal cells and hypomethylation in maternal cells. …”
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