ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1 by Živa Frangež, Deborah Gérard, Zhaoyue He, Marios Gavriil, Yuniel Fernández-Marrero, Yuniel Fernández-Marrero, S. Morteza Seyed Jafari, Robert E. Hunger, Philippe Lucarelli, Shida Yousefi, Thomas Sauter, Lasse Sinkkonen, Hans-Uwe Simon, Hans-Uwe Simon, Hans-Uwe Simon, Hans-Uwe Simon

“…Our results support the concept that reduced autophagic activity contributes to melanoma development and progression, and identifies NRF1 as a novel TF involved in the regulation of both ATG5 and ATG7 genes.…”
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Mutual-information of meteorological-soil and spatial propagation: Agricultural drought assessment based on network science by Qingzhi Wen, Xinjun Tu, Lei Zhou, Vijay P Singh, Xiaohong Chen, Kairong Lin

“…By building a meteorological and soil mutual-information index, this paper developed a novel method for assessing agricultural drought from a network science perspective. …”
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Endoscopic band ligation alone and combined with clipping for colonic diverticular bleeding: A retrospective comparative study by Noritaka Ozawa, Kenji Yamazaki, Nae Hasebe, Kazuki Yamauchi, Kaori Koide, Hiroyuki Murase, Saeka Hayashi, Takaaki Hino, Daiki Hirota, Atsushi Soga, Kiichi Otani, Naoya Masuda, Hiroki Taniguchi, Shogo Shimizu, Masahito Shimizu

“…We have established a novel method combining EBL and clipping (EBL-C) for the hemostasis of CDB (Endoscopy E-videos); this study evaluated its usefulness. …”
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Wedge‐Like Microstructure of Al2O3/i‐Ti3C2Tx Electrode with “Nano‐Pumping” Effect for Boosting Ion Diffusion and Electrochemical Defluoridation by Junce Wang, Jinfeng Chen, Ningning Liu, Jingjing Lei, Hong‐Wen Gao, Fei Yu, Fanghui Pan, Jie Ma

“…The physicochemical coupling strategy opens a novel approach to optimizing the interlayer structure and in situ modification interface of MXene, which also provids a universal idea for efficient capture of varisized ions of intercalation materials.…”
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Taung and beyond: The mining history, geology and taphonomy of Australopithecus in South Africa by Rieneke Weij, Stephanie E. Baker, Tara R. Edwards, Job Kibii, Georgina Luti, Robyn Pickering

“…We offer a perspective on future research areas: more standardised excavation practices and techniques to raise the quality of data collected from the caves and new techniques to date and extract palaeoclimate data from cave deposits themselves, to provide novel insights into the world of the early australopiths. …”
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A Comparative Analysis of Explainable Artificial Intelligence Models for Electric Field Strength Prediction over Eight European Cities by Yiannis Kiouvrekis, Ioannis Givisis, Theodor Panagiotakopoulos, Ioannis Tsilikas, Agapi Ploussi, Ellas Spyratou, Efstathios P. Efstathopoulos

“…Our machine learning models consist of a novel and comprehensive dataset collected from a network of strategically placed sensors, capturing not only electromagnetic field readings but also additional urban features, including population density, levels of urbanization, and specific building characteristics. …”
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Diagnostic accuracy in coronary CT angiography analysis: artificial intelligence versus human assessment by James K Min, Paul Knaapen, Nick S Nurmohamed, Erik S G Stroes, Andrew D Choi, Ibrahim Danad, James Earls, Michiel J Bom, Ruben W de Winter, Rachel Bernardo, Ruurt Jukema, Ralf Sprengers

“…This study evaluated a novel algorithm for coronary stenosis quantification (atherosclerosis imaging quantitative CT, AI-QCT).Methods The study included 208 patients with suspected coronary artery disease (CAD) undergoing CCTA in Perfusion Imaging and CT Coronary Angiography With Invasive Coronary Angiography-1. …”
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Reseeding promotes plant biomass by improving microbial community stability and soil fertility in a degraded subalpine grassland by Debao Li, Sicheng Li, Hao Chen, Jianping Wu

“…As such, our findings provide new evidence to guide reseeding practices in degraded southern grasslands and offer novel theoretical insights into plant-soil-microbe interactions under grass-legume mixtures reseeding.…”
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Gastric Peroral Endoscopic Myotomy (G-POEM) as a Treatment for Refractory Gastroparesis: Long-Term Outcomes by Jiaxin Xu, Tianyin Chen, Shaimaa Elkholy, Meidong Xu, Yunshi Zhong, Yiqun Zhang, Weifeng Chen, Wenzheng Qin, Mingyan Cai, Pinghong Zhou

“…Gastric peroral endoscopic myotomy (G-POEM) has been regarded as a novel and minimally invasive therapy for refractory gastroparesis. …”
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Multi-Objective Optimal Trajectory Planning for Woodworking Manipulator and Worktable Based on the INSGA-II Algorithm by Jiaping Yi, Changqing Zhang, Sihan Chen, Qinglong Dai, Hang Yu, Guang Yang, Leyuan Yu

“…Optimized by the improved NSGA-II algorithm, the optimal total running time is 4.5400 s, and the optimal jerk is 17.934 <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="normal">m</mi><mo>(</mo><mi mathvariant="normal">r</mi><mi mathvariant="normal">a</mi><mi mathvariant="normal">d</mi><mo>)</mo><mo>/</mo><msup><mrow><mi mathvariant="normal">s</mi></mrow><mrow><mn>3</mn></mrow></msup></mrow></semantics></math></inline-formula>. This provides a novel approach to solving the inefficiencies and operational instability prevalent in traditional woodworking equipment.…”
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Viral Transcript and Tumor Immune Microenvironment-Based Transcriptomic Profiling of HPV-Associated Head and Neck Squamous Cell Carcinoma Identifies Subtypes Associated with Progno... by Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden

“…Unsupervised clustering analysis revealed five distinct and novel TME subtypes across patients (immune-enriched, highly immune and B-cell enriched, fibrotic, immune-desert, and immune-enriched luminal). …”
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TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis by Philippe Zizzari, Ashley Castellanos-Jankiewicz, Selma Yagoub, Vincent Simon, Samantha Clark, Marlene Maître, Nathalie Dupuy, Thierry Leste-Lasserre, Delphine Gonzales, Kristina Schoonjans, Valérie S. Fénelon, Daniela Cota

“…These studies also reveal a novel key function for TGR5 in SF1 neurons in the regulation of whole-body insulin sensitivity, providing new insight into the role played by neuronal TGR5 in the regulation of metabolism.…”
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The multifaceted anti-atherosclerotic properties of herbal flavonoids: A comprehensive review by Meiwen Huang, Xuena Xie, Rong Yuan, Qiqi Xin, Shudong Ma, Hongai Guo, Yu Miao, Chunyu Hu, Yizhun Zhu, Weihong Cong

“…This comprehensive review endeavors to synthesize and analyse the most recent findings on herbal flavonoids, shedding light on their anti-atherosclerotic potential and the underlying protective mechanisms and related-targets, which might pave the way for the development of novel drug candidates or the optimization of flavonoid-based therapies.…”
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Adrenomedullin 2 attenuates anxiety-like behaviors by increasing IGF-II in amygdala and re-establishing blood–brain barrier by Denian Wang, Zhi Yang, Pengfei Wu, Qingyan Li, Chunyan Yu, Ying Yang, Yuefan Du, Mengwei Jiang, Junpeng Ma

“…Herein, we show that adrenomedullin 2 (ADM2), a novel angiogenic growth factor, alleviates autistic and anxiety-like behaviors in mice. …”
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TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis by Jing Li, Yosuke Nagasaka, Hongtao Shen, Xinyu Zhou, Jianjie Ma, Dilza Trevisan-Silva, Nicholas E. Sherman, Jayakrishna Ambati, Bradley D. Gelfand, Lian-Wang Guo

“…These findings identify TMEM97 as a novel regulator of RPE-cell pEMT through the CTNND2-ADAM10 axis, highlighting potential new targets for therapeutic intervention in RPE-related pathophysiology.…”
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Evolution of sub-ice-shelf channels reveals changes in ocean-driven melt in West Antarctica by Karen E. Alley, Richard B. Alley, Alex D. Crawford, Naomi Ochwat, Christian T. Wild, Juliana Marson, Tasha Snow, Atsuhiro Muto, Erin C. Pettit, Sarah F. Child, Martin Truffer, Gabriela Collao-Barrios, Ted A. Scambos

“…By applying a model of channel-path evolution dominantly controlled by ice flow and ocean melt, we show that the majority of channels surveyed exhibit non-steady behavior that serves as a novel proxy for increased ocean forcing in West Antarctica starting at least in the early 1970s.…”
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A case-matched series comparing functional outcomes for robotic-assisted unicompartmental knee arthroplasty versus functionally aligned robotic-assisted total knee arthroplasty by Jonathan R. Manara, Macdaniel Nixon, Beth Tippett, Wil Pretty, Dermot Collopy, Gavin W. Clark

“…Functional alignment (FA) is a novel technique for performing a TKA and shares many principles with UKA. …”
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Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin by Prastika Krisma Jiwanti, Dewi Kartika Azizah Sukardi, Anis Puspita Sari, Mai Tomisaki, Siti Wafiroh, Sri Hartati, Arramel, Yew Hoong Wong, Pei Meng Woi, Joon Ching Juan

“…This study addresses these concerns by introducing an innovative electrochemical sensor utilizing a screen-printed electrode (SPE) enhanced with a novel rGO-SnO2 nanocomposite for the precise monitoring of CIP concentration. …”
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Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status by S. Nooij, N. Plomp, I. M. J. G. Sanders, L. Schout, A. E. van der Meulen, E. M. Terveer, J. M. Norman, N. Karcher, M. F. Larralde, R. H. A. M. Vossen, S. L. Kloet, K. N. Faber, H. J. M. Harmsen, G. F. Zeller, E. J. Kuijper, W. K. Smits, Q. R. Ducarmon

“…Together, we present a large R. gnavus resource that will be available to the scientific community and provide novel biological insights into the global distribution and genomic variation of R. gnavus.…”
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PDZRN3 regulates adipogenesis of mesenchymal progenitors in muscle by Hiroki Iida, Minako Kawai-Takaishi, Yoshihiro Miyagawa, Yasuhiko Takegami, Akiyoshi Uezumi, Takeshi Honda, Shiro Imagama, Tohru Hosoyama

“…Since ectopic fat accumulation is frequently found in the skeletal muscles of older adults and also muscular dystrophy patients, PDZRN3 and its related pathways may represent a novel therapeutic target for these muscle pathologies.…”
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