Development and validation of the age-associated dementia policy (AgeD-Pol) computer simulation model in the USA and Europe by Anand Viswanathan, Lee H Schwamm, Krishna P Reddy, Emily P Hyle, Fatma M Shebl, Kenneth A Freedberg, Julia H A Foote, Yiqi Qian, Shibani S Mukerji, Nattanicha Wattananimitgul, Ankur Pandya

“…Objective To develop and validate a novel, microsimulation model that accounts for the prevalence and incidence of age-associated dementias (AAD), disease progression and associated mortality.Design, data sources and outcome measures We developed the AAD policy (AgeD-Pol) model, a microsimulation model to simulate the natural history, morbidity and mortality associated with AAD. …”
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Multimodal Pain Recognition in Postoperative Patients: Machine Learning Approach by Ajan Subramanian, Rui Cao, Emad Kasaeyan Naeini, Seyed Amir Hossein Aqajari, Thomas D Hughes, Michael-David Calderon, Kai Zheng, Nikil Dutt, Pasi Liljeberg, Sanna Salanterä, Ariana M Nelson, Amir M Rahmani

“…ConclusionsThis study presents a novel, multimodal machine learning framework for objective pain recognition in postoperative patients. …”
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Septuple XBi2Te4 (X=Ge, Sn, Pb) intercalated MnBi2Te4 for realizing interlayer ferromagnetism and quantum anomalous hall effect by Ruixia Yang, Xiaoxiao Man, Jiahui Peng, Jingjing Zhang, Fei Wang, Fang Wang, Huisheng Zhang, Xiaohong Xu

“…In this study, we propose a novel approach to achieve interlayer ferromagnetic (FM) coupling in MBT bilayer by intercalating the septuple-layer of topological insulators XBi2Te4 (X=Ge, Sn, Pb). …”
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Impact of Long-Term Cold Storage on the Physicochemical Properties, Volatile Composition, and Sensory Attributes of Dried Jujube (<i>Zizyphus jujuba</i> Mill.) by Shaoxiang Pan, Xuemei Liu, Xiaodong Zheng, Jihong Wu, Mengnan Tan, Ning Cao, Xinyu Zhao, Maoyu Wu, Yu Han, Xinhuan Yan, Ye Song

“…This study investigates the quality changes of grey jujubes during storage from sensory and physicochemical perspectives, aiming to provide a novel approach for differentiating between newly harvested and aged grey jujubes. …”
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Atomically resolved imaging of radiation-sensitive metal-organic frameworks via electron ptychography by Guanxing Li, Ming Xu, Wen-Qi Tang, Ying Liu, Cailing Chen, Daliang Zhang, Lingmei Liu, Shoucong Ning, Hui Zhang, Zhi-Yuan Gu, Zhiping Lai, David A. Muller, Yu Han

“…This important insight advances our understanding of the rapidly evolving electron ptychography technique and provides a novel approach to high-resolution imaging of various sensitive materials.…”
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Hydrological-hydraulic modelling to assess Nature-Based Solutions for flood risk mitigation in an urban area of Catania (Sicily, Italy) by L. Sciuto, F. Licciardello, E.R. Giuffrida, S. Barresi, V. Scavera, D. Verde, S. Barbagallo, G.L. Cirelli

“…To achieve the objective, a novel approach incorporating the integrated utilization of both hydraulic (HEC-RAS) and hydrological models (EPA SWMM), as well as images from traffic and mobile phone cameras, is implemented and validated. …”
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High nature value farming systems in Europe: A dataset encompassing the environmental impact assessment of farms and extensive ruminant food productsFigshare by M. Torres-Miralles, P. Jeanneret, M. Lamminen, F. Joly, B. Dumont, H. Tuomisto, I. Herzon

“…The main outcome is a unique and novel dataset for HNV farming systems, addressing critical gaps in available information. …”
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Optomechanical energy enhanced BF-QEPAS for fast and sensitive gas sensing by Weilin Ye, Linfeng He, Weihao Liu, Zhile Yuan, Kaiyuan Zheng, Guolin Li

“…Traditional beat frequency quartz-enhanced photoacoustic spectroscopy (BF-QEPAS) are limited by short energy accumulation times and the necessity of a decay period, leading to weaker signals and longer measurement cycles. Herein, we present a novel optomechanical energy-enhanced (OEE-) BF-QEPAS technique for fast and sensitive gas sensing. …”
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Possible linking and treatment between Parkinson’s disease and inflammatory bowel disease: a study of Mendelian randomization based on gut–brain axis by Beiming Wang, Xiaoyin Bai, Yingmai Yang, Hong Yang

“…Thus, we aimed to identify the causal relationships and novel therapeutic targets shared between them based on their common pathophysiological mechanisms in gut–brain-axis (GBA). …”
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Mutation in CDC42 Gene Set as a Response Biomarker for Immune Checkpoint Inhibitor Therapy by Kun Wang, Yingying Zhang, Zhaoming Su, Bei Wang, Yuanyang Zhou, Xiaochu Tong, Chengying Xie, Xiaomin Luo, Sulin Zhang, Mingyue Zheng

“…Conclusions Our study suggests that the CDC42 gene set mutations could potentially serve as a novel biomarker for the clinical response to ICI treatment. …”
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The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study by Lingling Xu, Dongling Li, Zongwei Song, Jin Liu, Yang Zhou, Junwei Yang, Ping Wen

“…Background Monocyte to high-density lipoprotein cholesterol ratio (MHR) was confirmed as a novel inflammatory marker and strongly associated with the risk of several diseases. …”
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Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication by Hu Xiaomiao, Zhao Ruihong, Li Wei, Pan Xiaocheng, Dai Yin, Wu Huimin, Wu Yantao, Zhang Chengcheng

“…Overall, this research provides valuable insights into elucidating the function of the p17 protein and sheds light on the pathogenic mechanism involving ARV-induced cellular apoptosis while offering novel perspectives for exploring therapeutic targets against ARV.…”
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Innovative Deep Learning Architecture for the Classification of Lung and Colon Cancer From Histopathology Images by Menatalla M. R. Said, Md. Sakib Bin Islam, Md. Shaheenur Islam Sumon, Semir Vranic, Rafif Mahmood Al Saady, Abdulrahman Alqahtani, Muhammad E. H. Chowdhury, Shona Pedersen

“…This study leveraged the LC25000 dataset, encompassing 25,000 images of lung and colon tissue, introducing an innovative approach by employing a self-organized operational neural network (Self-ONN) to accurately detect lung and colon cancer in histopathology images. Subsequently, our novel model underwent comparison with five pretrained convolutional neural network (CNN) models: MobileNetV2-SelfMLP, Resnet18-SelfMLP, DenseNet201-SelfMLP, InceptionV3-SelfMLP, and MobileViTv2_200-SelfMLP, where each multilayer perceptron (MLP) was replaced with Self-MLP. …”
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Transforming 5G Mega-Constellation Communications: A Self-Organized Network Architecture Perspective by Marius Corici, Marius Caus, Xavier Artiga, Alessandro Guidotti, Benjamin Barth, Tomaso de Cola, Justin Tallon, Hemant Zope, Daniele Tarchi, Fanny Parzysz, David Naseh, Swapnil Sadashiv Shinde

“…To cope with this technology gap, this paper introduces a novel architecture for 5G services relying on satellite mega-constellations, which adhere to the principles of self-organized networks. …”
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Evaluating the relative predictive validity of measures of self-referential processing for depressive symptom severity by Ethel Siew Ee Tan, Hong Ming Tan, Kah Vui Fong, Sheryl Yu Xuan Tey, Nikita Rane, Chong Wei Ho, Zhao Yuan Tan, Rachel Jing Min Ong, Chloe Teo, Jerall Yu, Maxine Lee, An Rae Teo, Sin Kee Ong, Xin Ying Lim, Jin Lin Kee, Jussi Keppo, Geoffrey Chern-Yee Tan

“…Participants completed the standard SRET and its variations, including Likert scales and matrix formats. Both standard and novel SRET measures were calculated and compared for their relative and incremental contribution to their associations with depression, with mean squared error (MSE) used as the primary metric for measuring predictive accuracy. …”
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Exercise medicine as adjunct therapy during RADIation for CAncer of the prostaTE to improve treatment efficacy – protocol for the ERADICATE study: a phase II randomised controlled... by Oliver Schumacher, Robert U. Newton, Colin Tang, Raphael Chee, Sjoerd B. Vos, Ronny S. Low, David Joseph, Dennis R. Taaffe, Daniel A. Galvão

“…Discussion The ERADICATE study will investigate exercise as a novel therapeutic approach for sensitising prostate cancer to EBRT by targeting a known mechanism of treatment resistance. …”
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Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design by Xiaoyi Li, Zechen Zhou, Yujia Ma, Kexin Ding, Han Xiao, Tao Wu, Dafang Chen, Yiqun Wu

“…<b>Conclusions</b>: <i>MRPS33</i>, <i>PIH1D2</i>, and <i>SD1HD</i> are associated with increased T2D risk through the environment influenced by paternal genotype, suggesting a novel perspective on paternal contributions to the T2D predisposition.…”
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Through each other's eyes: initial results and protocol for the co-design of an observational measure of adolescent-parent interaction using first-person perspective by Nicky Wright, Rebecca M. Pearson, Rebecca M. Pearson, Danielle Crook, Danielle Crook, Alice Bond, Tom Jewell, Tom Jewell

“…We hope to develop an observational measure using novel technological methods that can be used across a range of research and therapeutic settings.…”
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Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung by Yuanyuan Jia, Xuehong You, Ningxia Ma, Hui Li, Guopan Liu, Ying Wang, Jing Xue, Juan Shi, Jun Wei, Yong Li, Jiali Yang, Xiaoming Liu

“…Therefore, characterization of stem/progenitor cells in porcine organs or tissues may provide a novel avenue to better understand the biology and function of stem cells in humans. …”
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Evaluation of Renal Gene Expression of Protein Kinase C (PKC) Isoforms in Diabetic and Nondiabetic Proliferative Glomerular Diseases by Salwa Ibrahim, Laila Rashed, Sawsan Fadda

“…The protein kinase C (PKC) family consists of 13 members categorized as conventional or novel depending on whether diacylglycerol, calcium, or phosphatidylserine is required for activation. …”
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