evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat... by Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

“…Abstract Background Disease-modifying therapies targeting the diverse pathophysiology of Alzheimer’s disease (AD), including neuroinflammation, represent potentially important and novel approaches. The glucagon-like peptide-1 receptor agonist semaglutide is approved for the treatment of type 2 diabetes and obesity and has an established safety profile. …”
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Rumen DNA virome and its relationship with feed efficiency in dairy cows by Xiaohan Liu, Yifan Tang, Hongyi Chen, Jian-Xin Liu, Hui-Zeng Sun

“…The integration of these data offers novel insights into the mechanisms by which rumen viruses may regulate nutrient utilization, potentially influencing FE in dairy cows. …”
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The Evaluation of Serum KIM-1 in a Pediatric Cohort of Renal Transplantation—A Pilot Study by Paul Luchian Aldea, Roxana Andreea Turbuleasa-Jurje, Bogdan Bulata, Dan Delean, Florin Ioan Elec, Lorena Ciumarnean, Andreea Liana Bot (Rachisan)

“…Further studies are needed in order to clarify the utility of these novel biomarkers in the prediction of graft survival in renal transplantation patients.…”
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Exploring the Use of Smartwatches and Activity Trackers for Health-Related Purposes for Children Aged 5 to 11 years: Systematic Review by Lauren Thompson, Sydney Charitos, Jon Bird, Paul Marshall, Amberly Brigden

“…The proliferation of wearables, such as smartwatches and activity trackers, that support the collection of and reflection on personal health data highlights an opportunity to consider novel approaches to supporting health in young children (aged 5-11 y). …”
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CXCR4 promotes tumor stemness maintenance and CDK4/6 inhibitors resistance in ER-positive breast cancer by Qiangfeng Shi, Wang Yang, Yiye Ouyang, Yujie Liu, Zijie Cai

“…To address this challenge, novel strategies are required to overcome resistance, necessitating a deeper understanding of its mechanisms. …”
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Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension by Justin H. Berger, Yuji Shi, Timothy R. Matsuura, Kirill Batmanov, Xian Chen, Kelly Tam, Mackenzie Marshall, Richard Kue, Jiten Patel, Renee Taing, Russell Callaway, Joanna Griffin, Attila Kovacs, Dinesh Hirenallur-Shanthappa, Russell Miller, Bei B. Zhang, Rachel J. Roth Flach, Daniel P. Kelly

“…The ability to assess genetic and pharmacologic interventions is hampered by the lack of robust preclinical mouse models of HFpEF. We developed a novel “two-hit” model, which combines obesity and insulin resistance with chronic pressure overload to recapitulate clinical features of HFpEF. …”
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Protein identification using Cryo-EM and artificial intelligence guides improved sample purification by Kenneth D. Carr, Dane Evan D. Zambrano, Connor Weidle, Alex Goodson, Helen E. Eisenach, Harley Pyles, Alexis Courbet, Neil P. King, Andrew J. Borst

“…This issue is particularly problematic for self-assembling protein nanomaterials, where unexpected geometries may reflect novel assembly states, cross-contamination, or native proteins originating from the expression host. …”
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Fault tolerant & priority basis task offloading and scheduling model for IoT logistics by Asif Umer, Mushtaq Ali, Ali Daud, Lal Hussain, Amal Bukhari, Ali Imran Jehangiri

“…This paper introduces a novel Fault-Tolerant, Priority-Based Task Offloading and Scheduling Model (FP-TOSM) for IoT logistics. …”
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N88S seipin-related seipinopathy is a lipidopathy associated with loss of iron homeostasis by Mariana O. Ribeiro, Mafalda Oliveira, Verónica Nogueira, Vítor Costa, Vitor Teixeira

“…Importantly, we unraveled a novel link between inositol metabolism and activation of the iron regulon in cells expressing the N88S seipin mutation. …”
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BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations by Vera P. Mourits, Valerie A. C. M. Koeken, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Wern Cui Chu, Xiaoli Xu, Helga Dijkstra, Heidi Lemmers, Leo A. B. Joosten, Yue Wang, Reinout van Crevel, Mihai G. Netea

“…This study increases our understanding about the role of MDP in BCG-induced trained immunity, which might help to optimize vaccine efficacy and explore novel applications of BCG vaccination.…”
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Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology by James Johnson, PhD, Ben Gadomski, PhD, Daniel Regan, DVM, PhD, DACVP, Jed Johnson, PhD, Brad Nelson, MS, PhD, DVM, DACVS, Kirk McGilvray, PhD, Kevin Labus, PhD, Anthony Romeo, MD, Jeremiah Easley, DVM, Dipl, ACVS

“…This study investigates the efficacy of a novel, fully synthetic, bioresorbable nanofiber scaffold in restoring the native enthesis and enhancing the biomechanical properties and overall success of rotator cuff repairs, particularly in the context of chronically degenerated tendons. …”
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Membrane-bound model of the ternary complex between factor VIIa/tissue factor and factor X by Melanie P. Muller, Alex Mortenson, Josepha C. Sedzro, Po-Chao Wen, James H. Morrissey, Emad Tajkhorshid

“…This lipid dependence has made experimental characterization of the EC structure challenging. Using a novel computational methodology combining rigid-body protein-protein docking and extensive nonequilibrium molecular dynamics simulations in the explicit presence of a membrane, we developed, to our knowledge, the first atomic-level model of the EC, taking full account of the role of the membrane. …”
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Human adenovirus species B knob proteins as immunogens for inducing cross-neutralizing antibody responses by Zhenwei Liu, Yuting Xian, Jixian Lan, Zhichao Zhou, Xiao Li, Rong Zhou, Dehui Chen, Xingui Tian

“…This study provides a novel insight into the immunogenicity of HAdV species B knob proteins.…”
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Antrodia cinnamomea ameliorates neointimal formation by inhibiting inflammatory cell infiltration through downregulation of adhesion molecule expression in vitro and in vivo by Yan Zhang, Aijin Ma, Hao Xi, Ning Chen, Rong Wang, Chenhui Yang, Jinbang Chen, Pin Lv, Fuping Zheng, Wenyi Kang

“…Altogether, our results reveal a novel function of A. cinnamomea in suppressing vascular inflammation upon ligation injury during neointimal formation, likely through inhibition of inflammatory cell infiltration via downregulating the adhesion molecules in VSMCs. …”
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Mechanically powered negative pressure dressing reduces surgical site infection after stoma reversal by Brian Williams, MD, Aubrey Swinford, MD, Jordan Martucci, MD, Johnny Wang, MD, Jordan R. Wlodarczyk, MD, Abhinav Gupta, MD, Kyle G. Cologne, MD, Sarah E. Koller, MD, Christine Hsieh, MD, Marjun P. Duldulao, MD, Joongho Shin, MD

“…However, use of this approach has not been widely adopted due to high cost of the devices. We present a novel approach to stoma closure in which a self-contained mechanically powered negative pressure dressing (MP-NPD) is applied to primarily closed stoma reversal wounds. …”
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The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated Central Sensitization in Acupuncture Analgesia by Zhongxi Lyu, Yongming Guo, Yinan Gong, Wen Fan, Baomin Dou, Ningcen Li, Shenjun Wang, Yuan Xu, Yangyang Liu, Bo Chen, Yi Guo, Zhifang Xu, Xiaowei Lin

“…Taken together, inhibition of central sensitization modulated by neuroglial plasticity is central in acupuncture analgesia, providing a novel insight for the clinical application of acupuncture analgesia.…”
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Nomogram model and risk score predicting overall survival and guiding clinical decision in patients with Hodgkin’s lymphoma: an observational study using SEER population-based data... by Yue Yang, Shang Li, Xiao Zhu, Yi Kong, Mingtao Zhang, Xiangping Liang, Zherui Zhang, Shuzhen Tan, Yingqi Li, Yueyuan Zhong, Yingqi Shao, Jiayi Xu, Zesong Li

“…Patients with HL had good long-term outcomes but novel therapies are still in need for fewer complications.…”
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Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease by Jing Xue, Miaomiao Nian, Yangyang Liang, Zeqin Zhu, Zhenyu Hu, Yuanyuan Jia, Shuhong Chi, Juan Chen

“…Conclusions These findings suggest that targeting NETs may be a novel therapeutic approach for treating ILD in RA patients.…”
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Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) by Shishi Yu, Jinya Wu, Yuan Jing, Ping Lin, Lang Lang, Yifan Xiong, Wangzhong Chen, Wenhua Liu, Changpeng Sun, Yuntao Lu

“…The androgen receptor was identified as a promising but underexplored therapeutic target.ConclusionsResearch on glioma chemoradiotherapy resistance has seen substantial growth, with increasing emphasis on immune modulation, the tumor microenvironment, and novel therapeutic targets such as the androgen receptor. …”
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Ultra robust negative differential resistance memristor for hardware neuron circuit implementation by Yifei Pei, Biao Yang, Xumeng Zhang, Hui He, Yong Sun, Jianhui Zhao, Pei Chen, Zhanfeng Wang, Niefeng Sun, Shixiong Liang, Guodong Gu, Qi Liu, Shushen Li, Xiaobing Yan

“…Meanwhile, based on the high temperature stability of the device, a voltage-temperature fused multimodal impulse neural network was constructed to achieve 91.74% accuracy in classifying digital images with different temperature labels. This work offers a novel approach to build FN neuron circuits using NDR memristors, and provides a more competitive method to build a highly reliable neuromorphic hardware system.…”
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