Harnessing the Power of Machine Learning Guided Discovery of NLRP3 Inhibitors Towards the Effective Treatment of Rheumatoid Arthritis by Sidra Ilyas, Abdul Manan, Chanyoon Park, Hee-Geun Jo, Donghun Lee

“…In this study, a multidisciplinary approach combining machine learning, quantitative structure–activity relationship (QSAR) modeling, structure–activity landscape index (SALI), docking, molecular dynamics (MD), and molecular mechanics Poisson–Boltzmann surface area MM/PBSA assays was employed to identify novel NLRP3 inhibitors. The ChEMBL database was used to retrieve compounds with known IC₅₀ values to train machine learning (ML) models using the Lazy Predict package. …”
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Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…RNAseq experiments allowed the identification of 170 differentially expressed genes, including known Wnt/β-catenin target genes such as Notum, Axin2, and Lef1, as well as novel potential candidates Fam84a, Stk32a, and Itga9. …”
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Evaluation of the merit of ethanolic extract of Annona reticulata as an anti-cancer agent in human colon cancer cell lines (HCT-116) [version 2; peer review: 2 approved, 1 not appr... by Sri Pragnya Cheruku, Krishnananda Prabhu, Akshatha G Nayak, Vijetha Shenoy Belle, Vanishree Rao, Pooja Prakash Rao, Nitesh Kumar

“…Background Colon cancer is the third most common cancer type worldwide. Novel alternative therapeutic anti-cancer drugs against colon cancer with less toxicity are to be explored . …”
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The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer by Giuseppe Di Lorenzo, Carlo Buonerba, Raffaele Baio, Eleonora Monteleone, Francesco Passaro, Antonio Tufano, Vittorino Montanaro, Vittorio Riccio, Ilaria Gallo, Francesca Cappuccio, Federica Fortino, Anna Buonocore, Federica Monaco, Antonio Verde, Anna Rita Amato, Oriana Strianese, Ferdinando Costabile, Luca Scafuri

“…Methods: This study validated the REST Questionnaire, a novel fatigue assessment tool, in a sample of 268 adults. …”
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In silico identification of the anticataract target of βB2-crystallin from Phaseolus vulgaris: a new insight into cataract treatment by Sunday Amos Onikanni, Sunday Amos Onikanni, Adewale Oluwaseun Fadaka, Tran Nhat Phong Dao, Tran Nhat Phong Dao, Valens Munyembaraga, Valens Munyembaraga, Vincent Nyau, Nicole Remaliah Samantha Sibuyi, Morenike Grace Ajayi, Nguyen Thi Ai Nhung, Emmanuel Ejiofor, Basiru Olaitan Ajiboye, Basiru Olaitan Ajiboye, Minh Hoang Le, Hen-Hong Chang, Hen-Hong Chang, Hen-Hong Chang

“…The Schrödinger platform was employed to screen bioactive compounds and simulate molecular interactions in order to analyze binding and structural changes.ResultsOur results indicated that these phytochemicals are stable near S175G/H181Q.DiscussionThese findings suggest novel approaches that could potentially be developed into effective anticataract medications through further refinement and additional testing, ultimately resulting in the creation of more potent agents for cataract treatment.…”
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Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart by Camila Munoz, Eunji Lim, Pedro F. Ferreira, Dudley J. Pennell, Sonia Nielles-Vallespin, Andrew D. Scott

“…Methods: Here we introduce a novel STEAM-IVIM sequence incorporating phase cycling to obtain true non-diffusion weighted images (b = 0 s/mm2). …”
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Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study by Zhao Qing, Weiping Li, Zuzana Nedelska, Wenbo Wu, Fangfang Wang, Renyuan Liu, Hui Zhao, Weibo Chen, Queenie Chan, Bin Zhu, Yun Xu, Jakub Hort, Bing Zhang

“…These findings may provide a novel insight of the brain mechanism associated with SN impairment in MCI and indicated a stage specificity of brain-behavior correlation in dementia. …”
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In silico development of a multi-epitope-based vaccine against Burkholderia cepacia complex using reverse vaccinology by Donya Ghorbani, Donya Ghorbani, Masoumeh Beig, Masoumeh Beig, Narjes Noori Goodarzi, Mohammad Sholeh, Mohammad Sholeh, Behzad Shahbazi, Behzad Shahbazi, Yaser Moghaddam, Farzad Badmasti

“…An optimized MEV was explicitly designed for B. multivorans and B. cenocepacia. The novel MEV platform exhibited high binding affinity to immune receptors and favorable molecular docking characteristics. …”
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Evaluation of in-office tooth whitening treatment with violet LED: protocol for a randomised controlled clinical trial by Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Maria Fernanda Setúbal Destro Rodrigues, Ana Eliza Castanho Garrini dos Santos, Marcelo Mendes Pinto, Dácio Antonio Pantano Junior, Aldo Brugnera Jr, Fátima Antonia Aparecida Zanin

“…Introduction In-office tooth whitening treatment using violet light emited diode (LED) (405 nm) is a novel bleaching method that causes less sensitivity while offering the same effectiveness as the gold standard (35% hydrogen peroxide, H2O2). …”
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A dynamic knee function scoring system for anterior cruciate ligament injuries based on normative six-degree-of-freedom gait pattern by Junqiao Li, Yunhe Mao, Tian Lan, Liang Huangfu, Yan Xiong, Jian Li

“…Based on the large sample dataset, a novel 6-DOF scoring system was developed using the dynamic time warping algorithm. …”
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Temperature-Dependent Hydrogen Modulations of Ultra-Scaled a-IGZO Thin Film Transistor Under Gate Bias Stress by Muhammad Aslam, Shu-Wei Chang, Min-Hui Chuang, Yi-Ho Chen, Yao-Jen Lee, Yiming Li

“…A systematic electrical characterization of a-IGZO TFT related to reliability issues, such as positive bias temperature stress (PBTS) and negative bias temperature stress (NBTS), would entitle its integration into novel electronics systems. Unexpectedly, PBTS is characterized by the transition of positive V_th shift to negative V_th shift (ΔV_th, the positive shift followed by the stress and temperature activated negative shift). …”
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In vivo and in silico study of europinidin against streptozotocin-isoproterenol-induced myocardial damage via alteration of hs-CRP/CPK-MB/Caspase-3/Bcl-2 pathways by Khalid Saad Alharbi, Muhammad Afzal, Fahad A. Al-Abbasi, Ehssan Moglad, Salwa D. Al-Qahtani, Naif A. R. Almalki, Faisal Imam, Nadeem Sayyed, Imran Kazmi

“…Abstract Europinidin is a novel anthocyanidin found in the petals of Plumbago europea that exhibits several physiological effects. …”
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Position-based assessment of head impact frequency, severity, type, and location in high school American football by Amirhossein Bagherian, Alireza Abbasi Ghiri, Mohammadreza Ramzanpour, James Wallace, Sammy Elashy, Morteza Seidi, Marzieh Memar

“…Head impact kinematics were input into a head finite element model to determine the 95th percentile of the maximum principal strain and strain rate. Several novel and systematic approaches, such as normalization, binning, and clustering, were introduced and utilized to investigate the frequency and severity of head impacts across the three aforementioned factors while addressing some of the limitations of previous methodologies in the field. …”
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Enhancing aboveground biomass estimation in Moso bamboo forests: the role of on-year and off-year phenomena in remote sensing by Nan Li, Nan Li, Nan Li, Mengyi Hu, Jingyi Xie, Linjia Wei, Tianzhen Wu, Wei Zhang, Wei Zhang, Wei Zhang, Shuangxi Gu, Shuangxi Gu, Shuangxi Gu, Longwei Li, Longwei Li, Longwei Li, Longwei Li

“…In this study, Sentinel-2 remote sensing imagery and plot survey data were selected, a novel change detection algorithm to assess plot level AGB dynamics between 2018 and 2019 was developed, a hierarchical classifier was proposed to map the spatial distributions of on-year and off-year MBFs, and a time series model was developed for estimating the AGB of MBFs to characterize AGB dynamics between November and December. …”
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Capital formation and production of carbon emissions in low-carbon development by E.S. Siregar, S.U. Sentosa, A. Satrianto

“…Low carbon development is a new platform to maintain economic growth through reducing carbon emissions and reducing the use of natural resources, because it was predicted that reducing emissions will increase economic growth while preventing forest loss, improving air quality and living standards, and reducing mortality rates.METHODS: Utilizing a quantitative method, this study integrates a novel viewpoint by combining low-carbon development with related emission factors. …”
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Interpreting machine learning models based on SHAP values in predicting suspended sediment concentration by Houda Lamane, Latifa Mouhir, Rachid Moussadek, Bouamar Baghdad, Ozgur Kisi, Ali El Bilali

“…In this regard, the current study presents a novel framework involving four standalone ML models (extra trees (ET), random forest (RF), categorical boosting (CatBoost), and extreme gradient boosting (XGBoost)) and their combination with genetic programming (GP). …”
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Occurrence, risks, and mitigation of antibiotic pollution in Bangladeshi aquaculture systems by Umma Salma, Anwar Hossain, Md. Shafiujjaman, Yuri Nishimura, Masahiro Tokumura, Rumi Tanoue, Tatsuya Kunisue, Kozo Watanabe, Mohammad Raknuzzaman, Kazushi Noro, Takashi Amagai, Masakazu Makino

“…These findings underscore the urgent need for responsible antibiotic use and effective wastewater management in Bangladeshi aquaculture. By providing novel insights into antibiotic contamination and proposing ozonation as a potentially effective treatment method, this study contributes to mitigating the environmental and public health risks associated with antibiotic pollution.…”
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Phytochemical and Biological Investigations of Crude Extracts of <i>Astragalus pisidicus</i> by Esra Aydemir, Elif Odabaş Köse, Serap Özkaya Gül, Alaaddin Korkut, A. Cansu Kilit, Mehmet Engin Celep, Mustafa Yavuz, R. Süleyman Göktürk, Cengiz Sarikurkcu

“…<b>Conclusions</b>: <i>A. pisidicus</i> elicited apoptotic cell death in cancer cells selectively by the activation of caspases and subsequent DNA fragmentation and may serve as a novel source of an apoptosis-inducing anticancer drug.…”
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Entrepreneurship education for women through project-based flipped learning: The impact of innovativeness and risk-taking on course satisfaction by Seung-chul Yoo, Tu Anh Truong, Kwanghee Jung

“…ORIGINALITY AND VALUE: Our research presents a novel approach to fostering women entrepreneurs in the media sector through PBFL. …”
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Follistatin-Like 1: A Potential Mediator of Inflammation in Obesity by Nengguang Fan, Haiyan Sun, Yufan Wang, Yifei Wang, Lijuan Zhang, Zhenhua Xia, Liang Peng, Yanqiang Hou, Weiqin Shen, Rui Liu, Jiajing Yin, Yongde Peng

“…Follistatin-like 1 (FSTL1) is a novel proinflammatory cytokine that is expressed in adipose tissue and secreted by preadipocytes/adipocytes. …”
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