Thermography in posterior scleritis by A. Kawali, S. Sanjay, P. Mahendradas, R. Shetty

“…</i> </p> <p> <i><b>Conclusion</b>: this article describes a novel technique of the measurement and monitoring of OST. …”
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Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders by Huanxin Ding, Yue Jiang, Qing Sun, Yingchao Song, Shuohui Dong, Qian Xu, Linzehao Li, Chuxuan Liu, Bingjun Li, Hengxuan Jiang, Bichen Peng, Shi Peng, Chumeng Zhang, Jiankang Zhu, Mingwei Zhong, Guangyong Zhang, Xiao Chang

“…Significant genetic correlations were found between these disorders, especially in irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), depression (DEP), and neuroticism (NE). MTAG identify 60 novel pleiotropic loci for IBS and 14 for GERD, predominantly located near genes associated with neurological pathways. …”
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Leveraging machine learning and rule extraction for enhanced transparency in emergency department length of stay prediction by Waqar A. Sulaiman, Charithea Stylianides, Andria Nikolaou, Andria Nikolaou, Zinonas Antoniou, Ioannis Constantinou, Lakis Palazis, Anna Vavlitou, Theodoros Kyprianou, Theodoros Kyprianou, Efthyvoulos Kyriacou, Antonis Kakas, Antonis Kakas, Marios S. Pattichis, Andreas S. Panayides, Constantinos S. Pattichis, Constantinos S. Pattichis

“…To enhance interpretability, a novel rule extraction method for GB model was implemented using relevant important predictors, such as triage acuity, comorbidity scores, and arrival methods. …”
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Lake pulses driven by glacier melting and climate variability by Songtao Ai, Shoukat Ali Shah, Yi Cai, Jiajun Ling, Xinde Chu, Shijin Wang, Yuande Yang, Runchuan Ouyang, Jiachun An, Wolfgang Rack

“…Additionally, we quantify the water flux from BMLV across various timescales, highlighting the substantial contribution of glacial meltwater. This novel study systematically examines the hydrological dynamics of BMLV. …”
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Musician’s dystonia: a perspective on the strongest evidence towards new prevention and mitigation treatments by Joy Grifoni, Joy Grifoni, Valeria Crispiatico, Anna Castagna, Rosa Maria Converti, Marina Ramella, Angelo Quartarone, Teresa L’Abbate, Teresa L’Abbate, Karolina Armonaite, Karolina Armonaite, Luca Paulon, Luca Paulon, Francescaroberta Panuccio, Franca Tecchio

“…To address these challenges, we propose a novel application of the FeeSyCy principle (feedback-synchrony-plasticity), which emphasizes the pivotal role of feedback in guiding inter-neuronal synchronization and plasticity—the foundation of learning and memory. …”
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Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers by Weiping Ji, Ye Fang, Liwei Chen, Yitong Zheng, Yifei Pei, Changqiu Mei, Meng Zhou

“…Moreover, m6A-TEX crosstalk influenced responses to immune checkpoint blockade therapies. Our findings provide novel insights into the role of m6A in TEX regulation and underscore the potential of m6A regulators as biomarkers and therapeutic targets for advancing cancer immunotherapy.…”
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Characteristics of the First Italian Older Adults Vaccinated with an Adjuvanted Respiratory Syncytial Virus (RSV) Vaccine by Alexander Domnich, Andrea Orsi, Piero Luigi Lai, Elvira Massaro, Carlo-Simone Trombetta, Julieta Pastorino, Charlott Roihl, Marianna Pianta, Giancarlo Icardi, Donatella Panatto

“…<i>Conclusions</i>: The first Italian users of the novel RSVPreF3 OA vaccine were represented by high-risk individuals with a comparatively high prevalence of co-morbidities, high uptake of the seasonal respiratory vaccines and high trust in immunization.…”
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The forgotten link: how the oral microbiome shapes childhood growth and development by Raymond Rubianto Tjandrawinata, Nurlinah Amalia, Nurlinah Amalia, Nurlinah Amalia, Yosi Yohanes Putra Tandi, Ariq Fadhil Athallah, Caesaroy Afif Wibowo, Muhammad Reva Aditya, Muhammad Reva Aditya, Athaya Rahmanardi Muhammad, Athaya Rahmanardi Muhammad, Maghfira Rahma Azizah, Maghfira Rahma Azizah, Farizky Martriano Humardani, Ammar Nojaid, Jeremy Alvaro Christabel, Alfi Agnuristyaningrum, Fahrul Nurkolis, Fahrul Nurkolis

“…Furthermore, the potential for microbiome-targeted diagnostics and interventions, including probiotics and prebiotics, offers novel strategies to address stunting. A deeper understanding of these interactions may inform innovative diagnostic tools and therapeutic interventions aimed at mitigating stunting through oral microbiome modulation. …”
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Students Participating as Ambassadors for Research in Kentucky (SPARK): A health equity undergraduate research training program by Ariel A. Arthur, Rebecca L. deLacerda Allen, Fidelis Y. Sesenu, Maxwell A. Groznik, Carrie B. Oser, Justin X. Moore, Jessica R. Thompson, Alexis N. James, Madeline N. Dunfee, Philip A. Kern, Nancy E. Schoenberg

“…The Students Participating as Ambassadors for Research in Kentucky (SPARK) program provides novel health equity research training and targeted mentorship for undergraduates, particularly those from groups underrepresented in the biomedical and behavioral research and workforce. …”
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Enrichment of electrotrophic microorganisms from contrasting shallow-sea hydrothermal environments in bioelectrochemical reactors by Antoine Carissimo, Victoria Comes, Alenica Heussner, Anne-Hélène Prime, Roy E. Price, Gaël Erauso, Pierre-Pol Liebgott, Sven Kerzenmacher, Guillaume Pillot

“…In reactors reproducing the Prony Bay hydrothermal conditions, known facultative methylotrophs, such as Sphingomonas and Methylobacterium, were dominant and appeared to consume formate (provided as carbon source) but no electrons from the cathode.ConclusionThese results provide new insights into the distribution and diversity of electrotrophs in shallow-sea hydrothermal vents and allow the identification of potential novel biocatalysts for Microbial Electrosynthesis whereby electricity and carbon dioxide are converted into value-added products.…”
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Additively manufactured biodegradable Zn metamaterials with tunable Poisson’s ratio and enhanced mechanical properties by Yixuan Shi, Jiaqi Gao, Xuan Li, Zui Tao, Chengcong Huang, Shangyan Zhao, Yuzhi Wu, Youwen Yang, Yabin Yang, Yageng Li, Lu-Ning Wang

“…This study introduces a novel reinforced unit cell, optimised in 3D to retain NPR characteristics while significantly enhancing scaffold strength. …”
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A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor-specificity by Alyssa Synan, Nila C. Wu, Roberto Velazquez, Thomas Gesner, Claude Logel, Kathrin Mueller, Andrew Green, Patrizia Barzaghi-Rinaudo, Quincey Simmons, Samuele Mercan, Xingyi Shi, Xun Li, Vivek Sagar, Joshua Korn, Margaret McLaughlin, William R. Tschantz, Dominik Hainzl, Anthony Malamas, Thomas Huber, Regis Cebe, Kathleen T. Xie, Joseph A. D’Alessio

“…This co-expression profile presents a novel and attractive opportunity for a dual targeting approach using an antibody–drug conjugate (ADC). …”
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Study protocol for a stepped-wedge implementation study investigating the intersectoral collaboration of implementing the TREAT INTERACT intervention for primary school teachers an... by Ane-Marthe Solheim Skar, Ingunn Marie S. Engebretsen, Nora Braathu, Harriet Aber, Harald Bækkelund, Melf-Jakob Kühl, Marjorie Mukisa, Joyce Sserunjogi Nalugya, Norbert Skokauskas, Vilde Skylstad, Tore Wentzel-Larsen, TREAT research consortium, Juliet Ndimwibo Babirye

“…The main objective of the TREAT INTERACT study is to adapt, implement, and evaluate the impact of a novel, intersectoral approach to prevent, identify, refer, and treat mental health problems in children through a user centred task-sharing implementation of the TREAT INTERACT intervention, inspired by the World Health Organization (WHO) Mental Health Gap Action Programme Intervention Guide (mhGAP-IG) for primary school staff in Mbale, Uganda. …”
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Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice by Jing Ye, Ling Liu, Qingwei Ji, Ying Huang, Ying Shi, Lei Shi, Jianfang Liu, Menglong Wang, Yao Xu, Huimin Jiang, Zhen Wang, Yingzhong Lin, Jun Wan

“…The downregulation of IL-22 may be a novel therapeutic strategy to prevent cardiac hypertrophy.…”
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Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma by Liuyan Chen, Lvying Wu, Minying Tang, Yuanhang Cheng, Kuanyin Wang, Jianan Zhang, Wenyi Deng, Lingfeng Zhu, Jin Chen

“…Therefore, it was proposed that DBF4 could serve as a novel potential prognostic biomarker and molecular target for ccRCC. …”
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Deep learning-based algorithm for classifying high-resolution computed tomography features in coal workers’ pneumoconiosis by Hantian Dong, Biaokai Zhu, Xiaomei Kong, Xuesen Su, Ting Liu, Xinri Zhang

“…Conclusion We successfully applied a data augmentation strategy to develop a deep learning model by combining DenseNet with ECA-Net. We used our novel model to automatically classify CWP clinical imaging features from 2D HRCT images. …”
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Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence by Keyu Kong, Baixing Li, Yongyun Chang, Chen Zhao, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Liao Wang, Yansong Qi, Yongsheng Xu, Zanjing Zhai, Peixiang Ma, Huiwu Li

“…Conclusions In summary, this study presents a novel approach superior to recombinant protein alone and holds promise as a new therapeutic strategy for OA. …”
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Neuroprotective Efficacy of <i>Astragalus mongholicus</i> in Ischemic Stroke: Antioxidant and Anti-Inflammatory Mechanisms by Yongjae Hong, Geon Ko, Yeong-Jae Jeon, Hyeon-Man Baek, Juni Lee, Donghun Lee, Jieun Park, Jaehong Kim, Keun-A Chang

“…Motor and cognitive functions were assessed using cylinder, rotarod, and novel object recognition (NOR) tests. AM treatment significantly reduced ischemic damage and improved neurological outcomes in both acute and chronic stages of PTB and tMCAO models. …”
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Targeting accuracy of neuronavigation: a comparative evaluation of an innovative wearable AR platform vs. traditional EM navigation by Marina Carbone, Marina Carbone, Nicola Montemurro, Nicola Montemurro, Nadia Cattari, Nadia Cattari, Martina Autelitano, Martina Autelitano, Fabrizio Cutolo, Fabrizio Cutolo, Vincenzo Ferrari, Vincenzo Ferrari, Emanuele Cigna, Emanuele Cigna, Sara Condino, Sara Condino

“…This study evaluates the benefits of a novel AR platform, VOSTARS, by comparing its targeting accuracy to that of the gold-standard electromagnetic (EM) navigation system, Medtronic StealthStation® S7®. …”
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Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study by Rongrong Xu, Yanping Zhang, Tingting Wu, Hao Liu, Jianhao Peng, Zhanshan Wang, Te Ba, Baorong Zhang, Zhigang Li, Yongjie Wei

“…Our findings reveal VOCs in the road are another key air pollutant and provide novel mechanism for the respiratory effects of TRAP from the perspective of microbiome.…”
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