Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects by Kaitlin Garofano, Vera Mariani, Kameron Rashid, Sumanun Suwunnakorn, Alfateh Sidahmed, Anelia Horvath, Sanjay B. Maggirwar, Travis J. O’Brien, Minoli A. Perera, Michael Whalen, Norman H. Lee

“…In summary, PLPs lack many transcriptomic, molecular and functional features of platelets and possess novel anti-tumorigenic properties. These findings indicate that PLPs may have a potential therapeutic role in targeting and disrupting the oncogenic signaling between platelets and cancer cells, offering a new avenue for anti-cancer strategies.…”
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Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway by Mei Yang, Wangbin Xu, Chaofu Yue, Rong Li, Xian Huang, Yongjun Yan, Qinyong Yan, Shisheng Liu, Yuan Liu, Qiaolin Li

“…ADSCs can be directionally recruited to intestinal tissue, upregulate tight junction proteins, and reduce apoptosis and oxidative stress by inhibiting the p38MAPK signaling pathway. This study provides novel insights into the treatment of intestinal injury. …”
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Downregulation of the immunoproteasome subunit PSMB8 attenuates sepsis-associated acute kidney injury through the NF-κB pathway by Min Li, Wenjia Tong, Chao Dai, Guoping Lu, Danqun Jin, Fang Deng

“…These findings reveal the pathogenic role of PSMB8 in AKI and suggest a novel therapeutic target for the condition.…”
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Fc-binding nanodisc restores antiviral efficacy of antibodies with reduced neutralizing effects against evolving SARS-CoV-2 variants by Jaehyeon Hwang, Soyun Choi, Beom Kyu Kim, Sumin Son, Jeong Hyeon Yoon, Kyung Won Kim, Wonbeom Park, Hyunjoo Choo, Suhyun Kim, Soomin Kim, Seokhyeon Yu, Sangwon Jung, Sang Taek Jung, Min-Suk Song, Sang Jick Kim, Dae-Hyuk Kweon

“…To overcome these challenges, we propose a novel prophylactic strategy involving the intranasal delivery of an antibody in combination with an Fc-binding nanodisc. …”
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Methionine-driven methylation modification overcomes plasmid-mediated high-level tigecycline resistance by Dan Fang, Tianqi Xu, Fulei Li, Yue Sun, Jingyi Sun, Yanqing Yin, Haijie Zhang, Zhiqiang Wang, Yuan Liu

“…Abstract Tigecycline is a last-resort antibiotic to treat complicated infections caused by multidrug-resistant pathogens, while the emergence of plasmid-mediated tet(X) family severely compromises its clinical efficacy. Novel antimicrobial strategies not limited to new antibiotics in pharmaceutical pipeline are urgently needed. …”
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Valproic acid targets IDH1 mutants through alteration of lipid metabolism by Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi, Yue Qin, Alvaro G. Alvarado, Brandon Gruender, Haocheng Qi, Tie Li, Albert Lai, Maria G. Castro, Pedro R. Lowenstein, Matthew C. Garrett, Harley I. Kornblum

“…We conclude that targeting fatty acid metabolism through HDAC inhibition and/or FASN inhibition may be a novel therapeutic opportunity in IDH1 mutant gliomas.…”
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A Broad‐High Temperature Ceramic Capacitor with Local Polymorphic Heterogeneous Structures by Binglong Zheng, Ying Lin, Haibo Yang, Hongmei Jing, Hu Nan, Yifei Wang, Fang‐Zhou Yao, Minquan Wang, Qibin Yuan

“…Herein, this work introduces a novel lineup of lead‐free ceramics with local polymorphic heterogeneous structures, defined by the formula (1‐x)[0.92BaTiO3‐0.08Sr(Mg1/2Ti3/4)O3]‐x(Na0.5Bi0.5)TiO3 (BT‐SMT‐xNBT). …”
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Special Staining of the Liquid-Based Cytopathology Test in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients by Yue Hu, Lin Zheng, Deng Pan, Lei Shao, Xianfa Xu, Yiming Yu, Qidong Zhuang, Zaichun Deng, Zhongbo Chen

“…This study showed that special staining of LCT in BAL fluid may be a novel method for the diagnosis of IPA, and the GMS of LCT had higher sensitivity and specificity, which was superior to PAS.…”
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Characterizing the microbiome recruited by the endangered plant Firmiana danxiaensis in phosphorus-deficient acidic soil by Jiayu Li, Jiayu Li, Jiayu Li, Guangda Tang, Guangda Tang, Hongwei Liu, Xiaoying Luo, Juntao Wang, Juntao Wang, Juntao Wang

“…Taken together, this study provided novel evidence that endangered plants recruited a unique microbiome characterized by Udaeobacter spp. favoring high N habitat. …”
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Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration by Wen Jie Zhu, Jun Liu, Wan Hua Li, Zhi Ying Zhao, Chongquan Huang, Jian Yuan Yang, Hon Cheung Lee, Yong Juan Zhao

“…Our results demonstrate a novel intercellular regulation mechanism of SARM1 and reveal a protective role of healthy tissue against AxD induced by injury or neuroinflammation.…”
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The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

“…Further researches on SCO may help understand its in-depth mechanisms of action and pave the way for the development of novel drugs to prevent and treat various immune-mediated inflammatory disorders as well as hepatic diseases, thereby significantly advancing its innovations and pharmaceutical applications.…”
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A first attempt to model global hydrology at hyper-resolution by B. van Jaarsveld, N. Wanders, E. H. Sutanudjaja, J. Hoch, J. Hoch, B. Droppers, J. Janzing, J. Janzing, J. Janzing, R. L. P. H. van Beek, M. F. P. Bierkens, M. F. P. Bierkens

“…To achieve this, two key limitations are addressed, namely the lack of high-resolution meteorological data and insufficient representation of lateral movement of snow and ice. Thus, a novel meteorological downscaling procedure that better incorporates fine-scale topographic climate drivers is incorporated, and a snow module capable of lateral movement of frozen water resembling glaciers, avalanches, and wind movement is included. …”
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Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction by Qiu-Yang Zhang, Hui-Ying Zhang, Si-Guo Feng, Mu-Di Yao, Jing-Juan Ding, Xiu-Miao Li, Rong Ye, Qing Liu, Jin Yao, Biao Yan

“…Collectively, circSPECC1 emerges as a novel regulator of macrophage-mediated vascular integrity and inflammation. …”
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Rapid Screening and Quantitative Determination of Illegal Phosphodiesterase Type 5 Inhibitors (PDE-5i) in Herbal Dietary Supplements by Thi Oanh Nguyen, Cao-Son Tran, Thi Thu Hang Do, Thi Minh Hoa Nguyen, Quang-Dong Bui, Cao-Tien Bui, Hong-Ngoc Nguyen, Thu-Hien Dang, Viet-Chien Dinh, Thi Anh Huong Nguyen, Thi Hong Hao Le

“…Fourteen PDE-5i including conventional and novel analogous were detected and measured in eighteen food supplements and two formulation ingredient samples.…”
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H-AMR FORGE’d in FIRE. I. Magnetic State Transitions, Jet Launching, and Radiative Emission in Super-Eddington, Highly Magnetized Quasar Disks Formed from Cosmological Initial Cond... by Nicholas Kaaz, Matthew Liska, Alexander Tchekhovskoy, Philip F. Hopkins, Jonatan Jacquemin-Ide

“…This remapping generates magnetic monopoles, which we erase using a novel divergence cleaning approach. Despite the toroidal magnetic field's dominance at large radii, vertical magnetic flux builds up near the event horizon, leading to a magnetic state transition within the inner 200 gravitational radii of the disk. …”
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Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Klebsiella pneumoniae Infections by Yan T, Wang Q, Ma C, Teng X, Gong Z, Chu W, Zhou Q, Liu Z

“…Current therapeutic strategies are no longer able to meet the clinical needs; therefore, there is an urgent need to develop novel therapeutic strategies. This study aimed to evaluate the efficacy of phage therapy in treating bacterial infections.Methods: Isolated phage vB_Kpn_HF0522 and phage morphology were observed using transmission electron microscopy. …”
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HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells by Yoo-Wook Kwon, Hyo-Suk Ahn, Jin-Woo Lee, Han-Mo Yang, Hyun-Jai Cho, Seok Joong Kim, Shin-Hyae Lee, Heung-Mo Yang, Hyun-Duk Jang, Sung Joo Kim, Hyo-Soo Kim

“…These engineered iPSCs might provide a novel translational approach to treat multiple recipients from a limited number of cell donors.…”
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A Quantitative Particle-Based Approach for the Geometallurgical Assessment of Tailings Deposits by Rosie Blannin, Max Frenzel, Raimon Tolosana-Delgado, Kai Bachmann, Alexandra Gomez Escobar, Lucas Pereira, Jens Gutzmer

“…This study explores a novel combination of methods for incorporating particle data, derived from automated mineralogy, into geometallurgical models of tailings deposits to better understand their reprocessing potential and the economic feasibility of re-mining. …”
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Impact of the external knee flexion moment on patello-femoral loading derived from in vivo loads and kinematics by Adam Trepczynski, Paul Kneifel, Mark Heyland, Marko Leskovar, Philippe Moewis, Philipp Damm, William R. Taylor, Stefan Zachow, Georg N. Duda

“…The peak EFM ranged from 3.2 to 5.9 %BW times body height, and was a good predictor of the PF contact force (R2 = 0.95 and 0.88 for sit-stand-sit and squat, respectively).DiscussionThe novel combination of in vivo TF contact forces and internal patellar kinematics enabled a reliable assessment of PF contact forces. …”
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Early selective attention to the articulating mouth as a potential female-specific marker of better language development in autism: a review by Itziar Lozano, Charlotte Viktorsson, Elena Capelli, Teodora Gliga, Valentina Riva, Przemysław Tomalski

“…Ultimately, we aim to target a novel protective candidate of language acquisition, informing tailored interventions that consider sex as an important source of individual variability.…”
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