Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors by Lu Wang, Li Ding, Gang Chen, Zhou Xu, Yanqing Zhang, Bin Deng, Xiya Wang, Yemin Xu, Mengyue Wu, Yinhe Xia, Zhennan Cao, Ruilong Song

“…Systemic administration of surface-engineered T cells resulted in superior infiltration in solid tumors and improved antitumor efficacy by enhancing the secretion of cytotoxic molecules, thereby prolonging the survival of mice bearing colorectal carcinoma and melanoma xenografts.Conclusions Lipid-metabolically remodeled T cells with delayed senescence increase efficacy in tumor microenvironment, highlighting a novel strategy for solid tumor immunotherapy.…”
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GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis by Wen-Ke Wang, Hui-Yu Lin, Che-Hsuan Lin, Hsun-Hua Lee, Yen-Lin Chen, Yu-Hsien Kent Lin, Hui-Wen Chiu, Shry-Ming Sheen-Chen, Yuan-Feng Lin

“…Conclusion Our results not only provide a novel mechanism for TNBC metastasis but also offer a new therapeutic strategy to combat metastatic TNBC via targeting GRK6 activity.…”
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Identification of EGR1 as a Key Diagnostic Biomarker in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Through Machine Learning and Immune Analysis by Wu X, Pan T, Fang Z, Hui T, Yu X, Liu C, Guo Z, Liu C

“…Furthermore, additional cellular experiments and animal model validations confirmed that the expression trends of EGR1 are highly consistent with our analytical findings.Conclusion: Our research has confirmed EGR1 as a key gene in MASLD, providing novel insights into the disease’s pathogenesis and identifying new therapeutic targets for its treatment.Keywords: metabolic dysfunction-associated steatotic liver disease, immune infiltration, machine learning, TF-miRNA-mRNA network, EGR1…”
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Impaired Fibrinolysis in Angiographically Documented Coronary Artery Disease by Adriano Basques Fernandes, Luciana Moreira Lima, Marinez Oliveira Sousa, Vicente de Paulo Coelho Toledo, Rashid Saeed Kazmi, Bashir Abdulgader Lwaleed, Maria das Graças Carvalho

“…Hypofibrinolysis due to high levels of plasminogen activator inhibitor-1 (PAI-1) has been reported in CAD. A novel regulator of fibrinolytic activity, thrombin activatable fibrinolysis inhibitor (TAFI), has attracted attention in recent years. …”
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Measuring above-ground carbon stock using spatial analysis and the InVEST model: application in the Thoria Watershed, India by Zhe Guo, Himani Sharma, Mahesh Jadav, Upeksha Hettiarachchi, Chiranjit Guha, Wei Zhang, Pratiti Priyadarshini, Ruth S Meinzen-Dick

“…This study introduces a novel methodology for evaluating above-ground carbon storage and sequestration in the Thoria watershed, India, using time-series open-access remotely sensed datasets and the InVEST (Integrated Valuation of Environmental Services and Tradeoffs) carbon model. …”
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ANGPTL3 overcomes sorafenib resistance via suppression of SNAI1 and CPT1A in liver cancer by Yang-Hsiang Lin, Cheng-Yi Chen, Hsiang-Cheng Chi, Meng-Han Wu, Ming-Wei Lai, Chau-Ting Yeh

“…In conclusion, we identify a novel association between ANGPTL3, SNAI1 and CPT1A on sorafenib therapeutic response. …”
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Quality of life and clinical correlates in cognitively-able autistic adults: A special focus on sensory characteristics and perceived parental support by Chun-Yi Lin, Yi-Lun Wu, Yi-Ling Chien, Susan Shur-Fen Gau

“…Furthermore, our findings revealed the importance of sensory symptoms and paternal support in QoL of autistic adults, which was a novel finding in this population.…”
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Combined Methods for Diabetic Retinopathy Screening, Using Retina Photographs and Tear Fluid Proteomics Biomarkers by Zsolt Torok, Tunde Peto, Eva Csosz, Edit Tukacs, Agnes M. Molnar, Andras Berta, Jozsef Tozser, Andras Hajdu, Valeria Nagy, Balint Domokos, Adrienne Csutak

“…Therefore our aim was to develop a novel automated method for DR screening. Methods. 52 patients with diabetes mellitus were enrolled into the project. …”
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Ground-Based Polarimetric Remote Sensing of Dust Aerosol Properties in Chinese Deserts near Hexi Corridor by Hua Xu, Zhengqiang Li, Donghui Li, Li Li, Xingfeng Chen, Yisong Xie, Kaitao Li, Cheng Chen, Yuhuan Zhang

“…This is partially due to calcite or hematite in the soil in Minqin or the influence of anthropogenic aerosols containing carbon. Moreover, from our novel polarimetric measurement, the scattering phase function (F11) and degree of linear polarization for incident unpolarized light (-F12/F11) of dust aerosols were also obtained within this deserted area.…”
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A targeted and synergetic nano-delivery system against Pseudomonas aeruginosa infection for promoting wound healing by Chang Ni, Xisheng Li, Haiye Jiang, Shumin Gui, Heng Yin, Xinmin Nie

“…Conclusion: Apt-pM@UCNPmSiO2-Cur-CAZ is a novel targeted nano-delivery system with promising potential in combating Pseudomonas aeruginosa infections, and it may serve as a new therapeutic approach for treating skin wound infections.…”
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Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male by Silvia Migliaccio, Davide Francomano, Roberto Bruzziches, Emanuela A. Greco, Rachele Fornari, Lorenzo M. Donini, Andrea Lenzi, Antonio Aversa

“…This new relationship with skeletal health has relevant implications for the aging male, suggesting OSCA as a novel marker of metabolic and gonadal health status.…”
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SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

“…Manipulating SHP2 expression or its target protein β-catenin may offer a novel approach to TNBC therapy.…”
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Assessment of bacterial positivity rate changes in anesthesia machine internal circuits within recovery rooms and associated risk factors by Shuxiao Zhang, Jingwu Ge, Xuelong Zhou, Yanhong Ji, Junjie Hong, Wensu Xu, Tonglai Li

“…This measure was introduced during the COVID-19 pandemic, in alignment with a novel prevention and control strategy. Methods Using the observational technique, we analyzed anesthesia machines in PACUs between July and September 2022. …”
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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…The non-canonical STING-NF-κB pathway is the crucial signaling pathway that initiates and links apoptosis, pyroptosis, and immunogenic cell death.Conclusions Our study is the first to show that Clo, an FDA-approved drug, induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53-STING-NF-κB signaling pathway, providing a novel strategy for the clinical therapy of melanoma and lung cancer.…”
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Self‐Healing Hyaluronic Acid‐based Hydrogel with miRNA140‐5p Loaded MON‐PEI Nanoparticles for Chondrocyte Regeneration: Schiff Base Self‐Assembly Approach by Wei Zhu, Han Wang, Bin Feng, Guangli Liu, Yixin Bian, Tianhao Zhao, Qi Wang, Xisheng Weng

“…These findings demonstrate that this novel hydrogel (miR140‐5p‐CaP@mSF‐HA‐NB) effectively encapsulates and releases miR140‐5p, exhibits excellent biocompatibility, and promotes enhanced cartilage regeneration in both in vitro and in vivo models. …”
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The Prognostic Significance of the CALLY Index in Ampullary Carcinoma: An Inflammation-Nutrition Retrospective Analysis by Xi P, Huang G, Huang K, Qin D, Yao Z, Jiang L, Zhu Q, He C

“…Pu Xi,1,* Guizhong Huang,1,* Kewei Huang,2,* Dailei Qin,1 Zehui Yao,1 Lingmin Jiang,1 Qi Zhu,1 Chaobin He1 1Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2State Key Laboratory of Oncology in South China, Department of Clinical Laboratory, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chaobin He, Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road E, Guangzhou, Guangdong, 510060, People’s Republic of China, Email hechb@sysucc.org.cnBackground: As a novel inflammatory-nutritional biomarker, the C-reactive protein–albumin–lymphocyte (CALLY) index has demonstrated significant prognostic value in various malignancies. …”
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Microbial phenolic metabolites are associated with better frontal lobe cognition by Inés Domínguez-López, Isabella Parilli-Moser, Anna Vallverdú-Queralt, Anna Tresserra-Rimbau, Cinta Valls-Pedret, Zenaida Vázquez-Ruiz, Olga Castañer, Ramon Estruch, Emili Ros, Rosa M. Lamuela-Raventós

“…This cross-sectional analysis was performed with 200 participants of the PREDIMED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid, enterodiol glucuronide, enterolactone glucuronide, urolithin B glucuronide, and vanillic acid glucuronide), and cognitive function was evaluated with neuropsychological tests. …”
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Assessment of Geriatric Problems and Risk Factors for Delirium in Surgical Medicine: Protocol for Multidisciplinary Prospective Clinical Study by Henriette Louise Möllmann, Eman Alhammadi, Soufian Boulghoudan, Julian Kuhlmann, Anica Mevissen, Philipp Olbrich, Louisa Rahm, Helmut Frohnhofen

“…This collectively raises novel challenges due to higher age heavily impacting treatment. …”
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miR-424-5p Promotes Proliferation, Migration and Invasion of Colorectal Cancer Cells via the Targeting TXNIP/Hippo Axi by Zhang F, Zhu KL, Chen R, Su F

“…Mechanically, TXNIP overexpression significantly inhibited YAP/TAZ transcriptional activity, and the highly expressed miR-424-5p in CRC targeted TXNIP mRNA.Conclusion: The study clarify a novel miR-424-5p/TXNIP/Hippo signaling pathway that facilitated CRC cells proliferation, migration and invasion. …”
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The Ethical Challenges of Gamification in Iran: Uncovering the Dark Side by Mona Jami Pour, Hamideh Binaei

“…This study identifies and prioritizes a set of ethical challenges of gamification to provide a holistic understanding of the darker aspects of implementing this novel approach within the cultural, social, and religious context of Iran. …”
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