Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024 by Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H

“…Contemporary research focal points primarily concentrate on the activation and inhibition pathways of the NLRP3 inflammasome, the exploration of novel HF targets, and the association between HF and mitochondrial function. …”
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BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation by Jialu Xu, Chunyu Li, Rongping Fan, Jiaxin Yin, Lei Xie, Xuemin Peng, Jing Tao, Weijie Xu, Shujun Zhang, Xiaoli Shi, Kun Dong, Xuefeng Yu, Xi Chen, Yan Yang

“…Collectively, these results underscore the significant role of BMAL1 in T2DM-associated cognitive impairment, proposing a novel intervention strategy for individuals exposed to risk factors of T2DM.…”
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Development and usability testing of an online platform for provider training and implementation of cognitive-behavioral therapy guided self-help for eating disorders by Laura D’Adamo, Agatha A. Laboe, Jake Goldberg, Carli P. Howe, Molly Fennig Steinhoff, Bianca DePietro, Marie-Laure Firebaugh, Zafra Cooper, Denise E. Wilfley, Ellen E. Fitzsimmons-Craft

“…This study developed a novel “all-in-one” online platform for disseminating training for mental health providers in cognitive-behavioral therapy guided self-help (CBTgsh) for EDs and supporting its implementation. …”
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COVID-19 Viral Pneumonia Complicated with Acute Pulmonary Embolism: A Descriptive Study by Hoda Salah Darwish, Mohamed Yasser Habash, Waleed Yasser Habash

“…To evaluate acute pulmonary embolism in patients with 2019 novel coronavirus (COVID-19) pneumonia using pulmonary CT angiography. …”
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Preoperative anemia is associated with prolonged hospital stay and increased facility discharges after glioblastoma resection by Ahmad K. Almekkawi, Ammar Adenwalla, James P. Caruso, William H. Hicks, Benjamin Rail, Carlos A. Bagley, Jonathan D. Breshears, Tarek Y. El Ahmadieh, Tomas Garzon-Muvdi, Samuel A. Goldlust

“…As such, we provide a novel analysis that examines associations between preoperative hematologic data and postoperative outcomes following GBM resection.MethodsWe performed a retrospective analysis of patients who underwent GBM resection from January 2016 to December 2020. …”
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Review of Challenges in Performing Real-World Evidence Studies for Nonprescription Products by Maihöfner C, Mallick-Searle T, Vollert J, Kalita P, Sood Sethi V

“…Although case reports and expert opinion should not be discounted, in the absence of other information they provide few actual data. Novel approaches using smartphone apps and artificial intelligence may provide new opportunities to collect RWE for nonprescription products, but these areas of research are in their infancy. …”
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Automated Generation of Multiple-Choice Questions for Computer Science Education Using Conditional Generative Adversarial Networks by Muhammad Shoaib, Ghassan Husnain, Nasir Sayed, Yazeed Yasin Ghadi, Masoud Alajmi, Ayman Qahmash

“…This work presents a novel perspective towards generating automated multiple-choice questions (MCQs)-a task fundamentally different due to the highly dynamic nature of computer science education, which spans several sub-domains. …”
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Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington’s disease phenotypes by Danielle A. Simmons, Sridhar Selvaraj, Tingshuo Chen, Gloria Cao, Talita Souto Camelo, Tyne L.M. McHugh, Selena Gonzalez, Renata M. Martin, Juste Simanauskaite, Nobuko Uchida, Matthew H. Porteus, Frank M. Longo

“…These results demonstrate that BDNF delivery via a novel hPSC-based platform incorporating safety switches could be a safe and effective HD therapeutic.…”
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Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility by Sophie Debaenst, Tamara Jarayseh, Hanna De Saffel, Jan Willem Bek, Matthieu Boone, Ivan Josipovic, Pierre Kibleur, Ronald Y Kwon, Paul J Coucke, Andy Willaert

“…Our results establish zebrafish crispant screening as a robust tool for FBD gene validation, combining skeletal and molecular analyses across developmental stages to uncover novel insights into gene functions in bone biology.…”
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Low Systemic Inflammation Response Index Predicts Good Prognosis in Locally Advanced Pancreatic Carcinoma Patients Treated with Concurrent Chemoradiotherapy by Erkan Topkan, Huseyin Mertsoylu, Ahmet Kucuk, Ali Ayberk Besen, Ahmet Sezer, Duygu Sezen, Yasemin Bolukbasi, Ugur Selek, Berrin Pehlivan

“…Pretreatment SIRI is a novel independent prognosticator that may further enhance the conventional tumor-node-metastases staging system in a more precise prediction of the OS and PFS outcomes of LAPC patients after radical CRT.…”
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CST2 promotes cell proliferation and regulates cell cycle by activating Wnt-β-catenin signalling pathway in serous ovarian cancer by Xiaohua Wang, Sufen Zhao, Yanwei Guo, Chunhui Wang, Shuyu Han, Xingcha Wang

“…Additionally, our findings suggest that CST2 is a promising novel biomarker with potential applications in therapeutic, prognostic, and diagnostic strategies for SOC.…”
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Mechanism of melanoma suppression by Prosopis juliflora derived alkaloids: Apoptosis induction and signaling pathway inhibition by Jasoda Choudhari, Snehal K. Nimal, Shridhar Chougule, Trupti Shinde, N.R. Dhatrak, Gopal C. Kundu, Rajesh N. Gacche

“…This research contributes to the development of novel, safe, and cost-effective agents for metastatic melanoma treatment and as a potential candidate for further cancer research.…”
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Brain near-infrared study of upstairs movement after anterior cruciate ligament reconstruction by Ziyuan Cao, Hao Zhang, Xipeng Wu, Yuxuan Zhang, Jiangli Yu, Wei Li

“…Interventions targeting these brain regions may represent a novel rehabilitation approach. This provides a theoretical basis for incorporating fNIRS into the rehabilitation assessment of patients undergoing ACLR. …”
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β-Caryophyllene and Statins in Bone Fracture Healing – A Narrative Review by Marom H, Khan MA, Darvish N, Tornetta III P, Khoury A, Weil YA, Skelley NW, Allison DC, Meiron S, Ehrmann Barr T

“…While individual effects are supported preclinically, further studies investigating synergies, formulations, and clinical translation are needed to develop this promising novel therapeutic approach for improving fracture repair outcomes.Keywords: bone regeneration, fracture repair, osteoblast, osteogenesis, piezoelectric effect…”
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Computational network analysis of two popular skin cancers provides insights into the molecular mechanisms and reveals common therapeutic targets by Md Sujan Mahmud, Bikash Kumar Paul, Md. Rakibul Hasan, K.M. Tanjida Islam, Imran Mahmud, Shahin Mahmud

“…This computational analysis provides valuable insights into the shared molecular mechanisms of BCC and AK, revealing common pathways and potential therapeutic targets for developing novel treatment strategies and repurposing existing drugs for these prevalent skin cancers. …”
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Effect of recycling on the time- and temperature-dependent mechanical properties of PP/MWCNT composite liner materials by Attila Bata, Péter Gerse, Krisztián Kun, Emese Slezák, Ferenc Ronkay

“…The glass transition temperature of the recycled composites minimally declined, and the Cole-Cole curves broadened yet retained the same character as the unfilled base material, indicating composite homogeneity. A novel method was applied in physical-mechanical measurements to evaluate MWCNT efficiency, predicting its effect across the temperature range typical for hydrogen-powered vehicles and determining the optimal filler content for maximum reinforcement efficiency. …”
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Magnetocaloric Effect in 3D Gd(III)-Oxalate Coordination Framework by Fang-Wen Lv, Mei-Xin Hong, Xue-Ting Wang, Haiquan Tian, Chun-Chang Wang, Xiu-Ying Zheng

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Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…Promotion and encouragement for use of animal-free innovations among the next-generation of scientists, alongside knowledge acquisition and training in the increased capabilities of novel technologies, are fundamental for advancing science and the welfare of animals used for scientific purposes. …”
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Spacer-type tibial osteotomy versus open wedge high tibial osteotomy and unicompartmental knee arthroplasty for Kellgren-Lawrence grade 3–4 medial unicompartmental knee osteoarthri... by Yi Zhang, Xiangzhi Yin, Jinli Chen, Yingze Zhang, Tengbo Yu

“…Abstract Background Spacer-type tibial osteotomy have been proven a novel and effective osteotomy to treat osteoarthritis, while lack of comparison with other surgical methods in younger patients. …”
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Effects of Bilateral M1 Anodal Transcranial Direct Current Stimulation on Pain and Mood in Patients with Non-Specific Chronic Low Back Pain by LU Xuefang, YUAN Peng, DENG Shukun, SU Qiuju, FANG Xiangming, CHEN Gangrui, YANG Han, SHEN Ying

“…ObjectiveTo observe the effects of a novel transcranial direct current stimulation (tDCS) device known as "Halo Sport" on pain and mood in patients with non-specific chronic low back pain (NSCLBP), by specifically targeting the bilateral primary motor cortex (M1 region).MethodsForty-two patients with NSCLBP who were treated in the Rehabilitation Medicine Department of Wuxi People's Hospital Affiliated to Nanjing Medical University from July 2023 to March 2024 were recruited. …”
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