Method for assessing visual saliency in children with cerebral/cortical visual impairment using generative artificial intelligence by Kate Matsunaga, Kleanthis Avramidis, Mark S. Borchert, Mark S. Borchert, Shrikanth Narayanan, Melinda Y. Chang, Melinda Y. Chang

“…Together, these findings would suggest that AI-enabled saliency analysis using eye tracking can objectively quantify abnormalities of lower- and higher-order visual processing in children with CVI. This novel technique has the potential to guide individualized interventions and serve as an outcome measure in future clinical trials.…”
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Noninvasive Assessment of Liver Fibrosis by Magnetic Resonance Elastography in Patients with Rheumatic Disease on Long-Term Methotrexate Treatment by Arindam Nandy Roy, Anjani Kumar Darapureddy, Yarram Ashok Kumar

“…Magnetic resonance elastography (MRE) is a novel, reliable, and noninvasive imaging technique with excellent diagnostic accuracy for staging hepatic fibrosis and cirrhosis. …”
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Clinical relevance of macromolecular complexes involving integrins, potassium and sodium ion channels and the sodium/proton antiporter in human breast cancer by Elena Lastraioli, Jessica Iorio, Francesco Piazza, Chiara Capitani, Michele Santillo, Claudia Duranti, Simonetta Bianchi, Icro Meattini, Scott P. Fraser, Mustafa B. A. Djamgoz, Andrea Becchetti, Annarosa Arcangeli

“…The NHE1/hERG1/β1/nNaV1.5 complex can be considered a novel biomarker and potential target for therapy for BCa patients.…”
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SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…Conclusions Our data deciphered the mechanism of ETV1-mediated M2 macrophage infiltration in the TME of ESCC, which has important implications for the development of novel prognostic and therapeutic targets to optimize current therapies against ESCC.…”
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Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression by Pedro J Romero, Mauro Delorenzi, Amaia Martínez-Usatorre, Laura Ciarloni, Noushin Hadadi, Eric Durandau, Sylvain Monnier-Benoit, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Stephan Morgenthaler, Brian Hashemi, Sahar Hosseinian-Ehrensberger

“…Here we propose the host immune response to the onset of cancer as an alternative approach for early detection of CRC.Methods We perform whole transcriptome analysis of peripheral blood mononuclear cells (PBMCs) isolated from individuals with CRC, precancerous lesions or negative colonoscopy in two independent cohorts using next-generation sequencing.Results We discover and validate novel early CRC RNA biomarkers. Taking into account, and adjusting for, the sensitivity of PBMCs transcriptomes to processing times, we report distinct transcriptomic changes in the periphery related to specific CRC stages. …”
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Population structure and genetic diversity of Toona sinensis revealed by whole-genome resequencing by Lei Wang, Chang Lu, Zhi-Gang Bao, Meng Li, Fusheng Wu, Yi-Zeng Lu, Bo-Qiang Tong, Mei Yu, Yong-Jun Zhao

“…This comprehensive genomic resource provides novel insights into the genetic architecture of T. sinensis, facilitating the elucidation of population structure and supporting future breeding programs. …”
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Visible, near-infrared, and shortwave-infrared spectra as an input variable for digital mapping of soil organic carbon by Vahid Khosravi, Asa Gholizadeh, Radka Kodešová, Prince Chapman Agyeman, Mohammadmehdi Saberioon, Luboš Borůvka

“…This study proposes a novel methodology to employ discrete point spectra as input variable for digital mapping of soil organic carbon (SOC). …”
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CO2 capture performance and foaming mechanism of modified amine-based absorbents: A study based on molecular dynamics by Yucong Ge, Zeyu Wang, Li Yang, Xunxuan Heng, Zhenzhen Zhang, Yi Wang, Fang Liu, Xiao Yang, Bo Liu, Kunlei Liu

“…This study demonstrates the potential of foaming absorbents in CO2 capture and introduces a novel approach to enhancing absorbent performance through interfacial regulation and microstructural optimization, providing important theoretical and practical insights for the development of efficient, low-energy carbon capture technologies.…”
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Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review by Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Zhenhong Liu, Kegang Cao, Kegang Cao

“…., The scope of our review included various aspects of migraine such as ictal and interictal phases; episodic or chronic migraine; menstrual-related migraine; and migraine with or without aura (PROSPERO registration number: CRD42024470268).ResultsA total of 38 studies were ultimately included, highlighting a range of genetic variations, transcriptional abnormalities, protein function alterations, and disruptions in metabolic pathways associated with migraine.These multi-omics findings underscore the pivotal roles played by mitochondrial dysfunction, inflammatory responses, and oxidative stress in the pathophysiology of migraine.ConclusionMulti-omics approaches provide novel perspectives and tools for comprehending the intricate pathophysiology of migraine, facilitating the identification of potential biomarkers and therapeutic targets.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?…”
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New acorane-sesequiterpenes and anti-retinoblastoma constituents from the marine algicolous fungus Trichoderma harzianum NTU2180 guided by molecular networking strategy by Andrea Gu, Fan-Li Lin, Chung-Kuang Lu, Tz-Wei Yeh, Yih-Fung Chen, Ho-Cheng Wu, Tzong-Huei Lee

“…Altogether, the results revealed the novel potential of T. harzianum for developing natural therapeutics against retinoblastomas.…”
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Occupational exposure to flame retardants following production replacement and their effect on thyroid function indicators by Ling Meng, Tingting Guo, Yizhi Liu, Han Wu, Kang An, Xizhu Xu, Yuancheng Li

“…With the ban of commercial Penta-BDEs, Octa-BDEs, and Deca-BDEs, many manufacturers have been transition to the production of novel brominated flame retardants (NBFRs), organophosphate ester flame retardants (OPFRs), and other alternatives. …”
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Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration by Yared Nigusu, Teshome Bekana, Eshetu Chilo, Sisay Teferi, Dereje Oljira Donacho, Dereje Gemeda, Tefera Darge, Abeza Mitiku, Abdi Geda Gedefa, Tadesse Sime, Wubishet Gezimu, Oda Gizaw, Gemechu Tadila, Miressa Bekana, Berhanu Erko

“…Strategies to end the disease as a public health threat, mainly in remote and endemic areas, should consider novel integrated strategies targeting the life cycle of schistosomes besides the large-scale mass drug administration.…”
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Understanding and reducing delayed dental care for early childhood caries: a structural equation model approach by Mengmeng Wang, Yu Zhang, Xiaofei Li, Xin Liu

“…Conclusion The present study developed a novel model to study the ECC treatment delay, elucidated the causal links between the identified variables, and proposed potential intervention strategies to enhance oral health awareness, knowledge, and skills among young children and their parents. …”
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Synthesis and evaluation of antitumor activity of new 4-substituted thieno[3,2-d]pyrimidine and thienotriazolopyrimidine derivatives by Hafez Hend N., El-Gazzar Abdel-Rhman B. A.

“…3-Methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin- 4(1H)-one (2), on treatment with phosphorous oxychoride, affored 4-chloro-3-methyl-6-phenyl -thieno[3,2-d]pyrimidine- 2(3H)-thione (3). A series of novel 6-phenyl-thieno[3,2-d]pyrimidine derivatives 4-9 bearing different functional groups were synthesized via treatment of compound 3 with different reagents. …”
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Detecting glacial lake water quality indicators from RGB surveillance images via deep learning by Zijian Lu, Xueyan Zhu, Jinfeng Li, Mingyue Li, Jie Wang, Wenqiang Wang, Yili Zheng, Qianggong Zhang

“…Our study demonstrates the potential of RGB imagery and deep learning for the long-term, continuous, and high-resolution monitoring of water quality in remote glacial lakes. It presents a novel and cost-effective approach for monitoring these newly emerged and swiftly changing water systems at high altitudes, offering a significant advancement in tracking environmental changes in these critical high mountain regions.…”
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Analytic and clinical validity of thyroid nodule mutational profiling using droplet digital polymerase chain reaction by Vincent L. Biron, Ashlee Matkin, Morris Kostiuk, Jordana Williams, David W. Cote, Jeffrey Harris, Hadi Seikaly, Daniel A. O’Connell

“…Conclusions DdPCR offers a novel and ultrasensitive method of detecting RAS and BRAF mutations from thyroid FNABs. …”
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Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing by Xiaofei Wang, Xiaowen Cheng, Huiling Liu, Xiaohuan Mu, Hao Zheng

“…In this review, we propose utilizing scRNA-seq to more effectively capture the subtle and complex effects of food chemicals, and how they may lead to health problems at single-cell resolution. This novel technique will be valuable to elucidate the underlying mechanism of both the health benefits of food nutrients and the detrimental consequences food toxicants at the cellular level.…”
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Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods by Jakub Dziewic, Maria Przygoda, Joanna Śnieżna, Gabriela Trestka, Kamila Stępień, Sabina Adamczyk, Urszula Zelik, Wojciech Florczak, Wiktoria Domino, Jagienka Włodyka, Karol Dzwonnik

“…It focuses on the most updated treatment modalities, discussing, among other methods, microfracture, osteochondral grafts, autologous chondrocyte implantation (ACI), novel approaches of matrix-assisted autologous chondrocyte transplantation (MACT) and mesenchymal stem cell (MSC) treatments, with especial regard toward the use of platelet-rich plasma (PRP) in relation to other intra-articular injections, namely hyaluronic acid and ozone therapy. …”
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Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy by Claudio Azzolini, Ilaria Stefania Pagani, Cristina Pirrone, Davide Borroni, Simone Donati, Muna Al Oum, Diana Pigni, Anna Maria Chiaravalli, Riccardo Vinciguerra, Francesca Simonelli, Giovanni Porta

“…Individuating the genetic pathways of PVR represents a novel approach to PVR therapies.…”
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Toxicokinetics and tissue dynamics approaches to evaluate the accumulation and elimination of cadmium in black soldier fly larvae by Jie Zhang, Xuelian Xu, Chunyan Tang, Zhihui Shi, Yujia Wan, Huan Qiu, Rui Feng, Fengfeng Li, Fen Zhu

“…Our research focused on the toxicokinetic and the dynamic tissue changes of cadmium (Cd) in BSFL exposed to low (50 mg/kg), moderate (300 mg/kg), and high levels (700 mg/kg) of Cd stress, with the goal of offering a novel perspective on this matter. Our results demonstrated a negative correlation with the BAFkinetic and a positive correlation with the BAF as Cd concentrations increased. …”
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