Thermal radiation effects of ternary hybrid nanofluid flow in the activation energy: Numerical computational approach by Hakeem Ullah, Syed Arshad Abas, Mehreen Fiza, Aasim Ullah Jan, Ali Akgul, Magda Abd El-Rahman, Seham M. Al-Mekhlafi

“…Purpose: This study introduces a novel investigation into heat transport phenomena of ternary hybrid, hybrid and nanofluid containing copper, silver and alumina nanoparticles within two stretchy rotating disks maintaining a constant distance. …”
Get full text

Inhibition of NLRP3 enhances pro-apoptotic effects of FLT3 inhibition in AML by Helene Sieberer, Michela Luciano, Diana Amend, Constantin Blöchl, Anna Eglseer, Alina Steinkellner, Sebastian Rieser, Ancuela Andosch, Philip Steiner, Laura Hummer, Peter W. Krenn, Hieu-Hoa Dang, Christian G. Huber, Fritz Aberger, Theresa Neuper, Jutta Horejs-Hoeck

“…Given the highly heterogeneous nature of AML, there is an urgent need for novel targeted therapies that address the disease from multiple angles. …”
Get full text

Patient‐derived acellular ascites fluid affects drug responses in ovarian cancer cell lines through the activation of key signalling pathways by Katharina Bischof, Andrea Cremaschi, Lena Eroukhmanoff, Johannes Landskron, Lise‐Lotte Flage‐Larsen, Alexandra Gade, Line Bjørge, Alfonso Urbanucci, Kjetil Taskén

“…Combinations of SCDs and novel therapeutics such as trametinib, fludarabine or rapamycin were superior in another third. …”
Get full text

Phenotypic age mediates the associations between platelet-to-lymphocyte ratio and all-cause and cause-specific mortality: A prospective cohort study by Xiangjun Li, Jia Wang, Mengqi Zhang, Yujing Li, Xiaoxuan Li, Jiaqi Zhang, Lihua Zhang, Yixuan Zhang, Zhenkang Qiu

“…Objectives: The platelet-to-lymphocyte ratio (PLR) is a novel indicator of inflammation, but research on the links and mechanisms between the PLR and long-term health conditions is lacking. …”
Get full text

Predicting 28-day all-cause mortality in patients admitted to intensive care units with pre-existing chronic heart failure using the stress hyperglycemia ratio: a machine learning-... by Xiao-han Li, Xing-long Yang, Bin-bin Dong, Qi Liu

“…The stress hyperglycemia ratio (SHR) is a novel metric for accurately assessing stress hyperglycemia, which has been correlated with adverse outcomes in various major diseases. …”
Get full text

A Green Approach to the Production of Hybrid Diindolylmethane-Phenylboronic Acids via a 3MCR: Promising Antineoplasic Molecules by Mónica Zarco Juarez, Joel Omar Martínez, Olivia Noguez Cordova, María Inés Nicolás Vazquez, Teresa Ramírez-Apan, Javier Pérez Flores, René Miranda Ruvalcaba, Gabriel Arturo Arroyo Razo

“…Then, the green approach to the production of three novel hybrid diindolylmethanes-phenylboronic acids via a 3MCR is discussed, which features the following: solventless conditions, the use of microwave irradiation to activate the reactions, the absence of catalyst, and an efficient atom economy. …”
Get full text

Epidemiological and genomic analysis of Acinetobacter baumannii strains from retailed raw meat by Leila Hamze, Raquel Garcia-Fierro, Antoine Drapeau, Pauline François, Andrea Endimiani, Jean-Yves Madec, Marisa Haenni, Vincent Perreten, Agnese Lupo

“…Strains from raw meat were able to acquire genes conferring carbapenem-resistance in vitro.If A. baumannii cannot be considered as a food-borne pathogen, colonization of raw meat can favor the propagation of this species in the community, facilitating the entrance of novel clones in the hospital environment. Once entering hospital settings, susceptible clones could turn into multidrug-resistant lineages under strong selective pressure. …”
Get full text

In Silico Identification of New Anti-SARS-CoV-2 Main Protease (Mpro) Molecules with Pharmacokinetic Properties from Natural Sources Using Molecular Dynamics (MD) Simulations and Hi... by Harrison Onyango, Patrick Odhiambo, David Angwenyi, Patrick Okoth

“…The quick development of novel therapeutic compounds is required in the fight against such pathogenic agents. …”
Get full text

Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced by E. coli by Yunjia Ren, Li Hua, Xiuping Meng, Yue Xiao, Xu Hao, Sheng Guo, Peiyan Zhao, Luowei Wang, Boqi Dong, Yongli Yu, Liying Wang

“…Together, the data may help understand novel roles of PMNs in septic peritonitis.…”
Get full text

Manganese metal organic frame work assisted magnetic ionic liquid single crystal by Naima Sharmin, Md. Jahidul Islam

“…This research focuses on the synthesis and characterization of a Metal-Organic Framework Assisted Ionic Liquid (MOFIL) with the chemical formula of [Mn(Cy)(R)2]R·2H2O; where, Cy is cyclam- (1,4,8,11-tetraazacyclotetradecane) and R is 4-tetradecyloxy benzoate- (4-CH3(CH2)13OC6H4COO-). This novel ionic liquid crystal is synthesized in a multistep process. …”
Get full text

Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease by Tian Meng, Yazhou Zhang, Yuan Ye, Hui Li, Yongsheng He

“…These findings provide new insights for research on Alzheimer's disease in the context of mitochondrial–immune interactions, further exploring the pathogenesis of Alzheimer's disease and offering new perspectives for the clinical development of novel drugs. Conclusions Five mitochondrial and immune biomarkers, i.e., TSPO, HIGD1A, NDUFAB1, NT5DC3, and MRPS30, with diagnostic value in Alzheimer's disease, were screened by machine-learning algorithmic models, which will be a guide for future clinical research of Alzheimer's disease in the mitochondria–immunity-related direction.…”
Get full text

Serum Periostin as a Potential Biomarker in the Evaluation of Allergic Rhinitis: A Pilot Study by Zhu XJ, Lu MP, Chen RX, Mao ZF, Yang YF, Han J, Cheng L

“…Therefore, we aimed to assess the potential of periostin as a novel candidate biomarker for diagnosing and assessing the severity of AR.Patients and Methods: A total of 40 patients with AR and 22 healthy controls, all aged over 18 years, were recruited for the study. …”
Get full text

Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol by Shehzadi Naureen, Hussain Khalid, Islam Muhammad, Bukhari Nadeem Irfan, Khan Muhammad Tanveer, Salman Muhammad, Siddiqui Sabahat Zahra, Rehman Aziz-Ur, Abbasi Muhammad Athar

“…The study describes the development and preliminary validation of a simple reverse-phase chromatographic method for determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2-thiol (OXCPM), in bulk and stressed solution, in order to find out the intrinsic stability behavior of the compound. …”
Get full text

Mono-allelic epigenetic regulation of polycistronic transcription initiation by RNA polymerase II in Trypanosoma brucei by Rudo Kieft, Laura Cliffe, Haidong Yan, Robert J. Schmitz, Stephen L. Hajduk, Robert Sabatini

“…In this study, we found reversible Pol II transcriptional silencing of two adjacent polycistronic gene arrays that correlate with the novel DNA base J modification of the shared promoter region. …”
Get full text

Decreased Levels of Insulin-Regulated Aminopeptidase (IRAP) in Gestational Diabetes Mellitus: A Prospective Cohort Study by Osman Köse, Koray Gök, Elif Köse, Sezen Irmak Gözükara, Abdullah Tüten, Mehmet Sühha Bostancı

“…These findings suggest that low serum IRAP level could be a novel biomarker for the prediction of GDM. …”
Get full text

Enhanced energy storage in electric double-layer capacitors using boron-doped graphene and upcycled carbon quantum dots derived from spent coffee grounds as electrode materials by Grishika Arora, Nuur Syahidah Sabran, Bo Zhang, H.K. Jun

“…In the pursuit of high-efficiency and sustainable energy storage solutions, we investigate a novel electrode material: boron-doped graphene (BG) combined with carbon quantum dots (CQDs) derived from upcycled, medium-roasted local Liberica spent coffee grounds. …”
Get full text

Reagent-free Hyperspectral Diagnosis of SARS-CoV-2 Infection in Saliva Samples by Brandon Saint-John, Alejandro Wolf-Yadlin, Daniel E. Jacobsen, Jamie L. Inman, Serge Gart, Matt Keener, Cynthia McMurray, Antoine M. Snijders, Harshini Mukundan, Jessica Z. Kubicek-Sutherland, James B. Brown

“…To generate these spectral signatures, we present the ProSpectral ^TM V1, a novel, miniaturized hyperspectral platform with high spectral resolution with two mini-spectrometers. …”
Get full text

Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches by Stéphane Auvin, Alexis Arzimanoglou, Mercè Falip, Pasquale Striano, J. Helen Cross

“…The resulting consensus document is based on current evidence from clinical trials and clinical practice and the panel's expert opinion, focusing on new ASMs with novel mechanisms of action, such as highly purified cannabidiol and fenfluramine. …”
Get full text

SS316/CCA laminated metal composite fabricated by additive friction stir deposition: Microstructure and mechanical properties by Ravi Sankar Haridas, Anurag Gumaste, Eric Kusterer, Devin Davis, Supreeth Gaddam, Brandon McWilliams, Kyu C. Cho, Rajiv S. Mishra

“…For the first time, the present study investigated the potential of the novel solid-state additive friction stir deposition (AFSD) technique to additively manufacture an LMC containing SS316 and Fe40Co20Mn20Cr15Si5 complex concentrated alloy (CS-CCA) exhibiting transformation induced plasticity (TRIP). …”
Get full text

3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects by Kai Chen, Fang Wang, Xiumei Sun, Wenwei Ge, Mingjun Zhang, Lin Wang, Haoyu Zheng, Shikang Zheng, Haoyu Tang, Zhengjie Zhou, Guomin Wu

“…This study introduces a novel method for constructing piezoelectric ceramic scaffolds exhibiting outstanding osteogenic, angiogenic, and antibacterial properties under the combined influence of LIPUS, offering a promising treatment strategy for infectious bone defects.…”
Get full text