Investigating the relationship between the immune response and the severity of COVID-19: a large-cohort retrospective study by Riccardo Giuseppe Margiotta, Emanuela Sozio, Fabio Del Ben, Fabio Del Ben, Antonio Paolo Beltrami, Antonio Paolo Beltrami, Daniela Cesselli, Daniela Cesselli, Marco Comar, Alessandra Devito, Martina Fabris, Martina Fabris, Francesco Curcio, Francesco Curcio, Carlo Tascini, Carlo Tascini, Guido Sanguinetti

“…Overall, our study sheds light on the immuno-inflammatory aspects observed in COVID-19 patients prior to vaccination, providing insights for guiding the clinical management of first-time infections by a novel virus.…”
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Phytoreduced gold nanoparticles from vitalmelon promote white adipocyte browning in murine cells by targeting phospholipase D2 by Sun Young Park, He mi Kang, Kangmin Park, Lu Guo, Jin-Woo Oh, Geuntae Park, Nam Jun Kang, Young-Whan Choi

“…These findings suggest that VW-GNPs represent a promising novel therapeutic strategy to combat obesity by modulating adipocyte metabolism and increasing energy expenditure via adipocyte browning.…”
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Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis by Salvatore Dimonte, Paywast Jamal Jalal, Hiwa Abdulrahman Ahmad, Safa Bakr Karim, Taib Ahmed Hama Soor, Salar Ibrahim Ali, Muhammed Babakir-Mina, Francesco Greco

“…The phylogenetic trees for all human coronaviruses with the novel Coronavirus have been built using a several complete amino acid sequences of the four known structural proteins, S (spike), E (envelope), M (membrane), and N (nucleocapsid). …”
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A modern scientific perspective on the flavor and functional properties of diverse teas in traditional cuisine “tea-flavored fish”: From macroscopic quality to microscopic variatio... by Wenxia Wang, Kun Liu, Chunlong Liu, Bei Yang, Hao Dong, Wenzhen Liao, Xingfen Yang, Qi He

“…Furthermore, minor compositional variations were observed in the final product. These findings offer novel insights into the application of modern scientific concepts to elucidate the principles underlying traditional craftsmanship.…”
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Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage by Yoichiro Nakagawa, Takashi Kusayama, Sho Tamai, Yuta Nagamori, Kazutaka Takeuchi, Shuhei Iwaisako, Taishi Tsutsui, Tomoya Kamide, Kouichi Misaki, Soichiro Usui, Kenji Sakata, Mitsutoshi Nakada, Masayuki Takamura

“…We aimed to measure skin sympathetic nerve activity (SKNA), a novel method to estimate stellate ganglion nerve activity, and investigate its association with electrocardiogram (ECG) alterations after SAH. …”
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A land-cover-assisted super-resolution model for retrospective reconstruction of MODIS-like NDVI data across the continental United States by blending Landcover300m and GIMMS NDVI3... by Zhicheng Zhang, Zhenhua Xiong, Xuewen Zhou, Kun Xiao, Wei Wu, Qinchuan Xin

“…This study introduces a novel deep learning-based model, termed the Land-Cover-assisted Super-Resolution SpatioTemporal Fusion model (LCSRSTF), designed to produce biweekly 500-meter MODIS-like data spanning from 1992 to 2010 across the Continental United States (CONUS). …”
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Rapid Adaptation to Prevent Drug Use (RAPD): protocol of a pilot randomized trial to enhance the impact of an evidence-based intervention for youth by Andria B. Eisman, Christine Koffkey, Robert T. Partridge, Suzanne Brown, Bo Kim

“…Aim 2: design and pilot test RAPD (Rapid Adaptation to Prevent Drug use) based on aim 1 findings. RAPD refers to a novel set of implementation strategies designed to enhance the capacity of an existing, widely adopted evidence-based universal prevention curriculum (MMH) to respond to emerging drug issues among youth. …”
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Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer by Giovanni Pecoraro, Ilaria Leone, Silvia Nuzzo, Santiago Negueruela, Giovanni Smaldone, Lorena Buono

“…ResultsWe identified over 6,200 circRNAs, of which 33 were differentially expressed during NED. Among them, a novel circRNA, circPCDH11Y, was highly upregulated during the transition of LNCaP cells from an epithelial to neuroendocrine phenotype, while its levels remained unchanged in DU145 cells. …”
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Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications by Franco Lerzo, Giuseppe Peri, Andrea Doni, Paola Bocca, Fabio Morandi, Angela Pistorio, Anna Maria Carleo, Alberto Mantovani, Vito Pistoia, Ignazia Prigione

“…Long pentraxin PTX3 is a novel inflammatory parameter that could play a protective cardiovascular role by regulating inflammation. …”
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Magnesium extraction of ferronickel slag processed by alkali fusion and hydrochloric acid leaching by Prasetyo A.B., Khaerul A., Mayangsari W., Febriana E., Maksum A., Andinie J., Firdiyono F., Soedarsono J.W.

“…The specific objective is to determine the optimum conditions of magnesium extraction in the process of alkali fusion followed by hydrochloric acid leaching. A novel method for magnesium extraction from ferronickel slag was carried out through reducing silica content followed by acid leaching method. …”
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EV‐Elute: A universal platform for the enrichment of functional surface marker‐defined extracellular vesicle subpopulations by Willemijn S. deVoogt, Rowan Frunt, Raul M. Leandro, Casper S. Triesscheijn, Bella Monica, Ioanna Paspali, Mark Tielemans, Jerney J. J. M. François, Cor W. Seinen, Olivier G. deJong, Sander A. A. Kooijmans

“…Taken together, we developed a novel, easy‐to‐use platform to isolate and functionally compare surface marker‐defined EV subpopulations. …”
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Simultaneous optimization of power factor and thermal conductivity via charge transfer effect and enhanced scattering of phonons in Si80Ge20P1/CoSi2 composites by Runze Shi, Jie Gao, Lei Miao, Chengyan Liu, Ying Peng, Jun-Liang Chen, Huajun Lai, Kun Hu

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Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer by Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, María Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López

“…Cytotoxicity studies showed selective cytotoxicity in tumoral cell lines, especially in the leukaemia cells, where co-encapsulation resulted in an additive pharmacological effect against individually loaded NLC. This novel and natural treatment could open a new therapeutical window in cancer treatment.…”
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A rare intersection: squamous cell carcinoma of the tonsil and the anti-TIF1 syndrome masquerade by Manush Sondhi, Megan Lear, Saleha Dar, Madiha Tariq

“…We present a case of dermatomyositis in a male patient positive for anti-TIF1 antibodies, subsequently diagnosed with squamous cell carcinoma of the tonsil, a novel association not previously documented. Early recognition of such associations is crucial for timely intervention and improved outcomes in these patients. …”
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Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis by Qi Xu, Xiaoyu Feng, Siyuan Qin, Yu Hong, Rui Cui, Jia Liang, Zhuya Xiao, Yuan Li

“…The focus of TNBC clinical trial research has shifted from understanding the biology, such as breast cancer subtyping and genotyping, to novel therapeutic approaches. The major advancement in clinical trials is the switch from late-stage palliative treatment to early preoperative neoadjuvant therapy, as more TNBC cases are discovered at an early stage. …”
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Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases by Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu

“…This study investigates the causal links between variations in mitochondrial protein genes and neurodegenerative diseases, aiming to elucidate their potential contributions to disease progression and identify novel therapeutic strategies. Methods Herein, we utilized data from genome‐wide association studies (GWAS) on mitochondrial proteins and neurodegenerative diseases. …”
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NKX6.3 modulation of mitotic dynamics and genomic stability in gastric carcinogenesis by Jung Hwan Yoon, Jeong-Kyu Kim, Jung Woo Eun, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Won Sang Park

“…The findings suggest that targeting NKX6.3 may offer a novel therapeutic strategy for improving treatment outcomes in gastric cancer by restoring mitotic fidelity and genomic stability. …”
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Skeletal Site-Specific Lipid Profile and Hematopoietic Progenitors of Bone Marrow Adipose Tissue in Patients Undergoing Primary Hip Arthroplasty by Drenka Trivanović, Marko Vujačić, Aleksandra Arsić, Tamara Kukolj, Milica Rajković, Nikola Bogosavljević, Zoran Baščarević, Mirjana Maljković Ružičić, Jovana Kovačević, Aleksandra Jauković

“…These findings might bring forth new inputs for defining BMAT biology and setting novel directions in OA disease investigations.…”
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The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas by Juan Du, Anli Tong, Fen Wang, Yunying Cui, Chunyan Li, Yushi Zhang, Zhaoli Yan

“…Inhibiting multiple pathways might be a novel therapeutic approach for PPGLs.…”
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Microbiological profile and antimicrobial susceptibility of bacteria associated with urinary tract infections in Ukrainian adults by K.S. Barannik, O.V. Ishchenko, R.V. Duka, R.M. Molchanov, D.O. Stepanskyi

“…Antimicrobial susceptibility of Enterobacterales was variable, and the best results were obtained for carbapenems, novel antibiotics (cefiderocol, ceftolozane-tazobactam and ceftazidime-avibactam), aminoglycosides and tigecycline. …”
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