Mechanisms and Production Enhancement Effects of CO₂/CH₄ Mixed Gas Injection in Shale Oil by Xiangyu Zhang, Qicheng Liu, Jieyun Tang, Xiangdong Cui, Shutian Zhang, Hong Zhang, Yinlong Lu, Xiaodong Dong, Hongxing Yan, Mingze Fu, Yuliang Su, Zheng Chen

“…This research offers a theoretical foundation and novel insights into shale oil development.…”
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Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis by Jiaxin Ou, Kangxin Li, Hui Yuan, Shaohua Du, Tingting Wang, Qiannan Deng, Huimei Wu, Weiyan Zeng, Kui Cheng, Kutty Selva Nandakumar

“…Conclusion These findings uncover a novel mechanism in S. aureus-infected wounds, highlighting how the disruption of efferocytosis via the TLR2-MyD88-p38 MAPK-MerTK axis becomes a key force behind impaired healing of wounds. …”
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Inexperienced Evaluator Identification of Hand Ischemia Via Video Processed with Pigment-Enhancing Technology by Max Horowitz, BS, Aygul Iskandarova, MD, Gabriel Yohe, MS, Shihab Rahman, BS, Nicholas Durr, PhD, Aviram M. Giladi, MD, MS

“…Purpose: Eulerian video magnification (EVM)+waveform is a novel video processing software that enhances visualization of tissue perfusion and has been shown to improve hand surgeon identification of ischemia via video alone. …”
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Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi by Mireia Larrosa-Godall, Joshua X. D. Ang, Philip T. Leftwich, Estela Gonzalez, Lewis Shackleford, Katherine Nevard, Rob Noad, Michelle A. E. Anderson, Luke Alphey

“…Urgent efforts are required to develop novel and more efficient strategies for targeted vector control. …”
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Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis by Zebo Zhang, Haiyan Qian, Li Wang, Zhenbo Tao, Keai Cheng, Kaiyue Wang, Yanqing Xie, Lina Zhang

“…This study may deepen our understanding of the potential role of circRNA-miRNA-mRNA regulation network in CAD and suggest novel diagnostic biomarkers and therapeutic targets for CAD.…”
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Combining interictal intracranial EEG and fMRI to compute a dynamic resting-state index for surgical outcome validation by Varina L. Boerwinkle, Kristin M. Gunnarsdottir, Bethany L. Sussman, Sarah N. Wyckoff, Emilio G. Cediel, Belfin Robinson, William R. Reuther, Aryan Kodali, Sridevi V. Sarma

“…IntroductionAccurate localization of the seizure onset zone (SOZ) is critical for successful epilepsy surgery but remains challenging with current techniques. We developed a novel seizure onset network characterization tool that combines dynamic biomarkers of resting-state intracranial stereoelectroencephalography (rs-iEEG) and resting-state functional magnetic resonance imaging (rs-fMRI), vetted against surgical outcomes. …”
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Unveiling the molecular and cellular links between obstructive sleep apnea-hypopnea syndrome and vascular aging by Wei Liu, Le Zhang, Wenhui Liao, Huiguo Liu, Wukaiyang Liang, Jinhua Yan, Yi Huang, Tao Jiang, Qian Wang, Cuntai Zhang, Peifang Wei

“…Taken together, these findings suggest that OSAHS may serve as a novel risk factor for VA and related vascular disorders, and that targeting these features may offer therapeutic potential to mitigate the vascular risks associated with OSAHS.…”
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Nanosensor-based imaging of realtime dopamine release in neurons derived from iPSCs of patients with Parkinson's disease by Nayeon Lee, Dakyeon Lee, Jae Hyeok Lee, Bo Seok Lee, Sungjee Kim, Jae Ho Kim, Sanghwa Jeong

“…Despite its important role in neuronal function, the impact of DA release/uptake on neurochemical imbalances during neuronal development remains unclear. We propose a novel application of near-infrared catecholamine nanosensor (NIRCat) for real-time visualization of DA neurotransmission among neurodegenerative disease cells. …”
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Availability in ECMO Reduces the Failure to Rescue in Patients With Pulmonary Embolism After Major Surgery: A Nationwide Analysis of 2.4 Million Cases by Johannes Diers, MD, Nikolas Baumann, MD, Philip Baum, MD, Konstantin L. Uttinger, MD, Johanna C. Wagner, MD, Peter Kranke, MD, Patrick Meybohm, MD, Christoph-Thomas Germer, MD, Armin Wiegering, MD

“…Postoperative pulmonary embolism (PE) is a rare but potentially life-threatening complication, which can be treated with extracorporeal membrane oxygenation (ECMO) therapy, a novel therapy option for acute cardiorespiratory failure. …”
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Metabolic Blockade-Based Genome Mining of <i>Malbranchea circinata</i> SDU050: Discovery of Diverse Secondary Metabolites by Hu Yang, Xiaowei Luo, Zhuo Shang, Kunlong Li, Jian Cai, Yingying Chen, Longchao Xin, Jianhua Ju

“…This study reports the isolation and identification of four classes of secondary metabolites from wild-type <i>M. circinata</i> SDU050, alongside five additional metabolite classes, including three novel cytochalasins (<b>7</b>–<b>9</b>), obtained from a mutant strain through the metabolic blockade strategy. …”
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Fully integrated wearable control system for micro/nanorobot navigation by Zhanxiang Zhang, Lin Wang, Fengqi Jiang, Shimin Yu, Fengtong Ji, Tianhao Sun, He Zhang, Yanhe Zhu, Hao Chang, Tianlong Li, Jie Zhao

“…AI planner based on machine learning offers adaptive path planning in response to dynamically changing signals to generate magnetic fields for the on-demand manipulation of micro/nanorobots. Such a novel, feasible control strategy was validated in the biological experiment in which cancer cells were targeted and killed by photothermal therapy using micro/nanorobots and integrated control platform. …”
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Analysis and Recommendation of Outdoor Activities for Smart City Users Based on Real-Time Contextual Data by S. R. Mani Sekhar, D. M. Mushtaq Ahmed, G. M. Siddesh

“…This model addresses the dynamic and context-aware nature of Smart Cities by proposing a novel framework for real-time contextual information prediction and personalized outdoor activity suggestions for users. …”
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Identification of Crucial lncRNAs for Luminal A Breast Cancer through RNA Sequencing by Xinjian Jia, Hai Lei, Xuemei Jiang, Ying Yi, Xue Luo, Junyan Li, Yu Chen, Sha Liu, Chengcheng Yang

“…This study could be helpful in unraveling the pathogenesis and providing novel therapeutic strategies for luminal A breast cancer.…”
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Unlocking melanoma Suppression: Insights from Plasma-Induced potent miRNAs through PI3K-AKT-ZEB1 axis by Pradeep Bhartiya, Apurva Jaiswal, Manorma Negi, Neha Kaushik, Eun Ha Choi, Nagendra Kumar Kaushik

“…Although recent targeted and immune-based therapies have improved survival rates by 10–15%, effective melanoma treatment remains challenging. Therefore, novel, combinatorial therapy options such as non-thermal atmospheric pressure plasma (NTP) are being investigated to inhibit and prevent chemoresistance. …”
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Feasibility and acceptability of multiple methods of recording injecting drug use episode data among people who inject drugs in Melbourne, Australia: a pilot evaluation study proto... by Alexis Roth, Peter Higgs, Paul Dietze, Nick Scott, Daniel O’Keefe, Filip Djordjevic, Ashleigh Cara Stewart, Dylan Vella-Horne, Zoe Gleeson, Damian Pavlyshyn, Matthew Gill, Rebekka Petrovic, Ben Cocchiaro

“…The In-The-Moment-Expanded (ITM-Ex) study will evaluate the feasibility and acceptability of multiple novel data collection methods to capture in situ drug injecting data.Methods and analysis ITM-Ex will purposively recruit 50 participants from an existing longitudinal cohort (SuperMIX study) of people who inject drugs in Melbourne, Australia. …”
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Newly identified single-nucleotide polymorphism associated with the transition from nonalcoholic fatty liver disease to liver fibrosis: results from a nested case-control study in... by Yitong Ling, Yu Xuan Yang, Yan Chun Chen, Jing Hao Wang, Dong Ge Feng, Shi Jian Xiang, Xiaoyu Zhang, Jun Lyu, Sha Sha Li

“…Genome-wide association analysis identified nine significant loci, including the novel rs2073080 variant, strongly associated with NAFLD-associated hepatic fibrosis. …”
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Proximal Policy Optimization for Crowd Evacuation in Complex Environments&#x2014;A Metaverse Approach at Krung Thep Aphiwat Central Terminal, Thailand by Sushank Chaudhary, Nitinun Sinpan, Pruk Sasithong, Sunita Khichar, Panithan la-Aiddee, Natt Leelawat, Amir Parnianifard, Suvit Poomrittigul, Lunchakorn Wuttisittikulkij

“…This study introduces a novel dynamic emergency evacuation route generator using the Proximal Policy Optimization (PPO) algorithm within a custom-built 3D simulation environment developed in Unity. …”
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The maternal and newborn health eCohort to track longitudinal care quality: study protocol and survey development by Catherine Arsenault, Katherine Wright, Tefera Taddele, Ashenif Tadele, Anagaw Derseh Mebratie, Firew Tiruneh Tiyare, Rose J. Kosgei, Jacinta Nzinga, Bethany Holt, Irene Mugenya, Emma Clarke-Deelder, Adiam Nega, Dorairaj Prabhakaran, Sailesh Mohan, Nompumelelo Gloria Mfeka-Nkabinde, Londiwe Mthethwa, Damen Haile Mariam, Gebeyaw Molla, Theodros Getachew, Prashant Jarhyan, Monica Chaudhry, Munir Kassa, Margaret E. Kruk

“…The MNH eCohort will answer novel questions to guide health system improvements and to fill data gaps in implementing countries.…”
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LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia by Mihaela Butiulca, Mihaela Butiulca, Lenard Farczadi, Silvia Imre, Silvia Imre, Camil Eugen Vari, Laurian Vlase, Bogdan Cordos, Leonard Azamfirei, Leonard Azamfirei, Alexandra Elena Lazar, Alexandra Elena Lazar

“…The varied use of local anesthetics, as well as the fact that anesthetics can sometimes have low therapeutic indices and numerous adverse drug reactions, makes any novel pharmacokinetics information valuable. The present manuscript describes a pharmacokinetic study of ropivacaine carried out after plane block anesthesia on an animal model, using high sensitivity, accurate, and precise LC-MS/MS bioanalysis. …”
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Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence by Fatma Al-zahraa A. Yehia, Hisham A Abbas, Tarek M. Ibrahim, Basem Mansour, Zuhier A. Awan, Mohammed W. Al-Rabia, Wesam H. Abdulaal, Mustafa Adnan Zeyadi, Solomon Z. Okbazghi, Tarek S. Ibrahim, Wael A. H. Hegazy, Salwa E. Gomaa

“…The rapid emergence of azole resistance in C. albicans, in addition to the limited available antifungal agents, complicates the treatment and emphasizes the urgent need for novel therapeutic options. Efflux-mediated azole resistance is a common resistance mechanism in fluconazole (FLZ)-resistant C. albicans. …”
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