Classification of Epileptic Seizures by Simple Machine Learning Techniques: Application to Animals’ Electroencephalography Signals by Illia Pidvalnyi, Anna Kostenko, Oleksandr Sudakov, Dmytro Isaev, Oleksandr Maximyuk, Oleg Krishtal, Olena Iegorova, Ievgen Kabin, Zoya Dyka, Steffen Ortmann, Peter Langendorfer

“…This paper presents a novel approach using machine learning techniques to detect seizures onset using intracranial electroencephalography (EEG) signals. …”
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PLIN5 contributes to lipophagy of hepatic stellate cells induced by inorganic arsenic by Haomiao Li, Xuri Xie, Tianming Qiu, Jingyuan Zhang, Jie Bai, Guang Yang, Ningning Wang, Xiaofeng Yao, Xiance Sun

“…This research offers a novel perspective on the mechanisms of arsenic-induced HSCs activation and liver lipid metabolism, potentially guiding new strategies for the prevention and treatment of arsenic-related liver diseases.…”
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Energy Poverty and Its Effect on Economic Growth in Türkiye by Yahya Algül

“…Hence, unlike other studies that use energy access rate, this study utilizes per capita household electricity consumption as an indicator of energy poverty, which could provide a more precise evaluation, especially for Türkiye. This introduces a novel viewpoint in the research on energy poverty and economic growth. …”
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Detection and subtyping of Blastocystis sp. in human and animal stool samples using high-resolution melting analysis by Ghodratollah Salehi Sangani, Ahmad Hosseini-Safa, Bibi Razieh Hosseini Farash, Pooria Salehi Sangani, Mehdi Zarean, Elham Moghaddas, Saeid Zoghdar Moghadam, Lida Jarahi, Ali Gholizadeh, Fariba Berenji

“…Abstract Objective This study aimed to investigate the prevalence and subtype distribution of the genus Blastocystis using high-resolution melting curve analysis (HRM), a novel molecular technique. Blastocystis sp., a unicellular, anaerobic, and zoonotic parasite, is commonly found in the digestive tracts of humans and animals. …”
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Combined oven/freeze drying as a cost and energy-efficient drying method for preserving quality attributes and volatile compounds of carrot slices by Zobabalo Progress Mina, Tafadzwa Kaseke, Tafadzwa Kaseke, Tobi Fadiji, Yardjouma Silue, Olaniyi Amos Fawole, Olaniyi Amos Fawole

“…Combined drying represents a novel approach that addresses the shortcomings of conventional methods by balancing energy consumption, cost, and product quality.MethodsThis study evaluated the impact of combining oven drying (OD) with freeze-drying (FD) on drying behavior, energy requirements, costs, enzyme activity, and the physicochemical and sensory properties of dried carrots. …”
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Mutual mediation effects of homocysteine and PCSK9 on coronary lesion severity in patients with acute coronary syndrome: interplay with inflammatory and lipid markers by Ping Jin, Juan Ma, Peng Wu, Yitong Bian, Xueping Ma, Shaobin Jia, Qiangsun Zheng

“…These results highlight the complex interactions between lipid metabolism and inflammation in the pathophysiology of ACS, suggesting that targeting both Hcy and PCSK9 may offer novel therapeutic strategies to mitigate severe coronary lesions among high-risk patients.…”
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Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation by Hermine Counil, Rummenigge Oliveira Silva, Jean‐Michel Rabanel, Charlotte Zaouter, Mohamed Haddad, Mohamed Raâfet Ben Khedher, Davide Brambilla, Tamas Fülöp, Shunmoogum A. Patten, Charles Ramassamy

“…These findings contribute to novel insights into the fate of pEVs following their passage through the BBB in vitro and in vivo, and demonstrate for the first time that pEVs from AD patients affect microglia activity. …”
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Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing by Anitha S, Nandini Robin Nadar, Srividya Shivakumar, Sharma S C, Siddharth P, Surekha Varalakshmi V, Rajesh Lenka, Rajadurai S

“…The synergistic approach results in novel scaffold designs that promote cell functions and mimic the extracellular matrix (ECM) to further enhance wound healing. …”
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Impact of #PCOSweightloss: A global X hashtag analysis study of weight loss narratives in the PCOS community by Munaza Afaq, Kumar Vashisht, Areen Al-Dhoon, Divya Abraham, Atanas G. Atanasov, Maima Matin, Zara Arshad, Rahul Kashyap, Faisal A. Nawaz

“…The prevailing neutral tone showcases a community engaged primarily in an informational exchange, setting the stage for more profound discussions of novel PCOS weight loss strategies.…”
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On-chip non-contact mechanical cell stimulation - quantification of SKOV-3 alignment to suspended microstructures by Sevgi Onal, Maan M. Alkaisi, Volker Nock

“…Cell alignment analysis was performed in a novel, label-free approach by measuring elongation angles of whole cell bodies with respect to micro-piston peripheries. …”
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Assessing patient risk, benefit and outcomes in drug development: an observational study of regorafenib clinical trials by Matt Vassar, Vinay Prasad, Ryan McIntire, Alyson Haslam, Brody Dennis, Chance Bratten, Griffin K Hughes, Andriana M Peña, Chase Ladd, Brooke Gardner, William Nowlin, Reagan Livingston, Jordan Tuia

“…Objective Our objective of this study was to analyse all oncological clinical trials using regorafenib to create a complete risk/benefit profile for the drug.Background Creating a novel chemotherapy is costly both in time and capital spent for drug manufacturers. …”
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Associations of lamplight exposure during sleep and sleep duration with attention-deficit/hyperactivity disorder among preschool children in China by Hui Jiang, Bin Yu, Yuanyang Liu, Hui Gao, Ruijuan Song, Siyue Tan, Shufen Han, Hui Zuo, Hui Zuo, Hui Zuo

“…Also, both sleep duration of <10 hours/day and >12 hours/day increased the likelihood of ADHD. Our novel findings suggest the importance of sleeping habit on the prevention of ADHD. …”
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Near‐room‐temperature π‐conjugated nematic liquid crystals in molecules with a flexible seven‐membered ring structure by Riki Iwai, Hiroyuki Yoshida, Yuki Arakawa, Shunsuke Sasaki, Yuuto Iida, Kazunobu Igawa, Tsuneaki Sakurai, Satoshi Suzuki, Masatoshi Tokita, Junji Watanabe, Gen‐ichi Konishi

“…Recent advancements have extended the scope of NLC molecules to large calamitic π‐conjugated systems, which heralds prospects for novel applications that exploit their superior electronic or optical functionalities in, for example, electric field controlled fluorescence switch devices. …”
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Heterogeneity of cancer-associated fibroblast subpopulations in prostate cancer: Implications for prognosis and immunotherapy by Chen Ding, Jiange Wang, Jie Wang, Jiqiang Niu, Zhikai Xiahou, Zhou Sun, Zhenzhen Zhao, Dongyang Zeng

“…Objective: This study endeavors to elucidate the multifaceted roles of cancer-associated fibroblasts within the tumor microenvironment of prostate cancer, with a focus on their implications for disease prognosis and the potential for novel immunotherapeutic strategies. Methods: Leveraging advanced single-cell RNA sequencing technology, we meticulously characterized the diverse CAF subpopulations within prostate cancer samples. …”
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Impacts of hyperthermic chemotherapeutic agent on cytotoxicity, chemoresistance-related proteins and PD-L1 expression in human gastric cancer cells by Bor-Chyuan Su, Guan-Yu Chen, Chun-Ming Yang, Wei-Ting Chuang, Meng-Chieh Lin, Pei-Ling Hsu, Chu-Wan Lee, Chih-Cheng Cheng, Shih-Ying Wu, Bo-Syong Pan, Hsin-Hsien Yu

“…Conclusion: Taken together, our findings provide insights that may aid in the development of novel therapeutic strategies and enhanced therapeutic efficacy of HIPEC.…”
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Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response by Shamma Almuraikhy, Maha Alser, Khaled Naja, Aisha Al-Malki, Nayef A. Mazloum, Mohamed A. Elrayess

“…Pharmacological or genetic targeting of GATA-3 will allow us to understand the function of GATA-3 in regulating metabolism, insulin signaling, and inflammation. Pyrrothiogatain, a novel small molecule inhibitor of GATA family proteins, has emerged as a promising tool for modulating GATA-3 activity. …”
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Fuzzy Delphi and DEMATEL Approaches in Sustainable Wearable Technologies: Prioritizing User-Centric Design Indicators by Chin-Wen Liao, Kai-Chao Yao, Ching-Hsin Wang, Hsi-Huang Hsieh, I-Chi Wang, Wei-Sho Ho, Wei-Lun Huang, Shu-Hua Huang

“…Wearable innovations for health management have introduced novel approaches to physiological monitoring and early disease detection, contributing to an improved quality of life. …”
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Cross-Sectional Survey to Assess Tobacco and Nicotine Product Use since the Introduction of Heated Tobacco Products in Japan: Wave 2 by Prasad Krishna, Shetty Mandara, Edward Lauren, Kanitscheider Claudia, Marczykowski Felix

“…Providing data on usage patterns is key to assessing the reduced-risk potential of novel tobacco and nicotine products as compared to conventional cigarettes at a population level. …”
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Maximal and Explosive Muscle Strength During Hip Adduction Squeeze and Hip Abduction Press Test Using A Handheld Dynamometer: An Intra- and Inter-tester Reliability Study by Lasse Ishøi, Kristian Thorborg, Laura Krohn, Lars Louis Andersen, Asger Møller Nielsen, MIkkel Bek Clausen

“…An alternative to unilateral testing, is the long-lever hip adduction squeeze test and a novel bilateral hip abduction press test. While promising intra-tester reliability has been found for maximal strength during the long-lever hip adduction squeeze test, inter-tester reliability may be more challenging during both maximal and explosive strength measurements…”
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Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders by Muhammad Waleed Iqbal, Muhammad Shahab, Zakir ullah, Guojun Zheng, Irfan Anjum, Gamal A. Shazly, Atrsaw Asrat Mengistie, Xinxiao Sun, Qipeng Yuan

“…Due to the specificity and selectivity problems of previously discovered inhibitors like dasatinib and bosutinib, we employed an integrated machine learning and structure-based drug repurposing strategy to find novel, targeted, and non-toxic Src kinase inhibitors. …”
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