Trio-based whole-exome sequencing reveals mutations in early-onset high myopia by Ding Chen, Xiu-Feng Huang, Juan Huang, Yi-Ming Guo, Junhan Wei, Lu Ye, Yi-Xin Cai, Jiejing Bi, Fen-Fen Li

“…Subsequently, computational methodologies were employed for functional annotations and pathogenicity assessments.Results Our investigation identified 7 genes and 10 variants associated with HM across 7 families, including a novel mutation in the ARR3 gene (c.139C>T, p.Arg47*) and two mutations in the P3H2 gene (c.1865T>C, p.Phe622Ser and c.212T>C, p.Leu71Pro). …”
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Phasor-FSTM: a new paradigm for multicolor super-resolution imaging of living cells based on fluorescence modulation and lifetime multiplexing by Luwei Wang, Yue Chen, Jiaqing Guo, Xiaoyu Weng, Wei Yan, Jun Song, Tong Ye, Junle Qu

“…These challenges arise from the conflicting requirements of using different fluorophores for multicolor labeling and fluorophores with specific properties for super-resolution imaging. We propose a novel multicolor super-resolution imaging method called phasor-based fluorescence spatiotemporal modulation (Phasor-FSTM). …”
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Transforming Education: Case-Based Integrated Learning Development and Implementation – A Mixed Methods Study at a Private Medical College by RAHILA ALI, AZAM AFZAL, SARA SHAKIL, AMBER SULTAN, SHAZIA BABAR, JAVERIA REHMAN, MARIB GHULAM RASOOL MALIK, MOHAMMAD SHAHZAIB QADIR, SADAF KHAN, SANA SAEED

“…To address these challenges, Case-Based Integrated Learning (CBIL) was developed as a novel approach combining immersive and interactive learning techniques. …”
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Characterizations of Effective Parameters and Circuit Modeling of U-Coupled Hybrid Ring Resonator Band Pass Filter by Atul Varshney, Duygu Nazan Gencoglan, Issa Elfergani, Jonathan Rodriguez, Chemseddine Zebiri, T. Mary Neebha

“…The designed resonator is novel with a hybrid ring which comprises a square ring, a circular ring, and two U-shaped couplers for effective mutual coupling between rings and microstrip feeds. …”
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Dynamic analysis and optimal control of a hybrid fractional monkeypox disease model in terms of external factors by Saima Rashid, Abdul Bariq, Ilyas Ali, Sobia Sultana, Ayesha Siddiqa, Sayed K. Elagan

“…To further bolster the operator’s effectiveness, a number of tests of this novel kind of operator were conducted. We remark that in various time scale domains $$\mathbb {N}_{\ell }$$ , the investigated discrete formulations will be $$\rho ^{2}$$ -nonincreasing or $$\rho ^{2}$$ -nondecreasing by examining $$\rho$$ -monotonicity formulations and the basic properties of the suggested operator. …”
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Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline by Ge Gao, Ge Gao, Caipeng Lin, Caipeng Lin, Ruibo Li, Xi Xie, Hai-Bin Luo, Hai-Bin Luo

“…The study also established an OSF model in Sprague-Dawley rats, induced by ARE, with pathological changes characterized using HE and Masson’s staining, further assessing the impact of ARE on ECM-related protein expression in rat oral tissues through RT-qPCR and Western blot methods.ResultsEGCG effectively suppressed the ARE-induced ECM components while concurrently improving the OSF pathological process in vitro and in vivo.ConclusionThe results indicate that the natural product EGCG effectively suppressed the increased ECM components induced by ARE and concurrently improved the OSF pathological process, indicating that EGCG could be potentially a novel anti-fibrotic candidate drug for the treatment of OSF.…”
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Discrimination of Radiologists' Experience Level Using Eye-Tracking Technology and Machine Learning: Case Study by Stanford Martinez, Carolina Ramirez-Tamayo, Syed Hasib Akhter Faruqui, Kal Clark, Adel Alaeddini, Nicholas Czarnek, Aarushi Aggarwal, Sahra Emamzadeh, Jeffrey R Mock, Edward J Golob

“…ObjectiveThe objective of this study is to provide an alternative method for distinguishing between radiologists by means of captured eye-tracking data such that the raw gaze (or processed fixation data) can be used to discriminate users based on subconscious behavior in visual inspection. MethodsWe present a novel discretized feature encoding based on spatiotemporal binning of fixation data for efficient geometric alignment and temporal ordering of eye movement when reading chest x-rays. …”
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Development of the children's primitive reflex integration assessment scale by Meng Wang, Jing Yu, Hongyao Li, Chongran Zhao, Yichao Li, Xinyue Yang

“…Therefore, in the present study, we describe the development of a measurement scale for PR integration, a novel assessment tool to evaluate PR integration in children.MethodsCombining a literature review, practical experience, and results of specialized group discussions, a preliminary draft of the Children's Primitive Reflex Integration Measurement Scale (CPRIMS) was formulated. …”
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Evaluation of the Diversities in the Inflammatory Responses in Cats With Bacterial and Viral Infections by Songul Erhan, Bengu Bilgic, Ezgi Ergen, Mert Erek, Elif Ergul Ekiz, Mukaddes Ozcan, Mehmet Erman Or, Banu Dokuzeylul, Erdal Matur

“…Conclusion This study revealed significant differences between bacterial and viral infections regarding the fashion of inflammatory responses in cats, and the relevant data will undoubtedly contribute to the management and control of feline infectious diseases, rendering the development of novel therapeutic strategies.…”
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Correlation of irisin with lipid profile in type 2 diabetes mellitus by Wahengbam Diana Devi, Oinam Prabita Devi, Ursula Khwairakpam, Takhelmayum Paras Singh

“…Background: Irisin, a novel adipo-myokine, improves insulin sensitivity by browning of white adipose tissue and also promotes pancreatic β-cell proliferation. …”
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Carbon-carbon triple bond cleavage and reconstitution to achieve aryl amidation using nitrous acid esters by Zi-Ying Wang, Shoujun Wang, Nan-Nan Dai, Yao Xiao, Yu Zhou, Wen-Chan Tian, Dongru Sun, Qiang Li, Yong Wang, Wen-Ting Wei

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Colony Formation, Migratory, and Differentiation Characteristics of Multipotential Stromal Cells (MSCs) from “Clinically Accessible” Human Periosteum Compared to Donor-Matched Bone... by Heather E. Owston, Payal Ganguly, Giuseppe Tronci, Stephen J. Russell, Peter V. Giannoudis, Elena A. Jones

“…Live cell tracking allowed determination of unique morphological and migration characteristics of periosteal MSCs that can be used for the development of novel bone graft substitutes to be preferentially repopulated by these cells.…”
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Global regional and national burden of intracerebral hemorrhage between 1990 and 2021 by Zhao-wei Wang, Mei-ping Wan, Jia-hui Tai, Yong Wang, Min-yi Yin

“…From 1990 to 2021, while absolute ICH cases increased globally, age-standardized incidence rates declined. Our novel geographic analysis revealed East Asia bearing the highest burden, with Eastern Europe showing the highest age-standardized rates. …”
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Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis by Gabriel Romero Liguori, Qihui Zhou, Tácia Tavares Aquinas Liguori, Guilherme Garcia Barros, Philipp Till Kühn, Luiz Felipe Pinho Moreira, Patrick van Rijn, Martin C. Harmsen

“…These data suggest that nanotopography may be a novel tool for inhibiting fibrosis.…”
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The Architecture of BaTiO₃ Nanoparticles Synthesis via Temperature-Responsive for Improved Oil Recovery: A Molecular Dynamics Simulation and Core-Flooding Experimental S... by Surajudeen Sikiru, Hassan Soleimani, Amir Rostami, Leila Khodapanah

“…This shows that the wettability of the rock surface changed from oil-wet to water-wet with the novel application of BaTiO₃ nanoparticles. …”
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Unveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis by Wei B, Wang S, Li S, Gu Q, Yue Q, Tang Z, Zhang J, Liu W

“…Our study explored the novel role of cuproptosis-related genes (CRGs) in AS, focusing on immune cell infiltration and molecular clustering.Methods: By analyzing the peripheral blood gene expression datasets obtained from GSE73754, GSE25101, and GSE11886, we identified the expression patterns of cellular factors and immune infiltration cell related to cuproptosis. …”
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Development and Characterization of Anti-Nitr9 Antibodies by Radhika N. Shah, Ivan Rodriguez-Nunez, Donna D. Eason, Robert N. Haire, Julien Y. Bertrand, Valērie Wittamer, David Traver, Shila K. Nordone, Gary W. Litman, Jeffrey A. Yoder

“…The novel immune-type receptors (NITRs), which have been described in numerous bony fish species, are encoded by multigene families of inhibitory and activating receptors and are predicted to be functional orthologs to the mammalian natural killer cell receptors (NKRs). …”
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Transcriptome integration analysis revealed that miR-103-3p regulates goat myoblast proliferation by targeting FGF18 by Kunyu Li, Yize Song, Yekai Fan, Hui Zhang, Mingxing Chu, Yufang Liu

“…A total of 408 known miRNAs and 86 novel miRNAs were identified, with 32 miRNAs exhibiting differential expression between the two groups. …”
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Identification of Five m6A-Related lncRNA Genes as Prognostic Markers for Endometrial Cancer Based on TCGA Database by Li Shan, Ye Lu, Cheng-Cheng Xiang, Xiaoli Zhu, Er-Dong Zuo, Xu Cheng

“…In this study, we explored the expression profiles of m6A-related lncRNAs of patients with UCEC and identified novel prognostic markers for UCEC. Methods. Gene expression and clinical data were extracted from The Cancer Genome Atlas. …”
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Silencing circ_0043256 inhibited CoCl2-induced proliferation, migration, and aerobic glycolysis in gastric cancer cells by Wenting Ou, Rongjian Tan, Jiawei Zhai, Lijun Sun, Zhenhao Quan, Xianjin Huang, Feipeng Xu, Qingwen Xu, Caijin Zhou

“…Targeting this axis may offer a novel therapeutic approach for treating GC.…”
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