Proinflammatory Tear Cytokines in Human Adenoviral Keratoconjunctivitis and Clinical Eye Severity by Santacruz Valdés C, Ponce-Rosas ER, Jimenez-Martinez MC

“…IL-10 was detected in both eyes, suggesting a possible regulatory counterbalance.Discussion: This study offers novel insights into the pathophysiology of human adenoviral keratoconjunctivitis and its association with clinical data.Plain language summary: Despite the clinical significance of adenoviral keratoconjunctivitis, most studies have concentrated on defining its genotype. …”
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Experimental study on the engineering characteristics of expansive soil improved conjointly using enzyme induced carbonate precipitation and eggshell powder by Mudassir Mehmood, Yuancheng Guo, Yunlong Liu, Lei Wang, Wen Nie, Bantayehu Uba Uge, Sharafat Ali, Chen Xuanyu, Yingao Zhao

“…In this experimental study, a novel approach that combines EICP and eggshell powder (ESP) to strengthen the engineering characteristics of natural expansive soil has been implemented. …”
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Thermal performance analysis of a parabolic trough collector based solar water heater using revolving absorber tube by Rasaiah Naveenkumar, Pradeep Kumar Singh, Manickam Ravichandran, Vinayagam Mohanavel, Rajaraman Venkateshkumar, Ankit Kedia, Sathish Kannan, Manzoore Elahi M. Soudagar

“…In this experimental investigation a novel intermittent rotation absorber tube in PTC for the application of hot water generation were developed and made a comparison between conventional method. …”
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Identification of core biomarkers for tuberculosis progression through bioinformatics analysis and in vitro research by Zhanpeng Chen, Qiong Wang, Quan Ma, Jinyun Chen, Xingxing Kong, Yuqin Zeng, Lanlan Liu, Shuihua Lu, Xiaomin Wang

“…Transcriptomics is a highly effective tool for the development of novel anti-tuberculosis drugs. However, most studies focus only on changes in gene expression levels at specific time points. …”
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Rapid and sensitive detection of Haemophilus influenzae using multiple cross displacement amplification combined with CRISPR-Cas12a-based biosensing system by Xinbei Jia, Wenjian Xu, Fei Xiao, Nan Jia, Xiaolan Huang, Yiqin Zhang, Juan Zhou, Yi Wang, Jun Tai

“…In this study, we established a novel diagnostic method by integrating the CRISPR-Cas12a detection platform with multiple cross-displacement amplification (MCDA), termed the Hi-MCDA-CRISPR assay. …”
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Upregulation of GSTP1 mediated by chimeric TFE3 promotes TFE3-tRCC progression by targeting JNK signaling pathway by Weixu Chen, Mengtong Wu, Lin Du, Changhua Fang, Hao Wang, Wendi Wang, Chengwei Zhang, Hongqian Guo, Gutian Zhang

“…This study aimed to unravel the pathogenic mechanisms and uncover novel therapeutic targets. Methods The transcriptional characterization of TFE3-tRCC was conducted by RNA sequencing on 14 untreated primary TFE3-tRCC patients. …”
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Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics by George S. Biggs, Emma E. Cawood, Aini Vuorinen, William J. McCarthy, Harry Wilders, Ioannis G. Riziotis, Antonie J. van der Zouwen, Jonathan Pettinger, Luke Nightingale, Peiling Chen, Andrew J. Powell, David House, Simon J. Boulton, J. Mark Skehel, Katrin Rittinger, Jacob T. Bush

“…High-content screening approaches to expand the ligandable proteome offer the potential to expedite the discovery of novel chemical probes to study protein function. …”
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Designing smartphone-based cognitive assessments for schizophrenia: Perspectives from a multisite study by Aishwarya Raje, Abhijit R. Rozatkar, Urvakhsh Meherwan Mehta, Ritu Shrivastava, Ameya Bondre, Manaal Amir Ahmad, Anshika Malviya, Yogendra Sen, Deepak Tugnawat, Anant Bhan, Tamonud Modak, Nabagata Das, Srilakshmi Nagendra, Erlend Lane, Juan Castillo, John A. Naslund, John Torous, Soumya Choudhary

“…Thematic analysis reinforces the importance of feedback and data sharing, although this presents a challenge, given the novel nature of smartphone-based cognitive measures that have not yet been standardized or validated.…”
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Uncertainty Inspired Early Autism Spectrum Disorder Screening via Contrastive Image-Viewing Paradigm by Ying Zhang, Yaping Huang, Jiansong Qi, Sihui Zhang, Mei Tian, Yi Tian, Fanchao Meng, Lin Guan, Tianyi Chang

“…Besides, by synthesizing two images with the opposite semantic representations and recruiting ASD and TD subjects aged 2-6, we construct a new CI4ASD dataset, which offers a novel contrastive image-viewing paradigm for better diagnosis of ASD in children. …”
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Foodborne toxin Aflatoxin B1 induced glomerular podocyte inflammation through proteolysis of RelA, downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway by Jie Zhang, Shuang Yang, Baocai Xu, Zihui Qin, Xinyi Guo, Ben Wei, Qinghua Wu, Kamil Kuca, Tushuai Li, Wenda Wu

“…Our findings indicated that ubiquitin-dependent proteolysis of RelA, downregulation of miR-9, and activation of CXCR4/TXNIP/NLRP3 pathway played an essential role in AFB1-induced glomerular podocyte inflammation. Our study revealed a novel mechanism, via RelA, for the control of AFB1’s nephrotoxicity, leading to an effective protection of food safety and public health.…”
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Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice by Brecht Attema, Montserrat A. de la Rosa Rodriguez, Evert M. van Schothorst, Sander Grefte, Guido JEJ. Hooiveld, Sander Kersten

“…Accordingly, regulation by PPARα could be a screening tool to identify novel genes involved in hepatic lipid metabolism. …”
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The first two mitochondrial genomes for the genus Ramaria reveal mitochondrial genome evolution of Ramaria and phylogeny of Basidiomycota by Qiang Li, Lijiao Li, Ting Zhang, Peng Xiang, Qian Wu, Wenying Tu, Zhijie Bao, Liang Zou, Cheng Chen

“…We further found frequent intron loss/gain and potential intron transfer events in Phallomycetidae mitogenomes during the evolution, and the mitogenomes of R. rubella contained a novel intron P44. Phylogenetic analyses using both Bayesian inference (BI) and Maximum Likelihood (ML) methods based on a combined mitochondrial gene dataset obtained an identical and well-supported phylogenetic tree for Basidiomycota, wherein R. cfr. rubripermanens and Turbinellus floccosus are sister species. …”
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Accelerated dynamic light sheet microscopy: unifying time-varying patterned illumination and low-rank and sparsity constrained reconstruction by Marco Tobia Vitali, Alessia Candeo, Andrea Farina, Paolo Pozzi, Alessia Brix, Andrea Bassi, Teresa M Correia

“…Building on this advancement, we now introduce a novel spatio-temporal patterned illumination strategy and volume reconstruction method that incorporates low-rank and sparsity constraints, effectively leveraging the temporal and spatial redundancy present in sequential volumetric acquisitions. …”
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Alginate-Based Hydrogels with Amniotic Membrane Stem Cells for Wound Dressing Application by Fitriani N, Wilar G, Narsa AC, Elamin KM, Wathoni N

“…Nurul Fitriani,1,2 Gofarana Wilar,3 Angga Cipta Narsa,2 Khaled M Elamin,4 Nasrul Wathoni1 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia; 2Pharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, 75119, Indonesia; 3Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, 45363, Indonesia; 4Graduate School of Pharmaceutical Sciences, Kumamoto University, Chuo-ku, Kumamoto, 862-0973, JapanCorrespondence: Nasrul Wathoni, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia, Tel/Fax +6222 842 888888, Email nasrul@unpad.ac.idObjective: Chronic wounds are a common clinical problem that necessitate the exploration of novel regenerative therapies. We report a method to investigate the in vitro wound healing capacity of an innovative biomaterial, which is based on amniotic membrane-derived stem cells (AMSCs) embedded in an alginate hydrogel matrix. …”
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Prevalence and antimicrobial resistance of three clones (ST1223, ST2198, ST2250) of Staphylococcus argenteus clinical isolates in northern Japan by Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Mina Hirose, Kenji Kudo, Masahiko Ito, Nobumichi Kobayashi

“…These isolates had intact haemolysin genes and promoter regions; however, a novel deletion mutation in hlg-component A was detected in some haemolytic and non-haemolytic isolates. …”
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An intraoperative nomogram for predicting secondary margin positivity in breast conserving surgery utilizing frozen section analysis by Cheng Li, Yan Jiang, Xumiao Wu, Yong Luo, Qi Li

“…The optimal threshold was set at 97 points in the nomogram, yielding a sensitivity of 0.66 (0.54-0.77), specificity of 0.80 (0.74-0.85), PPV of 0.56 (0.47-0.64) and NPV of 0.86 (0.82-0. 90) for the training set, and a sensitivity of 0.65 (0.46-0.84), specificity of 0.88 (0.79-0.95), PPV of 0.68 (0.53-0.85) and NPV of 0.87 (0.81-0.93) for the testing set, demonstrating the model’s effectiveness in both sets.ConclusionsThis study successfully developed a novel predictive model for secondary margin positivity applicable to BCS with FSA-assisted excisional biopsy and margin assessment. …”
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Non3 is an essential Drosophila gene required for proper nucleolus assembly by E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin

“…Here, we report the characterization of the Drosophila Non3 (Novel nucleolar protein 3) gene, which encodes a protein homologous to the human Brix domain-containing Rpf2 that has been shown to control ribosomal RNA (rRNA) processing. …”
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Exploring avocado consumption and health: a scoping review and evidence map by Stephen A. Fleming, Tristen L. Paul, Rachel A. F. Fleming, Alison K. Ventura, Megan A. McCrory, Corrie M. Whisner, Paul A. Spagnuolo, Louise Dye, Jana Kraft, Jana Kraft, Nikki A. Ford

“…Blood lipids, nutrient bioavailability, cardiovascular risk, glycemia, and anthropometric variables were the most common outcomes reported across all studies.ConclusionFuture recommendations for novel research include the study of: European, Asian, adolescent or younger, and senior populations; dose–response designs and longer length interventions; dietary compensation; and the need for greater replication. …”
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Enrichment of Cancer‐Associated Fibroblasts, Macrophages, and Up‐Regulated TNF‐α Signaling in the Tumor Microenvironment of CMS4 Colorectal Peritoneal Metastasis by Eirik Høye, Chakravarthi Kanduri, Annette Torgunrud, Susanne Lorenz, Bjørn Edwin, Stein G. Larsen, Åsmund A. Fretland, Vegar J. Dagenborg, Kjersti Flatmark, Christin Lund‐Andersen

“…Targeting CAF‐associated pathways, macrophages, and TNF‐α signaling through NR4A could represent potential novel therapeutic approaches in CMS4 PM.…”
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Mapping decision-making pathways: Determination of intervention entry points for diagnostic tests in suspected serious infection [version 2; peer review: 2 approved] by Raasti Naseem, Sara Pretorius, Nicola Howe, Clare Lendrem, Cameron Williams, Enitan D Carrol, Philip Pallmann

“…Background PROTECT (Platform Randomised evaluation of clinical Outcomes using novel TEChnologies to optimise antimicrobial Therapy) has brought together a team of researchers to design a platform trial to rapidly evaluate and adopt into care multiple diagnostic technologies, bringing immediate benefit to patients. …”
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