Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study by Zhao HW, Liu ST, Wang XJ, Zhang XM, Ma X

“…Understanding the mechanisms of periodontitis, particularly the role of hypoxia in inflammation, is critical for identifying novel therapeutic strategies. This study investigated the effects of the prolyl hydroxylase (PHD) inhibitor DMOG on pro-inflammatory cytokine expression in human periodontal ligament stem cells (hPDLSCs) and examined the involvement of the HIF-1α/YAP signaling path ay in modulating inflammation.Materials and Methods: hPDLSCs were cultured and treated with lipopolysaccharide (LPS) to induce inflammation, followed by DMOG treatment. …”
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Toward measurements of absolute membrane potential in Bacillus subtilis using fluorescence lifetime by Debjit Roy, Xavier Michalet, Evan W. Miller, Kiran Bharadwaj, Shimon Weiss

“…While optical measurement based on Nernstian indicators have been successfully used, they do not provide absolute or precise quantification of MP or its changes. We present a novel, calibrated MP recording approach to address this gap. …”
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Synthesis, characterization, and application of MnFe2O4/FeVO4/modified zeolite nanocomposite as an effective photocatalyst for methylene blue degradation and benzothiophene desulfu... by Shima H. Khabbaz, Ahmad Bagheri, Mehdi Mousavi-Kamazani

“…This study details the synthesis of a novel ternary nanocomposite composed of MnFe2O4, FeVO4, and modified zeolite, achieved through a two-step process. …”
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Determination of Vibration Properties and Reliable Frequency Estimation for Synchronous Vibrations Through Improved Blade Tip Timing Techniques Without a Once-per-Revolution Sensor by Marios Sasakaros, Luca Mann, Markus Schafferus, Manfred Wirsum

“…Specifically, the blades are identified by unique characteristics resulting from manufacturing tolerances, while the blade deflections are calculated through a novel method, which relies on the impeller’s circumferential position. …”
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Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants by Li Yang, Shengyi Liu, M. Eric Schranz, Klaas Bouwmeester

“…Conclusion This study provides novel findings on the evolution of ZAR1 and ZRK immune gene families across a wide range of plant species, suggesting that more potential exceptions can be expected when expanding the list of sequenced genomes from distinct orders. …”
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Polyethylene Glycol Loxenatide (PEX-168) Reduces Body Weight and Blood Glucose in Simple Obese Mice by Yuting Wu, Zeyuan Guo, Junlu Wang, Yong Wang, Daorong Wang, Ying Li, Lihua Zhu, Xiaofang Sun

“…At present, there is a lack of drug treatment for obese patients, so it is needed to find a drug that is effective and has few side effects to treat obesity. PEX-168 is a novel long-acting glucagon-like peptide-1 receptor agonist for T2DM. …”
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Role of Aging in Ulcerative Colitis Pathogenesis: A Focus on ETS1 as a Promising Biomarker by Ni M, Peng W, Wang X, Li J

“…The identified feature genes, particularly ETS1, could serve as novel diagnostic biomarkers for UC. These findings have the potential to enhance the understanding of the age-related mechanisms of UC. …”
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Hybrid Harmony Search Algorithm Integrating Differential Evolution and Lévy Flight for Engineering Optimization by Feng Qin, Azlan Mohd Zain, Kai-Qing Zhou, Norfadzlan Bin Yusup, Didik Dwi Prasetya, Rozita Abdul Jalil, Zaheera Zainal Abidin, Mahadi Bahari, Yusri Kamin, Mazlina Abdul Majid

“…This paper proposes HSA-DELF, a novel hybrid algorithm that combines differential evolution (DE) and Lévy flight (LF) techniques to enhance the performance of HSA. …”
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Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study by Min Liu, Na Yin, Yuhang Zhu, Aili Du, Chunyuan Cai, Pengyuan Leng

“…Sensitivity analyses further confirmed the robustness of these results, with no significant heterogeneity or pleiotropy found.ConclusionThis study furnishes novel causal evidence supporting the potential genetic correlation between the use of lipid-lowering drugs and the incidence of gout as well as urate levels. …”
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Pheromones in Crane Flies: Behaviorally Active Cuticular Compounds in <i>Tipula autumnalis</i> Loew (Diptera: Tipulidae) by Vincas Būda, Violeta Apšegaitė, Laima Blažytė-Čereškienė, Sigitas Podėnas, João Pedro de A. Souza, Paulo H. G. Zarbin, Linas Labanauskas, Tomas Paškevičius, Vilma Baužienė, Sandra Radžiutė

“…Among the semiochemicals, the established stereostructure of (<i>Z</i>, <i>E</i>)-6,9-pentacosadiene and the olfactory/behavioral effects of (<i>R</i>)- and (<i>S</i>)-3-methylheneicosane were novel findings in insects.…”
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Colorectal cancer in Lynch syndrome families: consequences of gene germline mutations and the gut microbiota by Xuexin Wang, Zhijun Zheng, Dongliang Yu, Xiaojue Qiu, Ting Yang, Ruoran Li, Jing Liu, Xin Wang, Peng Jin, Jianqiu Sheng, Nan Qin, Na Li, Junfeng Xu

“…Conclusion This study found the development of CRC in the LS families can be attributed to the combined effects of gene germline mutations as well as the gut microbiota and provided novel insights into the prevention and treatment of CRC in the LS families.…”
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Benzothiazole (BTH) Induced Resistance of Navel Orange Fruit and Maintained Fruit Quality during Storage by Huaying Du, Ying Sun, Rui Yang, Wei Zhang, Chunpeng Wan, Jinyin Chen, İbrahim Kahramanoğlu, Liqin Zhu

“…Recently, a synthetically prepared novel BTH was introduced that elicits the induction of resistance against various diseases of fruits. …”
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Efficient and accurate tobacco leaf maturity detection: an improved YOLOv10 model with DCNv3 and efficient local attention integration by Yi Shi, Hong Wang, Fei Wang, Yingkuan Wang, Jianjun Liu, Long Zhao, Hui Wang, Feng Zhang, Qiongmin Cheng, Shunhao Qing

“…This research presents the tobacco industry with a novel rapid detection instrument for tobacco leaf maturity, endowed with substantial practical utility and broad prospects for application. …”
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Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications by Jialian Wang, Xingyu Tao, Zhengyang Liu, Yuan Yan, Peifeng Cheng, Bin Liu, Huimin Du, Bailin Niu

“…By integrating advancements in high-throughput sequencing technologies, this review provides novel insights into the dual potential of ncRNAs as diagnostic biomarkers and therapeutic targets, offers new ideas for SA-ALI diagnosis and treatment research and highlights potential challenges in clinical translation.…”
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New Technological Knowledge Integration in Industries with Long-Wave Innovation: Case Study of Iran Mining and Mineral Industry by akbar Mohammadi, Nima Garosi Mokhtarzade, Ahmad Jafar nejad

“…The primary aim of this research is to propose a framework aimed at enhancing the technological capabilities of enterprises with long-wave innovation through the integration of novel technological insights.   Methods The method of this research was based on a case study of successful projects in the mining and mineral industries (as an industry with similar characteristics to industries with long-wave innovation). …”
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Multidrug-Resistant Salmonella enterica Serovar Rissen Clusters Detected in Azores Archipelago, Portugal by Leonor Silveira, Miguel Pinto, Joana Isidro, Ângela Pista, Patrícia Themudo, Luís Vieira, Jorge Machado, João Paulo Gomes

“…We also investigated the genetic basis driving the observed multidrug resistance. By integrating 60 novel genomes with all publicly available serovar Rissen genomes, we observed a low degree of genetic diversity within this serovar. …”
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Cranioplasty infection in porous hydroxyapatite: Potential antibacterial properties by Ismail Zaed, Corrado Iaccarino, Francesca Faedo, Laura Grillini, Elisabetta Galassi, Alessandro Dotti, Angelo Nataloni, Francesca Carolina Mannella, Andrea Cardia

“…Introduction: Intensive research is dedicated to the development of novel biomaterials and medical devices to be used as grafts in reconstructive surgery, with the purpose of enhancing their therapeutic effectiveness, safety, and durability. …”
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Three-dimensional linkage analysis with digital PCR for genome integrity and identity of recombinant adeno-associated virus by Tam Duong, Michele Firmo, Chien-Ting Li, Bingnan Gu, Peng Wang

“…In our pursuit of further advancing rAAV analysis, we have developed a novel 3D ddPCR assay with advanced 3D linkage analysis. …”
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Atomic Ni-catalyzed cathode and stabilized Li metal anode for high-performance Li–O2 batteries by Tiansheng Bai, Jiaxian Wang, Hongqiang Zhang, Fengjun Ji, Wei Song, Shenyi Xiao, Dandan Gao, Jingyu Lu, Lijie Ci, Deping Li

“…The working mechanisms of these atomic Ni catalysts are revealed through carefully designed in situ experiments and theoretical calculations. This work provides a novel research paradigm for designing high-performance LOBs that are useable in practical applications.…”
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Advances, challenges and future applications of liver organoids in experimental regenerative medicine by Da Gong, Jiaye Mo, Jiaye Mo, Mei Zhai, Fulin Zhou, Guocai Wang, Shaohua Ma, Xiaoyong Dai, Xiaoyong Dai, Xuesong Deng

“…Liver organoid technology represents a novel in vitro culture system. After several years of refinement, human liver organoids can now accurately replicate the liver’s morphological structure, nutrient and drug metabolism, gene expression, and secretory functions, providing a robust model for liver disease research. …”
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